Abstract：
:We developed a rat spinal cord injury model and investigated whether endogenous endothelin (ET)-1 plays a role in astrocytic growth after injury. Immunohistochemical study showed that the number of immature astrocytes (ACs) exhibiting strong reactivity to the monoclonal antibody, RC1, markedly increased 24 h after the injury. Injection of a potent nonselective ET receptor antagonist, SB209670, into the lesion sites significantly inhibited the appearance of RC1-positive cells 24 h after the injury. In conjunction with this result, the increase in immunostaining density of 5-bromo-2'-deoxyuridine in the spinal cord 24 h after the injury was inhibited by the injection of SB209670. The tissue content of ET-1-LI was significantly increased 12 and 24 h after the injury. These results suggest that endogenous ET-1 is involved in astrocytic growth after spinal cord injury.
journal_name
Brain Resjournal_title
Brain researchauthors
Uesugi M,Kasuya Y,Hama H,Yamamoto M,Hayashi K,Masaki T,Goto Kdoi
10.1016/0006-8993(96)00524-0subject
Has Abstractpub_date
1996-07-29 00:00:00pages
255-9issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(96)00524-0journal_volume
728pub_type
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