Abstract：
:We found that local perfusion of COA-Cl (0.1, 0.4, or 1.0 mM) into the dorsal striatum of living mice produced a significant and dose-dependent increase in extracellular DA levels, with the highest dose of 1.0 mM COA-Cl producing an approximately 5-fold increase in DA. Consistent with in vivo findings, 0.1 and 0.2 mM COA-Cl significantly and dose-dependently enhanced DA release 3.0 to 5.0-fold in PC12 cells, an in vitro model of DA-responsive neurons. Interestingly, the increase in striatal DA levels by COA-Cl in vivo was similar in magnitude to that observed in PC12 cells. Treatment with 0.1 mM COA-Cl significantly increased both Ser31 and Ser40 phosphorylation of tyrosine hydroxylase (TH) in PC12 cells, and Ser40 phosphorylation in iCell neurons, without altering total TH protein levels. Further, we examined whether COA-Cl could stimulate neurite outgrowth in PC12 cells and iCell neurons and found that COA-Cl significantly induced neurite outgrowth in both cell lines. Our results provide the first evidence that COA-Cl can stimulate dose-dependent DA release and activation of TH phosphorylation, suggesting that COA-Cl may be a promising therapeutic candidate for the treatment of neurological dysfunction associated with low DA.
journal_name
Brain Resjournal_title
Brain researchauthors
Jamal M,Tsukamoto I,Takata M,Ito A,Tanaka N,Miki T,Takakura A,Ameno K,Kubota Y,Konishi R,Kinoshita Hdoi
10.1016/j.brainres.2018.10.026subject
Has Abstractpub_date
2019-03-01 00:00:00pages
68-74eissn
0006-8993issn
1872-6240pii
S0006-8993(18)30538-9journal_volume
1706pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:We investigated the effect of high dose tetrodotoxin (TTX) on microdialysis measurements of extracellular striatal glutamate and dopamine in normal female rats. Both halothane-anesthetized rats with acutely implanted microdialysis probes and awake rats with microdialysis probes implanted for 24 h were tested. Glutamat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00258-8
更新日期：1997-06-13 00:00:00
abstract：:Congenitally anophthalmic mice (ZRDCT-AN) have circadian rhythms which 'free-run' and are not light modulated. Their rhythms differ from those of controls in: duration of circadian period, length of active phase, and pattern/intensity of activity. Three different populations have been described based upon wheel-runnin...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03272-9
更新日期：2002-10-25 00:00:00
abstract：:In this study, we demonstrate the involvement of left frontoparietal cortices in neural processes for task-switching between skilled movements. Functional magnetic resonance imaging was conducted while thirty-two right-handed healthy participants performed two sequential finger-movement tasks with their left hands. On...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2019.146365
更新日期：2019-11-01 00:00:00
abstract：:Acute hyperammonemia is associated with motor disturbances that are thought to involve striatal dopaminergic dysfunction. Discharge of striatal dopaminergic neurons is controlled by N-methyl-D-aspartate (NMDA) receptors, the excessive activation of which contributes to ammonia neurotoxicity. Here we show that ammonium...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)02777-x
更新日期：2003-07-11 00:00:00
abstract：:Reactive oxygen species (ROS) are supposed to be involved in neurodegenerative processes like Parkinson's or Alzheimer's disease. Beside this there are an increasing number of studies indicating an involvement of ROS in traumatic brain injury. We therefore studied the potential role of astrocytes against neurotoxic ef...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)01029-3
更新日期：1996-12-16 00:00:00
abstract：:Post-hypoxic myoclonus is a movement disorder characterized by brief, sudden involuntary muscle jerks. Although the mechanism underlying this disorder remains unclear, earlier pharmacological studies indicated that aberrant activity of specific neuronal circuitry in the central nervous system causes this disorder. In ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.08.027
更新日期：2005-10-19 00:00:00
