Acute acidosis elevates malonaldehyde in rat brain in vivo.

abstract：:A novel and convenient assay was used to determine the effect of recombinant Interleukin-2 (IL-2) on the function of the blood-brain barrier (BBB). The assay is based on a variant of the West Nile virus, WN-25, which had lost its neuroinvasiveness but not its neurovirulence. WN-25, when injected intravenously, can cau...

journal_title：Brain research

authors： Kobiler D,Lustig S,Gozes Y,Ben-Nathan D,Akov Y

更新日期：1989-09-04 00:00:00

abstract：:The effects of target and non-target cells on the growth and function of intrastriatal grafts of mesencephalic dopamine neurons have been studied in rats with unilateral 6-hydroxydopamine-induced lesions of the nigrostriatal dopamine pathway. Cell suspensions of ventral mesencephalon from 14-15-day-old rat fetuses (ri...

journal_title：Brain research

authors： Brundin P,Isacson O,Gage FH,Björklund A

更新日期：1986-01-01 00:00:00

abstract：:Binge-like ethanol treatment of septal neurons blunts GABAAR-mediated miniature postsynaptic currents (mPSCs), suggesting it arrests synaptic development. Ethanol may disrupt postsynaptic maturation by blunting feedback signaling through immature GABAARs. Here, the impact of ethanol on the sensitivity of mPSCs to zolp...

journal_title：Brain research

authors： DuBois DW,Trzeciakowski JP,Parrish AR,Frye GD

更新日期：2006-05-17 00:00:00

abstract：:We investigated the electrophysiological properties of the area postrema neurons in acutely prepared rat brain slices using the whole-cell patch-clamp technique. Two different types of transient outward potassium current (I(to)), fast and slow, were found in the area postrema. Both the decay time constant and rise tim...

journal_title：Brain research

authors： Funahashi M,Mitoh Y,Matsuo R

更新日期：2002-06-28 00:00:00

abstract：:The frequency-dependent effect of various anticonvulsant drugs on the conduction in central axons was studied in the corpus callosum of rat and guinea pig brain slices from the parietal region. Extracellularly recorded compound action potentials (CAPs) were evoked by either single stimulus or high frequency stimulatio...

journal_title：Brain research

authors： Silberstein E,Schleifstein-Attias D,Grossman Y

更新日期：1992-07-24 00:00:00

abstract：:Bombesin (BN)- and substance P (SP)-containing neurons are found in the dorsal root ganglia, and project to the dorsal horn of the spinal cord. The present study was undertaken to determine if chronic deafferentation of the cat spinal cord would affect BN or SP receptors in the spinal cord. Ten and 30 days after a uni...

journal_title：Brain research

authors： Massari VJ,Shults CW,Park CH,Tizabi Y,Moody TW,Chronwall BM,Culver M,Chase TN

更新日期：1985-09-23 00:00:00

abstract：:Ontogeny of somatostatin (SRIF) neuron system of the rat cerebellum was investigated by means of the indirect immunofluorescent method. In addition, several operations were performed to provide the evidence of understanding the cerebellar SRIF innervation. SRIF-positive structures appeared in the primordium of the cer...

journal_title：Brain research

authors： Inagaki S,Shiosaka S,Takatsuki K,Iida H,Sakanaka M,Senba E,Hara Y,Matsuzaki T,Kawai Y,Tohyama M

更新日期：1982-04-01 00:00:00

abstract：:The preferential loss of GABAergic neurons in neocortex slab cultures after exposure to hypoxia was reinvestigated and confirmed using an improved morphometric analysis based on stereological principles. This preferential cell loss could be attenuated by treating the hypoxic slab cultures with the N-methyl-D-aspartate...

journal_title：Brain research

authors： Romijn HJ

更新日期：1989-10-30 00:00:00

abstract：:By means of silver impregnation and an HRP method, courses of the accessory optic tract were examined in albino and pigmented rats. The accessory optic tract is composed of 3 fasciculi: anterior, lateral and dorsal. The anterior fasciculus gives off fibers to the subthalamic nucleus and terminates in the medial termin...

journal_title：Brain research

authors： Yamadori T,Yamauchi KE

更新日期：1983-06-13 00:00:00

abstract：:Both amphetamine and cocaine lead to an intake pattern in chronic addicts in which the drug is taken repeatedly over prolonged periods. While continuously administered amphetamines, designed to mimic this intake pattern, have a neurotoxic effect on caudate dopamine terminals, several studies have failed to find simila...

