Abstract：
:In serum-free monolayer cultures of early postnatal weaver (wv/wv) cerebellum granule neurons show decreased attachment, survival and neurite outgrowth when compared to wild-type (+/+) littermate cultures. wv/wv Astrocytes display a more epithelioid morphology and altered proliferation. However, both morphology and proliferation of wv/wv astrocytes were reversed to a normal phenotype by addition of purified small neurons from early postnatal cerebella from +/+ animals. Attachment of +/+ neurons to wv/wv astrocytes was not significantly different from that of +/+ astrocytes and antigenic marker profiles of wv/wv and +/+ astrocytes differed only slightly. Attempts failed to revert the abnormal wv/wv phenotype in neurons by addition of gangliosides, triiodothyronine T3, prostaglandin A2, medium containing 1% horse serum, conditioned medium from +/+ cerebellar cultures, or by cocultivation with +/+ astrocytes. We would like to suggest that the primary defect of the wv/wv mutation is predominantly an abnormality in granule cell neurons, but not of the vast majority of astrocytes.
journal_name
Brain Resjournal_title
Brain researchauthors
Fischer G,Keilhauer G,Schachner Mdoi
10.1016/0165-3806(86)90026-xsubject
Has Abstractpub_date
1986-08-01 00:00:00pages
247-57issue
2eissn
0006-8993issn
1872-6240journal_volume
393pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Ghrelin can alleviate cancer chemotherapy-induced dyspepsia in rodents, though the neural mechanisms involved are not known. Therefore, ghrelin projections from the lateral hypothalamus (LH) and its involvement in the regulation of gastric motility in cisplatin-treated rats were investigated with a multi-disciplined a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2017.01.004
更新日期：2017-03-15 00:00:00
abstract：:Injections with [3H]leucine in the ventral parabrachial nuclei and nucleus Kölliker-Fuse of the cat revealed strong projections to the nucleus raphe magnus (NRM) and adjacent tegmentum, while similar injections in the adjacent nucleus subcoeruleus produced diffuse projections to large parts of the tegmentum, but not s...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90977-8
更新日期：1988-04-26 00:00:00
abstract：:Alteration of blood-brain barrier (BBB) permeability by 2450 MHz CW microwaves was assessed semi-quantitatively after intravenous injection of horseradish peroxidase (HRP) and exposure of conscious, unrestrained rats to incident power densities of 0, 20 or 65 mW/cm2 for 30, 90 or 180 min. Additional rats were exposed ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-0173(84)90022-5
更新日期：1984-05-01 00:00:00
abstract：:The in vitro model presented provides an approach to study the nature of cell volume control as well as of swelling mechanisms under pathophysiological conditions. Pertinent parameters of cell volume control can be analyzed in isolation due to a virtually infinite extracellular environment precluding secondary effects...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90180-4
更新日期：1983-11-21 00:00:00
abstract：:Transforming growth factor beta (TGFbeta) modulates a variety of growth related functions following traumatic injury. The cellular response to TGFbeta is predominantly mediated through TGFbeta receptor I (TGFbetaRI) and receptor II (TGFbetaRII) on the cell surface and SMAD proteins intracellularly. We investigated the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.03.028
更新日期：2004-06-25 00:00:00
abstract：:Following pulse labeling with [3H]arachidonic acid ([3H]AA), its incorporation pattern in brain reflects regional changes in neurotransmitter signal transduction using phospholipase A2, that is, functional activity. In a rat model of Parkinson's disease, unilateral 6-hydroxydopamine lesion in the substantia nigra, [3H...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00751-3
更新日期：1998-10-05 00:00:00
abstract：:The same cells in both the intact retina and retinal cultures of the rabbit retina take up exogenous serotonin or 5,7-dihydroxytryptamine. Both substances can be localised by immunohistochemistry using a monoclonal antibody directed against serotonin. The 5,7-dihydroxytryptamine can also be revealed directly in both f...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90125-3
更新日期：1986-09-10 00:00:00
abstract：:Seasonally breeding animals undergo numerous physiological changes in response to changes in the length of the photoperiod. In most warm-weather breeding rodents, these changes result in reproductive quiescence during short photoperiods. It has been hypothesized that this change is mediated by changes in the activity ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.08.083
