Abstract：
:The behavioral effects of lesions of the nucleus basalis magnocellularis (NBM) on two spatial discrimination tasks (place navigation and cross maze) were examined in the rat. These tasks were designed to test reference memory. Lesions by bilateral injection of ibotenic acid into the NBM led to a severe and permanent impairment in the learning of the cross maze task. In the learning of the place navigation task, the rats with lesions showed only a transient deficit. Immediately after the removal of the platform, the rats with lesions explored the quadrant (NE) previously containing the platform as long as controls and above chance levels. The rats with lesions did not extinguish exploration like the controls, seen as a reduction both in time spent in the NE quadrant and in swimming activity. Taken together, the results showed that (1) NBM lesions impair reference memory, but (2) spare other aspects of memory. On the basis of the results in the place navigation task, procedural memory was assumed to remain intact after lesion of the NBM. Biochemical assays of choline acetyltransferase (ChAT) in various brain regions in the lesioned animals demonstrated a reduced ChAT activity in the neocortical projections of the NBM but not in the hippocampus. However, it cannot be decided from this work whether behavioral deficits result from the lesion of cholinergic or of non-cholinergic cells in the NBM.
journal_name
Brain Resjournal_title
Brain researchauthors
Mayo W,Kharouby M,Le Moal M,Simon Hdoi
10.1016/0006-8993(88)90079-0subject
Has Abstractpub_date
1988-07-12 00:00:00pages
213-22issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(88)90079-0journal_volume
455pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:The enduring effects of postweaning subchronic methylphenidate (MP) treatment and/or previous early preweaning methamphetamine (MA) application on dopamine (DA) fiber density were investigated in multiple cortical and subcortical areas of the gerbil brain. The study aimed to explore three questions: (1) is the develop...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.06.107
更新日期：2007-10-24 00:00:00
abstract：:We investigated c-Met expression in cultured astrocytes and their regulation by cytokines. Immunocytochemistry revealed that c-Met was expressed in cultured astrocytes. Western blotting revealed that acidic and basic fibroblast growth factor (FGF) enhanced and hepatocyte growth factor (HGF) reduced c-Met expression. R...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03975-6
更新日期：2003-02-07 00:00:00
abstract：:The spiral ganglion accommodates the cell bodies of the acoustic nerve fibres connecting the hair cells to the central nervous system. As the ionic channels containing various voltage-gated K+ channel (Kv) subunits play pivotal roles in determining the functional properties and firing behaviour of the spiral ganglion ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.02.072
更新日期：2008-05-19 00:00:00
abstract：:To determine the presence and distribution of cerebrovascular Abeta production we investigated amyloid beta precursor protein (AbetaPP)-mRNA expression by RNA in situ hybridization in patients with hereditary cerebral hemorrhage with amyloidosis, Dutch type, Alzheimer disease and controls. In all subjects, AbetaPP-mRN...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01361-x
更新日期：1999-05-15 00:00:00
abstract：:Emotional events are preferentially retained in episodic memory. This effect is commonly attributed to enhanced consolidation and has been linked specifically to rapid eye movement (REM) sleep physiology. While several studies have demonstrated an enhancing effect of REM sleep on emotional item memory, it has not been...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2018.06.020
更新日期：2018-11-01 00:00:00
abstract：:Unilateral injections of 6-hydroxydopamine into the substantia nigra in the rat significantly attenuated cortical spreading depression (CSD)-induced eating from the hemisphere ipsilateral but not contralateral to the lesion. The lateralized decrease in elicited feeding was correlated with postlesion body weight loss, ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(79)90428-1
更新日期：1979-01-12 00:00:00
abstract：:Voltage-activated Na+ channels in the primary sensory neurons are important for generation of action potentials and regulation of neurotransmitter release. The Na+ channels expressed in different types of dorsal root ganglion (DRG) neurons are not fully known. In this study, we determined the possible difference in te...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.09.051
更新日期：2004-12-17 00:00:00
