当前位置： SCI文献检索 > BRAIN RESEARCH期刊下所有文献 > A single administration of methamphetamine to mice early in the light period decreases running wheel activity observed during the dark period.

A single administration of methamphetamine to mice early in the light period decreases running wheel activity observed during the dark period.

Abstract：

:Repeated intermittent administration of amphetamines acutely increases appetitive and consummatory aspects of motivated behaviors as well as general activity and exploratory behavior, including voluntary running wheel activity. Subsequently, if the drug is withdrawn, the frequency of these behaviors decreases, which is thought to be indicative of dysphoric symptoms associated with amphetamine withdrawal. Such decreases may be observed after chronic treatment or even after single drug administrations. In the present study, the effect of acute methamphetamine (METH) on running wheel activity, horizontal locomotion, appetitive behavior (food access), and consummatory behavior (food and water intake) was investigated in mice. A multi-configuration behavior apparatus designed to monitor the five behaviors was developed, where combined measures were recorded simultaneously. In the first experiment, naïve male ICR mice showed gradually increasing running wheel activity over three consecutive days after exposure to a running wheel, while mice without a running wheel showed gradually decreasing horizontal locomotion, consistent with running wheel activity being a positively motivated form of natural motor activity. In experiment 2, increased horizontal locomotion and food access, and decreased food intake, were observed for the initial 3h after acute METH challenge. Subsequently, during the dark phase period decreased running wheel activity and horizontal locomotion were observed. The reductions in running wheel activity and horizontal locomotion may be indicative of reduced dopaminergic function, although it remains to be seen if these changes may be more pronounced after more prolonged METH treatments.

journal_name

Brain Res

journal_title

Brain research

authors

Kitanaka N,Kitanaka J,Hall FS,Uhl GR,Watabe K,Kubo H,Takahashi H,Tatsuta T,Morita Y,Takemura M

doi

10.1016/j.brainres.2011.10.037

subject

Has Abstract

pub_date

2012-01-06 00:00:00

pages

155-63

eissn

0006-8993

issn

1872-6240

pii

S0006-8993(11)01967-6

journal_volume

1429

pub_type

杂志文章

在线工具

A single administration of methamphetamine to mice early in the light period decreases running wheel activity observed during the dark period.