Abstract：
:A microdialysis technique for the in vivo assessment of the monoaminergic and GABAergic levels in the ventromedial (VMN) and paraventricular nuclei (PVN) of the hypothalamus was used in order to examine the activities of neurons that project to the hypothalamic regions and are implicated in the regulation of ingestive behavior and energy balance. Cold exposure increased food intake, as well as the circulating levels of glucose, noradrenaline (NA), 3,5,3'-triiodothyronine, and corticosterone. The dialysate concentrations of NA, dopamine (DA), serotonin (5-HT), and gamma-aminobutyric acid (GABA) in the VMN all decreased after exposure to cold. The changes in extracellular NA, DA, and GABA in the PVN under cold conditions were similar to those in the VMN. NA release in the VMN or PVN was decreased after local electrolytic lesions, which significantly increased food intake. Thus, low activities of noradrenergic axons of neurons terminating in the VMN and PVN may be a good mechanism to induce feeding behavior. Extracellular 5-HT in the PVN was significantly increased, along with a significant decrease in 5-hydroxyindoleacetic acid, in cold-exposed rats, suggesting that serotonergic fibers terminating in the PVM are more closely related to the increases in adrenocortical and thyroid hormone secretion than to food intake. The neuronal activities, indicating that a sympathetic tone is activated on stimulation of the VMN and/or PVN, may be changes in GABAergic and/or serotonergic neurons.
journal_name
Brain Resjournal_title
Brain researchauthors
Ohtani N,Sugano T,Ohta Mdoi
10.1016/s0006-8993(99)01796-5subject
Has Abstractpub_date
1999-09-18 00:00:00pages
6-14issue
1eissn
0006-8993issn
1872-6240pii
S0006-8993(99)01796-5journal_volume
842pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Lavender belongs to the family Labiatae and has a variety of cosmetic uses as well as therapeutic purposes in herbal medicine. The present study was conducted to evaluate the protective effect of lavender oil against brain edema and its possible mechanisms in an experimental model of stroke. Under Laser-Doppler Flowme...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2013.12.019
更新日期：2014-02-22 00:00:00
abstract：:In order to analyze the mechanism of burst discharges intracellular recordings were made from 27 somatosensory thalamic reticular (S-TR) neurons in urethane-anesthetized rats. Burst discharges, composed of 2-7 spikes, were always superposed on a slow depolarization (SD) lasting for 40-60 ms, which appeared only when t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90539-8
更新日期：1989-03-13 00:00:00
abstract：:Afferents to th midbrain dorsal and median raphe nuclei in the rat were studied by means of the horseradish peroxidase (HRP) retrograde transport method. The HRP was given by means of a modified iontophoretic delivery technique. This technique permitted an efficient and localized deposition of a high concentration of ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(77)90291-8
更新日期：1977-02-18 00:00:00
abstract：:Studies evaluating the role of steroid hormones in sexual differentiation of the zebra finch song system have produced complicated and at times paradoxical results, and indicate that additional factors may be critical. Therefore, in a previous study we initiated a screen for differential gene expression in the telence...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.08.002
更新日期：2006-12-18 00:00:00
abstract：:The link between the immunolocalization of apolipoproteins E (apo E) and J (apo J) and the different severity of beta-amyloid deposition in various areas of Alzheimer's disease (AD) and Down's syndrome (DS) brain was analyzed. Both apolipoproteins were found in all types of senile plaques (SPs) in the cerebral cortex,...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00482-6
更新日期：1995-07-10 00:00:00
abstract：:Conscious male adult rats were concussed by a blow to the occiput with a blunt dart, shot from a spring-loaded pistol. Animals were decapitated within 2 sec, brains quickly removed, several brain regions homogenized in cold buffer and radioreceptor assays carried out. There was a 20% increase in binding of [3H]naloxon...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90835-0
更新日期：1981-11-30 00:00:00
abstract：:The expression of the immediate-early gene c-fos was used as a marker of neuronal activity to investigate the cervical spinal interneuron populations involved in the corticomotoneuronal pathway. Adult rats received unilateral kainate injections in the forelimb area of the primary motor cortex. After a survival period ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00365-4
更新日期：1996-06-24 00:00:00
