Abstract：
:Bilateral microinjection of kainic acid (30-117 pmol) into the substantia nigra induced convulsive seizures resembling those elicited from limbic system structures. The convulsive seizures, which consisted of facial and forelimb clonus with rearing and falling, developed after a latency of more than 30 min and were preceded by wet dog shakes and non-convulsive seizure activity registered electroencephalographically. The convulsant effect of intranigral kainic acid was strictly dose-dependent (ED50 = 60 pmol) and anatomically site-specific. Stimulation of nigral neurons by focal application of agonists for NMDA or quisqualate receptors, or by focal application of the GABA antagonist, bicuculline, was without convulsant effects. The convulsant action of intranigral kainic acid was prevented by the focal application of kynurenic acid (100 nmol) but not by 2-amino-7-phosphonoheptanoic acid (AP-7) (25 nmol) or 7-chlorokynurenic acid (20 nmol), suggesting that the convulsant effect of kainic acid in the substantia nigra does not depend upon activation of NMDA receptors in this region.
journal_name
Brain Resjournal_title
Brain researchauthors
Maggio R,Liminga U,Gale Kdoi
10.1016/0006-8993(90)91661-ysubject
Has Abstractpub_date
1990-10-01 00:00:00pages
223-30issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(90)91661-Yjournal_volume
528pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Dexmedetomidine (Dex) has the neuroprotective effect on cerebral ischemia-reperfusion injury (CIRI). But the mechanism is not yet clear. In this study, we established a model of middle cerebral artery occlusion (MCAO) and treated primary cortical neurons with oxygen glucose deprivation (OGD), followed by Dex treatment...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2018.09.007
更新日期：2018-12-15 00:00:00
abstract：:Microencephalic rats induced by methylazoxymethanol (MAM) were observed to have notable hyperactivity compared to control rats, as measured by several behavioral parameters in an automated field apparatus. Acute injection of the stimulant drug, methamphetamine (MAP), produced an increase in the incidence of locomotion...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)01307-4
更新日期：1995-01-23 00:00:00
abstract：:Visuomotor behavior and pattern discrimination were studied in a group of cats raised with one eye closed by eyelid suturing 7-10 days after birth. At the age of 8-10 months the animals were forced to use their deprived eye by reversal of eye closure (closing the normal eye and opening the deprived one). Visuomotor be...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90771-x
更新日期：1976-07-30 00:00:00
abstract：:In an autopsy study on 29 male Aborigines and 57 male Caucasians, macroscopic and microscopic parameters of postnatal cerebellar development were determined and described by mathematic growth functions. For the whole cerebellum and its cortical layers volume measurements revealed delayed maturation for Aborigines comp...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90782-8
更新日期：1989-10-16 00:00:00
abstract：:The distribution of iron in the brain of a vocal learning parrot, the budgerigar (Melopsittacus undulatus), was examined using iron histochemistry. In mammals, iron is a highly specific stain for the dorsal and ventral pallidal subdivision as well as specific cell groups in the brainstem, including the substantia nigr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)03110-9
更新日期：2001-12-07 00:00:00
abstract：:Adipose-derived stem cells (ASCs) are readily accessible multipotent mesenchymal stem cells and are known to secrete multiple growth factors, and thereby to have cytoprotective effects in various injury models. In the present study, the authors investigated the neuroprotective effect of ASCs in an intracerebral hemorr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.09.005
更新日期：2007-12-05 00:00:00
abstract：:The effect of MK-801 on striatal dopamine (DA) release was investigated by using an in vivo microdialysis technique in the freely moving rat. Systemic injection of MK-801 (0.25, 0.5, 1, 2 mg/kg, i.p.) reduced the extracellular level of DA significantly and produced no change in the level of 3,4-dihydroxyphenylacetic a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90197-j
更新日期：1990-09-24 00:00:00
abstract：:Dissimilarity of the electroencephalogram (EEG) between the two hemispheres was characterized by cross-approximate entropy (C-ApEn), an information statistical parameter applicable to nonlinear, aperiodic signals. EEGs were recorded bipolarly with pairs of epidural electrodes in the left and right frontal cortices. Th...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03358-9
