Abstract：
:Functionally activated sites usually have multiple specificities where coactivation is induced by inputs with different informational content. Using typical voxel-based functional mapping (univariate analysis), it is possible to show the presence of coactivation; however, it is not possible to distinguish whether coactivation occurs by independent or interactive processing units unless measurements are made at an extremely high spatial resolution. To address this problem, we have utilized the phenomenon of refractory suppression observable when two stimuli were given with a temporal separation of approximately 100 ms. This phenomenon is known to be noticeable in primary sensory areas. In this study, refractory suppression was investigated to determine its possible applications in higher functional sites. Two visual stimuli were presented in different hemifields, using a paradigm in which the first of the paired stimuli (face pictures) was placed in the left visual hemifield and the second stimulus was placed in the right hemifield. In this manner, the primary visual areas (V1) of the left and right hemispheres were independently activated. Along with independent activation in both V1, refractory suppression was indeed observed in higher functional areas, including the occipital and fusiform face areas in both hemispheres.
journal_name
Brain Resjournal_title
Brain researchauthors
Sung YW,Choi SH,Hong SJ,Choi US,Cho JH,Ogawa Sdoi
10.1016/j.brainres.2010.10.020subject
Has Abstractpub_date
2010-12-17 00:00:00pages
54-9eissn
0006-8993issn
1872-6240pii
S0006-8993(10)02258-4journal_volume
1366pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Gamma-hydroxybutyrate (GHB) at low doses (5-10 mg/kg i.p.) increased and at high doses (160-320 mg/kg i.p.) decreased the spontaneous firing rate of prefrontal cortex (PFC) neurons recorded in urethane-anesthetized rats. Only excitations were blocked by NCS-382, a specific GHB receptor antagonist; this suggests that t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)01461-p
更新日期：1995-02-27 00:00:00
abstract：:Central nervous system (CNS) disorders are important targets for gene therapy; however, delivery of therapeutic proteins and/or genes to the brain remains a major challenge due to the difficulty of efficiently delivering viral vectors across the blood-brain barrier (BBB). In the present work, we tested the ability of ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.03.014
更新日期：2011-05-10 00:00:00
abstract：:In this research, we investigated striatal neurogenesis in 3-, 6-, 12-, and 18-month-old rats after cerebral ischemic injury. All rats were subjected to a 20-min middle cerebral artery occlusion (MCAO), given 5'-bromodeoxyuridine (BrdU, 30 mg/kg, i.p.) once daily during days 4-7 and sacrificed 2 weeks after MCAO. Neur...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.06.043
更新日期：2007-08-29 00:00:00
abstract：:A major role of tooth receptors in signaling overt or impending tissue damage (nociception) has been previously established by substantial evidence from mechanical, thermal and chemical stimulation of exposed dentin. We report evidence showing that some intradental receptors in canine teeth of the cat detect mechanica...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90239-2
更新日期：1985-05-20 00:00:00
abstract：:The effects of brain and meningeal extracts from chick embryos on the proliferation of cultured neuroblasts from chick embryo cerebral hemispheres were studied. Morphological observations, counts of the cultured neurons, determination of DNA and protein contents as well as [3H]thymidine incorporation measurements were...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(81)90073-0
更新日期：1981-06-01 00:00:00
abstract：:Molecular events associated with mnemonic processes and neuronal plasticity are postulated to result in functional changes in synaptic structure. One possible site is the post-synaptic density, where activity-dependent changes modulate signal transduction cascades. In this report, we detail spatial-temporal changes fo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.02.023
更新日期：2005-04-18 00:00:00
abstract：:It is widely believed that substance use disorder (SUD) results from both pre-alterations (vulnerability) and/or post-alterations (drug effects) on cortico-striatal circuits. These circuits are essential for cognitive control, motivation, reward dependent learning, and emotional processing. As such, dysfunctions in co...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2015.03.048
更新日期：2015-12-02 00:00:00
