Amygdala afferents from the mediobasal hypothalamus: an electrophysiological and neuroanatomical study in the rat.

Abstract:

:Electrophysiological techniques and the retrograde transport of horseradish peroxidase (HRP) were used to determine the efferent projections from the caudal mediobasal hypothalamus to the amygdala. In pentobarbital anesthetized rats, the activity of 1780 mediobasal hypothalamic neurons was examined for response to stimulation sites in the amygdala and stria terminalis. Evidence of orthodromic activation from both stimulation sties was commonly observed. Sixty-five cells mostly located in the ventromedial nucleus displayed antidromic invasion from the basolateral, basomedial or cortical amygdala over a latency range of 5-34 msec (mean 15.3 +/- 6.7 msec S.D.). Three of 440 tested cells displayed antidromic activation from stimulation on the stria terminalis. Amygdala evoked antidromic responses were still present after lesions of the stria terminalis. May ipsilateral ventromedial hypothalamic neurons and a few cells in the ipsilateral arcuate nucelus and periventricular region and contralateral ventromedial nucleus displayed retrograde transport of HRP after an infection into the amygdala. Lesions of the stria terminalis had little effect on the numbers of HRP labeled neurons. Relatively more neurons were labeled retrogradely after medial injections than after lateral injections in the amygdala. Data from both electrophysiological and anatomical techniques therefore indicate that certain mediobasal hypothalamic neurons, particularly those located in the ipsilateral ventromedial nucleus, project to the amygdala probably via a route other than the stria terminalis. Thus there is substantial evidence in the rat for reciprocal connections between the amygdala and the hypothalamic ventromedial nucleus.

journal_name

Brain Res

journal_title

Brain research

authors

Renaud LP,Hopkins DA

doi

10.1016/0006-8993(77)90147-0

subject

Has Abstract

pub_date

1977-02-01 00:00:00

pages

201-13

issue

2

eissn

0006-8993

issn

1872-6240

pii

0006-8993(77)90147-0

journal_volume

121

pub_type

杂志文章
  • QRFP administration into the medial hypothalamic nuclei improves memory in rats.

    abstract::Even though several of RFamide peptides have been shown to modify memory and learning processes in different species, almost nothing is known regarding cognitive effects of recently discovered neuropeptide QRFP. Considering multiple physiological functions of QRFP, localization of QRFP-synthesizing neurons in the hypo...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2019.146563

    authors: Zagorácz O,Ollmann T,Péczely L,László K,Kovács A,Berta B,Kállai V,Kertes E,Lénárd L

    更新日期:2020-01-15 00:00:00

  • Distribution of stanniocalcin binding sites in the lamina terminalis of the rat.

    abstract::Stanniocalcin (STC-1), a 50 kDa glycoprotein hormone that regulates calcium/phosphate homeostasis in bony fish and mammals, has been shown to be expressed in central neurons and choroid plexus, and to exert a protective effect against hypercalcemic and hypoxic damage to neurons. Circumventricular organs are known to f...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2008.04.070

    authors: Ratkovic S,Wagner GF,Ciriello J

    更新日期:2008-07-07 00:00:00

  • Reduced cell proliferation and increased apoptosis in the hippocampal formation in a rat model of Hirschsprung's disease.

    abstract::Hirschsprung's disease (HSCR) is a congenital malformation characterized by the absence of enteric ganglia in the distal intestine and gut obstruction. Some HSCR patients also have associated neurological symptoms. We studied a rat model of HSCR, also known as spotting lethal (sl/sl) rat, which carries a spontaneous d...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2016.03.024

    authors: Xie D,Croaker GDH,Li J,Song ZM

    更新日期:2016-07-01 00:00:00

  • Biochemical characterization of the intramembrane interaction between neurotensin and dopamine D2 receptors in the rat brain.

    abstract::In order to better understand the neuroleptic-like effects of neurotensin in vivo, the effects of neurotensin in vitro on dopamine D2 and D1 agonist and antagonist binding sites were characterized in membranes from the neostriatum and the subcortical limbic area. Neurotensin increased the KD but not the Bmax value of ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(91)90753-i

    authors: von Euler G

    更新日期:1991-10-04 00:00:00

  • Cellular and intracellular localization of epsilon-subspecies of protein kinase C in the rat brain; presynaptic localization of the epsilon-subspecies.

    abstract::The cellular and intracellular localization of the epsilon-subspecies of protein kinase C (PKC) in the rat brain was demonstrated by immunocytochemistry using specific antibodies against epsilon-PKC. The epsilon-PKC-specific immunoreactivity was most abundant in the hippocampal formation, olfactory tubercle and Callej...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(93)91512-q

    authors: Saito N,Itouji A,Totani Y,Osawa I,Koide H,Fujisawa N,Ogita K,Tanaka C

    更新日期:1993-04-02 00:00:00

  • Alterations in tyrosine hydroxylase activity elicited by raphe nuclei lesions in the rat locus coeruleus: evidence for the involvement of serotonin afferents.

