当前位置： SCI文献检索 > BRAIN RESEARCH期刊下所有文献 > Measurement of cerebral microvessel diameters after embolic stroke in rat using quantitative laser scanning confocal microscopy.

Measurement of cerebral microvessel diameters after embolic stroke in rat using quantitative laser scanning confocal microscopy.

Abstract：

:Perfusion of the microcirculation after stroke is central to preserving neuronal function and improving functional outcome. Using laser scanning confocal microscopy (LSCM) and a novel computer software program, MIRAGE, we measured a reduction in cerebral microvessel diameter after 1 and 4 h of embolic middle cerebral artery (MCA) occlusion. The methodology used by MIRAGE for measurement of blood vessel diameter involves a linearly applied spherical inflation technique. Three-dimensional quantitative analysis revealed a significant (P<0.05) mean 10-12% reduction in vessel diameter in the ipsilateral cortex when compared to the homologous region in the contralateral hemisphere. This reduction was seen only in the cortex and not the striatum. A larger reduction in mean vessel diameter in the ipsilateral cortex, 16-30% (P<0.05) was observed when compared to sham control rats. These results are in strong agreement with other studies using different stroke models and imaging techniques. Our work represents a novel application of LSCM technology to the three dimensional investigation of microvessel diameter changes in acute stroke and identifies its potential as an important tool for investigation of cerebral pathology.

journal_name

Brain Res

journal_title

Brain research

authors

Morris DC,Davies K,Zhang Z,Chopp M

doi

10.1016/s0006-8993(00)02543-9

subject

Has Abstract

pub_date

2000-09-08 00:00:00

pages

31-6

issue

1-2

eissn

0006-8993

issn

1872-6240

pii

S0006-8993(00)02543-9

journal_volume

876

pub_type

杂志文章

相关文献

BRAIN RESEARCH文献大全
  • Epileptiform burst discharges in hippocampal CA3 neurons of young but not mature Noda epileptic rats (NER).

    abstract：:Noda epileptic rat (NER), originally found in a colony of Crj; Wistar rats, shows spontaneous tonic-clonic convulsion characterized by the appearance of high voltage polyspikes in cortical and hippocampal EEG once every 2-3 days after 2-4 months of age. Electrophysiological studies using hippocampal slice preparations...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/s0006-8993(02)03195-5

    authors： Hanaya R,Sasa M,Kiura Y,Ishihara K,Serikawa T,Kurisu K

    更新日期：2002-09-20 00:00:00

  • The paragigantocellular nucleus of the ventral medulla: a secondary source of cholinergic innervation of rat brainstem nuclei.

    abstract：:Many parts of the brainstem are known to be innervated by the cholinergic neurons of the pontomesencephalic tegmentum, but other possible sources of this innervation have rarely been considered. We sought to examine whether other cells in the brainstem were responsible for this cholinergic input using axonal tract tra...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(94)90185-6

    authors： Sherriff FE,Henderson Z

    更新日期：1994-02-04 00:00:00

  • Glucocorticoid binding sites in human temporal cortex.

    abstract：:This work describes the presence of glucocorticoid binding sites in human temporal cortex obtained following partial lobectomy in two epileptic patients. Using [3H]dexamethasone as radioligand and cold cortisol or RU 28362 as competitor we found an apparent Kd of approximately 2.8 nM with a Bmax of approximately 34 fm...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(88)91444-8

    authors： Sarrieau A,Dussaillant M,Sapolsky RM,Aitken DH,Olivier A,Lal S,Rostène WH,Quirion R,Meaney MJ

    更新日期：1988-02-23 00:00:00

  • Excitatory effects of cholecystokinin in rat hippocampus: pharmacological response compatible with 'central'- or B-type CCK receptors.

    abstract：:The effects of the sulfated octapeptide of cholecystokinin (CCK8-S), the non-sulfated homolog (CCK8-NS) as well as the C-terminal di-, tri- and tetrapeptidic fragments (respectively CCK2, CCK3 and CCK4) were studied in vitro in rat hippocampal slices by extracellular recording of the spontaneous action potential disch...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(88)90776-7

    authors： Böhme GA,Stutzmann JM,Blanchard JC

    更新日期：1988-06-07 00:00:00

  • Sturctural homologies in mammalian neurofilament proteins.

    abstract：:Antibody has been prepared to purified neurofilament protein extracted from calf brain. This antibody crossreacts with brain and nerve extracts from all mammals tested but fails to crossreact with frog, cod and chicken nerve extracts. Thus the serologic homology of these neurofilament proteins appears to be restricted...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(77)91074-5

    authors： Davison PF,Hong BS

    更新日期：1977-10-07 00:00:00

  • S-100 protein synthesis in cultured glioma cell is G1-phase of cell cycle dependent.

