Abstract:
:Ghrelin can alleviate cancer chemotherapy-induced dyspepsia in rodents, though the neural mechanisms involved are not known. Therefore, ghrelin projections from the lateral hypothalamus (LH) and its involvement in the regulation of gastric motility in cisplatin-treated rats were investigated with a multi-disciplined approach. Retrograde tracing combined with fluoro-immunohistochemical staining were used to investigate ghrelin fiber projections arising from LH and projecting to nucleus tractus solitaries (NTS). Results revealed that ghrelin fibers originating in LH project to NTS. Expression of ghrelin and its receptor growth hormone secretagogue receptor (GHS-R1a) in LH and NTS were detected by Western Blot. 2days after cisplatin dosing, expression of ghrelin in LH decreased while GHS-R1a in both LH and NTS increased. In electrophysiological experiments, the effects of N-methyl-d-aspartate (NMDA) microinjection in LH on neuronal discharge of gastric distension-responsive neurons in NTS and gastric motility were assessed. NMDA in LH excited most of ghrelin-responsive gastric distension (GD)-sensitive neurons in NTS and promoted gastric motility. This effect was partially blocked by ghrelin antibody in NTS. Furthermore, the excitatory effects of NMDA in cisplatin-treated rats were weaker than those in saline-treated rats. Behaviorally, cisplatin induced a significant increase of kaolin consumption and decrease of food intake. These studies reveal a decreased expression of ghrelin in LH and up-regulation of GHS-R1a in LH and NTS, which are involved in the regulation of GD neuronal discharge in NTS and gastric motility.
journal_name
Brain Resjournal_title
Brain researchauthors
Gong Y,Liu Y,Liu F,Wang S,Jin H,Guo F,Xu Ldoi
10.1016/j.brainres.2017.01.004subject
Has Abstractpub_date
2017-03-15 00:00:00pages
29-40eissn
0006-8993issn
1872-6240pii
S0006-8993(17)30004-5journal_volume
1659pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::The neural manifestations of food avoidance learning in the mollusc, Pleurobranchaea, survive the surgical reduction of the preparation to the nearly isolated brain. These manifestations include increased synaptic inhibition and reduced synaptic excitation of the phasic paracerebral feeding command interneurons (PCps)...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)91553-7
更新日期:1985-04-08 00:00:00
abstract::Microencephalic rats induced by methylazoxymethanol (MAM) were observed to have notable hyperactivity compared to control rats, as measured by several behavioral parameters in an automated field apparatus. Acute injection of the stimulant drug, methamphetamine (MAP), produced an increase in the incidence of locomotion...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)01307-4
更新日期:1995-01-23 00:00:00
abstract::The activity of single dopaminergic (DA) neurons (total n = 77) in the midbrain of awake, unrestrained rats was examined. The firing rates and patterns of ventral tegmental area (A10) cells (n = 39) were similar to those of identified DA neurons in anesthetized and paralyzed rats. Unit activity was briefly stimulated ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90988-7
更新日期:1987-03-03 00:00:00
abstract::Photic information that entrains circadian rhythms is transmitted to the suprachiasmatic nucleus (SCN) from the retina and from the retinorecipient intergeniculate leaflet (IGL). Expression of light-induced Fos protein in SCN neurons is correlated with the effectiveness of such light to induce phase shifts, and is pre...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00911-1
更新日期:1998-11-09 00:00:00
abstract::A phosphorylated, approximately 110 kDa laminin-binding protein (110 kDa LBP) from mouse brain has been previously identified. This protein recognizes a neurite-outgrowth promoting 19-amino acid synthetic peptide (PA 22-2) derived from the laminin A chain. In the present study, an antibody against the 110 kDa LBP was ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90356-z
更新日期:1991-08-02 00:00:00
