Abstract：
:Experiments were done in chloralose anesthetized, paralyzed and artificially ventilated cats to identify single units in ventrolateral medulla (VLM) projecting directly to the intermediate gray (IG) region of the upper thoracic cord and responding to inputs from pressor sites in the anterior lateral hypothalamus (Hla) and carotid sinus (CSN) and aortic depressor (ADN) nerves. Forty-eight units were antidromically activated in VLM to stimulation of the IG at the level of T2. Of these 48 units, 15 (31%) were orthodromically excited by stimulation of the Hla with a mean latency of 15.8 +/- 2.1 ms. In addition, 8 of the 15 units responding to Hla stimulation were also excited orthodromically by stimulation of either the CSN or ADN or both. Of the remaining 33 units, 15 responded to stimulation of only the buffer nerves and 18 were unresponsive to the tested inputs. These results provide electrophysiological evidence for the existence of neurons in VLM which receive hypothalamic and buffer nerve inputs and suggest that the VLM plays a role in integrating and relaying cardiovascular afferent information from peripheral baroreceptors and chemoreceptors and from supramedullary centers to provide effector signals to spinal autonomic neurons involved in the control of the circulation.
journal_name
Brain Resjournal_title
Brain researchauthors
Ciriello J,Caverson MM,Calaresu FRdoi
10.1016/0006-8993(85)90908-4subject
Has Abstractpub_date
1985-11-11 00:00:00pages
173-6issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(85)90908-4journal_volume
347pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Nitric oxide (NO), a potent vasodilator and nontraditional neurotransmitter, is an important mediator of the changes in cerebral blood flow (CBF) associated with increased neuronal activity (neurovascular coupling). In the present work, we investigated the role of NO and of its newly recognized precursor, nitrite, in ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.06.045
更新日期：2011-08-17 00:00:00
abstract：UNLABELLED:Mating in rabbits lasts only 3-5s but profoundly changes the female׳s physiology and behavior (e.g., inhibition of scent-marking and ambulation, changes in EEG, and release of GnRH). The behavioral responsiveness to copulation is reduced in lactating rabbits, relative to estrous does, but is enhanced after s...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.02.033
更新日期：2015-05-22 00:00:00
abstract：:Propofol is an intravenous anesthetic with neuroprotective effects against cerebral ischemia-reperfusion (I/R) injury. Few studies regarding the neuroprotective and neurobehavioral effects of propofol have been conducted, and the underlying mechanisms are still unclear. Because I/R may result in neuronal apoptosis, th...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.06.060
更新日期：2011-09-02 00:00:00
abstract：:Serotonin transporter (5-HTT) mRNA and 5-HTT sites were measured 3 days after treatment with p-chlorophenylalanine, a tryptophan hydroxylase inhibitor. While 5-HTT mRNA levels decreased (P < 0.001) in the dorsal raphe nucleus, 5-HTT binding sites remained unchanged, suggesting that an acute depletion of 5-HT may induc...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00539-3
更新日期：1995-08-07 00:00:00
abstract：:We consider a random synaptic pruning in an initially highly interconnected network. It is proved that a random network can maintain a self-sustained activity level for some parameters. For such a set of parameters a pruning is constructed so that in the resulting network each neuron/node has almost equal numbers of i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.07.050
更新日期：2012-01-24 00:00:00
abstract：:The regulation of corticotropin-releasing hormone (CRH) mRNA expression following maternal nutrient restriction was examined in the fetal hypothalamus. Pregnant guinea pigs were food restricted for 48 h or fed normally during late gestation. After nutrient restriction, CRH mRNA levels in the hypothalamic paraventricul...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02089-3
更新日期：2001-03-30 00:00:00
abstract：:We have recently reported spinal blood flow-metabolism uncoupling in an amyotrophic lateral sclerosis (ALS) animal model using Cu/Zn-superoxide dismutase 1 (SOD1)-transgenic (Tg) mice, suggesting a relative hypoxia in the spinal cord. However, the hypoxic stress sensor pathway has not been well studied in ALS. Here, w...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.07.040
更新日期：2012-09-14 00:00:00
