Abstract：
:The expression of two embryonic intermediate filaments, nestin and vimentin, in the rat brain at days 0 (control), 1, 4, 7 and 14 post-cryoinjury was studied to elucidate their roles in brain injury. Western blot analysis showed that both nestin and vimentin expressions in the ipsilateral cerebral cortex were significantly increased at 4 and 7 days post-cryoinjury, and were decreased at day 14 after cryoinjury. Immunohistochemistry showed that there were few nestin- and vimentin-positive cells in the cerebral cortex in normal controls. On days 4 and 7 post-injury, abundant glial cells in the periphery of the lesion were immunostained for nestin and/or vimentin; only vimentin was detected in the majority of inflammatory cells in the core lesion. These findings suggest that nestin and vimentin contribute to the repair of brain injury through the migration of activated cells and the formation of a glial scar.
journal_name
Brain Resjournal_title
Brain researchauthors
Moon C,Ahn M,Kim S,Jin JK,Sim KB,Kim HM,Lee MY,Shin Tdoi
10.1016/j.brainres.2004.09.022subject
Has Abstractpub_date
2004-12-03 00:00:00pages
238-42issue
2eissn
0006-8993issn
1872-6240pii
S0006-8993(04)01542-2journal_volume
1028pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Moyamoya disease (MMD) is a chronic occlusive cerebrovascular disease with unknown etiology that is characterized by the development of abnormal vascular networks at the base of the brain. Recent genome-wide studies identified RNF213 as an important MMD susceptibility gene. However, the exact mechanism by which the RN...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2014.11.014
更新日期：2015-01-12 00:00:00
abstract：:The effects of natural (mechanical and gustatory) stimulation of the nasopharynx or electrical stimulation of the pharyngeal branch of the glossopharyngeal (PH-IXth) nerve on the changes in heart rate (HR) and arterial blood pressure (BP) were investigated in paralyzed and anesthetized rats. Afferent responses in the ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91614-x
更新日期：1993-08-13 00:00:00
abstract：:The electrical property of delayed K+ currents (IKD) was studied in pyramidal neurones freshly isolated from the rat hippocampal CA1 region. The IKD was separated pharmacologically from other membrane currents. Activation and inactivation processes of the IKD were highly voltage-dependent in the potential range betwee...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91425-z
更新日期：1991-12-24 00:00:00
abstract：:Experiments have been performed on pentobarbitone anesthetized or decerebrated rats. The nature of the synchronous rhythmical activity which occurs in the inferior olive following the electrophoretic or systemic administration of harmaline, harmine, dihydro-beta-erythroidine and various other compounds, is described. ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90471-6
更新日期：1976-01-23 00:00:00
abstract：:The present study demonstrates changes in rat brain glial metabolism during the acute phase of epilepsy. Status epilepticus (SE) was induced using the lithium-pilocarpine model. Glial metabolism was measured with (14)C-acetate. Local cerebral blood flow and glucose metabolism were also measured using (14)C-N-isopropyl...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.10.074
更新日期：2010-01-22 00:00:00
abstract：:alpha-Motoneurons innervating the triceps surae and short plantar muscles were stained intracellularly with horseradish peroxidase (HRP) in 0-44-day-old kittens and adult cats. The terminal arborizations of the recurrent axon collaterals in the spinal cord were studied in the light microscope (LM). The short plantar m...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(85)90132-4
更新日期：1985-01-01 00:00:00