    abstract：:The kinetics of S-100 protein synthesis was studied in synchronized cultured glioma (C6) cells. The peak of the synthesis was detected at G1-phase of the cell cycle and apparently was not population density-dependent, since sparsely cultured G1-phase cells synthesized the same proportion of the protein per cell as tha...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(82)90462-0

    authors： Fan K

    更新日期：1982-04-15 00:00:00

  • Promoter polymorphisms which modulate insulin degrading enzyme expression may increase susceptibility to Alzheimer's disease.

    abstract：:Cerebral accumulation of amyloid beta protein (Abeta) is believed to play a central role in the pathogenesis of Alzheimer's disease (AD). Insulin degrading enzyme (IDE) is involved in Abeta degradation, therefore the gene encoding for insulin degrading enzyme is one of the candidate genes risky for AD. In Chinese Han ...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2008.10.034

    authors： Zuo X,Jia J

    更新日期：2009-01-16 00:00:00

  • Long-term administration of estrogen or tamoxifen to ovariectomized rats affords neuroprotection to hippocampal neurons by modulating the expression of Bcl-2 and Bax.

    abstract：:Recently we reported that chronic treatment with 17beta-estradiol (E2) or tamoxifen (TAM) regulates the ovariectomy-induced downregulation of the key molecules linked to hippocampal synaptic plasticity and signal transduction pathway. We now report modulation of the antiapoptotic (Bcl-2) and proapoptotic (Bax) protein...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2008.01.080

    authors： Sharma K,Mehra RD

    更新日期：2008-04-14 00:00:00

  • SH-SY5Y cells as a model for sigma receptor regulation of potassium-stimulated dopamine release.

    abstract：:Previous studies in our laboratory using rat brain tissue have shown that neuropeptide Y (NPY) can enhance NMDA- and potassium-stimulated dopamine release from various brain regions and that this enhancement is reversed by sigma (sigma) receptor antagonists. In the current study, we sought to determine whether SH-SY5Y...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/s0006-8993(00)02722-0

    authors： Ault DT,Werling LL

    更新日期：2000-09-22 00:00:00

  • Electrophysiological effects of MK-801 on rat nigrostriatal and mesoaccumbal dopaminergic neurons.

    abstract：:The electrophysiological effects of the non-competitive N-methyl-D-aspartate (NMDA) antagonist (+)-MK-801 (MK-801) on nigrostriatal and mesoaccumbal dopaminergic (DA) neurons were evaluated in chloral hydrate-anesthetized rats. MK-801 (0.05-3.2 mg/kg, i.v.) stimulated the firing rates of 14 (74%) of 19 nigrostriatal D...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(92)91091-r

    authors： Zhang J,Chiodo LA,Freeman AS

    更新日期：1992-09-11 00:00:00

  • Spinal projections of renal afferent nerves in the rat.

    abstract：:This study was designed to describe renal afferent information with respect to its intraspinal projections, convergence with cutaneous inputs, ascending projections, and modulation by descending fiber tracts. Extracellular recordings were made from neurons in the spinal gray while electrically stimulating the renal ne...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(88)91292-9

    authors： Knuepfer MM,Akeyson EW,Schramm LP

    更新日期：1988-04-12 00:00:00

  • Neurophysiological abnormalities in cultured dorsal root ganglion neurons from the trisomy-16 mouse fetus, a model for Down syndrome.

    abstract：:The trisomy-16 mouse is considered to be a model of human trisomy-21 (Down syndrome). We have examined the electrical membrane properties of cultured dorsal root ganglion (DRG) neurons from normal and trisomy-16 fetuses. Trisomy-16 neurons had significantly accelerated rates of action potential depolarization and repo...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(89)90678-1

    authors： Ault B,Caviedes P,Rapoport SI

    更新日期：1989-04-17 00:00:00

  • Effects of palatability-induced hyperphagia and food restriction on mRNA levels of neuropeptide-Y in the arcuate nucleus.

    abstract：:This study examined the effect of feeding either a bland cornstarch-based diet (BCD) or a highly palatable, high fat diet containing sucrose (HPD) on hypothalamic arcuate nucleus (ARC) gene expression for neuropeptide-Y (NPY). Male Sprague-Dawley rats received either BCD ad libitum, HPD ad libitum, HPD pair-fed to the...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/s0006-8993(98)00755-0

    authors： Kim EM,Welch CC,Grace MK,Billington CJ,Levine AS

    更新日期：1998-09-21 00:00:00

  • Aqueduct stenosis induced by a single injection of antivitamin.

