Abstract：
:The effects of various nucleotides on the fast tetrodotoxin-sensitive (f-TTX-S) and the slow tetrodotoxin-resistant (s-TTX-R) sodium currents in rat dorsal root ganglion (DRG) neurons were investigated using the patch-clamp technique. Nucleoside triphosphates (NTPs; ATP, GTP, UTP and CTP) and nucleoside diphosphates (NDPs; ADP, GDP, UDP and CDP) decreased f-TTX-S current, whereas they increased s-TTX-R current, when currents were evoked by step depolarizations to 0 mV from a holding potential of -80 mV. NTPs and NDPs shifted both the conductance-voltage relationship curve and the steady-state inactivation curve in the hyperpolarizing direction in both types of sodium currents. Most of them also increased the maximum conductance of s-TTX-R current. ITP, a derivative of ribonucleotide, and dTTP, a deoxyribonucleotide, modulated both types of sodium currents similarly to NTPs and NDPs. However, nucleoside monophosphates (NMPs; AMP, GMP, UMP and CMP) and adenosine had little or no effect on either type of sodium current. Therefore, it seems that nucleotides, regardless of the kind of base, should have two or more phosphates to be able to modulate sodium currents in DRG neurons. Extracellular nucleotides with di- or tri-phosphates would influence the perception by modulating sodium currents in sensory neurons. Particularly, the increase of the maximum conductance and the hyperpolarizing shift of the conductance-voltage relationship of s-TTX-R sodium current would result in an intensified nociception.
journal_name
Brain Resjournal_title
Brain researchauthors
Park SY,Kim HI,Shin YK,Lee CS,Park M,Song JHdoi
10.1016/j.brainres.2004.01.061subject
Has Abstractpub_date
2004-05-01 00:00:00pages
168-76issue
2eissn
0006-8993issn
1872-6240pii
S0006899304002136journal_volume
1006pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:To evaluate the role of the amygdala in pain modulation and opioid-mediated antinociception, a recombinant, replication-defective herpes virus carrying the human preproenkephalin cDNA was injected bilaterally into the rat amygdala. Four days after gene delivery nociceptive behavior was assessed by the formalin test. R...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00194-2
更新日期：1998-05-04 00:00:00
abstract：:Early adverse events have been shown to increase the incidence of interstitial cystitis/painful bladder syndrome in adulthood. Despite high clinical relevance and reports of stress-related symptom exacerbation, animal models investigating the contribution of early life stress to female urological pain are lacking. We ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.02.039
更新日期：2016-05-15 00:00:00
abstract：:Previous reports from our laboratory have demonstrated that ethanol- and cannabinoid-induced ataxia is modulated by cerebellar adenosine A(1) receptor because intracerebellar (i.c.b.) adenosine A(1) agonists potentiated and A(1) antagonist attenuated ataxia by these psychoactive drugs. In this study, the novel approac...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03599-0
更新日期：2002-12-06 00:00:00
abstract：:Parkinson's disease (PD) is a common neurodegenerative disease characterized by progressive loss of midbrain dopaminergic neurons. To gain an insight into the mechanisms underlying the progression of PD, gene expression analysis was performed using two different brain regions, the substantia nigra pars compacta (SN) a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.05.066
更新日期：2010-07-30 00:00:00
abstract：:Serotonin (5-HT) nerve terminals in the locus coeruleus (LC) of adult rat were visualized by high-resolution radioautography, in order to examine their distribution, fine structural features and intimate relationships with norepinephrine neurons. In animals pretreated with a monoamine oxidase inhibitor, prolonged intr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(78)90791-6
更新日期：1978-04-21 00:00:00
abstract：:Morphine chlorhydrate (0.25 mg/kg)produced a significant and constant reinforcement of post-discharge inhibition of alpha-motoneurons in both normal and paraplegic humans. This effect was reversed by naloxone hydrochloride (0.02 mg/kg). These data do not allow to differentiate the effects of morphine on recurrent inhi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90961-6
更新日期：1981-10-05 00:00:00
abstract：:The melanocortin (MC)4 receptor is important for food intake and weight homeostasis as it mediates the orexigenic and anorexigenic effects of the MCs. OLETF (Otsuka-Long-Evans-Tokushima-Fatty) rats are a selective inbred strain of polygenic variant rats which overeat and develop obesity with elevated leptin levels. We...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)02125-3
更新日期：2000-01-03 00:00:00