abstract：:The ionic basis of norepinephrine (NE) action was studied with intracellular recording techniques in the rat hippocampal slice. Topical application of NE caused, in CA1 neurons, a 3-4 mV hyperpolarization associated with a 10-20% decrease in input resistance. This effect was accompanied by a decrease in spontaneous ac...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90104-9
更新日期：1981-02-09 00:00:00
abstract：:Prairie voles are socially monogamous mammals that form pair bonds and display paternal care. This study was focused on the male prairie vole's neuronal responses to infant-related odors. Using the fos protein as a measure of neuronal activation, we examined the brain responses of males to infant-related odors. Prior ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2019.02.023
更新日期：2019-07-01 00:00:00
abstract：:Chemotherapy is an effective treatment but difficult to tolerate due to side effects like vomiting. Studies on the etiology of chemotherapy-related emesis have implicated brainstem nuclei and the neurotransmitter substance P, among other substrates. Since rodents do not vomit, other species have been necessary as alte...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.04.061
更新日期：2007-07-02 00:00:00
abstract：:Luteinizing hormone (LH) secretion during the reproductive cycle and in ovariectomized (OVX) rats is pulsatile and this pattern of secretion is determined by intermittent discharges of LH-releasing hormone (LHRH) into the hypophysial portal vessels. LHRH secretion is probably controlled by prior pulsatile norepinephri...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01548-6
更新日期：1999-06-26 00:00:00
abstract：:Cardiac arrest-induced cerebral hypoxic injury could induce posthypoxic movement disorders. Here we investigated the effects of memantine, an NMDA receptor channel blocker, on the neurodegeneration occurred in an established rat model of posthypoxic myoclonus. We found that administration of memantine for 7 days signi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.11.076
更新日期：2007-02-16 00:00:00
abstract：:SBA and NADPH-d histochemistries allow identification of functionally distinct components of the amphibian primary olfactory system. In Pipa, a secondarily aquatic frog, combination of both methodologies, using alternate sets of histological sections, reveals that, apart from Jacobson's organ, this species has a "wate...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00507-6
更新日期：1997-07-11 00:00:00
abstract：:Extracellular recording was used to investigate spontaneously active neurons in all four major nuclei of the rat vestibular nuclear complex (VNC) in brainstem slices. The density of spontaneously active neurons was highest in the medial vestibular nucleus (MVN), slightly lower in the superior (SuVN) and spinal (SpVN) ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)02361-2
更新日期：2002-04-26 00:00:00
abstract：:(2E)-(5-Hydroxy-5,7,8,9-tetrahydro-6H-benzo[a][7]annulen-6-ylidene) ethanoic acid (NCS-382) is an antagonist for gamma-hydroxybutyric acid (GHB) at GHB receptor sites. Advantages of using [(3)H]NCS-382 over [(3)H]GHB in radioligand binding studies are that unlike GHB, NCS-382 does not appear to bind to, activate, or i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)02865-8
更新日期：2003-07-25 00:00:00
abstract：:Motor behavior not seen in newborn cats can be revealed by spinal transection and is therefore normally suppressed. Motor performance of these spinal kittens after reaching adulthood surpasses that of chronic adult-operated spinal cats but the latter display a significant improvement when GABAergic inhibition is block...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90879-0
更新日期：1985-11-04 00:00:00
abstract：:Galectin-3 (Gal-3) is a member of a class of carbohydrate-binding proteins and plays a role in a number of cellular functions such as cell proliferation, angiogenesis and differentiation. We observed an up-regulated expression of Gal-3 in the ischemic brain following transient middle cerebral artery occlusion in rats....