    abstract：:Hydrocephalus with aqueduct stenosis was a consistent feature in mice which received a single intraperitoneal injection of 6-aminonicotinamide (6-AN) on day 5 postnatal. Chronological investigation revealed that 6-AN-treated mice had aqueductal obstruction with edematously swollen ependymal cells and spongy changes in...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0165-3806(85)90180-4

    authors： Aikawa H,Suzuki K

    更新日期：1985-10-01 00:00:00

  • Neuroanatomical localization of an internal clock: a functional link between mesolimbic, nigrostriatal, and mesocortical dopaminergic systems.

    abstract：:The effects of selective dopamine (DA) depleting lesions with 6-hydroxydopamine microinjection into the SN, CPu, and NAS, as well as radiofrequency lesions of the CPu on the performance characteristics of rats trained on a single-valued 20-s peak-interval (PI) timing procedure or a double-valued 10-s and 60-s PI proce...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2006.06.031

    authors： Meck WH

    更新日期：2006-09-13 00:00:00

  • 31P NMR phospholipid characterization of intracranial tumors.

    abstract：:Phospholipid extracts from 48 intracranial tumors were analyzed using 31P NMR. Phospholipids commonly identified in the tumor spectra included phosphatidylglycerol (PG), phosphatidic acid (PA), diphosphatidylglycerol (DPG), uncharacterized phospholipid (U), ethanolamine plasmalogen (EPLAS), phosphatidylethanolamine (P...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(94)91041-3

    authors： Merchant TE,van der Ven LT,Minsky BD,Diamantis PM,Delapaz R,Galicich J,Glonek T

    更新日期：1994-06-27 00:00:00

  • Phenidone, a dual inhibitor of cyclooxygenases and lipoxygenases, ameliorates rat paralysis in experimental autoimmune encephalomyelitis by suppressing its target enzymes.

    abstract：:This study examined whether phenidone, a dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LOX), affects the clinical symptoms of experimental autoimmune encephalomyelitis (EAE) in the rat, and the expression of both COX-1/-2 and 5-LOX in EAE spinal cords. Oral phenidone (200 mg/kg) significantly suppressed the...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2004.12.017

    authors： Moon C,Ahn M,Wie MB,Kim HM,Koh CS,Hong SC,Kim MD,Tanuma N,Matsumoto Y,Shin T

    更新日期：2005-02-28 00:00:00

  • Preferential loss of GABAergic neurons in hypoxia-exposed neocortex slab cultures is attenuated by the NMDA receptor blocker D-2-amino-7-phosphonoheptanoate.

    abstract：:The preferential loss of GABAergic neurons in neocortex slab cultures after exposure to hypoxia was reinvestigated and confirmed using an improved morphometric analysis based on stereological principles. This preferential cell loss could be attenuated by treating the hypoxic slab cultures with the N-methyl-D-aspartate...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(89)91031-7

    authors： Romijn HJ

    更新日期：1989-10-30 00:00:00

  • p75 and TrkA receptors are both required for uptake of NGF in adult sympathetic neurons: use of a novel fluorescent NGF conjugate.

    abstract：:We have developed and tested the biological activity and specificity of a novel fluorescent dextran-Texas Red-nerve growth factor (DTR-NGF) conjugate. DTR-NGF was found to promote survival and neurite outgrowth in cultured dissociated sympathetic neurons similarly to native NGF. The conjugate was taken up and transpor...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/s0006-8993(01)03099-2

    authors： Gatzinsky KP,Haugland RP,Thrasivoulou C,Orike N,Budi-Santoso AW,Cowen T

    更新日期：2001-11-30 00:00:00

  • Low but not high rate noxious radiant skin heating evokes a capsaicin-sensitive increase in spinal cord dorsal horn release of substance P.

    abstract：:Some kinds of nociception appear to be partially mediated by the release of substance P (SP) in the spinal cord dorsal horn from terminals of primary afferent nociceptors. Only some nociceptors contain and release SP however. Specifically, SP appears to be released by unmyelinated (C) nociceptive afferents when activa...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/s0006-8993(96)01466-7

    authors： Zachariou V,Goldstein BD,Yeomans DC

    更新日期：1997-03-28 00:00:00

  • Oxidative-induced retinal degeneration is attenuated by epigallocatechin gallate.

    abstract：:The aim of this investigation was to determine whether an ingredient of green tea, epigallocatechin gallate (EGCG) could attenuate oxidative stress-induced degeneration of the retina as occurs in age-related macular degeneration (AMD) and glaucoma. Initial in vitro studies on brain membranes showed that EGCG was appro...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2006.09.067

    authors： Zhang B,Osborne NN

    更新日期：2006-12-08 00:00:00

  • Spinal cord projections from the medial cerebellar nucleus in tree shrew (Tupaia glis).

