Abstract:
:Long-term potentiation (LTP) consists of an enhanced response to released transmitter by the quisqualate/AMPA subclass of glutamate receptors with little change in the slower currents generated by the NMDA receptor subclass. Recent computer simulations suggest that a decrease in the resistance of dendritic spines would selectively augment fast synaptic currents and this could produce the pattern of results found with LTP. The present experiments tested this hypothesis by asking whether non-NMDA responses slowed by low temperature to resemble NMDA responses could express LTP. Slow non-NMDA responses recorded at 25 degrees C did express LTP, indicating that the time courses of NMDA responses cannot explain why they do not express LTP. The results, therefore, do not support the hypothesis that spine resistance changes are responsible for the enhanced transmission.
journal_name
Brain Resjournal_title
Brain researchauthors
Larson J,Lynch Gdoi
10.1016/0006-8993(91)90454-4subject
Has Abstractpub_date
1991-01-11 00:00:00pages
347-50issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(91)90454-4journal_volume
538pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Although Rolling mouse Nagoya (RMN) has been considered to demonstrate cerebellar dysfunction, our previous metabolic and electrophysiological studies also revealed a dysfunction of the basal ganglia, with the presumable primary site of dysfunction being the striatum. In the present study, we investigated the neuroche...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)01577-9
更新日期:1996-04-01 00:00:00
abstract::The involvement of the nucleus intercollicularis (ICo) region of the midbrain, an estrogen-sensitive area, in the expression of estrogen-dependent female courtship behavior was examined with radiofrequency lesion and intracranial hormone implant techniques. Bilateral lesions in the ICo region caused a reduction in the...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)90365-6
更新日期:1981-03-02 00:00:00
abstract::Recordings of single unit activity before, during and after a 1-h continuous exposure were made from the mitral cell layer of the olfactory bulbs of awake rabbits. Thirteen complete 1-h exposures were performed using 8 neurons, while a further 6 neurons were lost before the end of the exposure. During the first few mi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90951-9
更新日期:1982-10-28 00:00:00
abstract::Corticosterone influences emotion and cognition via actions in a diversity of corticolimbic structures, including the amygdala. Since extracellular levels of corticosterone in brain have rarely been studied, we characterized a specific and sensitive enzymatic immunoassay for microdialysis quantification of corticoster...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2012.01.010
更新日期:2012-05-03 00:00:00
abstract::After traumatic brain injury, extracellular K(+) in brain can dramatically increase. We studied the effects of increased K(+) on the isolated pressurized rat middle cerebral artery (MCA). MCAs (200-250 microm OD) were isolated, cannulated with glass micropipettes, and pressurized. K(+) was increased in the extralumina...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02793-1
更新日期:2000-10-13 00:00:00
abstract::We sought to determine whether the global increase in regional cerebral blood flow (rCBF) produced by electrical stimulation of the rostral cerebellar fastigial nucleus (FN) is a consequence of excitation of intrinsic neurons of the FN or of axons of fibers passing through or projecting into it. Studies were conducted...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90312-0
更新日期:1989-10-23 00:00:00
abstract::Males show suppressed cell proliferation in the hippocampus in response to acute stress but no studies to date have examined cell proliferation in response to acute stress in females. In the current study, we examined the effects of acute exposure to a predator odor stressor [trimethyl thiazoline (TMT); the main compo...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(03)02542-3
更新日期:2003-06-13 00:00:00