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.06.073
更新日期：2009-09-08 00:00:00
abstract：:The neuropeptide nociceptin/orphanin FQ (N/OFQ) and its receptor are members of the endogenous opioid peptide family. In mammals N/OFQ modulates a variety of biological functions such as nociception, food intake, endocrine, control of neurotransmitter release, among others. In the molluscs Cepea nemoralis and Helix as...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2013.02.007
更新日期：2013-04-10 00:00:00
abstract：:During retinal development, common precursors give rise to various types of cells in a time course specific to each cell type. Previously, we demonstrated that the bHLH gene Hes1 inhibits neuronal differentiation whereas, in Hes1-null retina, precursors prematurely differentiate into neurons and form abnormal rosette-...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.01.045
更新日期：2004-04-09 00:00:00
abstract：:Antisense oligodeoxynucleotides (ODNs) are used for the selective inhibition of gene expression. Antisense ODNs are promising tools for the investigation of physiological implications of proteins in the central nervous system of rodents in vivo. We have previously demonstrated that a phosphorothioate antisense ODN to ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00463-0
更新日期：1997-08-08 00:00:00
abstract：:Previous work has shown that administration of corticotropin-releasing factor (CRF) into the lateral ventricle antagonizes the orexigenic effect of neuropeptide Y (NPY), and central injection of CRF antagonist, alpha-helical CRF(9-41) enhanced NPY-induced food intake in satiated rats. The aim of the present study was ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90431-l
更新日期：1993-07-30 00:00:00
abstract：:Intermediate filament aggregation within motor neurons is a hallmark of ALS pathogenesis. Changes to intermediate filament stoichiometry due to altered mRNA steady-state levels of NEFL, PRPH and INA is thought to drive protein aggregation, yet the exact cause of these changes is unknown. MicroRNAs (miRNAs)-master regu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2018.10.032
更新日期：2019-03-01 00:00:00
abstract：:Three groups of rats, one with amygdala lesions, one with hippocampal lesions and a control group were trained on a brightness discrimination task under one of three different conditions, enhancement of the negative cue, enhancement of the positive cue or a non-enhanced condition. Animals with amygdala lesions showed ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(77)90621-7
更新日期：1977-04-15 00:00:00
abstract：:The suspected functional role of dendritic spines as loci of neuronal plasticity (possibly memory and learning) is greatly enriched when active membrane properties are assumed at the spine head. Computations with reasonable electrical and structural parameter values (corresponding to an optimal range for spine stem re...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90333-6
更新日期：1985-01-28 00:00:00
abstract：:Kernicterus is a bilirubin-induced encephalopathy in newborn. Its spectrum ranges from subtle extrapyramidal to acute encephalopathy and chronic posticteric sequelae. Current treatment of this serious problem is far from optimal. Taurine has been documented to have protective effects on neuronal cells against ischemia...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.01.036
更新日期：2010-03-12 00:00:00
abstract：:The adult rat retina was evaluated following surgical lesion and after transplantation of embryonic day 15 (E15) retinal tissue. While a surgical incision caused degeneration and ganglion cell death peripheral to lesion site, the addition of an embryonic retinal implant to the lesion site resulted in a reduction of th...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90300-4
更新日期：1989-10-23 00:00:00
abstract：:The goal of the present study was to identify the projection from the subdivisions of the amygdaloid nuclear complex to specified subregions of the dorsal raphe (DR) nucleus and to attempt to compare the density of amygdaloid input to the DR with that of inputs from other limbic structures. Use of a retrograde tracer,...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.01.081
更新日期：2007-04-27 00:00:00
abstract：:Cerebellar explants derived from neonatal mice were exposed to cytosine arabinoside, an inhibitor of DNA synthesis. Following such exposure, the cortical regions of the explants contained numerous closely packed large neurons with few intervening elements and without lamination. The surviving large cortical neurons in...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)90984-1
更新日期：1980-03-31 00:00:00
abstract：:Human truncated tau protein is an active constituent of the neurofibrillary degeneration in sporadic Alzheimer's disease. We have shown that modified tau protein, when expressed as a transgene in rats, induced AD characteristic tau cascade consisting of tau hyperphosphorylation, formation of argyrophilic tangles and s...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.10.085
更新日期：2007-01-26 00:00:00
abstract：:We have previously demonstrated resiniferatoxin (RTX) to be an ultrapotent analog of capsaicin. Like capsaicin, RTX initially induces neurogenic inflammation, pain, and hypothermia and then causes desensitization of these responses. We examine here the duration of desensitization following acute treatment with the max...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91705-8
更新日期：1989-11-27 00:00:00
abstract：:Autism is marked by overgrowth of the brain at the earliest ages but not at older ages when decreases in structural volumes and neuron numbers are observed instead. This has led to the theory of age-specific anatomic abnormalities in autism. Here we report age-related changes in brain size in autistic and typical subj...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.09.101
更新日期：2011-03-22 00:00:00
