Insulin-like 6 immunoreactivity in the mouse brain and testis.

abstract：:Production of inflammatory cytokines, including tumor necrosis factor (TNF), interleukin-1 (IL-1) and interleukin-6 (IL-6), in the brain is increased in various diseases. To investigate the relationships between the effect of overproduction of IL-6 in the brain on central and peripheral production of TNF, IL-1 beta an...

journal_title：Brain research

authors： Di Santo E,Alonzi T,Fattori E,Poli V,Ciliberto G,Sironi M,Gnocchi P,Ricciardi-Castagnoli P,Ghezzi P

更新日期：1996-11-18 00:00:00

abstract：:Dorsal cells, are primary sensory neurons located in the lamprey spinal cord. They are of two types conveying touch (T) and pressure (P) and they have an ascending and/or a descending axon which joins the dorsal column. Dorsal cells have no initial axon segment. In the electron microscope synaptic boutons with spheric...

journal_title：Brain research

authors： Christenson J,Lagerbäck PA,Grillner S

更新日期：1988-02-02 00:00:00

abstract：:Transgenic mice expressing human APPswe and PS1-A264E mutations mimic certain neuropathological features of Alzheimer's disease (AD). These mice have elevated levels of the highly fibrillogenic amyloid beta1-42 peptide (Abeta42) and develop amyloid plaques around the age of 9 months. Our aim was to find whether these ...

journal_title：Brain research

authors： Wang J,Ikonen S,Gurevicius K,van Groen T,Tanila H

更新日期：2002-07-12 00:00:00

abstract：:A role for altered iron metabolism in the pathogenesis of Alzheimer's disease has been suggested by several reports associating the cardinal neuropathologic lesions with markers of free radical-induced damage and redox-active iron. We hypothesized that the abnormal distribution of iron in Alzheimer brain might result ...

journal_title：Brain research

authors： Smith MA,Wehr K,Harris PL,Siedlak SL,Connor JR,Perry G

更新日期：1998-03-30 00:00:00

abstract：:The effect of arginine vasopressin (AVP) on protein phosphorylation in rat hippocampal synaptic plasma membranes (SPM) was examined. With a crude SPM preparation, AVP (10(-8)-10(-5) M) stimulated phosphorylation of a number of proteins which included a brain-specific protein of 48 kDa called B50 or protein F1, which i...

journal_title：Brain research

authors： Hinko A,Kim Y,Pearlmutter AF

更新日期：1986-10-01 00:00:00

abstract：:The maturation and growth of fetal serotonergic raphe neurons have been studied immunohistochemically and biochemically between 1 week and 5 months after grafting to the hippocampal formation in 5,7-dihydroxytryptamine-pretreated adult rats. The average number of surviving neurons in each group was 1800, which is equi...

journal_title：Brain research

authors： Daszuta A,Strecker RE,Brundin P,Björklund A

更新日期：1988-08-16 00:00:00

abstract：:Insulin has emerged as an important neuropeptide. Central actions of insulin appear to oppose those in the periphery. Insulin is transported across the blood-brain barrier (BBB) by a saturable transport system. The permeability of the BBB to insulin is altered by various events, but no studies exist that have examined...

journal_title：Brain research

authors： Xaio H,Banks WA,Niehoff ML,Morley JE

更新日期：2001-03-30 00:00:00

abstract：:Microglial cyclo-oxygenase (COX) expression is considered to be important in the pathogenesis of Alzheimer's disease (AD) and, therefore, constitutes a key target for therapeutic intervention. We investigated the influence of AD plaque associated factors on COX-1 and COX-2 expression and activity in adult human microg...

journal_title：Brain research

authors： Hoozemans JJ,Veerhuis R,Janssen I,van Elk EJ,Rozemuller AJ,Eikelenboom P

更新日期：2002-10-04 00:00:00

abstract：:Conditions for the stimulation of taurine release by illumination or increased K+ concentrations were established. The effect of Mg2+, ruthenium red and verapamil on taurine release induced by both procedures was compared. All these agents antagonize Ca2+-dependent release of neurotransmitters. Illumination-induced re...

journal_title：Brain research

authors： López-Colomé A,Erlij D,Pasantes-Morales H

更新日期：1976-09-03 00:00:00

abstract：:The serotonin agonist 8-hydroxy-di-propylaminotetralin (8-OH-DPAT), injected systemically or directly into the medial preoptic area (MPOA), reduces the ejaculatory threshold in male rats. While 8-OH-DPAT has been characterized as an agonist at the 5-HT1A receptor, it also acts at other receptor sites including the dop...

