Abstract：
:SC1 is an extracellular matrix glycoprotein that is related to the multifunctional protein SPARC. These matricellular members play regulatory roles in modulating cellular interactions. SC1 expression is enriched in the central nervous system during embryonic and postnatal development as well as in the adult brain. In the rat cerebellum, SC1 is expressed at high levels in Bergmann glial cells and their radial fibers which project into the synaptic-rich molecular layer. At specific stages of development and in the adult, SC1 mRNA is selectively transported into cellular processes of these cells. In the present study, we have examined the effect of whole-body hyperthermia on the transport of SC1 mRNA in Bergmann glial cells of the rat cerebellum. Our results show that SC1 mRNA transport is diminished at 10 and 15 h post-hyperthermia, but returns to control levels by 24 h after heat shock. One of the characteristics of a heat shock on cells grown in tissue culture is a collapse of the cytoskeletal network. Intact components of the cytoskeleton are necessary for the transport of mRNA into peripheral processes of cells. However, in vivo hyperthermia does not appear to affect the morphology of the intermediate filament proteins GFAP, vimentin, or the beta-tubulin component of microtubules in Bergmann glial cell processes. During the hyperthermic time course, levels of vimentin protein increase, which is reflected by immunoreactivity of activated astrocytes and microvasculature in cerebellar white matter.
journal_name
Brain Resjournal_title
Brain researchauthors
Mothe AJ,Brown IRdoi
10.1016/s0006-8993(02)02270-9subject
Has Abstractpub_date
2002-03-29 00:00:00pages
146-58issue
2eissn
0006-8993issn
1872-6240pii
S0006899302022709journal_volume
931pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Mouse brain was found by immunoblot analysis to have a protein of Mr 23,000 (P23k) that was clearly different from recoverin and was labeled with an antiserum raised against the NH2-terminus of recoverin. P23k could not be detected by an antiserum raised against the COOH-terminus of recoverin. Blots with 45Ca demonstr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90676-z
更新日期：1992-02-07 00:00:00
abstract：:In the present study, the light responses of ganglion cells to chromatic stimulus were recorded from isolated retina of neonatal chick. It was found that for some non-color-opponent ganglion cells, the spatiotemporal patterns of the cells' light responses were related to the chromatic information that they received. W...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.07.077
更新日期：2005-10-12 00:00:00
abstract：:Affective disorders and memory impairments precede the classical motor symptoms seen in Parkinson's disease (PD) and the currently approved antiparkinsonian agents do not alleviate the non-motor symptoms as well as the underlying dopaminergic neuron degeneration. On the other hand, there is increasing evidence that in...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2013.03.029
更新日期：2013-06-04 00:00:00
abstract：:In rat hippocampal slices, the novel metabotropic glutamate receptor (mGluR) ligand, (1S,1'R,2'R,3'R)-2-(2,3-dicarboxycyclopropyl)glycine (DCG-IV) enhanced the stimulation of polyphosphoinositide (PPI) hydrolysis elicited by quisqualate or by submaximal concentrations of ibotenate or (1S,3R)-1-aminocyclopentane-1,3-di...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90857-5
更新日期：1994-10-03 00:00:00
abstract：:The insular cortex (IC) has been reported to modulate the cardiac parasympathetic activity of the baroreflex in unanesthetized rats. However, which neurotransmitters are involved in this modulation is still unclear. In the present study, we evaluated the possible involvement of local IC-noradrenergic neurotransmission...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.08.013
更新日期：2009-10-27 00:00:00
abstract：:A positive association between cardiorespiratory fitness (CRF) and white matter integrity has been consistently reported in older adults. However, it is unknown whether this association exists in adults over 80 with a range of chronic disease conditions and low physical activity participation, which can influence both...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2014.09.003
更新日期：2014-11-07 00:00:00
abstract：:Intracellular Ca2+, measured in NCB-20 cells with the fluorescent indicator fura-2, was elevated by K(+)-depolarization and by ethanol, but not by the excitatory amino acids L-glutamate and N-methyl-D-aspartate. These amino acids failed to raise intracellular Ca2+ levels even in the presence of elevated extracellular ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91639-i
更新日期：1991-01-25 00:00:00
abstract：:The present work shows the existence of adenosine-dependent cyclic adenosine monophosphate (AMP) accumulation in the chick optic tectum. When tecta from 18-day-old embryos were incubated with the phosphodiesterase inhibitor IBMX and RO 20-1724, the cyclic AMP level increased from 39.2 to 73.3 and 285.5 pmol/mg protein...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(87)90016-2
