当前位置： SCI文献检索 > BRAIN RESEARCH期刊下所有文献 > Deficits in working memory following inhibition of hippocampal nitric oxide synthesis in the rat.

Deficits in working memory following inhibition of hippocampal nitric oxide synthesis in the rat.

Abstract：

:In order to elucidate the roles of hippocampal nitric oxide (NO) synthesis in working and reference memory performance of rats, the effects of intrahippocampal injections of the NO synthase inhibitor, NG-nitro-L-arginine methyl ester (L-NAME), on this behavior were examined with a three-panel runway task. In the working memory task, L-NAME, injected bilaterally at 10 and 32 micrograms/side into the dorsal hippocampus, significantly increased the number of errors (attempts to pass through two incorrect panels of the three panel-gates at four choice points). This effect of intrahippocampal L-NAME (32 micrograms/side) on working memory was attenuated by concurrent injection of 100 micrograms/side L-arginine, the precursor of NO. Intrahippocampal injection of the inactive isomer D-NAME at doses up to 32 micrograms/side had no effect on the number of working memory errors. In the reference memory task, neither L-NAME nor D-NAME affected the number of errors when injected into the hippocampus at doses up to 32 micrograms/side. These results suggest that processes mediated by NO synthesis in the hippocampus are involved in working memory, but not in reference memory.

journal_name

Brain Res

journal_title

Brain research

authors

Ohno M,Yamamoto T,Watanabe S

doi

10.1016/0006-8993(93)91135-f

subject

Has Abstract

pub_date

1993-12-31 00:00:00

pages

36-40

issue

1-2

eissn

0006-8993

issn

1872-6240

pii

0006-8993(93)91135-F

journal_volume

632

pub_type

杂志文章

相关文献

BRAIN RESEARCH文献大全
  • Generalization of seizures parallels the formation of "dark" neurons in the hippocampus and pontine reticular formation after focal-cortical application of 4-aminopyridine (4-AP) in the rat.

    abstract：:Distribution and time course of the occurrence of "dark" neurons were compared with the EEG activity and behavior of rats during 4-aminopyridine (4-AP) induced epileptic seizures. A crystal of the K(+) channel blocker 4-AP (0.5 mg/kg) was placed onto the exposed parieto-occipital cortex of Halothane-anesthetized rats ...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2008.06.044

    authors： Baracskay P,Szepesi Z,Orbán G,Juhász G,Czurkó A

    更新日期：2008-09-04 00:00:00

  • Somatostatin- and neuropeptide Y-immunoreactive neurons in the neocortex in senile dementia of Alzheimer's type.

    abstract：:Morphological changes in neocortical somatostatin- and neuropeptide-Y-immunoreactive cells in senile dementia of the Alzheimer type (SDAT) were studied using light-microscopic immunohistochemical methods. The density of somatostatin-immunoreactive cells in the neocortex did not decrease in cases of SDAT compared with ...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(86)91099-1

    authors： Nakamura S,Vincent SR

    更新日期：1986-04-02 00:00:00

  • Abnormal gene expression in cerebellum of Npc1-/- mice during postnatal development.

    abstract：:Niemann-Pick Type C (NPC) disease is an autosomal recessive neurodegenerative disorder with abnormal lipid storage as the major cellular pathologic hallmark. Genetic analyses have identified mutations in NPC1 gene in the great majority of cases, while mutations in NPC2 account for the remainders. Yet little is known r...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2010.02.019

    authors： Liao G,Wen Z,Irizarry K,Huang Y,Mitsouras K,Darmani M,Leon T,Shi L,Bi X

    更新日期：2010-04-14 00:00:00

  • Reduced availability of brain amines during critical phases of postnatal development in a genetic mouse model of cognitive delay.

    abstract：:Serotonin (5-HT), dopamine (DA) and noradrenaline (NE) play important roles in brain postnatal maturation. Therefore, deficits in brain availability of biogenic amines during critical developmental phases might underlie neurodevelopmental disturbances associated with cognitive impairment. To test this hypothesis we ev...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2008.04.006

    authors： Pascucci T,Andolina D,Ventura R,Puglisi-Allegra S,Cabib S

    更新日期：2008-06-27 00:00:00

  • Post-ischemic hypothermia attenuates loss of the vascular basement membrane proteins, agrin and SPARC, and the blood-brain barrier disruption after global cerebral ischemia.

    abstract：:Vascular basement membrane (BM) stabilizes brain vessels and inhibits endothelial cell cycle. Cerebral ischemia causes BM breakdown with the loss of structural BM components including collagens and laminins. In this study, the expression changes of the BM proteoglycan agrin, and the non-structural BM constituent SPARC...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2009.02.062

    authors： Baumann E,Preston E,Slinn J,Stanimirovic D

    更新日期：2009-05-07 00:00:00

  • Presynaptic inhibition by noradrenaline of the EPSC evoked in neonatal rat sympathetic preganglionic neurons.