abstract::Intracerebral hemorrhage (ICH) is a devastating stroke with no clinically proven treatment. Deferoxamine (DFX), an iron chelator, is a promising therapy that lessens edema, mitigates peri-hematoma cell death, and improves behavioral recovery after whole-blood-induced ICH in rodents. In this model, blood is directly in...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.10.058
更新日期:2010-01-14 00:00:00
abstract::The aim of this study was to investigate the degree of functional and anatomical overlap between two major neuronal subpopulations in the rostral ventrolateral medulla: pre-sympathetic (sympathoexcitatory) neurons, and expiratory neurons of the Bötzinger complex. Extracellular recordings were made with dye-filled micr...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00814-7
更新日期:1995-11-13 00:00:00
abstract::mRNA prepared from rat small intestine was injected into Xenopus oocytes. The injected oocytes showed a clear electrical response to D-glucose (Glu) in the form of membrane depolarization and conductance increase, while none was shown to D-fructose. The membrane electrical response of the injected oocytes evoked by Gl...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0169-328x(87)90033-7
更新日期:1987-09-01 00:00:00
abstract::Single unit extracellular recordings were obtained from cat lumbar spinal cord dorsal horn neurons activated by cutaneous inputs. The effect of electrical conditioning stimuli applied to the red nucleus (RN) was predominantly that of inhibition although in some cases excitation was seen. All the neurons that projected...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)91413-6
更新日期:1984-10-08 00:00:00
abstract::This report examines the effect of decreasing serum osmolality on movement into the ventricular system of fluid and of test material injected into the brain. Trace quantities of 22NaCl and 125I-labeled cat serum albumin (CSA) were injected into cerebral white matter of cats. The rates of cerebrospinal fluid volume flo...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(78)90885-5
更新日期:1978-08-04 00:00:00
abstract::Altered noradrenergic function is associated with alcoholism. Reduced brain norepinephrine (NE) concentrations and beta-adrenergic receptor supersensitivity following chronic alcohol consumption suggest a reduced level of noradrenergic neurotransmission. To further elucidate the reason for changes in noradrenergic fun...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)90199-6
更新日期:1994-07-04 00:00:00
abstract::Although nitric oxide (NO) has been shown to play an important role in the pathophysiology of cerebral ischemia, its contribution to the pathogenesis of experimentally induced thromboembolic stroke is unknown. In this study, we pharmacologically manipulated NO levels in the acute post-thrombotic stage and determined t...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)00200-x
更新日期:1997-06-06 00:00:00
abstract::A selective 5-HT reuptake inhibitor, fluvoxamine (10 and 30 mg/kg, i.p.) suppressed long-term potentiation (LTP) in the hippocampal CA1 field of anesthetized rats. Fluvoxamine (30 mg/kg, i.p.)-induced suppression of LTP was completely reversed by the 5-HT(1A) receptor antagonist NAN-190 (0.5 mg/kg, i.p), but not by th...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)03756-3
更新日期:2003-01-03 00:00:00
abstract::The cholinergic nicotinic agonists (-)nicotine and lobeline were observed to partially inhibit whole-cell N-methyl-D-aspartate (NMDA)-induced responses in rat cortical neurons in culture. In addition we found that (-)nicotine, (+)nicotine, and lobeline, but not the nicotine metabolite (-)cotinine nor acetylcholine, we...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90958-x
更新日期:1991-06-14 00:00:00
abstract::We measured soleus H-reflex in the Sprague-Dawley rat as a function of time of day. H-reflex amplitude displayed a marked diurnal variation, even though background EMG and M-response amplitude were stable through the day. The H-reflex was largest in the late morning and smallest around midnight. Thus, its rhythm was o...