abstract::Monkeys were trained to depress a hold key for a period of 2 sec. After this hold period, either a red or a green cue lamp appeared in random sequence. The red lamp required the monkey to move his hand from the hold key to a target button within 1 sec of the cue presentation. The green lamp required continued depressi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(76)90986-0
更新日期:1976-01-09 00:00:00
abstract::Primary cultures of the 21 day foetal rat brain contain a cohort of astroblasts that concertedly acquire glial fibrillary acidic protein (GFAP) filaments between the 16th and 18th hour after plating. This burst of cytoskeletal differentiation is not observed in cultures initiated from the 18 day foetal brain and is no...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90637-7
更新日期:1985-07-22 00:00:00
abstract::With the aim of determining a possible role of the entorhinal cortex (EC) in the processing of olfactory information, its electrical activity was recorded during different types of odour sampling behaviour. The EC spontaneous field potentials (EEGs) were related to those recorded simultaneously from the more rostrally...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)91506-0
更新日期:1989-01-30 00:00:00
abstract::Multiple-unit activity (MUA) in the agranular medial prefrontal cortex (PFC) was recorded in conscious rabbits during a classical conditioning procedure involving repeated pairings of a 4-s tone conditioned stimulus (CS) with eye shock. Prior to behavioral training, significant tone-evoked increases in prefrontal MUA ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)91435-7
更新日期:1988-02-23 00:00:00
abstract::Amyloid β-protein (Aβ) is the major component of extracellular plaques in the brains of patients with Alzheimer's disease. It has been suggested that the interaction of Aβ with membrane cholesterol is essential for Aβ to exert neurotoxicity; however, the effect of phospholipids, another major membrane lipid component,...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2016.04.035
更新日期:2016-07-01 00:00:00
abstract::In the developing vertebrate retina, precise coordination of retinal progenitor cell proliferation and cell-cycle exit is essential for the formation of a functionally mature retina. Unregulated or disrupted cell proliferation may lead to dysplasia, retinal degeneration or retinoblastoma. Both cell-intrinsic and -extr...
journal_title:Brain research
pub_type: 杂志文章,评审
doi:10.1016/j.brainres.2007.04.076
更新日期:2008-02-04 00:00:00
abstract::(1) The levels of glycolytic intermediates in the brain tissue of 15-day-old homozygous and heterozygous Gunn rats were determined with or without novobiocin treatment in vivo, and the inhibitory effects of bilirubin on the glycolytic activity and the key glycolytic enzyme activities were investigated in vitro. (2) t...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(76)90945-8
更新日期:1976-08-27 00:00:00
abstract::Effects of pre-treatment of synaptic membranes with beta-adrenoceptor agonists and cholera toxin on [3H]clonidine and [3H]yohimbine binding were examined in rat cerebral cortex. Pre-incubation of cerebral cortical membranes with isoproterenol (10 or 200 microM) or dobutamine (1, 10 or 200 microM) at 37 degrees C for 4...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90531-1
更新日期:1985-03-11 00:00:00
abstract::Our previous studies have shown that tumor necrosis factor-alpha (TNF-alpha) activates solitary nucleus neurons involved in vago-vagal reflex control of gastric motility. Here, we describe the dual role of TNF-alpha as also modulating neurons in the dorsal motor nucleus of the vagus (DMN) that respond to gastric diste...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)03178-5
更新日期:2002-10-04 00:00:00
abstract::The ability to detect and cope with unpredictable novel events is fundamental for adapting to a rapidly changing environment and ensuring the survival of the organism. Despite knowledge of gender differences in emotional processing, little is currently known about the impact of gender on neural processing of emotion-i...
