Abstract:
:To determine the contribution by mast cells to the brain content of histamine (HA) and its metabolite tele-methylhistamine (t-MH), the number of mast cells, as well as the levels of HA and t-MH were measured in brain regions of mast cell-deficient (W/Wv) and control (+/+) mice. In agreement with earlier studies, mast cells were identified in control mouse brains, whereas W/Wv brains were devoid of mast cells. Contrary to earlier studies, no differences between these strains were found in the HA levels of any brain region, implying that mouse brain mast cells do not contribute significantly to brain HA levels. Brain t-MH levels were also not different between strains, except in hypothalamus, where W/Wv levels were higher; a significantly smaller W/Wv hypothalamus accounted for this difference. It is not certain that such differences are due to the absence of mast cells, since the W/Wv mutant is pleiomorphic, and the biochemical nature of this mutation remains uncertain. However, the absence of mast cells and presence of HA in the W/Wv mouse brain is direct evidence for the existence of non-mast cell HA in the brain. These results also show that mouse brain t-MH levels are predictive of non-mast cell HA in brain.
journal_name
Brain Resjournal_title
Brain researchauthors
Hough LB,Khandelwal JK,Goldschmidt RC,Diomande M,Glick SDdoi
10.1016/0006-8993(84)90897-7subject
Has Abstractpub_date
1984-01-30 00:00:00pages
133-8issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(84)90897-7journal_volume
292pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::The ability of diphenylhydantoin (DPH) to protect against hypoxia-induced neuronal damage was examined using electrophysiological recordings of extracellular evoked potentials from CA1 pyramidal neurons of rat hippocampal slices in vitro. In normal medium, a 15-min hypoxic insult (95% N2/5% CO2) produced rapid and com...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)91501-q
更新日期:1991-04-19 00:00:00
abstract::Glial cell line derived neurotrophic factor (GDNF) is a potent survival factor for several types of neurons. GDNF binds with high affinity to GDNF-family receptor alpha-1 (GFR alpha-1). This receptor is expressed in different areas of the brain, including the hippocampus and dentate gyrus. By using in situ hybridizati...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02682-2
更新日期:2000-09-22 00:00:00
abstract::There is evidence that acute exposure to kainic acid (KA) induces the release of endogenous ligands for opioid receptors and that mu-opioid agonists intensify KA-induced neurodegeneration. The aim of the present study was to investigate any acute toxic effects of KA upon mu-opioid receptors labelled with [3H]-DAMGO. 2...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00992-5
更新日期:1998-12-14 00:00:00
abstract::Phenylethanolamine N-methyltransferase (PNMT) activity was measured in adrenal glands and medulla oblongata from 4 inbred rat strains, Fischer 344, Buffalo, Lewis and Sprague-Dawley rats. Adrenal enzyme activity was markedly different among the strains with the highest in Fischer, followed by Sprague-Dawley, Lewis and...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)91476-9
更新日期:1986-04-30 00:00:00
abstract::This report deals with the effect of substance P (SP) and capsaicin on blood pressure and heart rate after administration into different sites of the nucleus tractus solitarii (NTS) of urethane-anesthetized rats. Microinjection of SP at 6 different coordinates throughout the NTS showed 3 sites where SP administration ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90938-3
更新日期:1987-10-06 00:00:00
abstract::Unilateral injections of 6-hydroxydopamine into the substantia nigra in the rat significantly attenuated cortical spreading depression (CSD)-induced eating from the hemisphere ipsilateral but not contralateral to the lesion. The lateralized decrease in elicited feeding was correlated with postlesion body weight loss, ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(79)90428-1
更新日期:1979-01-12 00:00:00
abstract::Endogenous opioids play a role in the regulation of LH-RH neurosecretion throughout the estrous cycle and during the preovulatory LH surge on proestrus. Experimental evidence suggests that opioid influence may be altered with age, and it has been hypothesized that these alterations may contribute to the loss of regula...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91717-7
更新日期:1993-01-22 00:00:00
abstract::Existing data on the expression of H(4) histamine receptor in the CNS are conflicting and inconclusive. In this report, we present the results of experiments that were conducted in order to elucidate H(4) receptor expression and localization in the brain, spinal cord, and dorsal root ganglia (DRG). Here we show that t...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.11.018
