Abstract：
:Effects of pre-treatment of synaptic membranes with beta-adrenoceptor agonists and cholera toxin on [3H]clonidine and [3H]yohimbine binding were examined in rat cerebral cortex. Pre-incubation of cerebral cortical membranes with isoproterenol (10 or 200 microM) or dobutamine (1, 10 or 200 microM) at 37 degrees C for 40 min caused a significant elevation of specific [3H]clonidine binding but treatment with salbutamol (10 or 200 microM) did not. Scatchard analysis showed that 200 microM isoproterenol treatment resulted in a significant elevation of high affinity component of [3H]clonidine binding which was significantly decreased by the addition of 10 microM GTP. A significant elevation in high affinity [3H]clonidine binding was observed by treatment with 100 micrograms/ml cholera toxin, while a significant decrease in low affinity one was by the treatment. Specific [3H]yohimbine binding was also elevated by 10 or 200 microM isoproterenol treatment. It is suggested that stimulation of beta-receptors, presumably beta 1-subtype, could elevate the number of agonist and antagonist binding sites in alpha 2-receptors in synaptic membranes by partially mediated by stimulatory and/or inhibitory GTP binding regulatory proteins.
journal_name
Brain Resjournal_title
Brain researchauthors
Kitamura Y,Nomura Ydoi
10.1016/0006-8993(85)90531-1subject
Has Abstractpub_date
1985-03-11 00:00:00pages
259-64issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(85)90531-1journal_volume
329pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Porcine calcitonin (pCT) encapsulated in sulfatide-containing reverse-phase evaporation vesicles (REVs) was shown to induce long-lasting and dose-dependent antinociceptive effect by systemic injection in mice. Its antinociceptive activity is found to be dependent on the route of administration. In contrast, neither un...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91311-f
更新日期：1993-02-12 00:00:00
abstract：:Two-day-old rats were pretreated with 50 mg/kg of capsaicin. After 3--4 months, specific binding of [3H]muscimol and [3H]strychnine was measured in membrane preparations from dorsal spinal cord. A 20-30% decrease of the number of [3H]muscimol binding sites was observed after capsaicin treatment. In contrast, [3H]stryc...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)90160-2
更新日期：1980-12-08 00:00:00
abstract：:Transport of the hexapeptide dalargin across the blood-brain barrier was accomplished using a nanoparticle formulation. The formulation consisted of dalargin bound to poly(butyl cyanoacrylate) nanoparticles by sorption, coated with polysorbate 80. Intravenous injection of this formulation to mice resulted in an analge...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00023-j
更新日期：1995-03-13 00:00:00
abstract：:Cross-sectional areas of the forebrain ventricles were measured from coronal sections in spontaneously hypertensive rats (SHRs) 4, 8, 12, 16, 21 and 56 weeks of age and in age-matched Wistar--Kyoto (WKY) and Sprague--Dawley (SD) normotensive rats. Progressive ventricular dilation and associated attrition of brain tiss...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90488-9
更新日期：1986-04-09 00:00:00
abstract：:Changes in GABA(A) receptor alpha(1) subunit gene expression occur in the globus pallidus and substantia nigra pars reticulata following lesions of the nigrostriatal tract. To determine whether these changes are translated at the protein level, we performed quantitative autoradiography with the alpha(1) selective liga...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02081-3
更新日期：2000-04-17 00:00:00
abstract：:Murine cortical cell cultures deprived of glucose for 6-8 h developed extensive neuronal degeneration, apparent both morphologically and by efflux of lactate dehydrogenase to the bathing medium. This neuronal damage could be substantially reduced by addition of D-2-amino-5-phosphonovalerate (D-APV), in a concentration...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90179-0
更新日期：1989-04-03 00:00:00
abstract：:The roles of the dorsal and ventral hippocampus in fear and memory are unclear. This study examined the effects of temporary inactivation of the dorsal or ventral hippocampus on unconditioned and conditioned fear, using the shock-probe test. In Experiment 1, rats received either dorsal or ventral hippocampal infusions...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.11.041
更新日期：2009-01-28 00:00:00
abstract：:Purkinje cells are the sole output from the cerebellar cortex and play a critical role during classical eyeblink conditioning. The present study revealed for the first time a learning-related change in individual Purkinje cell activity during successive eyeblink conditioning in decerebrate guinea pigs which permitted ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.10.090