abstract：:An acute pain animal model for fMRI study would provide useful spatial and temporal information for studying the supraspinal nociceptive neuronal responses. The aim of the present study was to investigate whether the nociceptive responses in different brain areas can be differentiated by using functional magnetic reso...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02094-7
更新日期：2001-04-06 00:00:00
abstract：:Suction lesions of the right frontal cerebral cortex in rats induce a period of spontaneous hyperactivity. The hyperactivity, as measured by an increase in running wheel activity begins about one week post-operatively and continues throughout the remainder of a 30-day observation period. The increased activity is acco...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)91303-2
更新日期：1981-08-10 00:00:00
abstract：:An experiment was performed in order to determine the role of the amygdala and surrounding cortex in quiet biting attack elicited from electrical stimulation of the hypothalamus. Stimulation of basal, cortical, and anterior amygdala as well as pyriform cortex and parahippocampal gyrus resulted in a suppression of the ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)90433-3
更新日期：1980-09-15 00:00:00
abstract：:Two selectively bred lines of mice, one responding with high (HA) and the other with low analgesia (LA) to 3 min swims at 20 degrees C were compared with respect to naloxone ability to reverse such swim induced pain threshold elevation. Also, the analgesic effect of morphine was tested in both lines of mice. Naloxone ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91380-6
更新日期：1986-11-05 00:00:00
abstract：:Primary rat neuronal cultures can be preconditioned against ischemic damage by several mechanisms. In the present study we established a new model system in order to characterize the "time window of protection' obtained by preconditioning of neurons with adenosine. Ischemia was simulated by exposure of the cultures to...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)00939-0
更新日期：1996-11-25 00:00:00
abstract：:Tinnitus, the perception of a phantom sound, is a common consequence of damage to the auditory periphery. A major goal of tinnitus research is to find the loci of the neural changes that underlie the disorder. Crucial to this endeavor has been the development of an animal behavioral model of tinnitus, so that neural c...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2012.03.044
更新日期：2012-11-16 00:00:00
abstract：:Intracerebroventricular (i.c.v.) infusion of sodium in rats increases cerebrospinal fluid (CSF) [Na], mimicking the effects of a high salt diet in salt-sensitive strains and causing sympathetic hyperactivity and a pressor response that are mediated via both an endogenous brain ouabainlike substance (OLS) and the brain...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.06.056
更新日期：2004-09-24 00:00:00
abstract：:The aim of the present study was to develop a model culture system for the study of factors controlling regeneration of axons from injured adult mammalian central nervous system. We show, for the first that retinal ganglion cells (RGC) dissociated from adult rat retina, regrow processes in vitro over long distances un...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(88)90204-0
更新日期：1988-07-01 00:00:00
abstract：:The action of 5-hydroxytryptamine (5-HT) via the 5-HT1A receptor on dissociated rat dorsal raphe neurons was characterized under the whole-cell mode by using the nystatin-perforated patch-clamp technique. Under voltage-clamp conditions, 5-HT induced an inwardly rectifying K+ current (I5-HT) in a concentration-dependen...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)01141-9
更新日期：1997-01-16 00:00:00
abstract：:A review of the available literature reveals that proliferation of ependyma occurs during embryological and early postnatal periods of development. Turnover, however, declines significantly during postnatal life and only low levels of residual activity persist into adulthood under normal conditions. In some regions of...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/0165-0173(85)90016-5
更新日期：1985-04-01 00:00:00
abstract：:The technique of intracranial microdialysis was used to investigate the effects of aging on the striatal dopaminergic system of the anesthetized Fischer 344 rat. Microdialysis probes were implanted into the striatum of young (2-8 months) and aged (24-28 months) urethane anesthetized rats. Striatal dialysate levels wer...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)01095-6
更新日期：1999-01-16 00:00:00
abstract：:Preganglionic sympathetic neurons were labelled by retrograde transport of horseradish peroxidase, while catecholamine axon varicosities were marked by the uptake of 5-hydroxydopamine in the intermediolateral nucleus of the rat. The direct synaptic contacts from the catecholamine axons to the preganglionic sympathetic...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90246-5
