Abstract:
:One hour after long-term potentiation (LTP) in the intact hippocampus, a selective increase in protein F1 in vitro phosphorylation was observed in homogenate prepared from dorsal hippocampus. Protein F1 phosphorylation was directly related to the magnitude and persistence of potentiation. No other phosphoprotein studied exhibited a relationship with synaptic enhancement. Low-frequency, non-potentiating stimulation did not increase protein F1 phosphorylation, and phosphorylation of F1 was not elevated when high-frequency stimulation did not produce potentiation. We also confirmed our earlier demonstration of a similar pattern of results 5 min after LTP. In related work we have previously observed: that protein F1 is a substrate for protein kinase C (PKC); that membrane PKC activity was increased by translocation from the cytosol following LTP; and that membrane PKC activity was directly related to the persistence of enhancement. We therefore predicted in the present study that protein F1 phosphorylation in a dorsal hippocampal membrane fraction would be related to LTP. Hippocampal membrane protein F1 was found to be directly related to both the magnitude and persistence of response enhancement. Thus the molecular events leading to prolonged potentiation may involve increased PKC/protein F1 association. Persistence of potentiation may be related to synaptic growth processes involving the growth-associated function of protein F1.
journal_name
Brain Resjournal_title
Brain researchauthors
Lovinger DM,Colley PA,Akers RF,Nelson RB,Routtenberg Adoi
10.1016/0006-8993(86)91510-6subject
Has Abstractpub_date
1986-12-10 00:00:00pages
205-11issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(86)91510-6journal_volume
399pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::The present study examined whether the inhibition of serotonin transporters (SERT) contributes to cocaine- and other local anesthetics-induced convulsions, and which subtypes of 5-HT receptor are involved in the convulsions. For this purpose, cocaine, meprylcaine and lidocaine, all of which have different effects on S...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.07.049
更新日期:2005-09-28 00:00:00
abstract::Levodopa (L-DOPA) is widely used for symptomatic management in Parkinson's disease. We recently showed that (-)-epigallocatechin-3-gallate, a tea polyphenol, not only inhibits L-DOPA methylation, but also protects against oxidative hippocampal neurodegeneration. In the present study, we sought to determine several oth...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2012.11.043
更新日期:2013-02-25 00:00:00
abstract::Mild acute hypertension was induced in rats pharmacologically and non-pharmacologically with metaraminol, angiotensin II or bilateral vagotomy. The extraction fraction of water (Ew) was measured in both hypertensive and normotensive animals. It was demonstrated that cerebral blood flow did not change during hypertensi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)91069-2
更新日期:1984-08-13 00:00:00
abstract::A neuron׳s response to a sound can be suppressed by the presentation of a preceding sound. It has been suggested that this suppression is a direct correlate of the psychophysical phenomenon of forward masking, however, forward suppression, as measured in the responses of the auditory nerve, was insufficient to account...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2016.02.043
更新日期:2016-05-15 00:00:00
abstract::The insula has emerged as a critical target for electrical stimulation since it influences pathological pain states. We investigated the effects of repetitive electrical stimulation of the insular cortex (ESI) on mechanical nociception, and general locomotor activity in rats subjected to chronic constriction injury (C...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2020.147237
更新日期:2021-01-02 00:00:00
abstract::The purpose of this study was to ascertain whether visual acuity or contrast sensitivity function (CSF) is proportional to visual cortical function based on fMRI volume and level of activation or Z-score. Forced choice procedures were utilized to measure the monocular log minimal angle of resolution (logMAR) visual ac...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.10.082
更新日期:2011-01-07 00:00:00
abstract::The present study is a determination of the numbers of axons in the sural nerve and nerve to the medial gastrocnemius muscle following section and regeneration of the sciatic nerve in the rat. The data indicate that there is a significant increase in both myelinated and unmyelinated axons in the nerve to the medial ga...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90819-9
更新日期:1984-03-12 00:00:00