abstract：:Using immunohistochemistry and immunoblots, we show that alterations in hippocampal microtubule-associated protein-2 appear to be highly correlated with contextual memory as measured by significantly heightened fear responses. Compared to naive controls, rats trained in a novel context showed significantly increased i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01064-1
更新日期：1999-03-06 00:00:00
abstract：:Earlier studies showed that pretreatment (3 and 6 h) of rats with the glucocorticoid hormone, dexamethasone, potentiated the drinking response to either central or peripheral administration of angiotensin II (AII). In the present study the specificity and mechanisms of this potentiation were examined. Intraperitoneal ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90093-b
更新日期：1991-06-28 00:00:00
abstract：:The generation of oscillatory activity may be crucial to brain function. The coordination of individual neurons into rhythmic and coherently active populations is thought to result from interactions between excitatory and inhibitory cells mediated by local feedback connections. By using extracellular recording wires a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02687-7
更新日期：2001-08-24 00:00:00
abstract：:The distribution of S-100-immunoreactive material was examined in the central nervous system of the gastropod snail. Helix pomatia, and electrophysiological properties of S-100-positive neurons were characterized. Immunocytochemical studies revealed S-100-like protein to be present in neurons localized in the cerebral...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01584-1
更新日期：1996-04-15 00:00:00
abstract：:Currently there are no uniform standard treatments for newborn suffering from cerebral hypoxia-ischemia (HI) and to find new and effective strategies for treating the HI injury remains a key direction for future research. Present study was designed to demonstrate that optimal dose (1 or 3%) of creatine monohydrate (Cr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2014.11.017
更新日期：2015-01-21 00:00:00
abstract：:Reward deficit, expressed as anhedonia, is one of the major symptoms associated with neuropsychiatric disorders, but the underlying maladaptations have not been understood. Herein, we test the hypothesis that the neuropeptide cocaine- and amphetamine-regulated transcript (CART) may participate in the process. The stud...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2019.146595
更新日期：2020-02-01 00:00:00
abstract：:The ependymocytes lining the central canal of the spinal cord in rats have prominent F-actin networks in the apical cytoplasm, exhibiting significant regional heterogeneity between differing spinal levels. It is not clear when and how this regional heterogeneity develops. We examined F-actin in the central canal durin...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.08.045
更新日期：2008-11-06 00:00:00
abstract：:IgLONs are a family of four GPI-anchored cell adhesion molecules that regulate neurite outgrowth, synaptogenesis and may act as tumour suppressor genes. IgLONs are thought to function as monomers or homodimers and we have proposed that IgLONs also act as heterodimeric complexes termed Dimeric IgLONs or DIgLONs. Here w...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.12.028
更新日期：2011-02-16 00:00:00
abstract：:Spontaneous intracerebral hemorrhage (ICH) is one of the most devastating subtypes of stroke. Since angiogenesis is a fundamental process to brain development and repair by new blood vessel formation from pre-existing ones, mediated by numerous angiogenic factors including vascular endothelial growth factor (VEGF), th...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.08.028
更新日期：2007-10-17 00:00:00
abstract：:Axotomy produced an increase in the spike width and a decrease in amplitude of the afterhyperpolarization which followed the action potential in C-cells of bullfrog sympathetic ganglia. Although no change in B-cell conduction velocity was noted, C-cell conduction velocity increased significantly and approached that of...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(87)80044-6
更新日期：1987-04-28 00:00:00
abstract：:Ongoing development of the dopamine system during adolescence may provide a partial mechanism for behavioral and psychiatric vulnerabilities. Despite early evidence for a hyperactive adolescent dopaminergic system, recent data suggest that adolescent dopamine may be functionally hypoactive compared to in adults. While...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.07.027
更新日期：2017-01-01 00:00:00
abstract：:To determine the effects of nerve injury on Fos expression, temporal and spatial distributions of Fos-positive neurons in the trigeminal nucleus caudalis were examined after tissue injury for isolation of the infraorbital nerve as controls and transection of this nerve as well as noxious chemical stimulation by formal...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00633-1
