Strain-dependent differences in responsiveness of mice to nitrous oxide (N2O) antinociception.

Abstract:

:N2O antinociception was assessed in eight inbred and two outbred mouse strains. Results indicated the following order of responsiveness among the 10 strains: A/J (most sensitive), C57BL/6ByJ, C57BL/6J, BALB/cByJ, C3H/HeJ, Swiss-Webster, CXBK/ByJ, ICR, CBA/J and DBA/2J (least sensitive). These results demonstrate significant strain-dependent differences in antinociceptive responsiveness to N2O. The weak antinociceptive response to N2O in the DBA/2J strain, which is sensitive to morphine and U-50, 488H, indicates some underlying neurobiological difference in the DBA/2J mouse that imparts resistance to N2O. The responsiveness of CXBK/ByJ mice to N2O indicates that mu-opioid receptors may not play an important role in N2O antinociception in mice.

journal_name

Brain Res

journal_title

Brain research

authors

Quock RM,Mueller JL,Vaughn LK

doi

10.1016/0006-8993(93)91017-m

subject

Has Abstract

pub_date

1993-06-18 00:00:00

pages

52-6

issue

1-2

eissn

0006-8993

issn

1872-6240

pii

0006-8993(93)91017-M

journal_volume

614

pub_type

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