Abstract:
:The jimpy gene is a sex-linked recessive mutation which produces severe hypomyelination throughout the central nervous system (CNS) in affected male mice. The female carrier also expresses the mutation, but the degree of hypomyelination varies considerably among the tracts. In the optic nerve, patches of unmyelinated tissue are interspersed with myelinated zones; in the brain, myelination is retarded during development but recovers in the adult. We have previously shown, in the male mutant, that an astroglial hypertrophy is associated with the white matter. The present study was undertaken to determine the existence and extent of astrogliosis in the female carriers. In this immunocytochemical investigation using antiserum to glial fibrillary acidic protein (GFAP), we show that the optic nerve of the female carriers exhibits patches of gliosis which are similar in appearance and intensity to those found in affected males. These patches are not present in the white matter of the carriers' brain and spinal cord, but GFAP-immunoreactivity is more intense than in control females. Throughout certain fiber tracts (e.g. optic tract and internal capsule), the number of immunostained astrocytes is increased in comparison to controls; they are larger, have more processes, and are more intensely immunoreactive. The results of the present study show that the retardation of myelin formation is accompanied by an astroglial response and that the intensity of the gliosis closely parallels the extent of the hypomyelination.
journal_name
Brain Resjournal_title
Brain researchauthors
Hatfield JS,Skoff RPdoi
10.1016/0006-8993(82)90958-1subject
Has Abstractpub_date
1982-10-28 00:00:00pages
123-31issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(82)90958-1journal_volume
250pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Spinal cord patterns of metabolic activity in a model of neuropathic pain were assessed in unanesthetized rats by the [14C]-2-deoxyglucose (2-DG) technique. Rats used in this procedure had demonstrable thermal hyperalgesia ipsilateral to sciatic nerve ligation and ipsilateral hindpaws that were lifted in a guarded pos...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)91468-g
更新日期:1991-11-15 00:00:00
abstract::Power spectral analysis of the electroencephalogram (EEG) is a non-invasive method to examine infant brain maturation. Preterm fetal growth restricted (p-FGR) neonates display an altered EEG power spectrum compared to appropriate-for-gestational-age (AGA) peers, suggesting delayed brain maturation. Longitudinal studie...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2017.10.010
更新日期:2018-01-01 00:00:00
abstract::We measured the effect of high PCO (500-550 Torr) on the pHi and [Ca2+]i in cultured glomus cells of adult rat carotid body (CB) as a test of the two models currently proposed for the mechanism of CB chemoreception. The metabolic model postulates that the rise in glomus cell [Ca2+]i, the initiating reaction in the sig...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00607-6
更新日期:1998-08-24 00:00:00
abstract::We have developed a novel imaging system "real-time bioradiography", which is able to estimate the dynamic changes of physiological function and metabolism in living tissues using positron emitter-labeled tracers and chemiluminescence probes. The apparatus is comprised of a photon-counting camera, image-controller, cu...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.11.034
更新日期:2006-03-10 00:00:00
abstract::Effects of lateral vestibular nucleus (LVN) stimulation on neuronal activity in the rat lateral hypothalamic area (LHA), including specific glucose-sensitive neurons, were investigated by extracellular and intracellular recordings in vivo. Stimulation of the contralateral LVN evoked 3 types of response in 46% (111/240...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90653-6
更新日期:1987-01-01 00:00:00
abstract::Ion channels are integral membrane proteins that allow passive diffusion of ions across membranes. In neurons and in other excitable cells, the harmonious coordination between the numerous types of ion channels shape and propagate electrical signals. Increased accumulation of reactive oxidative species (ROS), and subs...