abstract：:Autoradiographic analysis of [(35)S]GTPgammaS binding was used to investigate functional activation of dopamine receptors in rat striatum. Dopamine-stimulated [(35)S]GTPgammaS binding was observed with a maximal increase of 38% over basal activity. A similar stimulatory response was obtained with the D(2) agonist quin...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02981-4
更新日期：2000-12-01 00:00:00
abstract：:Perinatal overfeeding is a risk factor for overweight and diabetes during life. Underlying pathophysiological mechanisms are unclear. The peptide galanin is suggested to stimulate food intake by acting within the paraventricular hypothalamic nucleus (PVN). In early postnatally overfed rats overweight and hyperinsuline...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)01264-5
更新日期：1999-02-06 00:00:00
abstract：:The neuroactive steroid 5 beta-pregnan-3 alpha-ol-20-one (5 beta 3 alpha) modulates GABAA receptor function by potentiating postsynaptic GABA currents. While much is now known about the postsynaptic action of neurosteroids, far less is known about how they affect neurotransmission. We have investigated the synaptic ac...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00809-3
更新日期：1997-10-03 00:00:00
abstract：:Previous findings from our laboratory demonstrated [125I]angiotensin II (AII) binding to plasma membranes from rat but not gerbil circumventricular organs (CVOs), the presumed location of brain receptors for angiotensin-induced dipsogenicity. Since members of both species drink to intracranially applied AII, a degrada...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90822-9
更新日期：1984-03-12 00:00:00
abstract：:In a focused attention task saccadic reaction time (SRT) to a visual target stimulus (LED) was measured with an auditory (white noise burst) or tactile (vibration applied to palm) nontarget presented in ipsi- or contralateral position to the target. Crossmodal facilitation of SRT was observed under all configurations ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.05.081
更新日期：2008-11-25 00:00:00
abstract：:Ascending and descending projections of the nucleus reticularis gigantocellularis (NRGc) were studied in the cat by the anterograde tracer, Phaseolus vulgaris leucoagglutinin. Ascending fibers from the left or the right NRGc coursed through the bilateral medial reticular formation and some of them reached the dienceph...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91212-7
更新日期：1988-09-13 00:00:00
abstract：:A comparative study using membrane homogenate binding, autoradiography, and Western blot assays was carried out to determine the age-related changes in N-methyl-D-aspartate (NMDA) receptors in 4-, 12- and 24-month-old male Wistar rats, treated or not with vitamin E. Vitamin E treatment was 20 mg/kg i.p. daily for 15 d...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.09.008
更新日期：2004-12-03 00:00:00
abstract：:Neuroglobin (Ngb) and Cytoglobin (Cygb) are new members of the globin family and display heterotopic expression patterns. To examine the effect of different hypoxia profiles on expression of Ngb and Cygb in rodent brain, rats were exposed to either sustained hypoxia (SH; 10% O(2)) or intermittent hypoxia (IH; 10% and ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.04.063
更新日期：2006-06-22 00:00:00
abstract：:The Snell dwarf mouse (dw/dw) shows significantly decreased somatostatin levels in the hypothalamus whereas more or less increased somatostatin concentrations are observed in any central extrahypothalamic sites studied. These opposite results in hypothalamus and extrahypothalamic areas may be linked to the apparently ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91337-x
更新日期：1985-02-25 00:00:00
abstract：:The neurotoxic effects produced by ibotenic acid (IA) induced chemical lesions of the central nervous system (CNS) cholinergic system were examined on the opioid peptidergic system in adult rats. Forebrain cholinergic systems were bilaterally lesioned by the infusion of IA (1 or 5 micrograms/site) into the nucleus bas...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90668-y
更新日期：1992-02-07 00:00:00
abstract：:We have shown that high-concentration albumin therapy is markedly neuroprotective in focal cerebral ischemia. The present study was conducted to ascertain the degree to which hemodynamic alterations are responsible for this therapeutic effect. Normothermic, physiologically regulated male Sprague-Dawley rats received a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00674-x
更新日期：1998-08-31 00:00:00
abstract：:Proechimys, a rodent living in the Amazon region, has shown resistance to developing chronic epilepsy when submitted to different experimental models. Recently, many studies have attributed a potent anticonvulsant action to cannabinoid receptor CB1. This study investigated the distribution and expression of the CB1 re...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.03.031
