A test of the spine resistance hypothesis for LTP expression.

Abstract:

:Long-term potentiation (LTP) consists of an enhanced response to released transmitter by the quisqualate/AMPA subclass of glutamate receptors with little change in the slower currents generated by the NMDA receptor subclass. Recent computer simulations suggest that a decrease in the resistance of dendritic spines would selectively augment fast synaptic currents and this could produce the pattern of results found with LTP. The present experiments tested this hypothesis by asking whether non-NMDA responses slowed by low temperature to resemble NMDA responses could express LTP. Slow non-NMDA responses recorded at 25 degrees C did express LTP, indicating that the time courses of NMDA responses cannot explain why they do not express LTP. The results, therefore, do not support the hypothesis that spine resistance changes are responsible for the enhanced transmission.

journal_name

Brain Res

journal_title

Brain research

authors

Larson J,Lynch G

doi

10.1016/0006-8993(91)90454-4

subject

Has Abstract

pub_date

1991-01-11 00:00:00

pages

347-50

issue

2

eissn

0006-8993

issn

1872-6240

pii

0006-8993(91)90454-4

journal_volume

538

pub_type

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