journal_title:Brain research
pub_type: 杂志文章
doi:
更新日期:1994-06-13 00:00:00
abstract::An acute pain animal model for fMRI study would provide useful spatial and temporal information for studying the supraspinal nociceptive neuronal responses. The aim of the present study was to investigate whether the nociceptive responses in different brain areas can be differentiated by using functional magnetic reso...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)02094-7
更新日期:2001-04-06 00:00:00
abstract::The blood-brain barrier (BBB) permeability primarily increases in cerebral venules during acute hypertension. Methyl-β-cyclodextrin (MβCD), a cholesterol-depleting agent, decreases the expression of caveolins disrupting caveolar structures. We aimed to determine the effects of MβCD on the BBB permeability of angiotens...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2019.03.024
更新日期:2019-07-15 00:00:00
abstract::Activity produced by direct microelectrophoretic application of glutamate onto 19 convergent neurones in trigeminal nucleus caudalis, was strongly depressed during and after the application of heterotopic noxious conditioning stimuli: noxious heat (52 degrees C) applied to the tail, noxious pinches applied to the tail...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90695-4
更新日期:1984-10-29 00:00:00
abstract:BACKGROUND:Diminished dopaminergic neurotransmission contributes to decreased reward and negative eating behaviors in obesity. Bariatric surgery is the most effective therapy for obesity and rapidly reduces hunger and improves satiety through unknown mechanisms. We hypothesized that dopaminergic neurotransmission would...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.03.064
更新日期:2010-09-02 00:00:00
abstract::Histamine is one of the neurotransmitters suppressing appetite, but the interactions of histaminergic neurons with other neurons in satiety centers have not been clarified. Noradrenaline in the para-ventricular nucleus (PVN) has been shown to stimulate feeding. This study was designed to determine whether histamine mo...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01339-6
更新日期:1999-05-15 00:00:00
abstract::Axonal regeneration over long distances is dependent upon events occurring both in the distal stump and in the neuronal cell body. Little is known concerning how events in the distal stump influence the cell body response to injury, or the axon reaction. In the present study, we examined this relationship for one comp...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90558-5
更新日期:1993-10-29 00:00:00
abstract::Until now, there has been no effective therapy for chronic sensorineural hearing impairment. This study investigated the role of bone marrow cells (BMCs) in cochlear dysfunction. BALB/c mice (2 months of age), a non-presbycusis-prone mouse strain, were lethally irradiated and then transplanted with BMCs from SAMP1 mic...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.08.074
更新日期:2006-11-20 00:00:00
abstract::Extracellular recordings from 141 rat supraoptic nucleus neurons maintained in vitro in a perfused hypothalamic explant indicated that the excitability of 85% of cells was enhanced by the addition of 10-200 microM norepinephrine (NE) and the alpha-agonist methoxamine (MOXY), but not by isoproterenol, to the perfusion ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90499-2
更新日期:1984-07-30 00:00:00
abstract::Elevated levels of lactic acid can be deleterious to CNS tissue. Lactic acid is known to cause astroglial swelling and since glial swelling has been shown to inhibit L-glutamate (L-Glu) uptake, we examined whether one of the actions of lactic acid is to inhibit L-Glu uptake. Astrocyte cultures treated with lactic acid...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)01331-5
更新日期:1997-03-07 00:00:00
abstract::Cytochemistry was used to examine the distribution of two pathways of utilization of hydrogen (Type I and Type II H) generated by glucose-6-phosphate dehydrogenase (G6PD) in circumventricular organs (CVOs) and the hypothalamo-neurohypophysial system in cryostat sections of rat brain. Type I H is defined as that portio...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)91306-4
更新日期:1984-02-27 00:00:00
abstract::The effects of naltrexone, naltrindole (a selective delta opiate receptor antagonist) and beta-funaltrexamine (beta-FNA; a selective mu opiate receptor antagonist) on alcohol intake by C57BL/6 mice in a restricted access paradigm were examined. During the pretreatment baseline phase, mice consumed an average of 1.3 g/...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90672-a
更新日期:1993-12-10 00:00:00
abstract::The extracellular lactate concentration and blood flow in the cerebral cortex of urethane-anesthetized, paralyzed and artificially ventilated rats were monitored continuously and simultaneously using an enzyme electrode and a laser Doppler flowmeter (LDF), respectively, during chemical stimulation of the nucleus tract...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)01428-x
更新日期:1997-05-30 00:00:00
abstract::Pupil dilatation (PD) was produced by vaginocervical mechanical stimulation (VCMS) in intact rats, and in rats with spinal cord (SC) transection at level T7 (i.e., above the level of entry into SC of all genitospinal nerves). After transection of SC, bilateral vagotomy abolished PD in response to VCMS, providing evide...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.06.104
更新日期:2007-10-26 00:00:00