abstract：:In the present studies we have examined the effects of a new calcium channel blocker, LY393615 ((N-Butyl-[5,5-bis-(4-fluorophenyl)tetrahydrofuran-2-yl]methylamine hydrochloride, NCC1048) in a model of hypoxia-hypoglycaemia in vitro and in a gerbil model of global and in two rat models of focal cerebral ischaemia in vi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)03043-2
更新日期：2001-01-05 00:00:00
abstract：:The anteroventral subdivision of the medial amygdala (MeAV) is one of the vomeronasal structures involved in the control of hormonally dependent behaviors such as sexual and agonistic behaviors in rats. The present study investigates some anatomical and neurochemical parameters of this nucleus (volume, number of neuro...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.02.073
更新日期：2007-05-30 00:00:00
abstract：:Acute, progressive global brain ischemia was induced in awake or anesthetized rats for 5-75 min. Ischemia was achieved with a subclavian-carotid artery occlusion technique (SCOT). After thoracotomy, both subclavian arteries (proximal to their vertebral branches) were tied-off and carotid artery catheter-snares install...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90999-c
更新日期：1991-02-22 00:00:00
abstract：:In the present study, the effects of intra-central amygdala (CeA) injection of dopamine D1 receptor agonist and antagonist on morphine-induced conditioned place preference (CPP) were investigated in male Wistar rats. Our data showed that subcutaneous (s.c.) injection of morphine sulphate (0.5-10 mg/kg) significantly i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)04201-4
更新日期：2003-03-07 00:00:00
abstract：:Neurointermediate lobes of rats comprise elements which, when excited in vitro, bring about an inhibition of the release of melanocyte stimulating hormone (MSH). Superfusion of neurointermediate lobes of intact donor rats with medium containing 45 mM K+ induced a stimulation of the release of oxytocin, arginine-vasopr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(79)91047-3
更新日期：1979-08-10 00:00:00
abstract：:The distribution of calretinin containing neurons examined by in situ hybridization mapping was compared with that obtained by immunocytochemistry in the brain of octopus. Results revealed a close correspondence between the two types of investigations. Western blot analysis disclosed a 29 kDa protein immunostained wit...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.11.056
更新日期：2007-02-09 00:00:00
abstract：:Neurotrophins regulate many aspects of neuronal function and activity. Specifically, the binding of Brain-derived neurotrophic factor (BDNF) to Tyrosine receptor kinase-B (TrkB) or its truncated version, TrkB-T1, can cause growth and differentiation or dominant inhibition of receptor signaling, respectively. There is ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2017.06.008
更新日期：2017-08-15 00:00:00
abstract：:Vasoactive intestinal polypeptide (VIP)-like immunoreactivity in the anterior hypothalamic area (AHA) was studied in 15 bats which are seasonal hibernators, using the unlabeled antibody enzyme method of Sternberger. Our results showed that the density of immunoreactive fibers and terminal plexuses in the AHA was great...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91422-9
更新日期：1988-02-16 00:00:00
abstract：:A new quantitative staining technique for the assay of protein in tissue sections using the dye Coomassie brilliant blue G 250 is discussed. This densitometric procedure uses commercially available hardware and software employed in the quantitation of receptor autoradiographs. Rather than assuming a homogeneous distri...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90965-1
更新日期：1988-04-26 00:00:00
abstract：:We previously observed that substance P (SP) levels in the rat superior cervical ganglion (SCG) rise sharply when the ganglion is maintained in vitro. To define the cellular localization of SP, sections of cultured SCG were stained for the possible dual presence of SP and tyrosine hydroxylase (TOH). Immunoreactivity t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)91442-2
更新日期：1984-04-30 00:00:00
abstract：:We examined how adjective ordering is used in language comprehension by crossing order preference and concreteness in phrases consisting of two adjectives and a noun. We used both more typical phrases in which the preferred order has a concrete second adjective ("exhaustive hardback encyclopedia") and those with a con...
