Abstract：
:There is a high incidence of cardiac arrest and poorer post-resuscitation outcome in the elderly population. Cardiac arrest and resuscitation results in ischemia/reperfusion injury associated with oxidative stress, leading to post-resuscitation mortality and delayed selective neuronal cell loss. In this study we investigated recovery following cardiac arrest and resuscitation in the aged rat brain. Male Fischer 344 rats (6, 12 and 24 months old) underwent 7 minute cardiac arrest before resuscitation. Overall survival and hippocampal neuronal counts were determined at 4 days of recovery. Brainstem function was assessed by hypoxic ventilatory response (HVR). Mitochondria of brainstem, cortex and hippocampus were isolated and assessed for respiratory function. Effect of an antioxidant, alpha-phenyl-tert-butyl-nitrone (PBN) was used as a treatment strategy against oxidative stress in the 6 and 24-month old rats. The time course of mitochondrial function was established using 3-month old Wistar rats with 12-minute cardiac arrest. In the 24-month old rats, overall survival rate, hippocampal CA1 neuronal counts, HVR, and brain mitochondrial respiratory control ratio were significantly reduced following cardiac arrest and resuscitation compared to the younger rats, and PBN treatment improved outcome. The data suggest that (i) there was increased susceptibility to ischemia/reperfusion in aged rat brain; (ii) HVR was decreased in the aged rats; (iii) brain mitochondrial respiratory function related to coupled oxidation was decreased following cardiac arrest and resuscitation in rats, more so in the aged; and (iv) treatment with an antioxidant, such as PBN, reduced the oxidative damage following cardiac arrest and resuscitation.
journal_name
Brain Resjournal_title
Brain researchauthors
Xu K,Puchowicz MA,Sun X,LaManna JCdoi
10.1016/j.brainres.2010.02.080subject
Has Abstractpub_date
2010-04-30 00:00:00pages
181-9eissn
0006-8993issn
1872-6240pii
S0006-8993(10)00486-5journal_volume
1328pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:The content of serotonin (5-HT), 5-hydroxyindoleacetic acid (5-HIAA) and norepinephrine (NE) was analysed in 71 human spinal cords obtained post-mortem. The highest content of 5-HT, 5-HIAA and NE was found in the lumbar enlargement of the spinal cord. 5-HT and 5-HIAA content increased from fetal to adult spinal cord w...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91613-7
更新日期：1988-03-08 00:00:00
abstract：:Acute bouts of exercise have been shown to produce transient increases in regional cerebral glucose utilization, oxygen uptake, and cerebral blood flow in motor cortex, striatum, and hippocampus. The purpose of this study was to determine whether or not chronic exercise will cause long-term metabolic plasticity in bra...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)03200-5
更新日期：2001-02-09 00:00:00
abstract：:The cognitive reserve hypothesis proposes that the brain actively attempts to cope with age-related changes by using pre-existing cognitive networks (neural reserve) or enlisting compensatory processes (neural compensation). In a context of visual selective attention, the current study compared task-related activation...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.02.061
更新日期：2012-05-15 00:00:00
abstract：:Brief force perturbations were applied 30-120 ms prior to onset of step-tracking forearm movements by normal humans. The perturbations altered the first agonist burst of the movement-related triphasic EMG pattern. Perturbations opposing the movement resulted in an increase in the magnitude of the late part of the firs...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)91224-5
更新日期：1981-09-14 00:00:00
abstract：:The so-called on- and off-cells of the rostral ventromedial medulla (RVM) send their axons to the spinal dorsal horn. Activation of on-cells precedes and coincides with a facilitation, and activation of off-cells coincides with an inhibition, of withdrawal reflexes elicited by noxious agents. Considerable evidence sup...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2018.02.025
更新日期：2018-05-01 00:00:00
abstract：:A central component of Attention Deficit Hyperactivity Disorder (ADHD) is increased distractibility in response to visual and auditory stimuli, which is linked to the superior colliculus (SC). Furthermore, there is now mounting evidence of altered collicular functioning in ADHD and it is proposed that a hyper-responsi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.09.038
更新日期：2015-12-10 00:00:00
abstract：:To examine the effect of short-term and long-term adrenalectomy (ADX) on the glucocorticoid receptor (GR) expression, we performed an immunohistochemical study on the rat forebrain. One day after ADX, the GR-immunoreactivity significantly decreased or disappeared in most forebrain structures, while relatively strong G...