更新日期：1987-09-01 00:00:00
abstract：:Corticotropin-releasing hormone (CRH) and vasopressin (AVP) participate in the endocrine, autonomic, immunological and behavioral response to stress. CRH and AVP receptors are found in hippocampus and anterior pituitary, where mineralocorticoid (MR) and glucocorticoid (GR) receptors are abundant. We investigated the p...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)02585-x
更新日期：2003-06-27 00:00:00
abstract：:Water deprivation caused daily urinary Na output to more than double in normal sheep, but caused no increase in Na excretion in sheep (A3VL-sheep) in which the anterior third ventricle wall had been ablated. Dehydrated A3VL-sheep exhibited a much greater degree of hypernatremia than dehydrated normal sheep, although w...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90326-8
更新日期：1983-03-21 00:00:00
abstract：:Cerebral cortical blood flow (CBF) was measured autoradiographically in conscious mice without the monoamine oxidase B (MAOB) gene (KO, n=11) and the corresponding wild-type animals (WILD, n=11). Subgroups of animals of each genotype received a continuous intravenous infusion over 30 min of phenylethylamine (PEA), an ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01167-1
更新日期：1999-04-03 00:00:00
abstract：:The objective of the study was to investigate creativity in relation to brain function by assessing creative thinking in various neurological populations. Several measures were employed to assess different facets of creative thinking in clinical groups with frontal lobe, basal ganglia or parietal-temporal lesions rela...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.09.007
更新日期：2012-10-30 00:00:00
abstract：:In this study, we aimed at investigating the effect of an enriched environment (EE) on the recovery from chronic inflammatory pain. Inflammatory pain was induced by the injection of 2 mg of carrageenan (CAR) into the right knee of male Sprague-Dawley rats (n=34). Rats were housed either singly (S-housed) or in an EE (...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.04.039
更新日期：2009-06-18 00:00:00
abstract：:In zebra finches, androgens stimulate song production and promote growth of the neural regions controlling song. Early exposure to estrogen establishes this sensitivity to androgens and increases the number of androgen-accumulating cells in two song regions, the hyperstriatum ventralis pars caudalis (HVc) and the magn...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90715-4
更新日期：1989-05-29 00:00:00
abstract：:A push-pull perfusion technique was employed for in vivo study of adenosine 3',5'-monophosphate (cAMP) and guanosine 3',5'-monophosphate (cGMP) in the rat caudate nucleus. Addition of dopamine to the perfusion fluid elicited dose-dependent increases of both cAMP and cGMP perfusate concentrations. In separate experimen...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(79)90495-5
更新日期：1979-12-21 00:00:00
abstract：:The dorsal lateral geniculate nucleus of tree shrews is very susceptible to the neurotoxic effects of kainic acid. In addition to neuronal loss, there is a profound loss of retinal terminals that is manifested through a disruption of anterograde transport of WGA/HRP from the retina to the kainic acid-lesioned area of ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91516-2
更新日期：1987-07-21 00:00:00
abstract：:Elevated levels of lactic acid can be deleterious to CNS tissue. Lactic acid is known to cause astroglial swelling and since glial swelling has been shown to inhibit L-glutamate (L-Glu) uptake, we examined whether one of the actions of lactic acid is to inhibit L-Glu uptake. Astrocyte cultures treated with lactic acid...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)01331-5
更新日期：1997-03-07 00:00:00
abstract：:The relationship between the dorsal raphe neurons projecting to the caudate-putamen and those projecting to the substantia nigra was investigated using a fluorescent retrograde double labeling technique in the rat. The majority of the dorsal raphe neurons projecting to the substantia nigra were found to project also t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)90250-4
更新日期：1980-03-17 00:00:00
abstract：:This study investigates the reanalysis processes as a consequence of conflict between incompatible sentential representations in sentence comprehension. Using the event-related potential (ERP) technique, we examined the situation in which the sentential representation built upon world knowledge (i.e., the plausibility...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.01.090
更新日期：2008-04-08 00:00:00
abstract：:Intracerebroventricular (ICV) infusions of 2-deoxy-D-glucose (2-DG) elicited hyperglycemia and increased feeding at short latencies. If access to food was prevented for 6 h post-2-DG infusion, when blood glucose levels were normal and brain 2-DG concentrations were virtually zero, the rats still ate significantly more...