abstract::Infusion of 1 microgram of carbachol, a potent cholinergic agonist, into the lateral septum of the urethane-anaesthetized rat systematically caused the induction of clear-cut hippocampal theta (theta). However, infusion of an equivalent amount of the drug into the hippocampus, close to the recording electrode, failed ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91551-3
更新日期:1993-12-24 00:00:00
abstract::Newly synthesized serotonin (5-HT) can be released in the nodose ganglion from the nerve cell bodies of vago-aortic serotoninergic neurones. Free-calcium led to a decrease of spontaneous and potassium-evoked release. The veratridine-stimulating response was abolished by TTX. The concept that 5-HT released from perikar...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90877-1
更新日期:1984-06-18 00:00:00
abstract::Extracellular recordings were made in vitro from 212 single units in the rat subfornical organ (SFO) and 54 single units in the rat medial preoptic area (MPO). Units were exposed to solutions made hyper-osmotic or hypo-osmotic by 1.4-11%. A reversible 30% or greater change in frequency followed the osmotic challenge i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90251-x
更新日期:1988-10-04 00:00:00
abstract::The effects of selective dopamine antagonists on the pentazocine-like discriminative stimulus effects of morphine were investigated in the rat trained to discriminate 3.0 mg/kg of pentazocine from vehicle. Morphine (3.0 mg/kg), a mu-selective agonist, produced stimulus effects in common with pentazocine (3.0 mg/kg), i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)91088-i
更新日期:1991-02-08 00:00:00
abstract::Arginase-1, a marker for M2 phenotype alternatively activated macrophages, inhibits inflammation and is associated with phagocytosis of cell debris and apoptotic cells. We analyzed the expression of arginase-1, a competitive enzyme of inducible nitric oxide synthase (iNOS), in the spinal cords of Lewis rats with exper...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2012.03.023
更新日期:2012-05-09 00:00:00
abstract::The electric activities of cortical pyramidal neurons are supported by structurally stable, morphologically complex axo-dendritic trees. Anatomical differences between axons and dendrites in regard to their length or caliber reflect the underlying functional specializations, for input or output of neural information, ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2020.147069
更新日期:2020-12-01 00:00:00
abstract::To characterize optical responses (ORs) evoked by white matter (WM) stimulation in slices of rat visual cortex (VC) stained with voltage sensitive dyes, time course of ORs in each layer was investigated by recording ORs with a linearly aligned photodiode array, and the spatial patterns of the ORs at specified time aft...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(96)00767-6
更新日期:1996-10-28 00:00:00
abstract::Early environmental factors can modulate the development of the hypothalamic-pituitary-adrenal (HPA) axis response to stress, together with subsequent brain functions and emotional behaviors. Two rat strains, Sprague-Dawley (SD) and Fischer 344 (F344), are known to exhibit differences in HPA axis reactivity and anxiet...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.11.070
更新日期:2010-02-26 00:00:00
abstract::The objective of this study was to assess the influence of Ca2+ influx on intracellular pH (pHi) of neocortical neurons in primary culture. Neurons were exposed to glutamate (100-500 microM) or KCl (50 mM), and pHi was recorded with microspectrofluorometric techniques. Additional experiments were carried out in which ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00056-v
更新日期:1995-04-10 00:00:00
abstract::In rats kainic acid-induced seizures were accompanied by time-dependent cerebral cysteinyl-leukotriene (LT) and prostaglandin (PG) F2 alpha formation. Cysteinyl-LT were identified in the rat brain tissue extracts by their immunoreactive properties and their retention times upon reversed phase HPLC profiling. In perfus...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90579-z
更新日期:1990-05-07 00:00:00
abstract::This study examined the spatial organization of corticotropin-releasing factor (CRF) immunopositive climbing fibers in the mouse cerebellum by whole mount immunohistochemistry. A striking pattern of parasagittal stripes of CRF staining was revealed. Cryosections of whole mount CRF stained cerebellum showed that anti-C...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.05.029
更新日期:2008-07-30 00:00:00
abstract::Chronic neuropathic pain has demonstrated that coexisting psychiatric disorders are associated with disability and poorer treatment outcomes. Hyperpolarization-activated cyclic nucleotide-gated (HCN, Ih) channels play a major role in pain via hyperexcitability and facilitation of ectopic firing in neurons. Neuronal hy...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2019.03.036