更新日期：1986-08-20 00:00:00
abstract：:Intracranial microdialysis was used to measure dopamine (DA) release in the ventrolateral neostriatum of freely moving rats before and after unilateral tactile stimulation was applied to the orofacial region. Several behavioral parameters which have been linked to changes in nigrostriatal DA transmission (scanning, or...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90842-j
更新日期：1991-07-12 00:00:00
abstract：:In the present studies, we have evaluated the effects of N-[4-(2-¿[(3-Chlorophenyl)methyl]amino¿ethyl)phenyl]-2-thiophenecarbo ximidamide dihydrochloride (ARL 17477) on recombinant human neuronal NOS (nNOS) and endothelial NOS (eNOS). We then carried out pharmacokinetic studies and measured cortical nitric oxide synth...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02471-9
更新日期：2000-07-21 00:00:00
abstract：:Endogenous acetylcholine (ACh) release from rat striatal slices was measured by a chemiluminescent method. Several opiate agents were tested for their ability to modulate ACh release evoked by potassium ions (K+) or glutamic acid (GLU). Morphine, [D-Ala2,Gly(0l)5]-enkephalin (DAGO), [D-Ala2,D-Leu5]-enkephalin (DADLE) ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91633-r
更新日期：1990-07-16 00:00:00
abstract：:Reward anticipation is associated with activity in the dopaminergic midbrain as well as the ventral striatum, amygdala, and medial prefrontal cortex. Dopaminergic neuromodulation declines with age, suggesting that incentive processing should also undergo age-related change. However, the literature is mixed, perhaps re...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2014.09.063
更新日期：2015-07-01 00:00:00
abstract：:Responses of subthalamic neurons (STN) to the iontophoretic application of glutamate (Glu), acetylcholine (ACh) and GABA were studied in rats 2 or 3 weeks following bilateral decortication, and were compared to those obtained in normal animals. All the cells recorded in lesioned rats showed a decrease in their spontan...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90077-1
更新日期：1987-02-17 00:00:00
abstract：:Neurofilaments were assembled in vitro from the high speed supernatant of mammalian CNS homogenate in a disassembly buffer containing 4-morpholine-ethane sulfonic acid, MgCl2 and EGTA at 4 degrees C in the presence of 4 M glycerol. The assembled neurofilaments were depolymerized by dialysis against the disassembly buf...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(87)80010-0
更新日期：1987-07-01 00:00:00
abstract：:An apparent binding activity of [3H]glutathione was examined by using synaptic membrane preparations of the rat brain. The activity was found to be more than two times as high at 30 degrees C as that found at 2 degrees C. At 2 degrees C, the apparent binding sites consisted of a single component with a Kd of 0.77 micr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90524-0
更新日期：1988-10-25 00:00:00
abstract：:Microtubule organization in type I hair cells has been investigated during the synaptogenesis of vestibular receptors in mammals. The different steps in the maturation of the synapse between the hair cell and the nerve chalice were: a slight symmetrical membrane densification; the appearance of synaptic bodies alongsi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(86)90161-6
更新日期：1986-02-01 00:00:00
abstract：:Rabbit retina was used as a model to study the possible role of taurine in the retina. The taurine-synthesizing enzyme, cysteine sulfinic acid decarboxylase (CSAD), is localized immunohistochemically using specific antibodies against CSAD. The CSAD-immunoreactivity appears to be most prominent in the inner nuclear lay...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90066-6
更新日期：1985-07-01 00:00:00
abstract：:The mammalian circadian clock located in the suprachiasmatic nuclei (SCN) continues to oscillate when isolated in a brain slice preparation, and can be phase shifted in vitro by a variety of serotonergic (5-HTergic) agents. We have previously shown that 5-HT and a 5-HT agonist, quipazine, induce phase advances in the ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90348-4
更新日期：1994-04-25 00:00:00
abstract：:The neuroprotective effect of cilostazol, an antiplatelet drug, was examined after 24 h permanent middle cerebral artery (MCA) occlusion in mice, and explored the possible underlying mechanism by examining metallothionein (MT)-1 and -2 induction in vivo. Cilostazol (30 mg/kg) was intraperitoneally administered at 12 h...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.07.125
更新日期：2006-10-20 00:00:00