journal_title：Brain research
pub_type： 杂志文章
doi：
更新日期：1996-08-12 00:00:00
abstract：:The present study examined if olfactory bulbectomy (OBX) altered defensive behaviors on the elevated plus-maze and the open-field differently in male and female rats. Similar increases in defensive behaviors in male and female rats were observed in both tests following OBX. No significant correlations were detected be...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02421-0
更新日期：2001-06-08 00:00:00
abstract：:Highly specific antibodies to dynorphin A(1-13), infused into the lateral ventricle, elevated brain stimulation threshold for eliciting feeding behavior. Antibodies to beta-endorphin had little or no effect. Temporal analysis of the anorectic action indicated a striking similarity to the effect of systemically adminis...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90950-4
更新日期：1987-10-06 00:00:00
abstract：:Although there are several reports on the alteration of intracellular signal transduction during heat shock in somatic cells, the long term effects of heat shock on neuronal cells remain unknown. In this report, we investigated cyclic AMP (cAMP) accumulation and the expression of heat shock proteins following heat sho...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00072-9
更新日期：1998-04-20 00:00:00
abstract：:Previous examination of binge cocaine self-administration and 2 week withdrawal from cocaine self-administration on ionotropic glutamate receptor subunit (iGluRs) protein levels revealed significant alterations in iGluR protein levels that differed between the mesocorticolimbic and nigrostriatal pathways. The present ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.09.051
更新日期：2005-12-07 00:00:00
abstract：:Excitatory transmission along the perforant path from the entorhinal cortex to the granule cells of the dentate gyrus was evaluated two days after 10 min of transient cerebral ischemia in the rat. The amplitude of the population spike, and the amplitude and the initial slope of the population excitatory postsynaptic p...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91446-7
更新日期：1989-12-29 00:00:00
abstract：:It is well documented that VMAT2 protects nigrostriatal DA neurons against MPP(+) by sequestering it inside vesicles away from its mitochondrial site of neurotoxic action. However, the implication of the VMAT2 in the mechanism of action exerted by 6-OHDA has received little attention. Therefore, the aim of the present...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)03333-x
更新日期：2003-11-07 00:00:00
abstract：:Benzodiazepine binding sites are present on gamma-aminobutyric acid (GABA) receptors in hippocampal neurons. Diazepam is known to potentiate the amplitude and prolong the decay of GABA(A) receptor-mediated inhibitory postsynaptic currents (IPSCs). In this study, benzodiazepine involvement in long-term potentiation (LT...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.09.008
更新日期：2005-11-16 00:00:00
abstract：:This study was designed to evaluate the role of spinal glutamatergic receptors in the antinociception elicited by agmatine in mice. Intraperitoneal (i.p.) administration of agmatine (1.0-100.0 mg/kg) dose dependently inhibited the nociceptive response induced by intrathecal (i.t.) injection of glutamate, N-methy-D-asp...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.03.087
更新日期：2006-06-06 00:00:00
abstract：:The N400 is an event-related potential (ERP) component that is elicited by semantically meaningful stimuli; one of its defining characteristics is that it is amplified for sentence completions that are semantically unexpected or incongruous with the preceding context. Some prior reports using visual sentence reading p...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.07.099
更新日期：2010-10-08 00:00:00
abstract：:The objective was to determine if corticopetal basal forebrain neurons could co-synthesize different transmitters. Histochemical labeling of a molecular marker of connectivity (wheat germ agglutinin lectin-bound horseradish peroxidase [HRP]; axonal uptake and retrograde transport from neocortex) and immunohistochemica...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90099-1
更新日期：1989-07-03 00:00:00
abstract：:Neurons containing immunoreactivity to the endogenous lactose-binding lectin, RL-29, were examined in the L4 segment of the spinal cord of rats with an experimental neuropathy. The cells appeared by 5 days and were also present at 14 and 28 days postoperatively. All neurons were found in the dorsal horn ipsilateral to...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90271-n
更新日期：1993-08-20 00:00:00