更新日期：2002-11-01 00:00:00
abstract：:Calbindin D28k (CaBP)-containing splanchnic and cutaneous sensory neurons in the rat dorsal root ganglia (DRGs) were investigated immunocytochemically in combination with a fluorescent dye tracer (Fluoro gold). About 15% of the DRG neurons at Th9-10 levels showed CaBP-like immunoreactivity. Eighty-four % of the splanc...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91673-5
更新日期：1990-10-01 00:00:00
abstract：:Using the rapid Golgi method, the morphology of dendritic spines was quantified in the calyxes of groups of newly emerged, nurse, and forager honeybees. These groups were studied because they represented distinct stages of behavioral development and cumulative experience which, according to recent vertebrate findings,...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)91007-0
更新日期：1980-06-16 00:00:00
abstract：:Intracranial pressure (ICP) was monitored to evaluate the therapeutic effect of hyperbaric oxygen (HBO(2)) treatment following traumatic brain injury (TBI). This subject is controversial. The aim of our study was to determine whether HBO(2) treatment has a therapeutic effect on ICP dynamics and survival following seve...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.02.049
更新日期：2005-06-21 00:00:00
abstract：:We monitored biosynthetic activity of optic tract glia during regeneration of retinal ganglion cell axons in the goldfish and found that the greatest level of incorporated [3H]thymidine and [3H]leucine occurred in glia by 10-15 days after axotomy. During this period there was a marked increase in the number of oligode...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90624-9
更新日期：1985-07-22 00:00:00
abstract：:The aim of the present work was to study the effects of hyperammonemia on brain energy metabolism in neonatal rats. Rats were rendered hyperammonemic by ammonium acetate administration. This decreased brain ATP concentrations but enhanced brain ammonia and lactate levels in both adult and neonatal rats. In adult rats,...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)02529-0
更新日期：2003-05-23 00:00:00
abstract：:Descending protocerebral neurons in the male silkworm moth brain responding to the sexual pheromone (Bombykol) were identified. The neurons responded well with a tonic type of response and the high-frequency spikes evoked continued even after the end of the stimulus. Characteristics of the dose-response curves of the ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90885-1
更新日期：1986-07-09 00:00:00
abstract：:The action of gamma-aminobutyric acid (GABA) in the supraoptic nucleus was investigated using guinea pig brain slices. GABA produced a membrane depolarization accompanied by a decrease in the input resistance. The action of GABA was concentration-dependent throughout a wide range of concentrations (10(-7)-10(-3) M). I...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90059-x
更新日期：1987-02-17 00:00:00
abstract：:Infusion of 15 micrograms/microliters (approximately 120 micrograms/kg/h) of indomethacin within the ventral septal area of the rat brain significantly reduced a centrally induced prostaglandin E1 (PGE1) hyperthermia when compared with infusions of artificial cerebrospinal fluid. A bolus injection of a V1 receptor ant...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90599-4
更新日期：1989-08-14 00:00:00
abstract：:Multiple retrograde fluorescent tracing was employed to investigate the organization of the rat entopeduncular nucleus projections to the lateral habenula, ventral anterior-ventral lateral thalamus, parafasicular-centre median complex, and tegmenti pedunculopontis area of the brain stem. The results indicate that neur...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90064-0
更新日期：1981-04-27 00:00:00
abstract：:The cholinergic neurotoxin, AF64A-picrylsulfonate, was unilaterally infused into the dorsal hippocampus of Wistar rats (2 nmol/2 microliters/4 min; A 6.2, Ls 1.5, H 6.5, Paxinos and Watson). After 19 days the for immunohistochemical staining of choline acetyltransferase (ChAT). Morphometry and counting of ChAT-immunor...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91125-x
更新日期：1986-04-02 00:00:00
abstract：:Sex hormone binding globulin (SHBG) is produced in brain where it is often co-localized with oxytocin. Infusions of SHBG into the medial preoptic area-anterior hypothalamus facilitate female sexual receptivity. SHBG has receptors on plasma membranes of the prostate gland where binding of the 5alpha-reduced androgen di...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)02956-6