journal_title：Brain research

authors： Ellison G

更新日期：1992-12-11 00:00:00

abstract：:Tacrolimus (FK506), a potent immunosuppressive drug, is effective in attenuating brain infarction after cerebral ischemia. However, there has been no report characterizing the neuroprotective action and therapeutic time window of tacrolimus systematically using different types of stroke models and extended observation...

journal_title：Brain research

authors： Furuichi Y,Katsuta K,Maeda M,Ueyama N,Moriguchi A,Matsuoka N,Goto T,Yanagihara T

更新日期：2003-03-07 00:00:00

abstract：:In order to study the effects of treatment with monosodium glutamate (MSG) during the neonatal period on the intrinsic circadian timekeeping system in rats, the locomotor activity of blinded MSG-treated and control (saline-treated) rats was analyzed with power spectral analysis and cross-correlation. In contrast to a ...

journal_title：Brain research

authors： Miyabo S,Yamamura I,Ooya E,Aoyagi N,Horikawa Y,Hayashi S

更新日期：1985-07-29 00:00:00

abstract：:The accumulation of amyloid-β (Aβ) peptides in the brain of Alzheimer disease patients is associated to cognitive deficit, increased oxidative stress, and alterations in the circadian rhythms. Brain-derived neurotrophic factor (BDNF) and Neurogranin (RC3), play an important role in the synaptic plasticity underlying m...

journal_title：Brain research

authors： Navigatore-Fonzo L,Castro A,Pignataro V,Garraza M,Casais M,Anzulovich AC

更新日期：2017-04-01 00:00:00

abstract：:We examined the expression of IL-6 in the substantia nigra pars reticulata (SNr) at various time points after transient (3 h) middle cerebral artery occlusion (MCAO) in rats. The animals were killed at 1, 3, 7 or 14 days following operation. Coronal brain sections were processed for immunohistochemistry with antibodie...

journal_title：Brain research

authors： Dihné M,Block F

更新日期：2001-01-19 00:00:00

abstract：:Excitatory amino acids (EAAs) are likely to play a key role in sensory transmission in the spinal cord. In the present study, the microiontophoresis technique was used to investigate the effects of L-glutamate (GLUT), N-methyl-D-aspartate (NMDA), and quisqualate (QUIS), as well as an NMDA receptor antagonist, AP-7, on...

journal_title：Brain research

authors： Dougherty PM,Willis WD

更新日期：1991-02-22 00:00:00

abstract：:Nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) activity and the central terminal fields of branches of the mandibular and chorda tympani nerves were visualized histochemically at the same time using transganglionic transport of wheat germ agglutinin conjugated with horseradish peroxidase. The blue NA...

journal_title：Brain research

authors： Takemura M,Tsujio A,Iwase K,Shimada T,Shigenaga Y

更新日期：1998-01-19 00:00:00

abstract：:We previously showed indirectly that the increase in diacylglycerol (DAG) levels caused by exposing differentiating PC12 cells to nerve growth factor (NGF) must derive mainly from de novo synthesis and, to a lesser and transient extent, from the hydrolysis of [3H]phosphatidylinositol (PI). To explore further the bioch...

journal_title：Brain research

authors： Li J,Wurtman RJ

更新日期：1999-02-13 00:00:00

abstract：:The present work evaluated the reproducibility and variance of the cerebral blood flow (CBF) response to natural whisker stimulation in the barrel cortex of awake behaving mice. The animal was placed on an air float ball that allowed the animal to walk, while the head of the animal was fixed in a custom-made stereotac...

journal_title：Brain research

authors： Takuwa H,Autio J,Nakayama H,Matsuura T,Obata T,Okada E,Masamoto K,Kanno I

更新日期：2011-01-19 00:00:00

abstract：:In primary neuron cultures obtained from ventral mesencephalon of mouse fetuses, approximately 10-30% of the neurons were dopaminergic, as demonstrated by a rapid glyoxylic acid histofluorescence procedure, and another 10-30% were GABAergic as demonstrated by autoradiography. Resting membrane potentials averaged -58 m...

journal_title：Brain research

authors： Ort CA,Futamachi KJ,Peacock JH

更新日期：1988-04-01 00:00:00

abstract：:The developmental and age-related changes of the dopamine transporter (DAT), and the dopamine D1 and D2 receptor (D1R and D2R) subtypes were investigated in basal ganglia (BG) of human brain. DAT immunostaining was mainly observed in the neuropil, neurons, and glia of the striatum. The DAT-positive neuropil was detect...

