Abstract：
:Although the role of STAT3 in cell physiology and tissue development has been largely investigated, its involvement in the development and maintenance of nervous tissue and in the mechanisms of neuroprotection is not yet known. The potentially wide range of STAT3 activities raises the question of tissue- and gender-specificity as putative mechanisms of regulation. To explore the function of STAT3 in the brain and the hypothesis of a gender-linked modulation of STAT3, we analyzed a neuron-specific STAT3 knockout mouse model investigating the influence of STAT3 activity in brain protein expression pattern in both males and females in the absence of neurological insult. We performed a proteomic study aimed to reveal the molecular pathways directly or indirectly controlled by STAT3 underscoring its role in brain development and maintenance. We identified several proteins, belonging to different neuronal pathways such as energy metabolism or synaptic transmission, controlled by STAT3 that confirm its crucial role in brain development and maintenance. Moreover, we investigated the different processes that could contribute to the sexual dimorphic behavior observed in the incidence of neurological and mental disease. Interestingly both STAT3 KO and gender factors influence the expression of several mitochondrial proteins conferring to mitochondrial activity high importance in the regulation of brain physiology and conceivable relevance as therapeutic target.
journal_name
Brain Resjournal_title
Brain researchauthors
Di Domenico F,Casalena G,Sultana R,Cai J,Pierce WM,Perluigi M,Cini C,Baracca A,Solaini G,Lenaz G,Jia J,Dziennis S,Murphy SJ,Alkayed NJ,Butterfield DAdoi
10.1016/j.brainres.2010.09.074subject
Has Abstractpub_date
2010-11-29 00:00:00pages
1-12eissn
0006-8993issn
1872-6240pii
S0006-8993(10)02140-2journal_volume
1362pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Nitric oxide (NO) is an endothelium-derived relaxing factor and its main mechanism of action is activation of soluble guanylyl cyclase. NO and NO-related compounds have been reported to affect several neuronal functions in the central nervous system. In this study, we investigated the effects of NO donors (sodium nitr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00291-6
更新日期：1997-06-20 00:00:00
abstract：:A search for vasomotor depressor sites in the lateral medullary brainstem of anesthetized cat using microinjections of AMPA has delineated a longitudinal column of sympathoinhibitory neurons consisting of the rostral depressor area, the caudal ventrolateral medulla, and a new intermediate depressor area. Systematic bl...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91257-s
更新日期：1993-02-19 00:00:00
abstract：:Using a double-labeling method that combines retrograde tracing and immunocytochemistry, we demonstrated the presence of a hippocampofugal gamma-aminobutyric acid (GABA)-like immunoreactive (GABA-LI) neuron system in the rat. As a preliminary experiment, knife-cut of the dorsal fornix was made and it resulted in a rem...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90757-8
更新日期：1987-04-14 00:00:00
abstract：:Opioid antagonists block the positive hedonic response to food taste and are potent inhibitors of palatability-driven feeding. However, the specific brain regions within which opioid peptide secretion contributes to the maintenance of palatability-driven feeding have not been clearly established. In the present study,...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00719-7
更新日期：1998-09-14 00:00:00
abstract：:A member of the tumor necrosis factor receptor superfamily (TNFRSF), TROY/TNFRSF19/TAJ, is highly expressed in the brain of adult mice. Northern blot analysis using mRNA taken from regions of the adult CNS showed the expression of TROY in all regions examined, including the olfactory bulb, cerebral cortex, striatum, a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.06.068
更新日期：2006-09-19 00:00:00
abstract：:The patch clamp technique has been used to study ion channel activity in the apical (ventricular) membrane of epithelial cells from the rat choroid plexus. Two different classes of Cl(-)-selective channel were identified. A low conductance (26 pS) channel which was the predominant feature in cell-attached and inside-o...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90988-l
更新日期：1992-09-18 00:00:00
abstract：:Five normal rats and four rats with bilateral lesions of auditory cortex were tested by the conditioned suppression procedure to determine their abilities to discriminate between spatially separated sound sources. The discrimination involved detection of a change in location of a train of clicks from a speaker on the ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(78)90865-x
更新日期：1978-04-28 00:00:00