journal_title：Brain research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.brainres.2012.07.050
更新日期：2012-09-26 00:00:00
abstract：:Repeated electrode penetration of the dentate and interpositus nuclei in a rhesus monkey transformed an 11-13 Hz physiologic tremor into a much larger action tremor at 5-7 Hz. This tremor was associated with muscle spindle spike train modulation and reflexly evoked tremor modulation of interpositus and motor cortex ne...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90308-1
更新日期：1984-12-10 00:00:00
abstract：:Cortical projection areas and distribution and response characteristics of masseteric nerve-driven neurons (MDN) were studied by recording surface-evoked potentials and single neuronal activities elicited by stimulation of the contralateral masseteric nerve in cats. Neuronal activities of MDNs could be recorded in two...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91371-x
更新日期：1985-09-02 00:00:00
abstract：:The current study revisited the question of whether there are brain mechanisms specific to divided attention that differ from those used in selective attention. Increased neuronal activity required to simultaneously process two stimulus dimensions as compared with each separate dimension has often been observed, but r...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.03.058
更新日期：2008-06-18 00:00:00
abstract：:During the middle of the subjective day, circadian activity rhythms in Syrian hamsters can be phase advanced by a variety of stimuli including microinjection of neuropeptide Y (NPY) or muscimol into the suprachiasmatic nucleus (SCN). It is not known, however, if these treatments shift activity rhythms by acting direct...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00831-7
更新日期：1997-10-24 00:00:00
abstract：:Previous research has demonstrated that diabetes induces learning and memory deficits. However, the mechanism of memory impairment induced by diabetes is poorly understood. The present study investigated the effect of streptozotocin (STZ)-induced diabetes on spatial learning and memory using the Morris Water Maze. The...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.07.011
更新日期：2011-09-09 00:00:00
abstract：:The dorsolateral funiculus (DLF) spinal pathway has previously been identified as a major pathway involved in descending modulation of pain. While bilateral lesions of the DLF attenuated systemic morphine analgesia as measured by the tail-flick test, they failed to attenuate analgesia as measured by the formalin test....
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90582-7
更新日期：1985-05-13 00:00:00
abstract：:We carried out ligand binding experiments on membranes from rat brain cortical grey matter using radioiodinated beta/A4 8-17, with non-specific binding determined by the addition of 10 microM unlabelled peptide. Specific, reversible binding amounted to 60-75% of total binding and showed a clear dependence on time, tem...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90905-b
更新日期：1991-06-14 00:00:00
abstract：:Using the passive avoidance learning task in rats, the role of brain somatostatin in cognitive function was investigated with special reference to that of the brain cholinergic system. In addition, the involvement of both the brain somatostatinergic and cholinergic systems in the anti-amnesic action of a newly introdu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90900-8
更新日期：1994-04-11 00:00:00
abstract：:Endothelin-1 (ET-1) has been implicated in hematoma-induced cerebral vasoconstriction and modification of cerebral microvascular reactivity, particularly attenuation of vasodilation to cAMP-dependent dilators and enhanced vasoconstriction to ET-1. We examined effects of the ET-1 antagonist, BQ-123, on hematoma-induced...
journal_title：Brain research
pub_type： 杂志文章
doi：
更新日期：1996-09-23 00:00:00
abstract：:The molecular mechanisms regulating the retrograde axonal transport of nerve growth factor (NGF) are currently unknown. This study identifies some of the signalling events involved. The phosphoinositide 3-kinase (PI3-kinase) inhibitor wortmannin (1 nmol/eye) irreversibly inhibits the amount of 125I-betaNGF retrogradel...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00396-5
更新日期：1998-07-06 00:00:00
abstract：:Synapses onto dendritic spines in the lateral amygdala formed by afferents from the auditory thalamus represent a site of plasticity in Pavlovian fear conditioning. Previous work has demonstrated that thalamic afferents synapse onto LA spines expressing glutamate receptor (GluR) subunits, but the GluR subunit distribu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.11.045
更新日期：2007-02-23 00:00:00
abstract：:Physical activity has been proposed as a behavior intervention that promotes mental health and some of the benefits induced by exercise have been related to the glutamatergic system. Indeed, glutamate is the most abundant excitatory neurotransmitter in brain. Thus, we evaluated if voluntary exercise in mice could modu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.09.038
更新日期：2005-12-14 00:00:00
abstract：:Venous capacitance plays an important role in the control of cardiac output. However, the central nervous system sites and neurochemical signals involved in modulating venous function remain to be fully elucidated. The hypothalamic paraventricular nucleus (PVN) is an important site modulating autonomic outflow to the ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00128-5
更新日期：1997-05-09 00:00:00
