Stress-induced analgesia prevents the development of the tonic, late phase of pain produced by subcutaneous formalin.

Abstract:

:Subcutaneous injection of formalin produces a biphasic pain response: a transient early phase followed by a tonic late phase. It has recently been suggested that development of the late phase depends upon the presence of the early one. In support of this suggestion, we now demonstrate that blocking the early phase by stress-induced analgesia prevents development of the late phase, whereas the same stressor given after the first phase does not. Both phases are manifested when stress-induced analgesia is blocked by the N-methyl-D-aspartate (NMDA) or opiate antagonists, MK-801 and naloxone.

journal_name

Brain Res

journal_title

Brain research

authors

Vaccarino AL,Marek P,Liebeskind JC

doi

10.1016/0006-8993(92)90478-r

subject

Has Abstract

pub_date

1992-02-14 00:00:00

pages

250-2

issue

1-2

eissn

0006-8993

issn

1872-6240

pii

0006-8993(92)90478-R

journal_volume

572

pub_type

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