abstract：:The malformative cortical lesions in the cerebral cortex that are characteristic of focal cortical dysplasia type IIb (FCDIIb) and tuberous sclerosis complex (TSC) are well-recognized causes of chronic intractable epilepsy in children. Increasing evidence suggests that extracellular matrix molecules play important rol...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.03.009
更新日期：2012-05-09 00:00:00
abstract：:Six experimental and 3 unoperated cats were trained with a go, no-go shock avoidance procedure to discriminate increases from decreases in the rate of presentation of all auditory cortex between the suprasylvian sulcus and rhinal fissure while 3 cats had bilateral auditory cortex lesions plus ablation of the cortex of...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90249-3
更新日期：1976-10-29 00:00:00
abstract：:Mesenchymal stem cell (MSC) transplantation has been reported to improve neurologic function after ischemic injury. However, the detailed mechanisms by which MSCs promote functional recovery are not fully understood. Interleukin-10 (IL-10) is a well-known anti-inflammatory cytokine with neuroprotective effects with re...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.03.080
更新日期：2010-06-02 00:00:00
abstract：:Primary afferent neurons in mammalian dorsal root ganglia (DRGs) normally function as independent sensory communication elements. However, it has recently been shown that most DRG neurons are transiently activated when axons of neighboring neurons of the same ganglion are stimulated repetitively and the cross-depolari...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)02342-4
更新日期：2003-04-25 00:00:00
abstract：:Discrete axon-sparing lesions were placed unilaterally in the mesencephalon by the local injection of kainic acid. Unilateral lesions of the dorsal reticular formation just beneath the superior colliculus and lateral to the periacqueductal grey resulted in consistent ipsiversive apomorphine-induced circling. Only weak...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90579-5
更新日期：1981-03-16 00:00:00
abstract：:Electrophysiological techniques and the retrograde transport of horseradish peroxidase (HRP) were used to determine the efferent projections from the caudal mediobasal hypothalamus to the amygdala. In pentobarbital anesthetized rats, the activity of 1780 mediobasal hypothalamic neurons was examined for response to sti...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(77)90147-0
更新日期：1977-02-01 00:00:00
abstract：:Selective lesions of the noradrenergic systems of the paraventricular nucleus (PVN) of the hypothalamus with 6-hydroxydopamine (6-OHDA) lengthen the periodicity of the migrating myoelectric complex (MMC), an index of intestinal motility, in rats. These lengthening effects resemble those obtained after lesions of the l...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(10)80045-9
更新日期：1992-06-26 00:00:00
abstract：:Due to the structural similarity to N-methyl-4-phenyl pyridinium (MPP(+)), paraquat might induce dopaminergic toxicity in the brain. However, its blood--brain barrier (BBB) penetration has not been well documented. We studied the manner of BBB penetration and neural cell uptake of paraquat using a brain microdialysis ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02577-x
更新日期：2001-07-06 00:00:00
abstract：:Catecholamine concentrations were determined at central and peripheral level in high blood pressure (HBP), low blood pressure (LBP) and random bred (RB) mice. In HBP mice compared to LBP, the noradrenaline concentration was lower in the locus coeruleus, medullary A1-C1 and A2-C2 areas, thoracic spinal cord, posteroven...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90784-x
更新日期：1985-08-05 00:00:00
abstract：:To investigate the effects of ionic changes possibly associated with hibernation, hippocampal slices prepared from golden hamsters were studied in artificial cerebrospinal fluid (ACSF) of variable composition (K+ 3-5 mM, Ca2+ 2-4 mM, Mg2+ 2-4 mM, pH 7.0-7.7) at temperatures of 15-20 degrees C, just above the temperatu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00524-t
更新日期：1995-08-14 00:00:00
abstract：:The sexually dimorphic nucleus of the preoptic area (SDN-POA) is the most striking structure displaying a morphological sex difference in the rat brain. A potentially homologous nucleus has been identified in the human hypothalamus. The objective of the present study was to pursue the putative homology of the rat and ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)01005-0
更新日期：1996-12-02 00:00:00
abstract：:We have investigated, in 9 normal subjects, the time course of amplitude changes in the automatic long latency stretch reflex of wrist flexors during the preparatory period as a function of the precued direction of hand movement. Subjects maintained right hand position against a weak force and learned to compensate pr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)91172-1
