Abstract：
:Highly specific antibodies to dynorphin A(1-13), infused into the lateral ventricle, elevated brain stimulation threshold for eliciting feeding behavior. Antibodies to beta-endorphin had little or no effect. Temporal analysis of the anorectic action indicated a striking similarity to the effect of systemically administered naloxone. These findings suggest that central dynorphin is involved in the control of ingestive behavior and that the anorectic action of naloxone may result from antagonism of dynorphinergic transmission.
journal_name
Brain Resjournal_title
Brain researchauthors
Carr KD,Bak TH,Gioannini TL,Simon EJdoi
10.1016/0006-8993(87)90950-4subject
Has Abstractpub_date
1987-10-06 00:00:00pages
384-8issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(87)90950-4journal_volume
422pub_type
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