更新日期:2009-01-23 00:00:00
abstract::Superior cervical ganglionectomy (SCGx) has drastic effects on numerous hormonal circadian rhythms and particularly on pineal melatonin secretion. We investigated the hormonal consequences of ablation of the superior cervical ganglion on the corticotropic circadian rhythms in the male rat. Plasma were obtained by samp...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)90237-2
更新日期:1994-08-01 00:00:00
abstract::Rats with bilateral striatal cholinergic lesions induced by the neurotoxin AF64A were found to have increased spontaneous nocturnal locomotor activity as measured in terms of the amount of time spent moving, the total distance traveled and the number of episodes and time of stereotypic behaviors. No significant differ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90715-7
更新日期:1984-05-14 00:00:00
abstract::The role of the substantia innominata (SI) in the generation of a behavior mediated by the prefrontal (PF) cortex was examined in two Japanese monkeys. PF neuronal activities related to a visual tracking task by wrist movement were recorded and neural responses to SI stimulation were analyzed. Sixty-six neurons showed...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)90734-5
更新日期:1983-10-16 00:00:00
abstract::Smoking is considered the leading cause of preventable death in the United States, but studies in animals suggest that nicotine is only weakly reinforcing. The maintenance of a dangerous habit by a weakly reinforcing agent has been the topic of some dispute. Using a two-lever "choice" self-administration procedure dev...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)03215-2
更新日期:2002-01-04 00:00:00
abstract::Noradrenergic and dopaminergic regulation of thyrotropin (TSH) secretion was investigated in adult male Wistar rats. TSH secretion displayed a circadian variation with peak serum TSH levels at 10.00 h. The alpha 2-adrenoceptor agonist, clonidine (250 micrograms/kg, i.p.), was found to cause an enhancement of serum TSH...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)91378-3
更新日期:1987-02-24 00:00:00
abstract::Rhyme processing is reflected in the electrophysiological signals of the brain as a negative deflection for non-rhyming as compared to rhyming stimuli around 450 ms after stimulus onset. Studies have shown that this N450 component is not solely sensitive to rhyme but also responds to other types of phonological overla...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2012.09.018
更新日期:2012-11-05 00:00:00
abstract::The distribution of iron in the brain of a vocal learning parrot, the budgerigar (Melopsittacus undulatus), was examined using iron histochemistry. In mammals, iron is a highly specific stain for the dorsal and ventral pallidal subdivision as well as specific cell groups in the brainstem, including the substantia nigr...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)03110-9
更新日期:2001-12-07 00:00:00
abstract::Ischemic stroke is caused by the interruption of cerebral blood flow that leads to brain damage with long-term sensorimotor deficits. Stem cell transplantation may recover functional deficit by replacing damaged brain. In this study, we attempted to test whether the human neural stem cells (NSCs) can improve the outco...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2004.04.038
更新日期:2004-08-06 00:00:00
abstract::Inbred mouse strains differed significantly in sensitivity to convulsions induced by 9 convulsant drugs administered using a timed infusion procedure. Some strains (e.g. BALB/cJ, A/J) were generally seizure-susceptible, while some were generally seizure resistant (e.g. C57BL/6J, SWR/J). However, the overall pattern of...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90243-5
更新日期:1990-08-27 00:00:00
abstract::The impact of hyperglycemia after traumatic brain injury (TBI), and even the administration of glucose-containing solutions to head injured patients, remains controversial. In the current study adult male Sprague-Dawley rats were tested on behavioral tasks and then underwent surgery to induce sham injury or unilateral...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2015.04.022
更新日期:2015-07-21 00:00:00
abstract::The growth of corticospinal tract (CST) axons was studied quantitatively at the 7th cervical (C7) and the 4th lumbar (L4) spinal segments in the balb/cByJ mice at the ages of postnatal day (P) 0, 2, 4, 6, 8, 10, 14, and 28. The cross-sectional area of the CST increased progressively with time. Unmyelinated axons, the ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.02.036