journal_title：Brain research

authors： Meng SZ,Ozawa Y,Itoh M,Takashima S

更新日期：1999-10-02 00:00:00

abstract：:Single neurons in culture express a heterogeneity of neurotransmitter receptor subtypes. The study of the effects of neurotransmitters on neuronal function is complicated by this heterogeneity. It would therefore be useful to be able to identify live neurons that express the receptors of interest and then use these ne...

journal_title：Brain research

authors： Hoyt KR,Reynolds IJ

更新日期：1996-08-26 00:00:00

abstract：:Phenotypic diversity is shaped by both genetic and epigenetic mechanisms that program tissue specific patterns of gene expression. Cells, including neurons, undergo massive epigenetic reprogramming during development through modifications to chromatin structure, and by covalent modifications of the DNA through methyla...

journal_title：Brain research

authors： McGowan PO,Meaney MJ,Szyf M

更新日期：2008-10-27 00:00:00

abstract：:The major initiation process of intracranial aneurysms is thought to involve endothelial dysfunction due to hemodynamic stress. Angiotensin II type 1 receptor blockers and statins improve vascular endothelium function. The effects of olmesartan and pravastatin were investigated on the development of experimental aneur...

journal_title：Brain research

authors： Kimura N,Shimizu H,Eldawoody H,Nakayama T,Saito A,Tominaga T,Takahashi A

更新日期：2010-03-31 00:00:00

abstract：:We have established a cell line (TB) from a cerebrospinal fluid (CSF) specimen of a patient with a primary leptomeningeal melanomatosis. TB cell line was immunoreactive with the antibodies for low molecular weight neurofilament protein, vimentin, neuron-specific enolase, chromogranin, synaptophysin and HMB-45 (an anti...

journal_title：Brain research

authors： Sorrentino G,Monsurrò MR,Pettinato G,Vanni R,Zuddas A,Di Porzio U,Bonavita V

更新日期：1999-05-08 00:00:00

abstract：:The purpose of this study was to identify the functional fields activated in relation to the self-paced proximal and distal arm movements. The regional cerebral blood flow (rCBF) was measured with positron emission tomography (PET) and 15O-labelled H2O (H2(15)O) in eight healthy subjects. All subjects performed the fo...

journal_title：Brain research

authors： Kawashima R,Itoh H,Ono S,Satoh K,Furumoto S,Gotoh R,Koyama M,Yoshioka S,Takahashi T,Takahashi K,Yanagisawa T,Fukuda H

更新日期：1996-04-15 00:00:00

abstract：:The effect of a dihydropyridine Ca2+ antagonist, cilnidipine, on voltage-dependent Ca2+ channels was studied in acutely dissociated rat CA1 pyramidal neurons using the nystatin-perforated patch recording configuration under voltage-clamp conditions. Cilnidipine had no effect on low-voltage-activated (LVA) Ca2+ channel...

journal_title：Brain research

authors： Murai Y,Uneyama H,Ishibashi H,Takahama K,Akaike N

更新日期：2000-01-31 00:00:00

abstract：:Astaxanthin (AST) is a powerful antioxidant that occurs naturally in a wide variety of living organisms. Much experimental evidence has proved that AST has the function of eliminating oxygen free radicals and can protect organisms from oxidative damage. The present study was carried out to further investigate the neur...

journal_title：Brain research

authors： Lu YP,Liu SY,Sun H,Wu XM,Li JJ,Zhu L

更新日期：2010-11-11 00:00:00

abstract：:Using immunohistochemistry and immunoblots, we show that alterations in hippocampal microtubule-associated protein-2 appear to be highly correlated with contextual memory as measured by significantly heightened fear responses. Compared to naive controls, rats trained in a novel context showed significantly increased i...

journal_title：Brain research

authors： Woolf NJ,Zinnerman MD,Johnson GV

更新日期：1999-03-06 00:00:00

abstract：:Rat cerebral cortex slices were incubated in small volumes of medium in order to study the bidirectional movements of gamma-aminobutyric acid (GABA) between tissue and medium, and to measure the extent of release of endogenous amino acids of interest as potential neurotransmitters. The apparent uptake, real uptake, an...

journal_title：Brain research

authors： Cutler RW,Young J

更新日期：1979-04-13 00:00:00

abstract：:Previous research has shown that peripheral inflammation and peripheral nerve injury alter the properties of NMDA receptors in the spinal dorsal horn. However, there is no direct evidence that demonstrates the influence of peripheral nerve injury on NMDA receptor-mediated synaptic transmission in the spinal dorsal hor...

journal_title：Brain research

authors： Iwata H,Takasusuki T,Yamaguchi S,Hori Y

更新日期：2007-03-02 00:00:00