Abstract:
:The zebrafish, Danio rerio, has become an important model species for examining olfactory system structure and function, yet little is known about developmental changes in olfactory bulb morphology from embryo to adult. The present study examined both normal growth and the effects of deafferentation on the bulb from hatching to adulthood. In young animals, the bulb is small relative to body size and has a higher percentage of its volume occupied by incoming olfactory nerve fibers. Young animals are also more affected by sensory deafferentation. Olfactory rosette removal resulted in more than 50% reductions in laminar volumes, indicating that sensory input is important during periods of rapid development. In addition, three closely related species were examined to compare how differing bulb morphology might influence the effects of bulb manipulation. The cherry barb, Barbus (=Puntius) titteya, and giant danio, Danio aequipinnatus, have larger bulbs and laminar volumes relative to body size than the zebrafish or scissortail rasbora, Rasbora trilineata. Both are also more affected by deafferentation, with at least a 35% reduction in laminar sizes in many of the bulb layers. The studies are discussed in terms of the importance of the olfactory system to each species and are also compared to the effects of sensory manipulations in other animals.
journal_name
Brain Resjournal_title
Brain researchauthors
Poling KR,Brunjes PCdoi
10.1016/s0006-8993(99)02412-9subject
Has Abstractpub_date
2000-02-21 00:00:00pages
135-41issue
1-2eissn
0006-8993issn
1872-6240pii
S0006-8993(99)02412-9journal_volume
856pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::The purpose of this study is to reveal whether the application of immunohistochemical examinations to the peripheral nervous system (PNS) can be a reliable method for the quantitative analysis of the blood-nerve barrier (BNB) and the relationship between restoration of BNB and nerve regeneration. Sciatic nerves in rat...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2003.10.067
更新日期:2004-03-19 00:00:00
abstract::The molecular mechanisms regulating the retrograde axonal transport of nerve growth factor (NGF) are currently unknown. This study identifies some of the signalling events involved. The phosphoinositide 3-kinase (PI3-kinase) inhibitor wortmannin (1 nmol/eye) irreversibly inhibits the amount of 125I-betaNGF retrogradel...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00396-5
更新日期:1998-07-06 00:00:00
abstract::We investigated the effect of adenosine A1 receptors on the release of acetylcholine (ACh) and GABA, and on the intracellular calcium concentration ([Ca2+]i) response in cultured chick amacrine-like neurons, stimulated by KCl depolarization. The KCl-induced release of [3H]ACh, but not the release of [14C]GABA, was pot...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)02155-1
更新日期:2000-01-03 00:00:00
abstract::The effects of recombinant mouse stem cell factor (rmSCF) on paired-pulse facilitation (PPF) and long-term potentiation (LTP) in the mossy fiber (MF)-CA3 pathway were examined in mouse hippocampal slices by recording field EPSPs. When PPF was measured before and 30 min after tetanic stimulation, the initial PPF positi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)02879-2
更新日期:2002-08-16 00:00:00
abstract::We have found that daily subcutaneous injection with a maximum tolerated dose (MTD) of the mGluR2/3 agonist LY379268 (20mg/kg) beginning at 4 weeks dramatically improves the phenotype in R6/2 mice. For example, we observed normalization of motor function in distance traveled, speed, the infrequency of pauses, and the ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2012.07.026
更新日期:2012-09-14 00:00:00
abstract::Long-term potentiation (LTP) can be initiated in CA1, but not in the dentate, region of slices from rats with bilateral subcortical deafferentation at 8 week survival time. At about one week survival time, LTP is present in the CA1 region of all and also in the dentate of about 50% of slices. The results suggest that ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90981-g
更新日期:1990-06-04 00:00:00
abstract::Neurofibrillary tangles (NFTs) are a pathological hallmark of many neurodegenerative diseases including Alzheimer's disease (AD), Parkinson's disease (PD), and frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP17). However, the cellular origin and the consequence of the NFT formation are poorly un...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2004.05.106
更新日期:2004-10-01 00:00:00
