Abstract：
:We previously showed that local striatal injections of malonate produce age-dependent excitotoxic lesions. In the present study volumetric analysis confirmed that malonate produces age-dependent striatal lesions. Pretreatment with the non-competitive and competitive NMDA receptor antagonists, MK-801 and LY274614, and with lamotrigine resulted in significant protection in 4-month-old animals. In vivo magnetic resonance imaging of lesion area showed a significant correlation of increasing lesion size and lactate production in rats ranging from 1 to 12 months of age. Histological evaluation showed NADPH-diaphorase neurons were spared. The results provide further evidence that a subtle impairment of energy metabolism may play a role in neurodegenerative diseases.
journal_name
Brain Resjournal_title
Brain researchauthors
Henshaw R,Jenkins BG,Schulz JB,Ferrante RJ,Kowall NW,Rosen BR,Beal MFdoi
10.1016/0006-8993(94)91412-5subject
Has Abstractpub_date
1994-05-30 00:00:00pages
161-6issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(94)91412-5journal_volume
647pub_type
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