abstract：:Affective disorders and memory impairments precede the classical motor symptoms seen in Parkinson's disease (PD) and the currently approved antiparkinsonian agents do not alleviate the non-motor symptoms as well as the underlying dopaminergic neuron degeneration. On the other hand, there is increasing evidence that in...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2013.03.029
更新日期：2013-06-04 00:00:00
abstract：:In serum-free monolayer cultures of early postnatal weaver (wv/wv) cerebellum granule neurons show decreased attachment, survival and neurite outgrowth when compared to wild-type (+/+) littermate cultures. wv/wv Astrocytes display a more epithelioid morphology and altered proliferation. However, both morphology and pr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(86)90026-x
更新日期：1986-08-01 00:00:00
abstract：:Genetic abnormalities in amyloid precursor protein (APP) are associated with Down's syndrome and familial Alzheimer's disease where hallmark plaques contain A beta peptides derived from APP. Both APP and its derivatives are implicated in neurodegenerative processes and may play important physiological and pathophysiol...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.09.024
更新日期：2008-12-03 00:00:00
abstract：:A combined retrograde transport and immunocytochemical study was carried out to determine the projections of the large glycine-immunoreactive neurons in the ventral cochlear nucleus of the guinea pig. Horseradish peroxidase (HRP) was injected into the contralateral cochlear nucleus, and cochlear nucleus sections were ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90285-x
更新日期：1987-07-07 00:00:00
abstract：:The cortex receives a cholinergic input which is considered to be involved in mediating the effects of arousal. The experiments reported here have examined the nature of the cholinergic influence on the neuronal organization of the cat visual cortex. Out of 83 cells studied, 92% exhibited a modification in their visua...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90015-x
更新日期：1983-12-19 00:00:00
abstract：:The dopamine transporter from rat caudate-putamen was photolabeled with [125I]DEEP as previously described. Treatment of photolabeled membranes with neuraminidase and N-glycanase reduced the molecular weight of the [125I]DEEP photolabeled dopamine transporter complex, whereas treatment with alpha-mannosidase had no ef...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91627-d
更新日期：1991-01-25 00:00:00
abstract：:Phenylethanolamine N-methyltransferase (PNMT) activity was measured in adrenal glands and medulla oblongata from 4 inbred rat strains, Fischer 344, Buffalo, Lewis and Sprague-Dawley rats. Adrenal enzyme activity was markedly different among the strains with the highest in Fischer, followed by Sprague-Dawley, Lewis and...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91476-9
更新日期：1986-04-30 00:00:00
abstract：:A subset of olfactory receptor neurons of the Caribbean spiny lobster Panulirus argus possesses receptors for L-glutamate that can mediate both excitatory and inhibitory responses (P.C. Daniel, M.F. Burgess, C.D. Derby, Responses of olfactory receptor neurons in the spiny lobster to binary mixtures are predictable usi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00816-0
更新日期：1997-10-17 00:00:00
abstract：:Cultured astrocytes contain immunologically specific aromatic L-amino acid decarboxylase (AADC) protein and express the AADC gene. Following incubation with L-Dopa, glial cultures synthesize and metabolize dopamine. The addition of pyridoxal 5-phosphate did not change the rate of dopamine synthesis. The formation of d...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90592-b
更新日期：1993-10-29 00:00:00
abstract：:Recent anatomic studies indicate that the nucleus paragigantocellularis (PGi), located in the rostral ventrolateral medulla, strongly innervates the locus coeruleus (LC) while no such input derives from the more caudally located lateral reticular nucleus (LRN). In the present study, focal electrical stimulation of the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90510-5
更新日期：1987-11-10 00:00:00
abstract：:The present study was undertaken to examine the differential effect of estrogen (E) on the expression of tyrosine hydroxylase (TH) in the substantia nigra compacta (SNc) and in two subdivisions of the ventral tegmental area in ovariectomized (ovx) and ovx plus estradiol benzoate (ovx+E)-treated female rats. Cell count...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02323-4
更新日期：2000-06-23 00:00:00
abstract：:The dorsal lateral geniculate nucleus of tree shrews is very susceptible to the neurotoxic effects of kainic acid. In addition to neuronal loss, there is a profound loss of retinal terminals that is manifested through a disruption of anterograde transport of WGA/HRP from the retina to the kainic acid-lesioned area of ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91516-2
