Abstract：
:Adult Sprague-Dawley rats were exposed to a single session of 100 inescapable tail shocks (IS). Bromodeoxyuridine (BrdU) was administered 1 h, 2 days or 7 days later and hippocampal cell proliferation (CP) was assessed after a 2-h survival period. Measures of plasma corticosterone (CORT) levels were also obtained. Despite a large increase in CORT immediately following IS, no associated change in CP was observed. In fact, the only significant change in CP was seen 7 days after IS, at a time when CORT was unchanged from control levels. These data raise questions about the general nature of the relationship between CORT and CP. They also suggest that, under some conditions, changes in hippocampal CP may emerge only after an "incubation period".
journal_name
Brain Resjournal_title
Brain researchauthors
Fornal CA,Stevens J,Barson JR,Blakley GG,Patterson-Buckendahl P,Jacobs BLdoi
10.1016/j.brainres.2006.10.081subject
Has Abstractpub_date
2007-01-26 00:00:00pages
48-53issue
1eissn
0006-8993issn
1872-6240pii
S0006-8993(06)03174-Xjournal_volume
1130pub_type
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