Abstract：
:The cell-mediated inflammatory component of experimental autoimmune encephalomyelitis (EAE) in mice is measured by the radioisotopic technique. Mice are challenged with autologous spinal cord homogenate in Freund's complete adjuvant and at various time intervals after such immunization given [125I]5-iodo-2'-deoxyuridine which is incorporated into the mononuclear cell pool. The degree of cell-mediated inflammation is determined by radiometry of the brain and spinal cord tissues. Increased radiolabelling is detected in the brains 2 days prior to the onset of clinical signs of EAE; increased radioactivity of the spinal cord is concomitant with clinical signs. This technique is useful in staging the extent of EAE and may prove to be a powerful tool in studying cell-mediated reactions in other autoimmune diseases.
journal_name
Brain Resjournal_title
Brain researchauthors
Linthicum DS,Horvath L,Carnegie PRdoi
10.1016/0006-8993(79)90850-3subject
Has Abstractpub_date
1979-10-05 00:00:00pages
273-81issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(79)90850-3journal_volume
174pub_type
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