journal_title:Brain research
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.brainres.2011.12.017
更新日期:2012-02-09 00:00:00
abstract::Experimental allergic encephalomyelitis (EAE) was induced in young male Lewis rats. Blood-brain barrier permeability to radiotracers of different molecular sizes was studied at intervals after induction using a tissue sampling technique. The results were correlated to the clinical picture and to the histological appea...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90249-x
更新日期:1984-06-08 00:00:00
abstract::Immunohistochemical and retrograde tracing techniques were combined to demonstrate the occurrence of displaced ganglion cells (DGCs) exhibiting substance P-like immunoreactivity (SP-LI) in the pigeon retina. Following injections of rhodamine-labeled latex microspheres into the nucleus of the basal optic root (accessor...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)91159-x
更新日期:1991-04-12 00:00:00
abstract::We have previously found that crocin (crocetin di-gentiobiose ester) antagonizes the inhibitory effect of ethanol on long-term potentiation in the rat hippocampus in vivo and in vitro. To explore mechanisms underlying the antagonism of crocin against ethanol, we investigated the effects of ethanol and crocin on synapt...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)01505-9
更新日期:1998-03-16 00:00:00
abstract::The localization of immunoreactive glutamic acid decarboxylase (GAD) and enkephalin-like immunoreactivity was examined in serial, 4-micron frozen sections of the caudate nucleus from rats pretreated with colchicine. Colocalization was found in numerous caudate neurons of medium size. Cell counts of corresponding label...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90850-3
更新日期:1984-05-23 00:00:00
abstract::Dendrites were transected 100 microns from nerve cell somata. The probability of cell survival increased as a function of the extent of proximal segment retraction. The retraction effect is probably the result of increased resistance to calcium and sodium currents at the lesion. It is speculated that limitation of ner...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90526-9
更新日期:1987-11-10 00:00:00
abstract::Glutamic acid decarboxylase (GAD)- and gamma-aminobutyric acid (GABA)-like immunoreactivity was examined in the retina of the 13-lined ground squirrel (Spermophilus tridecemlineatus). Labeling was observed in the inner nuclear layer (INL), inner plexiform layer (IPL) and ganglion cell layer (GCL). The immunoreactive c...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)91346-3
更新日期:1991-11-08 00:00:00
abstract::Unilateral injections of 6-hydroxydopamine into the substantia nigra in the rat significantly attenuated cortical spreading depression (CSD)-induced eating from the hemisphere ipsilateral but not contralateral to the lesion. The lateralized decrease in elicited feeding was correlated with postlesion body weight loss, ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(79)90428-1
更新日期:1979-01-12 00:00:00
abstract::The inhibitory potency of ethanol upon excitatory amino acid induced depolarizations of rat hippocampal CA1 pyramidal cells was assessed in the presence and absence of magnesium (Mg2+) using the grease-gap technique. Ethanol shifted the N-methyl-D-aspartate (NMDA) dose-response curves to the right in a non-parallel ma...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)91486-k
更新日期:1991-04-19 00:00:00
abstract::During normal aging, men experience a significant decline in testosterone levels and a compensatory elevation in levels of gonadotropin luteinizing hormone (LH). Both low testosterone and elevated LH have been identified as significant risk factors for the development of Alzheimer's disease (AD) in men. It is unclear ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2012.05.011
更新日期:2012-07-23 00:00:00
abstract::Striatal kainic acid (KA) lesions induce behavioral and biochemical deficits which resemble symptoms encountered in patients suffering from Huntington's disease. In rats with KA lesions, fetal striatal transplants have shown to reverse the pervasive nocturnal hyperactivity induced by the lesion. In the present study 4...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)91313-3
更新日期:1988-04-12 00:00:00
abstract::Freeze-fracture examination of nodes of Ranvier from adult rat optic nerve demonstrates the presence of astrocytic processes at the majority of nodes of Ranvier. Astrocytic processes often run along the entire length of the nodal gap, although they do not necessarily encircle the entire nodal circumference. The E- and...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90919-3
更新日期:1984-08-06 00:00:00
abstract::We measured expression of the oxytocin gene in the supraoptic nucleus (SON) during pregnancy, parturition and lactation to examine its relationship to states of accumulation or depletion of oxytocin stores and to conditions of strong excitation of oxytocin neurons. The primary transcript (heterogeneous nuclear RNA, hn...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)01275-4
更新日期:1998-01-26 00:00:00
abstract::Evolutionary selection pressures have been one of the factors proposed to underlie sex differences in inhibitory control. Consequently, inhibitory control may vary as a function of the menstrual cycle and may be modulated by the stimuli being processed if these stimuli are related to reproductive success. We used func...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.05.061
更新日期:2008-08-11 00:00:00
abstract::The phonemic merger is a unique phenomenon which is referred to as acoustically very different phonemes are recognized as the same phoneme. In our previous study, we demonstrated that the merged speakers had lost the ability to discriminate the merged phonemes pre-attentively, as revealed by their failure in mismatch ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2020.146848
更新日期:2020-08-01 00:00:00
abstract::We investigated the effect of adenosine A1 receptors on the release of acetylcholine (ACh) and GABA, and on the intracellular calcium concentration ([Ca2+]i) response in cultured chick amacrine-like neurons, stimulated by KCl depolarization. The KCl-induced release of [3H]ACh, but not the release of [14C]GABA, was pot...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)02155-1
更新日期:2000-01-03 00:00:00