更新日期:2006-04-21 00:00:00
abstract::Previously, we have shown that intracisternal (i.c.) administration of beta-endorphin suppresses brain and liver DNA synthesis in rat pups. This finding is consistent with the view that endogenous CNS beta-endorphin plays an important role in controlling postnatal growth. Recent evidence suggests that brain CCK8, the ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)91175-4
更新日期:1994-10-24 00:00:00
abstract::Norepinephrine (NE), acting on brain adrenoceptors, plays an important role in barrel field neuronal activity and plasticity. For this reason, the distribution of alpha 1- and alpha 2-adrenoceptors in the somatosensory cortex barrel field was studied by autoradiographic techniques in rats undergoing plastic change or ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90005-8
更新日期:1993-09-24 00:00:00
abstract::We utilized nylon arrays to measure gene expression in mouse brains after various postmortem intervals (PMIs). Gene expression after overnight refrigeration or 4 h at room temperature then overnight refrigeration correlated highly and approximately equivalently to that in brains processed immediately. After 8-24 h at ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)02644-6
更新日期:2002-06-28 00:00:00
abstract::[35S]GTPgammaS autoradiography of slide-mounted tissue sections was used to examine G-protein coupling in the rat spinal cord, as stimulated by dopamine, the D1 receptor agonist SKF 38393, noradrenaline, and noradrenaline in the presence of the alpha adrenoceptor antagonist, phentolamine. Measurements were obtained fr...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.10.101
更新日期:2006-01-27 00:00:00
abstract::Electrical and pharmacological properties of currents induced by compounds having affinities for putative sigma receptors were investigated with NCB20 cells by use of the whole-cell patch-clamp technique. Antipsychotics and naloxone induced inward currents with a decrease in membrane conductance at a holding potential...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)91232-7
更新日期:1994-02-21 00:00:00
abstract::We previously showed that local striatal injections of malonate produce age-dependent excitotoxic lesions. In the present study volumetric analysis confirmed that malonate produces age-dependent striatal lesions. Pretreatment with the non-competitive and competitive NMDA receptor antagonists, MK-801 and LY274614, and ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)91412-5
更新日期:1994-05-30 00:00:00
abstract::A major mesolimbic projection towards the hippocampal formation (HF) has been extensively described, but no clear evidence of its dopaminergic content has been demonstrated. In order to evaluate the percentage of dopaminergic (DA) cells of ventral tegmental area (VTA-A10) and adjacent substantia nigra (SN-A9) projecti...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)90512-6
更新日期:1994-12-30 00:00:00
abstract::alpha-Motoneurons innervating the triceps surae and short plantar muscles were stained intracellularly with horseradish peroxidase (HRP) in 0-44-day-old kittens and adult cats. The terminal arborizations of the recurrent axon collaterals in the spinal cord were studied in the light microscope (LM). The short plantar m...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(85)90132-4
更新日期:1985-01-01 00:00:00
abstract::The effects of acute and chronic phencyclidine (PCP) administration on neurotensin-like immunoreactivity (NTLI) were investigated in discrete regions of rat brain. Both acute and chronic administration of PCP induced high locomotor activity, stereotypy and ataxia. On PCP administration, NTLI decreased significantly in...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)91601-4
更新日期:1985-05-06 00:00:00
abstract::Dynorphin and other kappa opioid agonists are thought to elicit aversive actions and changes in motor activity through direct or indirect modulation of dopamine neurons in ventral tegmental area (VTA) and substantia nigra (SN), respectively. We comparatively examined the immunoperoxidase localization of anti-dynorphin...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90693-h
更新日期:1993-02-05 00:00:00
abstract::Previous studies showed that hyperbaric oxygen (HBO) promoted cell proliferation in hypoxic-ischemic (HI) neonate rats. Neural stem cells (NSC) existed in the brain lifelong and can be activated. This study was undertaken to assess whether HBO treatment promoted the proliferation of NSC and repaired the brain damage r...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.05.016
更新日期:2008-07-30 00:00:00