Subpallidal-pedunculopontine projections but not subpallidal-mediodorsal thalamus projections contribute to spontaneous exploratory locomotor activity.

Abstract:

:The contribution of the pedunculopontine nucleus to exploratory locomotion was investigated in rats. Locomotor activity recorded in a standard open-field apparatus was increased more than two-fold when wooden panels were inserted. This novelty-elicited locomotion was reduced significantly when procaine was injected bilaterally into the pedunculopontine nucleus but not when procaine was injected bilaterally into the mediodorsal thalamus, a second major projection site of the subpallidal area. These results support observations from earlier studies implicating hippocampal-accumbens-subpallidal-pedunculopontine projections in exploratory locomotion.

journal_name

Brain Res

journal_title

Brain research

authors

Mogenson GJ,Wu M,Tsai CT

doi

10.1016/0006-8993(89)90584-2

subject

Has Abstract

pub_date

1989-04-24 00:00:00

pages

396-8

issue

2

eissn

0006-8993

issn

1872-6240

pii

0006-8993(89)90584-2

journal_volume

485

pub_type

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