更新日期：2007-11-14 00:00:00
abstract：:The interpeduncular nucleus (IPN) was stimulated electrically while single-cell activity was recorded in the nucleus raphe magnus (NRM) of rats under pentobarbital anesthesia. Two classes of NRM cell were examined, those inhibited (off-cells) and those excited (on-cells) by noxious mechanical skin stimulation. Off-cel...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91476-w
更新日期：1990-07-09 00:00:00
abstract：:Endogenous gamma-aminobutyric acid (GABA) release from the rat medial preoptic area (MPOA) was measured in an in vitro slice technique with sensitive HPLC analysis. Oestrogen is demonstrated to increase GABA activity in the ovariectomised, oestrogen-primed (OVX-EB) rat prior to the luteinising hormone (LH) surge compa...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91295-x
更新日期：1989-05-01 00:00:00
abstract：:Intracerebral hemorrhage (ICH) is a devastating stroke with no clinically proven treatment. Deferoxamine (DFX), an iron chelator, is a promising therapy that lessens edema, mitigates peri-hematoma cell death, and improves behavioral recovery after whole-blood-induced ICH in rodents. In this model, blood is directly in...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.10.058
更新日期：2010-01-14 00:00:00
abstract：:The relationship between placental antigen X-P2 (PAX)-immunoreactive glomeruli and intensely acetylcholinesterase-reactive (IAE) patchy regions was evaluated by comparison of neighboring cryostat sections of the rat olfactory bulb. Both groups of distribution show similar necklace patterns. Each IAE region consists of...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90440-x
更新日期：1993-07-30 00:00:00
abstract：:Synapses from Mauthner to giant fibers in the hatchetfish are chemically transmitting excitatory axo-axonic synapses located in the medulla. The synapses are 4--10 mum in diameter and easily identified for electron microscopy. Presynaptic vesicles are clustered near the contact regions and are round, clear and 40-60 n...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(75)90002-5
更新日期：1975-11-14 00:00:00
abstract：:Studies were undertaken to characterize the binding of [3H]estradiol ([3H]E2) to blood plasma and to brain cytosols collected from perinatal ferrets of both sexes. A dialysis experiment showed that the binding capacity of plasma for [3H]E2 was low in neonatal ferrets. Saturable, high-affinity binding of [3H]E2 to cyto...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(83)90075-5
更新日期：1983-03-01 00:00:00
abstract：:Brain capillaries form a selective interface, the blood-brain barrier (BBB), between the neural parenchyma and the blood. The factors which regulate this interface are poorly understood. Both the iris and retina possess vascular beds that express some BBB characteristics; therefore, they provide attractive models to f...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91323-k
更新日期：1993-12-03 00:00:00
abstract：:Cerebellar explants derived from neonatal mice were exposed to cytosine arabinoside, an inhibitor of DNA synthesis. Following such exposure, the cortical regions of the explants contained numerous closely packed large neurons with few intervening elements and without lamination. The surviving large cortical neurons in...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)90984-1
更新日期：1980-03-31 00:00:00
abstract：:In anaesthetized cats, effects of iontophoretic application of angiotensin II were studied in the nuclei of the tractus solitarius. Specifically, its effects were tested on single respiratory neurones, having rhythmic activity related temporally with the phrenic nerve discharge, and on presumed reflex interneurones, w...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91232-7
更新日期：1987-03-24 00:00:00
abstract：:Long-term potentiation (LTP) was demonstrated in a slice preparation of piriform (olfactory) cortex. LTP could be reliably induced in both afferent and association fiber pathways. The magnitude of the observed potentiation was greater in the association fiber pathway. 2-Amino-5-phosphonovalerate (APV) blocked inductio...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91337-g
更新日期：1990-08-13 00:00:00
abstract：:Milk ejection-related bursts of action potentials recurred at fairly regular intervals during suckling in oxytocin cells of anesthetized lactating rats. Additional milk ejection-related bursts were frequently induced in response to vaginal distension. The latency for the induced response was 2.9 +/- 0.2 s and the size...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91397-7