    abstract：:Electrolytic lesions were placed in the medial cerebellar nucleus in tree shrews (Tupaia glis) or in fibers issuing from this nucleus. Brains and spinal cords were processed according to Fink-Heimer procedure following survival times of 2-7 days. In control animals lesions were placed in the cerebellar cortex and, in ...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(79)91044-8

    authors： Ware CB,Mufson EJ

    更新日期：1979-08-10 00:00:00

  • Simulation of cerebral hemodynamics for preoperative risk assessment.

    abstract：BACKGROUND:An important part of the medical treatment of many cerebrovascular diseases is the occlusion of brain supplying arteries. Until now, the risk of this intervention can only be estimated by invasive diagnostics including the risk of cerebrovascular accidents. METHODS AND RESULTS:As a supporting tool, a comput...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2006.08.021

    authors： Roessler FC,Reith W,Siegel G

    更新日期：2006-11-06 00:00:00

  • Tetrodotoxin-sensitive and -resistant Na+ channel currents in subsets of small sensory neurons of rats.

    abstract：:Voltage-activated Na+ channels in the primary sensory neurons are important for generation of action potentials and regulation of neurotransmitter release. The Na+ channels expressed in different types of dorsal root ganglion (DRG) neurons are not fully known. In this study, we determined the possible difference in te...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2004.09.051

    authors： Wu ZZ,Pan HL

    更新日期：2004-12-17 00:00:00

  • The effects of electrical stimulation on neurite outgrowth of goldfish retinal explants.

    abstract：:The central nervous system (CNS) in adult mammals loses the ability to regenerate after injury. Although electrical stimulation (ES) has been shown to promote neural regeneration, the underlying mechanisms by which ES enhances CNS regeneration remain elusive. The aim of the present study was to investigate the effect ...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2012.08.041

    authors： Ou YT,Lu MS,Chiao CC

    更新日期：2012-10-22 00:00:00

  • Concentrations and distribution of vasoactive intestinal peptide (VIP), peptide histidine isoleucine (PHI) and peptide histidine valine (PHV) in the cerebral cortex and the suprachiasmatic nucleus of the mouse.

    abstract：:Prepro-vasoactive intestinal peptide (prepro-VIP) is processed to at least three biologically active peptides: VIP, peptide histidine isoleucine (PHI) and an extended PHI, peptide histidine valine (PHV). The aim of the present investigation was by chromatography combined with RIA and immunocytochemistry to determine w...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(94)91370-6

    authors： Mikkelsen JD,Fahrenkrug J

    更新日期：1994-09-05 00:00:00

  • Genetic influences on electrical seizure threshold.

    abstract：:C57BL/6J (B6) and DBA/2J (D2) mice have been characterized previously as seizure-resistant and seizure-sensitive, respectively, a distinction based primarily upon a differential response to the convulsant effects of various drugs. In the present study, electroconvulsive shock (ECS) was used to assess maximal electrosh...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/s0006-8993(98)01013-0

    authors： Ferraro TN,Golden GT,Snyder R,Laibinis M,Smith GG,Buono RJ,Berrettini WH

    更新日期：1998-11-30 00:00:00

  • In vivo neuroprotection by a creatine-derived compound: phosphocreatine-Mg-complex acetate.

    abstract：:Phosphocreatine-Mg-complex acetate (PCr-Mg-CPLX) is a creatine-derived compound that in previous in vitro research was able to increase neuronal creatine independently of the creatine transporter, thus providing hope to cure the hereditary syndrome of creatine transporter deficiency. In previous research we showed tha...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2009.06.009

    authors： Perasso L,Adriano E,Ruggeri P,Burov SV,Gandolfo C,Balestrino M

    更新日期：2009-08-18 00:00:00

  • Alterations in brain hexokinase activity associated with streptozotocin-induced diabetes mellitus in the rat.

    abstract：:The effects of streptozotocin-induced diabetes mellitus on the activity of discrete regions of the brain were studied with histochemical localization and photodensitometric quantification of the metabolic enzyme, hexokinase. Two weeks after a single injection of streptozotocin (65 mg/kg, i.p.), plasma glucose and osmo...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(90)91593-6

    authors： Krukoff TL,Patel KP

    更新日期：1990-07-02 00:00:00

  • Intracerebroventricular saccharide infusions inhibit thirst induced by systemic hypertonicity.

    abstract：:The effect of intracerebroventricular (i.c.v.) infusion of various iso- and hypertonic saccharide solutions on water intake stimulated by intracarotid (i.c.) infusion of hypertonic NaCl was studied in sheep. Without an i.c.v. infusion, water intake during a 10-min period following an i.c. infusion of 4 M NaCl (1.4 ml/...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(89)91006-8

    authors： Park R,Denton DA,McKinley MJ,Pennington G,Weisinger RS

    更新日期：1989-07-24 00:00:00