更新日期：1983-11-28 00:00:00
abstract：:Changes in the expression and activation of protein kinase C (PKC) have been implicated in the pathogenesis of diabetic neuropathy. Recent studies in liver, retina, and cardiovascular tissues from experimentally diabetic rats have demonstrated that diabetes has a selective effect on the expression and subcellular dist...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00062-0
更新日期：1997-04-18 00:00:00
abstract：:Almost anyone who has ever lost weight can attest that it is harder to sustain weight loss than to lose weight. Maintenance of a 10% or greater reduced body weight is accompanied by decreases in energy expenditure to levels significantly below what is predicted solely on the basis of weight and body composition change...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2010.05.062
更新日期：2010-09-02 00:00:00
abstract：:Cervical spinal cord hemisection leads to a disruption of bulbospinal innervation of phrenic motoneurons resulting in paralysis of the ipsilateral hemidiaphragm. We have previously demonstrated separate therapeutic roles for theophylline, and more recently serotonin (5-HT) as modulators to phrenic nerve motor recovery...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03097-4
更新日期：2002-11-22 00:00:00
abstract：:Opioid-binding cell adhesion molecule (OBCAM) is the member of the IgLON family, a subgroup of the immunoglobulin superfamily. In the present study, the functions and dynamics of OBCAM were investigated in hippocampal neurons in vitro. Western blotting revealed that OBCAM expression was low at early stages of culture ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.04.062
更新日期：2007-08-24 00:00:00
abstract：:Repeated administration of subconvulsant doses of lidocaine or cocaine results in the development of an increased susceptibility to seizures induced by the two drugs (pharmacological kindling). It has been hypothesized that the local anesthetic properties of cocaine are responsible for its convulsant and epileptogenic...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90628-9
更新日期：1991-10-25 00:00:00
abstract：:A large body of evidence indicates that both the altered cytokines that mediate the immune-inflammatory process and abnormal gray matter are associated with schizophrenia. Whether peripheral cytokines are related to cerebral structural abnormality remains unclear. Therefore, we aimed to investigate the association of ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2019.146463
更新日期：2019-12-01 00:00:00
abstract：:Hippocampal neurogenesis plays a very important role in learning and memory functions. In a search for best neurological drugs that protect neuronal cells and stimulate neurogenesis with no side effects, cannabinoids proved to be a strong group of substances having many beneficial properties. The aim of this study was...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.07.028
更新日期：2015-10-22 00:00:00
abstract：:Rabbits reared from birth in stroboscopic illumination have no experience of visual motion. In primary visual cortex of these animals there is a large reduction in the number of cells which are direction selective. This result, contrary to previous reports, shows that the rabbit visual system can be modified by early ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(81)90099-7
更新日期：1981-01-01 00:00:00
abstract：:Although platelet-derived growth factor (PDGF)-BB activates PDGF receptor-beta (PDGFR-beta) and, in turn, inhibits the glutamate N-methyl-D-aspartate (NMDA) receptor function, whether PDGF-BB modulates the CNS function mediated by another glutamate receptors, alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (A...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.05.037
更新日期：2007-07-23 00:00:00
abstract：:An intracerebral microdialysis technique was applied to study the effect of metabotropic glutamate receptor (mGluR) agonist on dopamine release in the striatum of methamphetamine (MAP)-sensitized rats. Rats were treated with MAP (1 mg/kg, i.p.) once daily for 6 consecutive days, followed by a 6-day withdrawal. Perfusi...
journal_title：Brain research
pub_type： 杂志文章
doi：
更新日期：1996-08-12 00:00:00
abstract：:We have recently reported that the burst firing neurons are found in layer III as well as in layer V of cat sensorimotor cortex in vitro. In the present study, we examined the synaptic excitability of layer III neurons by white matter stimulation and compared with their firing patterns against the current injections t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01850-8
更新日期：1999-09-18 00:00:00