journal_title：Brain research

authors： Matuszewich L,Lorrain DS,Trujillo R,Dominguez J,Putnam SK,Hull EM

更新日期：1999-02-27 00:00:00

abstract：:Histochemical investigation by means of light and electron microscopy revealed the presence of dipeptidylpeptidase IV activity in Meissner corpuscles of macaque glabrous skin. The enzyme activity was found in fibroblast-like cells forming an incomplete capsule around the Meissner corpuscle. Distinct electron-dense rea...

journal_title：Brain research

authors： Dubový P

更新日期：1988-09-27 00:00:00

abstract：:Binding of [125I]-labeled Bolton-Hunter substance P ([125I]-BHSP) to NK1 receptors was investigated in the spinal cord of young (3-4 month) and aged (14-16 month) rats. In homogenates of whole spinal cord, the affinity (equilibrium dissociation constant, approximately 210 pM) and maximum density of [125I]-BHSP binding...

journal_title：Brain research

authors： Maguire CM,Geraghty DP

更新日期：1998-03-09 00:00:00

abstract：:Breathing oxygen at sufficiently elevated pressures can trigger epileptiform seizures. Therefore, we tested the hypothesis that pre-treatment with FDA-approved antiepileptic drugs could prevent seizure onset in hyperoxia at 5 atmospheres absolute. We selected drugs from two putative functional categories, Na+-channel ...

journal_title：Brain research

authors： Demchenko IT,Zhilyaev SY,Moskvin AN,Krivchenko AI,Piantadosi CA,Allen BW

更新日期：2017-02-15 00:00:00

abstract：:Melatonin is synthesized rhythmically under control of circadian oscillators by the retinas of non-mammalian vertebrates. Here we report that the retinas of some strains of laboratory mice exhibit robust circadian rhythms of melatonin synthesis which can be entrained by light in vitro. The rd mutation results in progr...

journal_title：Brain research

authors： Tosini G,Menaker M

更新日期：1998-04-13 00:00:00

abstract：:Adult Wistar rats injected with the dopamine receptor agonist apomorphine display different types of motility patterns with respect to oral stereotypes and locomotor activities. It was tested whether phenotypes exhibiting either 'sniffing' or 'non-sniffing' behaviour differed in gene structures of dopamine receptors D...

journal_title：Brain research

authors： Germeyer S,Birke A,Schmitt U,Dahmen N,Hiemke C,Havemann-Reinecke U

更新日期：2002-02-01 00:00:00

abstract：:The functional influence of the cholinergic input to cat dLGN has been examined by assessing the action of iontophoretically applied acetylcholine (ACh) on the visual responses of cells in layers A and A1. Iontophoretically applied pulses of ACh exerted a strong excitatory action on all 113 cells studied within these ...

journal_title：Brain research

authors： Sillito AM,Kemp JA,Berardi N

更新日期：1983-12-05 00:00:00

abstract：:To test the hypothesis that neurons in the hypothalamic paraventricular nucleus (PVN) may be under both direct and indirect regulation by alpha melanocyte-stimulating hormone (alpha-MSH)-synthesizing neurons of the arcuate nucleus, we determined whether the retrogradely transported marker substance, cholera toxin beta...

journal_title：Brain research

authors： Singru PS,Fekete C,Lechan RM

更新日期：2005-12-07 00:00:00

abstract：:Axons in the adult mammalian CNS normally do not regenerate following axotomy even though they retain the capacity for growth under certain experimental conditions. Although this implies that the regeneration of adult axons is under regulative control, very little is known about the signaling pathways "responsible" fo...

journal_title：Brain research

authors： Bates CA,Meyer RL

更新日期：1996-04-01 00:00:00

abstract：:The effects of the epileptogenic agent pentylenetetrazole (PTZ) on membrane currents of native oocytes of Xenopus laevis were studied. PTZ elicits a response that consists of two inward currents. The first one is interpreted to be due to a decrease of potassium permeability since: (1) the input resistance is increased...

journal_title：Brain research

authors： Madeja M,Musshoff U,Kuhlmann D,Speckmann EJ

更新日期：1991-07-05 00:00:00

abstract：:The neural representation of facial expression within the human visual system is not well defined. Using an adaptation paradigm, we examined aftereffects on expression perception produced by various stimuli. Adapting to a face, which was used to create morphs between two expressions, substantially biased expression pe...