    abstract：:Visually identified and electrophysiologically characterized sympathetic preganglionic neurons (SPNs) were recorded using the whole-cell voltage clamp technique in slices of neonatal rat spinal cord. Monosynaptic excitatory postsynaptic currents (EPSCs) were evoked by electrical stimulation of the nucleus intercalatus...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/s0006-8993(97)01549-7

    authors： Miyazaki T,Kobayashi H,Tosaka T

    更新日期：1998-04-20 00:00:00

  • Expression of the proenkephalin gene in human neuroblastoma cell lines.

    abstract：:Several human tumour cell lines were screened for secretion of proenkephalin-derived peptides with an antiserum directed to its N-terminus, Met-enkephalin-Arg6,Phe7 and for proopiomelanocortin-derived peptides with an antiserum to beta-endorphin. The neuroblastoma SK-N-MC cell line secreted Met-enkephalin-Arg6,Phe7-im...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0169-328x(88)90060-5

    authors： Folkesson R,Monstein HJ,Geijer T,Påhlman S,Nilsson K,Terenius L

    更新日期：1988-04-01 00:00:00

  • Hippocampal neurotrophic factor: characterization and response to denervation.

    abstract：:The rat hippocampus contains an acidic macromolecular neurotrophic factor (NTF) which supports the survival of cultured chick ciliary ganglion cells. Hippocampal NTF increases approximately 2-fold from birth to adulthood with no further change with aging. Disruption of extrinsic inputs to the hippocampus from the ento...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(86)91015-2

    authors： Heacock AM,Schonfeld AR,Katzman R

    更新日期：1986-01-22 00:00:00

  • Comparison of [3H]baclofen binding to GABAB receptors in spontaneously hypertensive and normotensive rats.

    abstract：:Baclofen-sensitive GABAB receptor binding to various brain regions was compared in age-matched spontaneously hypertensive (SHR) and normotensive Wistar-Kyoto (WKY) rat. The specific [3H]baclofen binding was significantly higher in SHR cerebellum, hippocampus and nucleus tractus solitarii (NTS), but lower in medulla, w...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(85)90941-2

    authors： Singh R,Ticku MK

    更新日期：1985-12-09 00:00:00

  • Acute and chronic effects of neurotrophic factors BDNF and GDNF on responses mediated by thermo-sensitive TRP channels in cultured rat dorsal root ganglion neurons.

    abstract：:Neurotrophic factors (NTFs), beside regulating neuronal survival in the central and peripheral nervous system, are also involved in the modulation of neuronal function in the adult animal. Both brain-derived neurotrophic factor (BDNF) and glial cell-derived neurotrophic factor (GDNF) levels are altered in pathological...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2009.06.014

    authors： Ciobanu C,Reid G,Babes A

    更新日期：2009-08-11 00:00:00

  • Neuronal activity with cardiac rhythm in the nucleus of the solitary tract in cats and dogs. I. Different discharge patterns related to the cardiac cycle.

    abstract：:In anaesthetized, spontaneously breathing cats and dogs, extracellular recordings were made of the spontaneous activities of 28 single neurones with cardiac rhythm. It was confirmed by histological examination that the neurones were situated in the mediodorsal portion of the nucleus of the solitary tract. Different di...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(77)90049-x

    authors： Stroh-Werz M,Langhorst P,Camerer H

    更新日期：1977-09-09 00:00:00

  • Region-specific alterations of calbindin-D28k immunoreactivity in the rat hippocampus following adrenalectomy and corticosterone treatment.

    abstract：:The aim of this study was (i) to compare the immunocytochemical distribution of the calcium-binding protein calbindin-D28k (CB) in the hippocampus of rats with the pattern of neurodegeneration following adrenalectomy (ADX) using silver impregnation, and (ii) to investigate the CB-immunoreactivity in the hippocampus fo...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(95)00783-m

    authors： Krugers HJ,Medema RM,Postema F,Korf J

    更新日期：1995-10-23 00:00:00

  • In vivo tyrosine hydroxylation rate in retina: effects of phenylalanine and tyrosine administration in rats pretreated with p-chlorophenylalanine.

    abstract：:p-Chlorophenylalanine was administered to rats to inhibit hepatic phenylalanine hydroxylase activity. Two days later, phenylalanine injection was noted to produce substantial increases in serum phenylalanine levels, and relatively modest increments in serum tyrosine levels. Rats injected with p-chlorophenylalanine 2 d...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(89)90777-4

    authors： Fernstrom MH,Baker RL,Fernstrom JD

    更新日期：1989-10-16 00:00:00

  • The effects of antidromic discharges on orthodromic firing of primary afferents in the cat.