更新日期：2006-01-12 00:00:00
abstract：:Morphine chlorhydrate (0.25 mg/kg)produced a significant and constant reinforcement of post-discharge inhibition of alpha-motoneurons in both normal and paraplegic humans. This effect was reversed by naloxone hydrochloride (0.02 mg/kg). These data do not allow to differentiate the effects of morphine on recurrent inhi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90961-6
更新日期：1981-10-05 00:00:00
abstract：:Voltage-dependent calcium channels are important for calcium influx and the ensuing intracellular calcium signal in various excitable membranes. The beta subunits of these channels modify calcium currents through pore-forming alpha1 subunits of the high-voltage- activated calcium channels. In the present study, beta3 ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.05.041
更新日期：2007-07-30 00:00:00
abstract：:Intracisternal administration of aluminum maltolate to rabbits produces a marked argyrophilic neurofibrillary degeneration (NFD) which is also immunoreactive for both phosphorylated and non-phosphorylated microtubule associated protein tau. Using tissue fixation in PBF, the monoclonal antibodies Tau-2 and AT8 stain th...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)01297-u
更新日期：1995-01-16 00:00:00
abstract：:Effects of alpha-adrenoceptor agents on electrophysiologically and immunohistochemically identified supraoptic nucleus (SON) vasopressin (VP) units were investigated by intracarotid infusion. Clonidine, an alpha 2-adrenoceptor agonist always excited SON units and alpha 2-adrenoceptor antagonists consistently inhibited...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91526-x
更新日期：1986-12-10 00:00:00
abstract：:The early, prenatal formation of noradrenergic projections to the forebrain has led to the proposition that these axons exert a trophic influence on cerebral cortex during ontogeny. To test this hypothesis, we have examined a number of different structural features of cortical development following prenatal lesions of...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(82)90077-3
更新日期：1982-01-01 00:00:00
abstract：:Neurotensin (NT) is a neuropeptide neurotransmitter in the central nervous system. It has been implicated in the therapeutic and in the adverse effects of neuroleptics. Activity of NT in brain can only be shown by direct injection of the peptide into that organ. However, we have developed a novel analog of NT(8-13), N...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)02363-x
更新日期：2000-02-21 00:00:00
abstract：:Brain edema is a serious consequence of hemispheric stroke and traumatic brain injury and contributes significantly to patient mortality. In the present study, we measured water contents in hippocampal slices as an in vitro model of edema formation. Excitotoxic conditions induced by N-methyl-D-aspartate (NMDA, 300 mic...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.09.012
更新日期：2006-11-29 00:00:00
abstract：:Spatial neglect may involve neglect dyslexia resulting in a failure to identify words or parts of words in the contralesional hemispace. The present study explored a well-documented dissociation in neglect dyslexics' word processing, i.e. impaired reading aloud in the presence of good lexical decision performance for ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.10.069
更新日期：2008-01-16 00:00:00
abstract：:Extracellular recordings of action potentials were made from neurones antidromically identified as neurosecretory cells in the paraventricular and supraoptic nuclei of urethane-anesthetized female rats. Eighty-six neurones were examined for their responsiveness to 10 ng of angiotensin II (AII) injected into the third ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)90048-7
更新日期：1980-04-28 00:00:00
abstract：:Following acute intracerebroventricular injections of 1 ng of apamin and chronic apamin infusion (0.4 ng/microl, 0.5 microl/h, 14 days), the rat brains exhibited bilateral damage only in the cerebellum. The argyrophilic cells were Purkinje cells in copula pyramis, flocculus, paraflocculus, and paramedian lobules. Thes...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01165-7
更新日期：1997-12-19 00:00:00
abstract：:Functional magnetic resonance imaging studies on episodic memory (EM) retrieval have used a variety of paradigms/contrasts to yield many diverse findings, which raises the need for an integrative multifactorial view. To address this need, I begin by proposing a fourstage, quasi-sequential model of network activity dur...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2020.147049