journal_title：Brain research

authors： Fox CJ,Barton JJ

更新日期：2007-01-05 00:00:00

abstract：:We studied whether interleukin-1 (IL-1) affects the release of arginine vasopressin (AVP) from the superfused hypothalamo-neurohypophyseal complex (HNC) of rats. Involvement of the cholinergic system in the mediation of IL-1 on AVP release from HNC was also examined. Both human recombinant IL-1 alpha and -1 beta elici...

journal_title：Brain research

authors： Nakatsuru K,Ohgo S,Oki Y,Matsukura S

更新日期：1991-07-19 00:00:00

abstract：:The heterogeneous nature of vesicles has been studied by evaluating exocytotic events released from the cell body of a dopamine-containing neuron of Planorbis corneus. Vesicular exocytosis has been elicited by stimulation with in situ application of elevated potassium and has been monitored electrochemically with a ca...

journal_title：Brain research

authors： Chen G,Ewing AG

更新日期：1995-12-01 00:00:00

abstract：:2-Deoxy-d-glucose (2DG) is a glucose analogue that inhibits intracellular utilization of glucose and produces a characteristic behavioral response known as glucoprivic feeding. The area postrema (AP) is a caudal hindbrain structure shown previously to be involved in 2DG-induced glucoprivic feeding. In addition, periph...

journal_title：Brain research

authors： Edmonds BK,Edwards GL

更新日期：1998-08-10 00:00:00

abstract：:We have developed a RNA-RNA solution hybridization assay to quantitate the mRNA coding for prodynorphin precursor. This assay is extremely sensitive and highly specific. Using this assay we have measured the prodynorphin mRNA in various brain regions and reproductive tissues of rat. When we compared the distribution o...

journal_title：Brain research

authors： Devi L,Douglass J,Herbert E

更新日期：1987-07-01 00:00:00

abstract：:ACTH4-10, a fragment of the adrenocorticotropic hormone (ACTH) molecule, has marked effects on the compensation process following unilateral labyrinthectomy. In Rana temporaria ACTH4-10-treatment (5-250 micrograms/kg) influences both the acquisition and the maintenance of the compensated state. The compensation proces...

journal_title：Brain research

authors： Flohr H,Lüneburg U

更新日期：1982-09-23 00:00:00

abstract：:Whether functional changes of the non-primary motor areas, e.g., dorsal premotor (PMd) and supplementary motor (SMA) areas, after stroke, reflect reorganization phenomena or recruitment of a pre-existing motor network remains to be clarified. We hypothesized that cellular changes in these areas would be consistent wit...

journal_title：Brain research

authors： Cirstea CM,Nudo RJ,Craciunas SC,Popescu EA,Choi IY,Lee P,Yeh HW,Savage CR,Brooks WM

更新日期：2012-06-29 00:00:00

abstract：:Quantitative in situ hybridization histochemistry was used to compare the effects of AMPH administration on mRNAs coding for zif/268, a member of the zinc finger family of immediate early genes, and the opioid peptides, preprodynorphin (PPD) and preproenkephalin (PPE), in rat striatum after 3 dosing schedules: (1) acu...

journal_title：Brain research

authors： Wang JQ,McGinty JF

更新日期：1995-03-06 00:00:00

abstract：:The present investigation is aimed at studying the influence of the striate cortex (area 17 or V1) upon responses of area 18a. Electrical activity was recorded from neurons in area 18a through glass micropipettes. At the same time lidocaine hydrochloride was injected in the same retinotopic register of area 17. Forty ...

journal_title：Brain research

authors： Molotchnikoff S,Hubert F

更新日期：1990-03-05 00:00:00

abstract：:Using an isolated neonatal rat spinal cord preparation, we have studied the ability of hydrogen peroxide to act as a source of oxygen for mammalian central nervous system (CNS) maintained in vitro. We report here that hydrogen peroxide, in low concentrations (0.001-0.004%), can effectively provide the only source, or ...

journal_title：Brain research

authors： Walton K,Fulton B

更新日期：1983-11-14 00:00:00

abstract：:Near-total dopamine-depleting brain lesions produced in 3-day-old rats by intracerebroventricular injection of the neurotoxin 6-hydroxydopamine led to pronounced increases in striatal serotonin (5-HT) and 5-hydroxyindoleacetic acid contents 1-8 months later. This effect was associated with an increase in in vitro high...

journal_title：Brain research

authors： Stachowiak MK,Bruno JP,Snyder AM,Stricker EM,Zigmond MJ

更新日期：1984-01-16 00:00:00