更新日期：2010-06-04 00:00:00
abstract：:The impact of hyperglycemia after traumatic brain injury (TBI), and even the administration of glucose-containing solutions to head injured patients, remains controversial. In the current study adult male Sprague-Dawley rats were tested on behavioral tasks and then underwent surgery to induce sham injury or unilateral...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.04.022
更新日期：2015-07-21 00:00:00
abstract：:Intravenous administration of lipopolysaccharide (LPS) (0.9 mg/kg) has been shown to induce ischemic tolerance in spontaneously hypertensive rats (SHR). TNF-alpha is believed to play a crucial role in preconditioning as its inhibition with TNF-alpha-binding protein abolished tolerance. Our recent studies (Liu et al., ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02028-5
更新日期：2001-03-23 00:00:00
abstract：:Slow negative potentials, evoked by stimulation of the lumbar dorsal roots, have been demonstrated in the dorsal horn of an isolated, hemisected spinal cord preparation from golden hamsters. Paired stimuli revealed a period of partial suppression of this slow potential persisting for up to 2 s following the conditioni...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90940-4
更新日期：1982-02-04 00:00:00
abstract：:In the present study, we characterized the evoked electrical activity from T(13) to S(2) dorsal roots (DRs) during glass probe-stimulation of the vagina-cervix-uterus junction (VCUJ) of female Wistar rats. The results showed that gentle stimulation of VCUJ evoked high-amplitude electrical activity in L(3) and L(6) DRs...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.12.023
更新日期：2013-02-16 00:00:00
abstract：:Behavioral assessments of mouse models of neurodegenerative disorders are useful for investigating the molecular basis of the pathologies of the diseases. Here, we investigated the utility of a water-finding test using a video tracking system as a tool for evaluating cognitive deficits in Alzheimer's disease model mic...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.10.066
更新日期：2013-01-23 00:00:00
abstract：:Circadian and neural mechanisms important for the organization of reproductive behavior in the male golden hamster were examined. The sexual behavior of male hamsters exhibits diel variations; males are quicker to initiate copulation and to ejaculate in the dark phase than in the light phase of a daily light-dark cycl...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)91460-4
更新日期：1984-02-13 00:00:00
abstract：:Transplantation of olfactory ensheathing cells (OECs) into injured spinal cord results in improved functional outcome. Mechanisms suggested to account for this functional improvement include axonal regeneration, remyelination and neuroprotection. OECs transplanted into transected peripheral nerve have been shown to mo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.09.089
更新日期：2006-12-13 00:00:00
abstract：:The cholinergic innervation of the mediodorsal (MD) nucleus of the thalamus was visualized immunohistochemically in human brain postmortem, using an antibody against human choline acetyltransferase (ChAT). The ChAT staining of the MD nucleus was more intense than in the surrounding thalamic nuclei but weaker than that...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90585-y
更新日期：1990-05-07 00:00:00
abstract：:Multiple-unit activity (MUA) in the agranular medial prefrontal cortex (PFC) was recorded in conscious rabbits during a classical conditioning procedure involving repeated pairings of a 4-s tone conditioned stimulus (CS) with eye shock. Prior to behavioral training, significant tone-evoked increases in prefrontal MUA ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91435-7
更新日期：1988-02-23 00:00:00
abstract：:Extended incubation of hippocampus slices in the presence of fatty acid-free bovine serum albumin (FAF-BSA) strongly enhanced the release of D-[3H]aspartate and [14C]GABA induced by veratridine. Saturation of the FAF-BSA with oleic acid abolished the enhancing effect. Spontaneous release and K+-induced release were no...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90687-7
更新日期：1988-08-09 00:00:00
abstract：:Cajal-Retzius (CR) cells of the mammalian neocortex co-express the extracellular matrix protein Reelin and p73, a transcription factor involved in cell death and survival. Most neocortical CR cells derive from the cortical hem, with minor additional sources. We analyzed the distribution of Reelin and p73 immunoreactiv...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.11.015
更新日期：2007-02-09 00:00:00