    abstract::The time course of the variations in tyrosine hydroxylase (TH) activity was measured in the rat locus coeruleus (LC) after lesions of the nucleus raphe dorsalis (NRD), nucleus raphe centralis superior (NRCS) and nucleus raphe pontis (NRP). A certain number of lesions were performed in the raphe magnus (RM), the caudal...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(82)91008-3

    authors: McRae-Degueurce A,Berod A,Mermet A,Keller A,Chouvet G,Joh TH,Pujol JF

    更新日期:1982-03-11 00:00:00

  • Effects of cholinergic agonists on two non-pyramidal cell types in rat hippocampal slices.

    abstract::In the hippocampus, pyramidal cells (PCs) are not the only cell type sensitive to cholinergic stimulation. Two non-pyramidal cell types from animals as young as 8 days demonstrated clear, direct responses to application of cholinergic agonists. These cholinergic actions are excitatory, mostly blocked by muscarinic ant...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(91)91688-w

    authors: Reece LJ,Schwartzkroin PA

    更新日期:1991-12-06 00:00:00

  • Effects of chronic fenfluramine administration on hypothalamic neuropeptide mRNA expression.

    abstract::Appetite suppressants lose efficacy when given chronically; the mechanisms are unknown. We gave male rats once-daily dl-fenfluramine (dl-FEN, 5 mg/kg, i.p.) injections for 15 days and measured mRNA expression of corticotropin releasing factor (CRF), neuropeptide Y (NPY) and proopiomelanocortin (POMC) in hypothalamic n...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2006.02.129

    authors: Choi S,Blake V,Cole S,Fernstrom JD

    更新日期:2006-05-04 00:00:00

  • Learning and memory in the autoimmune BXSB mouse: effects of neocortical ectopias and environmental enrichment.

    abstract::Approximately 40-60% of BXSB mice have ectopic cell clusters in layer 1 of neocortex. Prior studies have shown distinct behavioral differences between those with ectopias and their non-ectopic littermates. In this study, female BXSB mice were reared after weaning in either enriched environments or standard cages. Foll...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:

    authors: Boehm GW,Sherman GF,Hoplight BJ 2nd,Hyde LA,Waters NS,Bradway DM,Galaburda AM,Denenberg VH

    更新日期:1996-07-08 00:00:00

  • Duration of desensitization and ultrastructural changes in dorsal root ganglia in rats treated with resiniferatoxin, an ultrapotent capsaicin analog.

    abstract::We have previously demonstrated resiniferatoxin (RTX) to be an ultrapotent analog of capsaicin. Like capsaicin, RTX initially induces neurogenic inflammation, pain, and hypothermia and then causes desensitization of these responses. We examine here the duration of desensitization following acute treatment with the max...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(89)91705-8

    authors: Szallasi A,Joo F,Blumberg PM

    更新日期:1989-11-27 00:00:00

  • Reduced cerebral monocarboxylate transporters and lactate levels by ethanol and normobaric oxygen therapy in severe transient and permanent ischemic stroke.

    abstract:OBJECTIVES:Neuroprotective benefits of ethanol (EtOH) and normobaric oxygenation (NBO) were previously demonstrated in transient and permanent ischemic stroke. Here we sought to identify whether the enhanced lactic acidosis and increased expression of monocarboxylate transporters (MCTs) observed after stroke might be a...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2015.01.040

    authors: Geng X,Sy CA,Kwiecien TD,Ji X,Peng C,Rastogi R,Cai L,Du H,Brogan D,Singh S,Rafols JA,Ding Y

    更新日期:2015-04-07 00:00:00

  • Protein phosphatase inhibitors prolong Ca(2+)-transients and divalent cation-dependent action potentials in leech Retzius cells.

    abstract::Elevation of [K+]o for 30 s from 4 to 120 mM produced a fast and reversible depolarization and transient increase in [Ca2+]i in fura-2 loaded Retzius cells of the leech. The protein phosphatase inhibitor, okadaic acid, significantly slowed the return of [Ca2+]i toward baseline without affecting the amplitude of depola...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(94)91800-7

    authors: Kleinhaus AL,Zeman RJ

    更新日期:1994-07-11 00:00:00

  • Prostaglandin E1 modifies porcine cerebral arterial tone through cyclooxygenase related eicosanoid(s) release.

    abstract::The effects of prostaglandin E1 (PGE1) on porcine cerebral arteries were studied in the absence and presence of cyclooxygenase inhibitors, 5 x 10(-6) M indomethacin or 10(-4) M aspirin. In preparations placed at a resting tension, 3 x 10(-9) to 10(-6) M PGE1 caused dose-dependent contractions. In prostaglandin F2 alph...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(89)91096-2

    authors: Fukuda S,Taga K,Tsukui A,Nishimura N,Kumagai Y,Shimoji K

    更新日期:1989-09-04 00:00:00

  • Blocking GABAA neurotransmission in the interposed nuclei: effects on conditioned and unconditioned eyeblinks.