abstract::Fluoro-Jade B is known as a high affinity fluorescent marker for the localization of neuronal degeneration during acute neuronal distress. However, one study suggested that fluoro-Jade B stains reactive astroglia in the primate cerebral cortex. In this study, we analyzed the staining of fluoro-Jade B alone or combined...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.05.050
更新日期:2007-01-12 00:00:00
abstract::The ability to detect moving objects is crucial for survival and is a basic capability in the animal kingdom. In the optic tectum, a major center of the visual pathway of birds, neurons have been found that seem to be perfectly suited to encode motion. These cells, located in the stratum griseum centrale, receive a di...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2016.01.022
更新日期:2016-03-15 00:00:00
abstract::In most vertebrates and several insects, melatonin (N-acetyl-5-methoxytryptamine) is synthesized enzymatically from serotonin (5-hydroxytryptamine) by the sequential action of arylalkylamine N-acetyltransferase (NAT) and hydroxyindole-O-methyltransferase (HIOMT). In the freshwater planarian Dugesia japonica, which bel...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01418-3
更新日期:1999-05-29 00:00:00
abstract::Accumulating evidence indicates that extensive microglia activation-mediated local inflammation contributes to neuronal injury in cerebral ischemia. We have previously shown that 4-(2-butyl-6, 7-dichloro-2-cyclopentyl-indan-1-on-5-yl) oxobutyric acid (DCPIB), a potent volume-regulated anion channel (VRAC) inhibitor, s...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2013.10.026
更新日期:2014-01-13 00:00:00
abstract::In order to study the biosynthesis of myelin-associated proteins in Schwann cells, we have induced proliferation of cultured Schwann cells from neonatal rat sciatic nerve by transformation with Simian Virus 40 (SV40). Homogeneous transformed Schwann cell lines were established by single cell cloning. The transformed p...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)91324-2
更新日期:1987-06-23 00:00:00
abstract::Expression of the protein products of the immediate-early genes (IEGs), members of the fos, jun and krox families (Jun, Fos, and Krox, resp.) was investigated in the spinal cord and sensory ganglia (DRG) of normal rats; and following transection of, block of axonal transport in, or electrical stimulation of their peri...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)91699-2
更新日期:1991-12-06 00:00:00
abstract::Development of noradrenergic responses in the rat dorsal motor nucleus of the vagus (DMV) from postnatal days 0 to 22 was studied by a conventional microelectrode technique using brain slice preparations. Between postnatal days 0 and 6, noradrenaline (NA) caused only alpha 1-adrenoceptor-mediated depolarizations. By p...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)91170-0
更新日期:1989-07-31 00:00:00
abstract::Effects of ketamine on glutamate-induced swelling of astrocytes in primary cell culture were studied. Following the exposure to 1 mM glutamate (Glu) for 4 h the intracellular water space (as measured by 3-O-methyl-[14C]glucose uptake) of astrocytes was increased by two-fold concomitant with cell swelling and disappear...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90845-7
更新日期:1989-05-22 00:00:00
abstract::The activities of GABA-transaminase (GABA-T) were examined in several brain regions of amygdala-kindled rats, pretreated either with or without gabaculine, an irreversible GABA-T inhibitor. Histochemical and biochemical studies demonstrated that GABA-T activities decreased significantly in some brain regions 16 h afte...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)90692-x
更新日期:1986-08-27 00:00:00
abstract::The pharmacology of excitatory cholinergic responses in CA1 pyramidal cells was examined in detail using intracellular recording from the hippocampal slice preparation. Acetylcholine (ACh), carbachol, muscarine and pilocarpine depolarized the membrane potential with an associated increase in input resistance. In addit...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90434-7
更新日期:1984-07-09 00:00:00
abstract::Data are presented which show that background electric activity of the human brain is reduced by visual stimulation. Occipital EEG amplitude decreases 5-15% for all frequencies analyzed (0.2-40 Hz) upon pattern stimulation. The reduction is stimulus-specific, i.e. is the strongest for stimuli that activate a large num...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90403-i
更新日期:1991-05-31 00:00:00
abstract::PGP 9.5 is a new cytoplasmic neuron-specific protein structurally and immunologically distinct from neuron-specific enolase. A specific antiserum has now shown that this protein is widely distributed in vertebrate brains and is also present in cells of the human diffuse neuroendocrine system. PGP 9.5 appears to be old...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)90241-x
