Release of amino acids from the maturing cobalt-induced epileptic focus.

Abstract:

:A study was made of the release of excitatory, inhibitory and other amino acids from epileptic foci induced in the sensorimotor cortex of rats by cobalt implantation. A new in vivo superfusion method was employed which gives free movement to the animals and allows study over periods of days and weeks. Most amino acids showed maximum release rates during the first 2 or 3 days after surgery. Glutamate showed maximum release rates during days 3-6 when epileptic limb jerks were at a maximum. This pattern was not seen for other physiologically active amino acids.

journal_name

Brain Res

journal_title

Brain research

authors

Dodd PR,Bradford HF

doi

10.1016/0006-8993(76)90781-2

subject

Has Abstract

pub_date

1976-07-30 00:00:00

pages

377-88

issue

2

eissn

0006-8993

issn

1872-6240

pii

0006-8993(76)90781-2

journal_volume

111

pub_type

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