abstract：:Attack by a cat on a rat was elicited by electrical stimulation of the ventral parabrachial nucleus or the paralemniscal pontine reticular formation. The attack was quiet and it differed from similar behavior elicited at other sites in that the cat not only bit the rat but struck it with its paw. Horseradish peroxidas...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(79)90009-x
更新日期：1979-03-23 00:00:00
abstract：:The changes in mean arterial pressure (MAP) and respiratory frequency (RF) in response to microinjection of NMDA or AMPA into the commissural subnucleus of the NTS (comNTS) at the calamus scriptorius level of awake rats were evaluated. Under tribromoethanol anesthesia, the rats received guide-cannulae in direction of ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.09.017
更新日期：2005-11-23 00:00:00
abstract：:The ventral tegmental area is a site of action by psychostimulants in the production of behavioral sensitization. Recently, G proteins of the ventral tegmental area have been implicated in behavioral sensitization to cocaine. To further investigate the specific role of G proteins, rats were treated with either 15 or 3...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90049-f
更新日期：1992-05-08 00:00:00
abstract：:Changes in GABA(A) receptor alpha(1) subunit gene expression occur in the globus pallidus and substantia nigra pars reticulata following lesions of the nigrostriatal tract. To determine whether these changes are translated at the protein level, we performed quantitative autoradiography with the alpha(1) selective liga...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02081-3
更新日期：2000-04-17 00:00:00
abstract：:The induction of gene expression has been correlated with long-lasting neuronal plasticity and long-term memory (LTM) formation. The fast activation of constitutive transcription factors by signaling mechanisms is thought to be the link between synaptic events and gene expression. However, only one constitutive transc...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)02358-6
更新日期：2000-02-14 00:00:00
abstract：:Agents such as 619C89 decrease extracellular glutamate concentrations by a primary action at voltage sensitive sodium channels, but NMDA antagonists also have been shown to decrease extracellular glutamate concentration after ischemia. To address the question as to whether 619C89's effect upon extracellular glutamate ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00868-q
更新日期：1995-11-13 00:00:00
abstract：:The structurally related Aconitum alkaloids aconitine, lappaconitine, and 6-benzoylheteratisine inhibited the orthodromic and antidromic population spike in hippocampal CA1 area in a frequency-dependent manner. Aconitine (1 microM) completely suppressed epileptiform activity induced by omission of Mg2+ as well as norm...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00990-0
更新日期：1996-10-28 00:00:00
abstract：:The response of granule cells and CA1 pyramidal neurones to NMDA was studied in the presence and absence of Mg2+ using an in vitro slice preparation. In the absence of Mg2+ the depolarizing response of hippocampal neurones to NMDA is accompanied by a decrease in input resistance. In the presence of Mg2+ ions, however,...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90107-0
更新日期：1984-10-08 00:00:00
abstract：:In many persons with temporal lobe epilepsy, dentate granule cells form an interconnected synaptic network. This recurrent mossy fiber circuit mediates reverberating excitation that may facilitate seizure propagation by synchronizing granule cell discharge. The involvement of specific glutamate receptors in granule ce...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02824-4
更新日期：2001-10-05 00:00:00
abstract：:Previous studies have shown behavioral changes in pre- and postnatal rats exposed to morphine before and during gestation. The present study has attempted to discover morphological correlates of these changes in the fetal rat spinal cord. Pregnant Wistar rats were injected subcutaneously on days 12-18 of gestation wit...
journal_title：Brain research
pub_type： 杂志文章
doi：
更新日期：1980-11-24 00:00:00
abstract：:During embryogenesis, transient expression of nestin in proliferating neuroepithelial stem cells signals the commitment of progenitor cells to differentiate. Although adult mammalian brain contains very little nestin, significant upregulation of nestin has been reported following cerebral injury, leading to speculatio...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2003.08.070
更新日期：2004-05-22 00:00:00
abstract：:The enzyme in brain that hydrolyzes 2',3'-cyclic nucleotides to the 2'-mononucleotides has been found by several authors to be concentrated in the myelin fraction. To facilitate further study of the enzyme, one of our objectives has been to develop a method of solubilizing the enzyme without the use of detergents. Whe...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(75)90719-2
更新日期：1975-05-23 00:00:00