    abstract::The interposed nuclei (IN) of the intermediate cerebellum are critical components of the circuits that control associative learning of eyeblinks and other defensive reflexes in mammals. The IN, which represent the sole output of the intermediate cerebellum, receive massive GABAergic input from Purkinje cells of the ce...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2009.07.053

    authors: Parker KL,Zbarska S,Carrel AJ,Bracha V

    更新日期:2009-10-06 00:00:00

  • Dye and electrical coupling between frog motoneurons.

    abstract::Coupling between lumbar motoneurons in the isolated frog spinal cord was studied by using intracellular recordings and intracellular injections of Lucifer Yellow CH. Physiological studies revealed intra- and intersegmental, short latency electrical interactions between many motoneurons. Injections of Lucifer Yellow in...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(83)90721-7

    authors: Brenowitz GL,Collins WF 3rd,Erulkar SD

    更新日期:1983-09-12 00:00:00

  • Sensory requirements for the lordosis reflex in female rats.

    abstract::(1) Visual, auditory and olfactory input were not necessary for the performance of the lordosis reflex by female rats. Since taste is not involved in this behavior, somatosensory input must be sufficient for triggering the lordosis reflex. (2) Surgical cutaneous denervation markedly reduced the frequency and strength ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(76)90987-2

    authors: Kow LM

    更新日期:1976-01-09 00:00:00

  • The nociceptin/orphanin FQ-like opioid peptide in nervous periesophageal ganglia of land snail Helix aspersa.

    abstract::The neuropeptide nociceptin/orphanin FQ (N/OFQ) and its receptor are members of the endogenous opioid peptide family. In mammals N/OFQ modulates a variety of biological functions such as nociception, food intake, endocrine, control of neurotransmitter release, among others. In the molluscs Cepea nemoralis and Helix as...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2013.02.007

    authors: León-Olea M,Miller-Pérez C,Sánchez-Islas E,Mendoza-Sotelo J,Garduño-Gutiérrez R,de Gortari P,Amaya MI

    更新日期:2013-04-10 00:00:00

  • Effects of 4-aminopyridine, GABA and bicuculline on cutaneous receptive fields of cat dorsal horn neurons.

    abstract::4-Aminopyridine (4-AP), bicuculline and GABA were applied locally to dorsal horn cells in the lumbar spinal cord in Nembutal-anaesthetized cats and in spinal cats. 4-AP expanded the cutaneous receptive field of 29 of 33 cells tested. Bicuculline and GABA had little or no effect on receptive field size. ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(85)90814-5

    authors: Saadé N,Jabbur SJ,Wall PD

    更新日期:1985-10-07 00:00:00

  • Inhibition of acetaldehyde metabolism decreases acetylcholine release in medial frontal cortex of freely moving rats.

    abstract::The effect of high acetaldehyde (ACe) on acetylcholine (ACh) release was studied in vivo in the medial frontal cortex (mfc) of freely moving rats using brain microdialysis coupled with high performance liquid chromatography and an electrochemical detector. Ethanol (EtOH) and ACe concentrations were quantified simultan...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2005.01.049

    authors: Jamal M,Ameno K,Wang W,Kumihashi M,Ameno S,Ikuo U,Shinji A,Ijiri I

    更新日期:2005-03-28 00:00:00

  • REM sleep-suppressing effects of atropine in cats vary with environmental temperature.

    abstract::Because the occurrence of rapid eye movement (REM) sleep is critically dependent upon an animal's thermal balance, acute pharmacological treatments may effect REM sleep through effects on thermoregulation. We describe how manipulating ambient temperature (T(a)) alters the REM sleep-suppressing effects of systemically-...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(94)90184-8

    authors: Szymusiak R,Danowski J,McGinty D

    更新日期:1994-02-04 00:00:00

  • Characterization of protein kinase C isoforms in primary cultured cerebellar granule cells.

    abstract::Protein kinase C (PKC) is a family of serine/threonine kinases comprised of 10 isoforms. Although commercial antibodies are available for all 10 isoforms, the specificity of these antibodies has been questioned. We have identified immunoblot conditions in which commercially purchased PKC antibodies are specific for th...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2006.01.110

    authors: Popp RL,Velasquez O,Bland J,Hughes P

    更新日期:2006-04-14 00:00:00

  • Non-linear kinetics of glutamyl-tRNA synthesis catalyzed by high molecular weight complexes from rat brain neuronal cells but not from glial cells.