更新日期:2019-08-15 00:00:00
abstract::Electrical stimulation of the dorsal hippocampal formation of the rat was employed to determine the effect of 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3), the hormonal form of vitamin D, on induced seizure thresholds. Stereotaxic injection of 100 micrograms or 50 micrograms 1,25-dihydroxyvitamin D3 in 2 microliter propyle...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)91153-3
更新日期:1984-04-23 00:00:00
abstract::The morphology, dendritic stratification and laminal position of the soma of retinal ganglion cells were analyzed in Golgi preparations and in other rabbit retinas containing cells backfilled from the superior colliculus. Only one type, among 40 Golgi-impregnated types identified, always had its cell body displaced to...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91838-8
更新日期:1990-12-03 00:00:00
abstract::Binge-like ethanol treatment of septal neurons blunts GABAAR-mediated miniature postsynaptic currents (mPSCs), suggesting it arrests synaptic development. Ethanol may disrupt postsynaptic maturation by blunting feedback signaling through immature GABAARs. Here, the impact of ethanol on the sensitivity of mPSCs to zolp...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.03.023
更新日期:2006-05-17 00:00:00
abstract::Previous studies have reported that schizophrenia (SZ) patients showed selective reinforcement learning deficits and abnormal feedback-related event-related potential (ERP) components. However, how the brain networks and their topological properties evolve over time during transient feedback-related cognition processi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2020.146979
更新日期:2020-11-01 00:00:00
abstract::The postnatal development of cat triceps surae gamma-motoneurones, retrogradely labelled with horseradish peroxidase (HRP), was studied light and electron microscopically. The mean diameter of the cell bodies of the gamma-motoneurones increased by about 25% from birth to the adult stage, which was much less than the i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(87)90251-3
更新日期:1987-12-15 00:00:00
abstract::Peripheral axotomy in neonatal rats induces neuronal death. We studied the anti-apoptotic protein Bcl-2 and cell death promoter Bax in spinal cord of neonatal rats after sciatic transection and treatment with melatonin, a neuroprotective substance. Pups were unilaterally axotomized at P2 and received melatonin (1 mg/k...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.07.021
更新日期:2006-09-27 00:00:00
abstract::Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the vertebrate brain. GABA activates both ionotropic (GABA(A)) and metabotropic (GABA(B)) receptors in mammals. Whether non-mammalian vertebrates possess receptors with similar characteristics is not well understood. We used a mammalian GABA(B)-...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.03.008
更新日期:2006-06-13 00:00:00
abstract::The central axon of a primary afferent neuron that responded to light mechanical stimulation of the lower premolar teeth in a fast adapting fashion was intra-axonally injected with horseradish peroxidase in the cat. The labeled terminals within the rostrodorsomedial (Vo.r) and dorsomedial (Vo.dm) parts of subnucleus o...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91588-j
更新日期:1993-03-19 00:00:00
abstract::Sleep deprivation leads to cognitive impairments in humans and, if sustained for 2-3 weeks in rats, it is invariably fatal. It has been suggested that neural activity associated with waking, if it is not interrupted by periods of sleep, may damage brain cells through excitotoxic or oxidative mechanisms and eventually ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01768-0
更新日期:1999-09-04 00:00:00
abstract::Trophic effects of neurturin, a member of the glial cell line-derived neurotrophic factor-family, have been demonstrated on mesencephalic dopaminergic neurons, suggesting its therapeutic potential for Parkinson's disease. This study was designed to test the neuroprotective and regenerative effects of an intrastriatal ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)02934-7
更新日期:2002-08-30 00:00:00
abstract::Perineal muscles essential for copulatory functioning are innervated by Onuf's nucleus in humans and the spinal nucleus of the bulbocavernosus (SNB) and dorsolateral nucleus (DLN) in rats. These structures sexually differentiate as a result of developmental androgen exposure in most species examined. The homologous st...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.05.056
更新日期:2010-07-30 00:00:00