abstract：:While exposure of cultured spinal neurons to mild hypothermia provides some protection from physical trauma (dendrotomy), profound cooling (< 17 degrees C) causes unrelated neuronal injury and death, which can be prevented by treatment with NMDA receptor antagonists. To investigate the mechanism of hypothermic neurona...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00726-7
更新日期：1995-09-18 00:00:00
abstract：:The presence of an adrenergic projection from the nucleus of the tractus solitarius (NTS) to the parabrachial nucleus (PB) was demonstrated by the immunocytochemistry combined with a retrograde tracing method. Numerous neurons containing both phenylethanolamine N-methyltransferase, a marker for adrenaline, and wheat g...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90654-3
更新日期：1988-09-06 00:00:00
abstract：:Synaptic responses evoked in phrenic motoneurones (PMNs) by stimulation of the superior laryngeal nerve (SLN) were analysed in anaesthetised cats. Stimulation of the SLN was followed by inhibition of ipsilateral phrenic nerve discharge with the latency of 9.5 +/- 2.3 ms (mean +/- S.D.) and hyperpolarizations of ipsila...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90530-1
更新日期：1989-05-08 00:00:00
abstract：:The medial septal area has been implicated in the control of the magnocellular neurosecretory cells of the hypothalamus, and in particular, in the regulation of neurons secreting oxytocin. The present study investigated the hypothesis that this medial septal pathway originates in the subfornical organ. Brief electrica...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)01278-p
更新日期：1995-02-20 00:00:00
abstract：:ACTH4-10, a fragment of the adrenocorticotropic hormone (ACTH) molecule, has marked effects on the compensation process following unilateral labyrinthectomy. In Rana temporaria ACTH4-10-treatment (5-250 micrograms/kg) influences both the acquisition and the maintenance of the compensated state. The compensation proces...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)91158-1
更新日期：1982-09-23 00:00:00
abstract：:Anxiety is a very common yet poorly understood symptom of Parkinson's disease. We investigated whether Parkinson's disease patients experiencing anxiety share neural mechanisms described in the general population with involvement of critical regions for the control of behaviour and movement. Thirty-nine patients with ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2020.147235
更新日期：2021-02-15 00:00:00
abstract：:In this study we investigated the functional connectivity in 23 Mild TBI (mTBI) patients with and without memory complaints using resting state fMRI in the sub-acute stage of injury as well as a group of control participants. Results indicate that mTBI patients with memory complaints performed significantly worse than...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2013.08.034
更新日期：2013-11-06 00:00:00
abstract：:The nonsteroidal anti-inflammatory drugs are presumed to produce their analgesic effects by inhibiting the cyclooxygenase catalyzed metabolism of arachidonic acid to hyperalgesic prostanoids. This study examined the hyperalgesic effect of a range of prostaglandins. We found, employing the rat paw-withdrawal test, that...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90389-s
更新日期：1990-12-24 00:00:00
abstract：:In intracellular recordings from the CA1 region of the hippocampal slice preparation, an infrequent cell type different from the predominant pyramidal cell has been characterized. The cells have very brief spikes, hyperpolarizing after-potentials, and tend to fire at a high spontaneous rate; unitary synaptic potential...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(78)90991-5
更新日期：1978-11-17 00:00:00
abstract：:Calcium accumulation and neuronal injury of rat cortical cell cultures in vitro were examined following oxygen deprivation under conditions of normal and low glucose. 45Ca2+ uptake and lactate dehydrogenase (LDH) release, measured at 12 and 24 h after oxygen deprivation, were significantly elevated in cultures exposed...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91527-y
更新日期：1993-04-02 00:00:00
abstract：:Alpha-synuclein is a natively unfolded protein playing a key role in the regulation of several neuronal synaptic functions in physiological and pathological conditions. Many studies, over the past years, have shown that it is actively involved in PD pathophysiology. Alpha-synuclein is integrated in a complex network o...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2012.04.014
更新日期：2012-10-02 00:00:00