    abstract：:This study investigated the effects of antidromically conducted nerve impulses on the transmission of orthodromic volleys in primary afferents of the hindlimb in decerebrated paralyzed cats. Two protocols were used: (A) Single skin and muscle afferents (N=20) isolated from the distal part of cut dorsal rootlets (L7-S1...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/s0006-8993(99)01236-6

    authors： Gossard JP,Bouyer L,Rossignol S

    更新日期：1999-04-17 00:00:00

  • Physical aggression and attentional bias to angry faces: An event related potential study.

    abstract：:This study aimed to identify the neural correlates of aggression-related attentional selectivity to angry faces in physical aggression. Physical aggression in a non-clinical sample of young men (N = 36) was measured using an aggression questionnaire. Visual attentional bias to angry faces was assessed using a dot-prob...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2019.146387

    authors： Crago RV,Renoult L,Biggart L,Nobes G,Satmarean T,Bowler JO

    更新日期：2019-11-15 00:00:00

  • Role of prostacyclin in the response of cerebral blood flow to CO2.

    abstract：:The prostacyclin (PGI2) formation in cerebral vessels, as reflected by the difference in concentration of internal carotid arterial and internal jugular venous radioimmunoassayed 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha), was determined under normocapnic and hypercapnic conditions in 5 patients with mild cereb...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(83)91272-6

    authors： Uyama O,Nagatsuka K,Fukunaga R,Kusunoki M,Takano T,Yoneda S,Kimura K,Abe H

    更新日期：1983-01-24 00:00:00

  • Augmentation of N-methyl-D-aspartate induced depolarizations by GABA in neocortical and archicortical neurons.

    abstract：:The influence of the inhibitory transmitter gamma-aminobutyric acid (GABA) on depolarizations elicited by the excitatory amino acid N-methyl-D-aspartate (NMDA) was tested in neurons of organotypic neocortical tissue cultures (newborn rat) and in CA3 neurons of the hippocampal slice (guinea pig). Drugs were applied thr...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(90)90737-v

    authors： Walden J,Speckmann EJ,Bingmann D,Straub H

    更新日期：1990-02-26 00:00:00

  • Actions of N-methyl aspartate and its antagonist aminophosphonovalerate on the A5 catecholamine cell group in rat.

    abstract：:When N-methyl-D,L-aspartic acid was injected into the A5 catecholamine cell group of the rat, a dose-dependent decrease in blood pressure and heart rate was obtained. These cardiovascular changes were subsequently blocked by the (-) and (+) isomers of the aspartate receptor blocker 2-amino-5-phosphonovalerate (2-amino...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(82)90076-2

    authors： Close JM,Neil JJ,Loewy AD

    更新日期：1982-10-14 00:00:00

  • Inhibitory influence of GABA on central serotonergic transmission. Involvement of the habenulo-raphé pathways in the GABAergic inhibition of ascending cerebral serotonergic neurons.

    abstract：:In order to explore the anatomical nature of the inhibitory GABAergic control of cerebral serotonergic neurons exerted at the level of the anterior raphé cells in the rat, we have studied the effect of GABA agonist agents (given systemically or infused locally into the raphé dorsalis or medianus) on cerebral 5-hydroxy...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(85)90717-6

    authors： Nishikawa T,Scatton B

    更新日期：1985-04-01 00:00:00

  • Cerebral cortical blood flow maps are reorganized in MAOB-deficient mice.

    abstract：:Cerebral cortical blood flow (CBF) was measured autoradiographically in conscious mice without the monoamine oxidase B (MAOB) gene (KO, n=11) and the corresponding wild-type animals (WILD, n=11). Subgroups of animals of each genotype received a continuous intravenous infusion over 30 min of phenylethylamine (PEA), an ...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/s0006-8993(99)01167-1

    authors： Scremin OU,Holschneider DP,Chen K,Li MG,Shih JC

    更新日期：1999-04-03 00:00:00

  • Changes in the visual system of monocularly sutured or enucleated cats demonstrable with cytochrome oxidase histochemistry.

    abstract：:Endogenous cytochrome oxidase activity within the mitochondria of neurons and neuropil was demonstrated histochemically under normal and experimental conditions. Since enzymatic changes were noted with chronic neuronal inactivity in the auditory system (Wong-Riley et al), the present study sought to examine functional...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(79)90728-5

    authors： Wong-Riley M

    更新日期：1979-07-27 00:00:00

  • The effects of monoamine uptake inhibitors and methamphetamine on neostriatal 6-hydroxydopamine (6-OHDA) formation, short-term monoamine depletions and locomotor activity in the rat.