journal_title：Brain research
pub_type： 杂志文章
doi：
更新日期：1980-11-24 00:00:00
abstract：:The main purpose of the present study was to determine whether specific lymphokines may be neurotrophic, by testing their effects on the survival of hippocampal neuronal cultures. Previous studies have shown that a variety of interleukins may be neurotrophic or neurotoxic, depending upon the culture conditions, as wel...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90400-h
更新日期：1993-01-08 00:00:00
abstract：:In the present study, the role of medial septal receptors in behaviour-induced increase in acetylcholine (ACh) release in hippocampus was investigated using dual-probe microdialysis in combination with a simple behavioural procedure. gamma-Aminobutyric acid (GABA) and glutamate receptor agonists and antagonists were a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01445-5
更新日期：1998-04-06 00:00:00
abstract：:Opioid receptor subtype antagonists differentially alter food intake under deprivation (24 h), glucoprivic (2-deoxy-D-glucose, 500 mg/kg, i.p.) or palatable (10% sucrose) conditions with mu (beta-funaltrexamine) and kappa (nor-binaltorphamine), but not delta1 ([D-Ala2,Leu5,Cys6]enkephalin) opioid antagonists reducing ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00539-8
更新日期：1997-08-29 00:00:00
abstract：:Intraventricular injections of kainic acid were used to destroy the hippocampal CA3-CA4 cells, thus denervating the inner third of the molecular layer of the fascia dentata and stratum radiatum and stratum oriens of area CA1. The responses of intact afferents to such lesions were then examined histologically. The hipp...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)90825-2
更新日期：1980-01-20 00:00:00
abstract：:The serotonin agonist 8-hydroxy-di-propylaminotetralin (8-OH-DPAT), injected systemically or directly into the medial preoptic area (MPOA), reduces the ejaculatory threshold in male rats. While 8-OH-DPAT has been characterized as an agonist at the 5-HT1A receptor, it also acts at other receptor sites including the dop...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)01331-6
更新日期：1999-02-27 00:00:00
abstract：:The effects of 17 beta-estradiol benzoate (EB), ethynodioldiacetate and ovine prolactin on dopamine (DA) turnover have been studied. As an index for a change in turnover, differences in DA depletion following tyrosine hydroxylase inhibition with alpha-methyl-tyrosine methylester were observed. DA was measured by means...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(78)90728-x
更新日期：1978-06-16 00:00:00
abstract：:In vitro uptake of labeled serotonin (5-HT) has allowed the radioautographic detection of serotoninergic fibers in the cat spinal cord at thoracic and lumbar levels. The specificity of labeling was ensured by the conditions of incubation ([3H]5-HT was 10(-7) M) and by test control experiments with concomitant 10(-6) M...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(78)90331-1
更新日期：1978-09-29 00:00:00
abstract：:The influence of the cortico-geniculate pathway on identified X and Y lateral geniculate cells was studied by reversibly cooling visual cortical areas 17 and 18. The majority (86.5%) of cells changed their response to visual stimulation when cortex was inactivated, and both X- and Y-cells were modulated by the cortica...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90568-0
更新日期：1981-03-16 00:00:00
abstract：:Adhesion molecules on the endothelial surface of the blood-brain barrier (BBB) play an important role in the pathogenesis of many encephalopathies, including multiple sclerosis (MS) and cerebral malaria (CM). The expression of four surface molecules of relevance to MS and CM on the immortalized human umbilical vein en...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01436-5
更新日期：1999-06-05 00:00:00
abstract：:Microarray analysis has been used to understand how gene regulation plays a critical role in neuronal injury, survival and repair following ischemic stroke. To identify the transcriptional regulatory elements responsible for ischemia-induced gene expression, we examined gene expression profiles of rat brains following...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.11.052
更新日期：2013-02-07 00:00:00