更新日期：2020-11-15 00:00:00
abstract：:Cortical sensory neurons synchronize their activity at multiple frequency bands after an external stimulation. In the somatosensory cortical areas, previous reports describe more discrete and somatotopically specific neural synchronization at the gamma band. Therefore, an efficient gamma synchronization of the neurons...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)03171-8
更新日期：2003-10-03 00:00:00
abstract：:The effect of dopamine (DA) on the calcium-activated potassium conductance underlying the slow afterhyperpolarization (AHP) which follows a train of action potentials in hippocampal pyramidal cells was studied utilizing the in vitro hippocampal slice preparation. Bath-applied DA (1-100 microM) significantly reduced th...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90773-0
更新日期：1986-08-06 00:00:00
abstract：:Nesfatin-1, an 82-amino acid peptide encoded by the secreted precursor nucleobinin-2 (NUCB2), exerts potent anorexigenic action independently of leptin signaling. This propensity has propelled this peptide and its analogues as potential anti-obesity drug candidates. However, a more extensive comprehension of its biolo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2019.01.032
更新日期：2019-05-15 00:00:00
abstract：:Estrogens exert a wide variety of actions on reproductive and non-reproductive functions. These effects are mediated by slow and long lasting genomic as well as rapid and transient non-genomic mechanisms. Besides the host of studies demonstrating the role of genomic actions at the physiological and behavioral level, m...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2006.07.098
更新日期：2006-12-18 00:00:00
abstract：:The recently developed technique of in vivo dialysis has permitted us to make direct measurements of serotonin release in a specific region of the spinal cord and to relate this to changes in blood pressure elicited by chemical stimulation of the brainstem. In the present experiments we have shown that chemical stimul...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91318-1
更新日期：1986-02-26 00:00:00
abstract：:We examined the electrophysiological properties of cholinergic and non-cholinergic neurons in the medial septum-diagonal band complex (MSDB) of the rat in the in vitro slice preparation. Cells were identified electrophysiologically, filled with Lucifer yellow, fixed and processed for immunohistochemistry with fluoresc...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91106-q
更新日期：1990-04-09 00:00:00
abstract：:These experiments examined the effects of intra-amygdala injections of NMDA receptor antagonists on the acquisition and retention of inhibitory avoidance. In Expt. I, rats received bilateral intra-amygdala injections of the NMDA antagonists D,L-AP5 (1-10 micrograms), D-AP5 (0.03-1 micrograms), CPP (0.125 or 0.375 micr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)91188-k
更新日期：1992-07-10 00:00:00
abstract：:The recent development of rodent models of bone cancer pain has started to provide the basis for demonstrating the particular neurochemical and behavioral entity of cancer pain. Behaviourally, both spontaneous pain and hyperalgesia related to mechanical, but not thermal, noxious stimuli have been described in cancer-b...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)02284-4
更新日期：2003-04-18 00:00:00
abstract：:The 'wobbler' mutant mouse can be recognized at about 4 weeks of age by its tremor and atrophy of forelimb muscles. In addition to degeneration of spinal motoneurons, especially in cervical spinal cord, selected bulbar motoneurons have also been reported to degenerate in the mutant. We examined a cranial motor nucleus...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91363-1
更新日期：1987-02-24 00:00:00
abstract：:Previous work had indicated that animals that were sleep-deprived and then trained on a passive avoidance task show poor retention of the task 24 h later after being allowed to sleep freely again. Cholinergic involvement is suggested by the fact that this effect is prevented by treatment with the muscarinic agonist pi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)02688-x
更新日期：2003-07-04 00:00:00
abstract：:Regeneration of descending supraspinal projections were identified in adult goldfish following administration of HRP to different levels of the spinal cord. While in the untreated normal fish 17 nuclei were shown to project into the spinal cord, only 11 of them seem to have participated in the process of regeneration....
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90159-k
更新日期：1993-08-27 00:00:00