更新日期：1987-07-21 00:00:00
abstract：:The postnatal development of soma size and cytochrome oxidase activity was examined in the perigeniculate nucleus (PGN) and reticular nucleus of the thalamus (RNT). Neurons in the PGN and RNT exhibited a rapid increase in soma size between 2 and 4 weeks of age. During this period of cell growth there is an increase in...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(87)90047-2
更新日期：1987-10-01 00:00:00
abstract：:Autoradiographic localization of binding sites for [3H]prostaglandin D2, E2 and F2 alpha in the monkey brain was investigated by using in vitro labeling and an image processing system. Specific binding sites were distinctly localized in various nuclei in the hypothalamus, thalamus, and limbic system and their localiza...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91486-8
更新日期：1989-01-23 00:00:00
abstract：:The focal ischemia obtained in an animal model of middle cerebral artery occlusion (MCAo) causes the "core" of damage in the striatum and the "penumbra" of damage in the fronto-parietal cortex. The latter is mainly functionally affected and shows changes in nNOS and iNOS expression during the acute phase of ischemia. ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.11.029
更新日期：2007-02-09 00:00:00
abstract：:Progestin-concentrating neurons in the preoptic area and hypothalamus that project to the midbrain in the female rat were identified using the combined steroid hormone autoradiography-retrograde axonal tracing technique. Progesterone target neurons were most abundant in the periventricular preoptic area and the medial...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91545-r
更新日期：1990-06-25 00:00:00
abstract：:The hippocampus plays an important role in learning and memory and possibly contributes to the formation of pain-related memory and emotional responses. However, there is currently little data linking the hippocampus to neuropathic pain. It has been reported that NF-κB is an important regulatory factor in memory conso...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.01.006
更新日期：2011-03-10 00:00:00
abstract：:The present study combined masked priming with electrophysiological recordings to investigate orthographic priming effects with nonword targets. Targets were pronounceable nonwords (e.g., STRENG) or consonant strings (e.g., STRBNG), that both differed from a real word by a single letter substitution (STRONG). Targets ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.02.050
更新日期：2011-04-22 00:00:00
abstract：:This study aimed to identify sites and mechanisms of long-term plasticity following lower limb muscle training. Two groups performing either a postural stability maintenance training (SMT) or a ballistic ankle strength training (BST) were compared to a non-training group. The hypothesis was that practicing of a self-i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.08.048
更新日期：2007-11-07 00:00:00
abstract：:Primary afferent neurons in mammalian dorsal root ganglia (DRGs) normally function as independent sensory communication elements. However, it has recently been shown that most DRG neurons are transiently activated when axons of neighboring neurons of the same ganglion are stimulated repetitively and the cross-depolari...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)02342-4
更新日期：2003-04-25 00:00:00
abstract：:The dorsolateral quadrant of the lateral septal nucleus receives projections from both the ipsilateral and the contralateral fimbria. In the adult rat the effect of fimbrial lesions on synapse formation has been studied by a quantitative electron microscopic analysis of the various types of synapses present, using ele...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)90010-4
更新日期：1980-05-05 00:00:00
abstract：:Nerve fibers and terminals immunoreactive for cholecystokinin (CCK) were demonstrated in the nucleus of the solitary tract (NTS) of the rat using light and electron microscopic immunocytochemistry. The following morphological and biochemical evidence suggests that CCK in the NTS seems to be of extrinsic, most probably...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90408-5
更新日期：1982-12-09 00:00:00
abstract：:The primary mechanism of action of bupropion, a smoking cessation drug, is commonly believed to involve the dopaminergic system although evidence exists that bupropion also has effects at nicotinic acetylcholine receptors (nAChRs). This study evaluated the disruptive effects of nicotine on response rates in the presen...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.07.110
更新日期：2006-10-30 00:00:00