    abstract::High molecular weight complexes of aminoacyl-tRNA synthetases isolated from rat brain catalyze the formation of glutamyl-tRNA with an initial lag time of the order of 1 min, as previously reported for the formation of glutamyl-tRNA and glutaminyl-tRNA catalyzed by similar complexes from bovine brain (Vadeboncoeur and ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0169-328x(86)90016-1

    authors: Lacoste L,Hertz L,Lapointe J

    更新日期:1986-07-01 00:00:00

  • Projections of the feline globus pallidus.

    abstract::The organization of globus pallidus (GP) projections was studied in cats using autoradiographic and horseradish peroxidase (HRP) techniques. Both methods confirmed the existence of a topographically organized projection to subthalamic nucleus (STN). Although all but the most caudal GP projects to STN, the heaviest pro...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(80)90003-7

    authors: McBride RL,Larsen KD

    更新日期:1980-05-05 00:00:00

  • Pharmacological characterization of grooming induced by a selective NK-1 tachykinin receptor agonist.

    abstract::Bilateral intranigral administration of the selective NK-1 tachykinin receptor agonist [AcArg6, Sar9, Met(O2)11]SP6-11 (0-1 nmol total bilateral dose) selectively induced grooming in rats. This response was blocked by concurrent intranigral administration of the NK-1 tachykinin receptor antagonist RP 67580 (2 nmol), b...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(95)00940-r

    authors: Stoessl AJ,Brackstone M,Rajakumar N,Gibson CJ

    更新日期:1995-11-27 00:00:00

  • Potential for brain accessibility and analysis of stability of selected flavonoids in relation to neuroprotection in vitro.

    abstract::Natural food sources constitute a promising source of new compounds with neuroprotective properties, once they have the ability to reach the brain. Our aim was to evaluate the brain accessibility of quercetin, epigallocatechin gallate (EGCG) and cyanidin-3-glucoside (C3G) in relation to their neuroprotective capabilit...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2016.09.020

    authors: Pogačnik L,Pirc K,Palmela I,Skrt M,Kim KS,Brites D,Brito MA,Ulrih NP,Silva RF

    更新日期:2016-11-15 00:00:00

  • Retinal origin of the fasciculus medialis tractus optici in adult goldfish.

    abstract::In teleosts, the fasciculus medialis tractus optici departs the optic tract and follows an aberrant path towards the midbrain tectum. To determine the retinal origin of the fascicle, horseradish peroxidase was injected into localized lesions of either the optic nerve or the retina. The fasciculus medialis axons of adu...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(85)90082-4

    authors: Fraley SM,Sharma SC

    更新日期:1985-07-01 00:00:00

  • Identification of recoverin-like immunoreactivity in mouse brain.

    abstract::Mouse brain was found by immunoblot analysis to have a protein of Mr 23,000 (P23k) that was clearly different from recoverin and was labeled with an antiserum raised against the NH2-terminus of recoverin. P23k could not be detected by an antiserum raised against the COOH-terminus of recoverin. Blots with 45Ca demonstr...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(92)90676-z

    authors: Takamatsu K,Uyemura K

    更新日期:1992-02-07 00:00:00

  • Substance P receptors in the human spinal cord: decrease in amyotrophic lateral sclerosis.

    abstract::The distribution of substance P receptors was examined by autoradiography at all levels of the human postmortem spinal cord using the ligand [125I]Bolton-Hunter substance P. Adjacent sections were used to localize substance P-like immunoreactivity by a radioimmunohistochemical technique. In the control spinal cord sub...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(89)90032-2

    authors: Dietl MM,Sanchez M,Probst A,Palacios JM

    更新日期:1989-03-27 00:00:00

  • Glycine reverses 7-chlorokynurenic acid-induced inhibition of [3H]MK-801 binding.

    abstract::7-Chlorokynurenic acid (7-Cl KYNA) has been reported to attenuate N-methyl-D-aspartate (NMDA) receptor functioning by a potent and selective inhibitory action mediated at the strychnine-insensitive glycine recognition site of the NMDA complex. Here we report that 7-Cl KYNA dose-dependently inhibits [3H]MK-801 binding ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(89)91378-4

    authors: Sircar R,Frusciante MJ,Javitt DC,Zukin SR

    更新日期:1989-12-18 00:00:00

  • Loss of parvalbumin-immunoreactive neurones from cortex in Alzheimer-type dementia.

    abstract::The type and cell size of parvalbumin-immunoreactive (PV-Ir) neurones were examined in 14 postmortem brains from elderly control and Alzheimer-type dementia (ATD) patients with the aid of an image analyser. Morphological features of PV-Ir neurones suggested the existence of PV in the non-pyramidal interneurones in the...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(87)90974-7

    authors: Arai H,Emson PC,Mountjoy CQ,Carassco LH,Heizmann CW

    更新日期:1987-08-18 00:00:00