abstract：:To clarify the effects of arachidonic acid (AA) and its metabolites on desensitization of nicotinic acetylcholine (ACh) receptor channel in mouse skeletal muscle cells, we investigated the time-dependent decrease in the channel opening frequency of ACh (1 microM)-activated channel currents by the cell-attached patch c...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)02206-4
更新日期：2000-01-03 00:00:00
abstract：:The D stereoisomer of dihydroxyphenylalanine (D-DOPA) and its alpha-keto acid metabolite 3,4-dihydroxyphenylpyruvic acid (DHPPA) when infused into the striatum, significantly increased in vivo extracellular dopamine levels. Following D-DOPA administration, the cumulative increase in dopamine levels was 30% of the incr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00116-3
更新日期：1996-04-29 00:00:00
abstract：:The astrocyte-derived protein S100B stimulates production of inducible nitric oxide synthase and nitric oxide (NO) in astrocytes [Hu et al., 1996, J. Biol. Chem. 271:2543], but its effect on microglia is not known. In addition, S100B's ability to modulate the activity of other glial activating agents has not been defi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)02251-9
更新日期：2000-01-17 00:00:00
abstract：:Focal electrical stimulation and glutamate microinjection in the nuclei reticularis gigantocellularis (NGC) and gigantocellularis pars alpha (NGC alpha) both inhibit the nociceptive tail-flick (TF) reflex in rats. The present experiments were undertaken to determine the transmitter(s) at the level of the lumbar spinal...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91825-2
更新日期：1990-12-03 00:00:00
abstract：:Microglial reactivity in the red nucleus of rats was studied following upper cervical and lower thoracic rubrospinal tractotomy using the lectin binding method. Following axotomy, the contralateral nucleus containing the axotomized neurons was identified using the retrograde tracer Fast blue. It was subdivided into do...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01418-7
更新日期：1996-04-09 00:00:00
abstract：:Music is an intriguing stimulus widely used in movies to increase the emotional experience. However, no brain imaging study has to date examined this enhancement effect using emotional pictures (the modality mostly used in emotion research) and musical excerpts. Therefore, we designed this functional magnetic resonanc...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.12.065
更新日期：2006-02-23 00:00:00
abstract：:Despite significant advancements in the understanding of the pathophysiological mechanisms of subarachnoid hemorrhage (SAH), little is known about the emotional consequences. The primary goal of this study was to describe the locomotor and behavioral patterns in rats following both a single-injection and double-inject...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.10.061
更新日期：2013-01-23 00:00:00
abstract：:To examine the hypothesis that the increased adrenocortical activity during lactation induced the loss of the prolactin (PRL) -releasing effect of morphine, we studied the effect of morphine in adrenalectomized (ADX) and sham-operated primiparous lactating Wistar rats. Animals were adrenalectomized 4 days after delive...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91530-e
更新日期：1991-11-01 00:00:00
abstract：:Swimmeret mechanostimulation initiates an abdominal extension program which includes flexion inhibition. Agonists and antagonists were used to examine the GABAergic nature of inhibitory responses recorded intracellularly from a flexion producing interneuron (FPI 303) and flexor motor neuron (f3) pair, and extracellula...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90440-7
更新日期：1991-01-11 00:00:00
abstract：:Prostaglandins are now thought to play an important role in nociceptive information transmission in the spinal cord. Prostaglandins are known to be produced by cyclooxygenase (COX), which catalyzes the conversion of arachidonic acid. Two forms of COX have been identified: COX-1, which is constitutively expressed in mo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)00817-7
更新日期：1996-11-11 00:00:00
abstract：:Small injections of the lectin Phaseolus vulgaris-leucoagglutinin (PHA-L) in the external segment of the pallidum (GPe) in the squirrel monkey (Saimiri sciureus) and in the rhesus monkey (Macaca mulatta) led to anterograde labeling of fibers in the internal segment of the pallidum (GPi). These fibers formed numerous l...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91813-v
更新日期：1990-11-12 00:00:00
abstract：:The content of the mRNAs that code for prepro-corticotropin releasing hormone (ppCRH), prepro-neurotensin/neuromedin N (ppNT/NMN) and prepro-enkephalin (ppENK) was measured using in situ hybridization histochemistry in the various subdivisions of the hypothalamic paraventricular nucleus (PVH) 4 h after a bout of ether...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90080-f
更新日期：1991-03-29 00:00:00
