Abstract:
:It is suggested that altered neuroplasticity contributes to the pathophysiology of schizophrenia and antipsychotics may exhibit some of their therapeutic efficacies by improving neurogenesis and/or proliferation of neural progenitors. The aim of this study is to investigate whether chronic antipsychotics treatment affect neurogenesis in adult mouse hippocampus. Animals were administered olanzapine, quetiapine, clozapine, risperidone, aripiprazole, or haloperidol via the osmotic minipump for 21days and then injected with 5-bromo-2'-deoxyuridine (BrdU) to label mitotic cells. BrdU-positive cells in the hippocampus were quantified by stereology. Aripiprazole, quetiapine, clozapine, and olanzapine significantly increased density of BrdU-positive cells in the hippocampus. Interestingly, other antipsychotic drugs had tendency to increasing BrdU-positive cells, whereas haloperidol had propensity to decrease with a marginal significance. These results suggest that differences of neurogenesis among these drugs may, at least in part, account for their pharmacological profiles.
journal_name
Brain Resjournal_title
Brain researchauthors
Chikama K,Yamada H,Tsukamoto T,Kajitani K,Nakabeppu Y,Uchimura Ndoi
10.1016/j.brainres.2017.09.006subject
Has Abstractpub_date
2017-12-01 00:00:00pages
77-82eissn
0006-8993issn
1872-6240pii
S0006-8993(17)30392-Xjournal_volume
1676pub_type
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