更新日期：1997-09-12 00:00:00
abstract：:Our previous work has demonstrated that 100-Hz electroacupuncture (EA) or 100-Hz transcutaneous electrical nerve stimulation (TENS) was very effective in ameliorating the morphine withdrawal syndrome in rats and humans. The mechanism was obscure. (1) Rats were made dependent on morphine by repeated morphine injections...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)02069-7
更新日期：1999-12-18 00:00:00
abstract：:Expression of the growth-associated protein GAP-43 is increased in the spinal cord of ALS patients and Wobbler (wr) mice, murine models of the disease. In this work we examined if expression of GAP-43 mRNA in control and wr mice was sensitive to steroid treatment. A group of control and wr mice received s.c. a 50 mg p...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01783-7
更新日期：1999-09-11 00:00:00
abstract：:Male guinea pigs were given 3 tests for sexual behavior. Animals that never ejaculated were classified as low activity (LA), animals that ejaculated on one test were classified as medium activity (MA), and animals that ejaculated on two or more tests were classified as high activity (HA). Subsequently, animals from ea...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90929-x
更新日期：1976-03-19 00:00:00
abstract：:Fascia dentata tissue from embryonic mice was grafted to the hippocampal region of newborn Kyoto rats. After 1-7 months the recipients received lesions of the entorhinal cortex on the side of transplantation. Three days later their brains were processed for electron microscopy. The xenografts were identified by their ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91036-5
更新日期：1987-06-16 00:00:00
abstract：:Tyrosine hydroxylase phenotype expression was investigated in the catecholaminergic population of the locus coeruleus neurons of two pure inbred mouse strains, Balb/C and C57Black/6. Therefore, we have characterized the precise organization of tyrosine hydroxylase-expressing perikarya population, in control animals an...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00074-1
更新日期：1996-05-20 00:00:00
abstract：:As a model of chronic inflammatory pain, Freund's adjuvant-induced polyarthritis has been shown to be associated with marked alterations in the activity of opioid- and calcitonin gene-related peptide (CGRP)-containing neurons in the dorsal horn of the spinal cord in rats. Possible changes in the interactions between t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00350-3
更新日期：1998-06-15 00:00:00
abstract：:Whether functional changes of the non-primary motor areas, e.g., dorsal premotor (PMd) and supplementary motor (SMA) areas, after stroke, reflect reorganization phenomena or recruitment of a pre-existing motor network remains to be clarified. We hypothesized that cellular changes in these areas would be consistent wit...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.04.052
更新日期：2012-06-29 00:00:00
abstract：:Horseradish peroxidase (HRP, 30% solution, 0.1-0.3 mul, 72 h) was injected unilaterally into the basal striatum (STR) and the dorsal ventricular ridge (DVR) of adult turtles (Chrysemys picta) in order to demonstrate the cells of origin of some afferents to these telencephalic structures. After selective STR injection,...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90161-x
更新日期：1976-05-21 00:00:00
abstract：OBJECTIVE:To investigate the effect of salvinorin A (SA) on brain injury and neurologic function post-brain ischemia/reperfusion (I/R) using a rat forebrain ischemia model and further explore the effect of kappa opioid receptor (KOR) inhibition by SA on aquaporin-4 (AQP4) expression in the hippocampus, cortex and stria...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.02.024
更新日期：2016-04-15 00:00:00
abstract：:The pars externa (PE) system of the anterior olfactory nucleus (AON) in a primate, Callithrix jacchus, was defined by its architecture and by its connection patterns with the main olfactory bulb (MOB) as revealed by tracing techniques. Focal, unilateral injections of wheat germ agglutinin-conjugated horseradish peroxi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90071-6
更新日期：1988-08-02 00:00:00
abstract：:Neural stem cells can be derived from the adult/embryonic nervous system as well as from more primitive embryonic stem cells but, because of the lack of specific markers, only their differentiated progeny can be characterized. We here report the presence of several endothelial and hematopoietic receptors (at protein a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)03291-7
更新日期：2002-01-25 00:00:00
