Abstract:
:Subcutaneous injection of formalin produces a biphasic pain response: a transient early phase followed by a tonic late phase. It has recently been suggested that development of the late phase depends upon the presence of the early one. In support of this suggestion, we now demonstrate that blocking the early phase by stress-induced analgesia prevents development of the late phase, whereas the same stressor given after the first phase does not. Both phases are manifested when stress-induced analgesia is blocked by the N-methyl-D-aspartate (NMDA) or opiate antagonists, MK-801 and naloxone.
journal_name
Brain Resjournal_title
Brain researchauthors
Vaccarino AL,Marek P,Liebeskind JCdoi
10.1016/0006-8993(92)90478-rsubject
Has Abstractpub_date
1992-02-14 00:00:00pages
250-2issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(92)90478-Rjournal_volume
572pub_type
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