更新日期：1987-02-24 00:00:00
abstract：:In order to elucidate the roles of hippocampal nitric oxide (NO) synthesis in working and reference memory performance of rats, the effects of intrahippocampal injections of the NO synthase inhibitor, NG-nitro-L-arginine methyl ester (L-NAME), on this behavior were examined with a three-panel runway task. In the worki...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91135-f
更新日期：1993-12-31 00:00:00
abstract：:Previous studies employing systemic administration of the dopamine agonist apomorphine have shown that the dose response curves for apomorphine's effects on penile reflexes and seminal emission differ, suggesting that experimentally separable populations of dopamine receptors regulate these two responses. The present ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90328-4
更新日期：1989-10-23 00:00:00
abstract：:The potential evoked in the pyriform cortex by single-pulse stimulation of the olfactory bulb was examined before and after single and repeated elicitation of an epileptiform afterdischarge produced by stimulation of the olfactory bulb. A single afterdischarge (AD) produced a rapid (i.e. within 5 min) increase in the ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91275-2
更新日期：1985-12-30 00:00:00
abstract：:The stress-hyperresponsive Wistar-Kyoto (WKY) rat strain exhibits a hyperalgesic phenotype and is a useful genetic model for studying stress-pain interactions. Peroxisome proliferator-activated receptor (PPAR) signalling in the midbrain periaqueductal grey (PAG) modulates pain. This study characterised PPAR signalling...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.11.022
更新日期：2017-02-15 00:00:00
abstract：:Circadian and neural mechanisms important for the organization of reproductive behavior in the male golden hamster were examined. The sexual behavior of male hamsters exhibits diel variations; males are quicker to initiate copulation and to ejaculate in the dark phase than in the light phase of a daily light-dark cycl...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)91460-4
更新日期：1984-02-13 00:00:00
abstract：:The aim of this study was to examine the involvement of the hypothalamic oxytocin (OXT) and vasopressin (AVP) neurons in acute phase reaction using quantitative dual-labeled immunostaining with Fos and either OXT and AVP in several hypothalamic regions. Administration of low dose (5 microg/kg) and high dose (125 micro...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)02418-x
更新日期：2000-03-06 00:00:00
abstract：:Oxidative stress has been suggested to play a key role in the neuropathogenesis of HIV infection. HIV proteins (gp120, Tat) and proinflammatory cytokines can trigger the production of reactive oxygen species (ROS), resulting in DNA and RNA lesions. Among all the lesions induced by ROS, one of the most abundant lesions...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.04.001
更新日期：2012-06-06 00:00:00
abstract：:Reduced neuronal plasticity in the striatum, hippocampus, and neocortex is a common feature of transgenic mouse models of Huntington's disease (HD). Doublecortin (DCX) and polysialylated neural cell adhesion molecule (PSA-NCAM) are associated with structural plasticity in the adult mammalian brain, are markers of newl...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.03.018
更新日期：2007-06-02 00:00:00
abstract：:Rodent models of focal and global ischemia were used to examine caspase activation. Several readouts were employed on identical tissue to provide correlative measurement of caspase induction, activation and enzymatic activity. In a rat focal ischemia model, caspase-3 enzymatic activity, as recorded by DEVD-AMC cleavag...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)02846-4
更新日期：2003-08-29 00:00:00
abstract：:An in vitro method has been developed to determine quantitatively the permeability of the perineurium to radiotracers at room temperature. The permeability to [14C]sucrose of the isolated perineurium of the sciatic nerve of the frog, Rana pipiens, was measured at rest length, when the perineurium was stretched and aft...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(79)90244-0
更新日期：1979-09-21 00:00:00
abstract：:Animal and cell experiments showed that inositol hexaphosphate (IP6) was protective on neurons in parkinson's disease (PD) model, but the underlying mechanism of this action was not extensively elucidated. To address this question, we established 6-hydroxydopamine (6-OHDA) induced human dopaminergic cell line SH-SY5Y ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.12.035
更新日期：2016-02-15 00:00:00