更新日期：2002-09-06 00:00:00
abstract：:Cholecystokinins in rat cerebral cortex were studied by radioimmunoassay using an antiserum specific for the COOH-terminus of CCK8. Total concentrations of immunoreactive CCK in cortex were 3-4 fold higher than in jejunum. Rat cerebral CCK was purified by immuno-affinity adsorption to the IgG fraction of CCK antisera ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)90564-8
更新日期：1980-04-21 00:00:00
abstract：:Hippocampal long-term potentiation (LTP) is considered as a cellular model of memory formation. Specific, electrical weak tetanization of distinct afferents such as the medial perforant path results in a short-lasting, protein synthesis-independent early-LTP (up to 4 h) within the dentate gyrus. A stronger tetanizatio...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.03.055
更新日期：2009-06-01 00:00:00
abstract：:Mitochondria critically regulate cytoplasmic Ca(2+) concentration ([Ca(2+)]c), but the effects of sensory neuron injury have not been examined. Using FCCP (1µM) to eliminate mitochondrial Ca(2+) uptake combined with oligomycin (10µM) to prevent ATP depletion, we first identified features of depolarization-induced neur...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2014.09.040
更新日期：2014-11-17 00:00:00
abstract：:Ontogeny of somatostatin (SRIF) neuron system of the rat cerebellum was investigated by means of the indirect immunofluorescent method. In addition, several operations were performed to provide the evidence of understanding the cerebellar SRIF innervation. SRIF-positive structures appeared in the primordium of the cer...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(82)90051-7
更新日期：1982-04-01 00:00:00
abstract：:Nitric oxide (NO) is a neuronal messenger that it is thought to be involved in the nociceptive transmission modulation. The activity of nicotinamide adenine dinucleotide phosphate diaphorase (NADPH-d) was shown to be identical to NOS activity in the brain. Since the periaqueductal gray matter (PAG) plays an important ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00255-8
更新日期：1998-05-18 00:00:00
abstract：:GPR56, a member of the G-protein-coupled receptor family, plays a role in the formation of the frontal and parietal brain lobes and cortical lamination in the embryonic stage. A recent report indicated the existence of GPR56 transcripts in the subventricular zone (SVZ) and hippocampal subgranular zone (SGZ) of the adu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.09.020
更新日期：2007-12-05 00:00:00
abstract：:The central nervous system of the mollusc Helix pomatia was stimulated with NO donors sodium nitroprusside (SNP), S-nitroso-N-acetylpenicillamine (SNAP) or hydroxylamine, in the presence of a phosphodiesterase inhibitor 1-methyl-3-isobutylxanthine (IBMX). Radioimmunoassay revealed that all of the three NO donors signi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01147-5
更新日期：1998-01-12 00:00:00
abstract：:The cellular mechanism for the suppression of GnRH gene expression by the phorbol ester PMA was investigated in GT1 cells. The protein synthesis inhibitor cycloheximide decreased GnRH primary transcript levels, indicating a protein synthesis requirement for basal GnRH transcription. PMA decreased GnRH primary transcri...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)01479-5
更新日期：1997-03-28 00:00:00
abstract：:Tyrosine hydroxylase immunohistochemical examination of the mesencephalon of severely parkinsonian MPTP-treated macaque fascicularis monkeys revealed a marked loss of substantia nigra pars compacta (SNc) neurons in both medial and central portions of the nucleus with a relative sparing of neurons in the dorsal-most po...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90691-3
更新日期：1987-05-12 00:00:00
abstract：:The existence of multiple brain melanocortin receptor types has been postulated, based on the complex pharmacology of intracerebrally administered melanocortin (melanocyte-stimulating hormone-related) peptides. In this study, this hypothesis was tested by determining whether different brain melanocortin receptor popul...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91434-6
更新日期：1994-01-28 00:00:00
abstract：:Whole cell and single channel Ca2+ currents were compared for hippocampal neurons of normal and ethanol-tolerant long-sleep and short-sleep mice. The properties of these currents were equivalent for normal LS and SS mice. In contrast, the peak amplitude of the whole cell Ca2+ current increased significantly for neuron...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90044-n
更新日期：1993-07-02 00:00:00