    abstract：:Monoamine uptake inhibitors block the neurotoxic effects of methamphetamine (MA) upon dopaminergic and serotonergic neurons in the rat. The neurotoxic effects of MA upon dopaminergic neurons have previously been suggested to be mediated via formation of 6-hydroxydopamine (6-OHDA) from endogenous stores of dopamine (DA...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(90)90889-j

    authors： Marek GJ,Vosmer G,Seiden LS

    更新日期：1990-05-14 00:00:00

  • Diffusion kurtosis imaging study on temporal lobe after nasopharyngeal carcinoma radiotherapy.

    abstract：PURPOSE:Diffusion kurtosis imaging (DKI) is a MRI technique which can measure alterations in the diffusion of water molecules to reflect tissue changes in both white and grey matter. This study evaluated the potential of DKI for the early diagnosis of radiation-induced temporal lobe changes in the grey and white matter...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2016.07.041

    authors： Wang D,Li YH,Fu J,Wang H

    更新日期：2016-10-01 00:00:00

  • Multiple ways to the prior occurrence of an event: an electrophysiological dissociation of experimental and conceptually driven familiarity in recognition memory.

    abstract：:Recent research has shown that familiarity contributes to associative memory when the to-be-associated stimuli are unitized during encoding. However, the specific processes underlying familiarity-based recognition of unitized representations are still indefinite. In this study, we present electrophysiologically dissoc...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2010.08.089

    authors： Wiegand I,Bader R,Mecklinger A

    更新日期：2010-11-11 00:00:00

  • Haemorrhage-induced release of noradrenaline, 5-hydroxytryptamine and uric acid in the supraoptic nucleus of the rat, measured by microdialysis.

    abstract：:Concentrations of monoamines and metabolites and uric acid were measured in sequential 15-min microdialysis samples taken from the area of the supraoptic nucleus (SON) in 9 urethane-anaesthetized rats. A decrease in blood pressure of 40 mm Hg was induced by withdrawing 3-4 ml of blood from an indwelling jugular cathet...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(88)91016-5

    authors： Kendrick KM,Leng G

    更新日期：1988-02-09 00:00:00

  • The rostral projection of small diameter primary afferents in Lissauer's tract.

    abstract：:The rostral projection of A delta and C primary afferents in Lissauer's tract (LT) was studied by assessing how far, rostrally, axons entering at a given level could be activated by electrical stimulation. Sural A delta primary afferents in LT exhibited a rostral projection at least as far as the L3/L4 border, 4 segme...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(86)90617-7

    authors： Traub RJ,Sedivec MJ,Mendell LM

    更新日期：1986-12-03 00:00:00

  • The electrophysiological and morphological characteristics of feline dorsal root ganglion cells.

    abstract：:The electrophysiological characteristics of physiologically typed L7 and S1 dorsal root ganglion (DRG) cells have been studied in the cat by intracellular recording. The injection of the fluorescent dye Lucifer Yellow has enabled us to study the morphology of these neurons. Our results show that over the entire range ...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(86)91391-0

    authors： Cameron AA,Leah JD,Snow PJ

    更新日期：1986-01-01 00:00:00

  • Expression of the calcium binding proteins Necab-1,-2 and -3 in the adult mouse hippocampus and dentate gyrus.

    abstract：:The family of EF-hand calcium binding proteins is composed of more than 250 members. In search for other neuronal markers, we studied the expression pattern of Necab-1, -2 and -3 in the Ammons horn of adult mice at the gene- and protein levels using in-situ hybridization and immunohistochemistry. The genes for the thr...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2013.06.004

    authors： Zimmermann B,Girard F,Mészàr Z,Celio MR

    更新日期：2013-08-28 00:00:00

  • Reformulation of the Papez circuit: absence of hippocampal influence on cingulate cortex unit activity in the primate.

    abstract：:Cingulate cortex (CC) unit responses to hippocampal volleys and afterdischarges were studied in 4 awake unsedated squirrel monkeys using extracellular microelectrodes. Stimuli were delivered via bipolar electrodes chronically implanted bilaterally in anterior and posterior hippocampus. A total of 412 units in 21 track...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(83)91253-2

    authors： Dagi TF,Poletti CE

    更新日期：1983-01-24 00:00:00

  • Modulation of brown adipose tissue-mediated thermogenesis by lesions to the nucleus tractus solitarius in the rat.

    abstract：:Given that relatively little is known regarding the central control of brown adipose tissue (BAT)-mediated thermogenesis the present study assessed whether the direct pharmacological stimulation of beta- or alpha-adrenergic receptors located on the brown adipocytes would result in a typical thermogenic response follow...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(91)91482-g

    authors： Fyda DM,Cooper KE,Veale WL

    更新日期：1991-04-19 00:00:00