更新日期:1983-11-14 00:00:00
abstract::Ingestion of 3, 4-methylenedioxymethamphetamine (MDMA) leads to heightened response to sensory stimulation; thus, MDMA is referred to as "ecstasy" because it produces pleasurable enhancement of such sensation. There have been no electrophysiological studies that report the consequences of MDMA on sensory input. The pr...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.09.048
更新日期:2009-12-11 00:00:00
abstract::The effect of different steady-state cocaine concentration maintenance on the microdialysis extraction fraction of cocaine (in situ recovery; Ed) in the medial prefrontal cortex (mPFC) was examined. Male, adult Sprague-Dawley rats anesthetized with chloral hydrate were used. All rats were randomly divided into three g...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00456-z
更新日期:1995-07-24 00:00:00
abstract::The importance of Na+/Ca2+ exchangers in the regulation of the physiological and pathological functions of the nervous system has been widely recognized. In this study, we used primary cultured E14.5 cortical neurons as a model system to study the possible roles of the reverse mode Na+/Ca2+ exchange activity in neurot...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.01.042
更新日期:2008-03-27 00:00:00
abstract::Previous studies have shown that steroid receptor coactivator-1 (SRC-1) is involved in the regulation of Purkinje cell development and motor learning, neural stem cell differentiation and reproductive-related plasticity. It is widely distributed in the adult brain, but the aging-related changes in the brain remain unc...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2011.01.024
更新日期:2011-03-25 00:00:00
abstract::The effects of different adrenoceptor agonists were investigated on mechanically induced Ca2+ waves in astroglial cells in astroglial-neuronal mixed cultures from rat hippocampus. In the initial part of the study some properties of the waves were characterized. The results show that the initiation of the Ca2+ waves wa...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00151-6
更新日期:1998-05-18 00:00:00
abstract::Prenatal exposure to chlorpyrifos (CPF) leads to cognitive impairments in adulthood. The cytoarchitectural basis is unclear. In the present study, we assessed the effects of prenatal CPF exposure on T-maze delayed alternation task and the win-shift/lose-shift responses associated with the morphology of the dorsal hipp...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2012.07.036
更新日期:2012-09-20 00:00:00
abstract::It is known that the execution of the motor response in a simple reaction time (RT) task can be delayed by transcranial magnetic stimulation (TMS). This paper is aimed at determining the site of action where the delay in RT occurs. A delay in RT was obtained only at those TMS sites over the motor cortex contralateral ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)01062-1
更新日期:1997-01-02 00:00:00
abstract::This study is focused to learn about the cellular localization of transcription factors binding to the cAMP response element-CREBs-in the brain of normal rats and in animals subjected to excitotoxic cell damage. For this purpose, CREB-1 and CREB-2 immunoreactivity is examined in the developing and adult rat brain unde...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)01527-2
更新日期:1996-03-11 00:00:00
abstract::The electrophysiological effects of the non-competitive N-methyl-D-aspartate (NMDA) antagonist (+)-MK-801 (MK-801) on nigrostriatal and mesoaccumbal dopaminergic (DA) neurons were evaluated in chloral hydrate-anesthetized rats. MK-801 (0.05-3.2 mg/kg, i.v.) stimulated the firing rates of 14 (74%) of 19 nigrostriatal D...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)91091-r
更新日期:1992-09-11 00:00:00
abstract::Neurons and glial cells can be stained by Lucifer Yellow CH in vitro to produce a Golgi-like fluorescent or electron-dense stain. This technique has been applied successfully in the retinas of several species, rat brain slices and embryonic chick spinal cord. The relative proportion of stained neurons residing in diff...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)90027-2
更新日期:1986-09-24 00:00:00
abstract::The activity of single dopaminergic (DA) neurons (total n = 77) in the midbrain of awake, unrestrained rats was examined. The firing rates and patterns of ventral tegmental area (A10) cells (n = 39) were similar to those of identified DA neurons in anesthetized and paralyzed rats. Unit activity was briefly stimulated ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90988-7
更新日期:1987-03-03 00:00:00