journal_title:Brain research
pub_type: 杂志文章,评审
doi:10.1016/j.brainres.2016.02.046
更新日期:2016-05-15 00:00:00
abstract::In order to study the biosynthesis of myelin-associated proteins in Schwann cells, we have induced proliferation of cultured Schwann cells from neonatal rat sciatic nerve by transformation with Simian Virus 40 (SV40). Homogeneous transformed Schwann cell lines were established by single cell cloning. The transformed p...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)91324-2
更新日期:1987-06-23 00:00:00
abstract::Dopamine neurons are overstimulated by drugs of abuse and suffer molecular alterations that lead to addiction behavior. Nurr1 is a transcription factor crucial for dopamine neurons survival and dopamine production, activating the transcription of key genes like tyrosine hydroxylase (TH). Interestingly, nuclear factor-...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2016.09.031
更新日期:2016-12-01 00:00:00
abstract::A startle-like response can be evoked at low currents by one-pulse electrical stimulation of reticular formation sites from the rostrolateral pons to the caudomedial medulla. To test whether this response is mediated by the same reticular formation neurons as those that mediate the acoustic startle, we delivered a bri...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91100-7
更新日期:1993-07-23 00:00:00
abstract::This study compared the responsivity of alpha 2-adrenoceptors to agonists in normotensive (WKY) and genetically hypertensive (SH) rats. Clonidine produced a greater degree of analgesia in SH as compared to WKY rats. This analgesia was antagonized by yohimbine. Neither naphazoline nor 4-hydroxy-clonidine produced analg...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90340-8
更新日期:1984-06-25 00:00:00
abstract::In non-neuronal cultures of cells dissociated from postnatal rat cerebellum astrocytes, identified by the presence of the marker protein glial fibrillary acidic protein (GFAP), displayed two distinct morphological forms. One class was stellate in shape with radially distributed fine processes, while the other class wa...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(83)90143-8
更新日期:1983-11-01 00:00:00
abstract:OBJECTIVE:There is an increasing interest concerning the contribution of astrocytes to the intrinsic bioremediation of ischemic brain injury. The aim of this work was to disclose the effects and mechanism of dexmedetomidine (DEX) on the apoptosis of astrocytes under oxygen glucose deprivation (OGD) condition. METHODS:...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2020.147141
更新日期:2021-01-01 00:00:00
abstract::In pentobarbitone-anesthetized cats, the spike sequences of dorsal horn neurons were recorded in response to random stimulation of branches of the suralis nerve. Combined frequency- and time-domain analysis was performed on the stimulus and spike trains. Coherence function estimates computed by spectral analysis were ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90598-7
更新日期:1988-10-11 00:00:00
abstract::Epileptic discharge patterns in an acute experimental model of epilepsy were analyzed. Epileptic foci were induced by epicortical application of penicillin on the rat motor cortex in vivo. Patterns with regular 1/s discharges, patterns with irregular discharges of about 0.5/s as well as compound patterns comprising di...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90221-8
更新日期:1993-07-09 00:00:00
abstract::There is growing behavioural evidence that the phospholipid growth factor lysophosphatidic acid (LPA) modulates nociceptive responses in vivo. The present study investigated further the effects of LPA on peripheral nociceptive processing. Effects of intraplantar injection of LPA on ongoing and peripheral mechanically ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2004.07.005
更新日期:2004-10-01 00:00:00
abstract::Soluble guanylyl cyclase is a heterodimeric (alpha, beta) enzyme generating the second messenger, cGMP, upon activation by the gaseous messenger, nitric oxide. The occurrence and distribution of alpha 1-, alpha 2-, beta 1- and beta 2-subunits were investigated in trigeminal and dorsal root ganglia on the mRNA and the ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(96)00097-2
更新日期:1996-05-20 00:00:00
abstract::The ability of midbrain raphe (MR) cells grafted into serotonin-depleted brain to restore hippocampal responses to synaptically released serotonin was studied using a serotonin-releasing drug, D-fenfluramine (FFA). In normal rats, FFA enhances reactivity of the dentate gyrus (DG) to perforant-path stimulation, while s...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91517-k
更新日期:1990-06-25 00:00:00
abstract::The aim of this study was to identify the medullary vagal nuclei involved in the different phases of swallowing activated physiologically in a species with an esophagus similar to human. In decerebrate cats, the pharyngeal (0.5-1.0 ml water in pharynx (N=6)) or esophageal (1-3 ml air in esophagus (N=5)) phases of swal...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2004.03.061
更新日期:2004-07-16 00:00:00
abstract::The enzyme in brain that hydrolyzes 2',3'-cyclic nucleotides to the 2'-mononucleotides has been found by several authors to be concentrated in the myelin fraction. To facilitate further study of the enzyme, one of our objectives has been to develop a method of solubilizing the enzyme without the use of detergents. Whe...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(75)90719-2
更新日期:1975-05-23 00:00:00
abstract::We previously reported that glial fibrillary acidic protein (GFAP) levels increased significantly at 3 days after stab wounds, relative to sham-operated controls, reaching a maximum of 200% of control value at 5-7 days. They then fell to near-normal values by 21 days. To determine whether these protein changes correla...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90142-x
更新日期:1990-11-26 00:00:00
abstract::Inducible cyclooxygenase 2 (COX 2) converts arachidonic acid to prostaglandins, which are thought to mediate various peripheral lipopolysaccharide (LPS)-induced central effects, including generation of fever and activation of the hypothalamic-pituitary-adrenal axis. To localize prostaglandin production in the brain fo...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00402-8
更新日期:1998-08-17 00:00:00
abstract::The effects of 2-day and 7-day cortisol treatment on immunoreactive corticotropin (ACTH) and beta-endorphin concentrations were measured in the cerebral cortex, hippocampus, hypothalamus, and cerebellum in male rats. Plasma ACTH, beta-endorphin, corticosterone, and cortisol levels were also measured in parallel. Corti...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90853-6
更新日期:1989-06-12 00:00:00
abstract::The distribution of calcitonin gene-related peptide (CGRP)-immunoreactive (IR) fibers and cell bodies was studied in the spinal cord and the medulla oblongata of the grey monkey (Macaca fascicularis) using peroxidase-antiperoxidase (PAP) immunohistochemistry. At all levels of the spinal cord many CGRP-IR motoneurons a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90787-v
更新日期:1991-09-06 00:00:00
abstract::Alteration of blood-brain barrier (BBB) permeability by 2450 MHz CW microwaves was assessed semi-quantitatively after intravenous injection of horseradish peroxidase (HRP) and exposure of conscious, unrestrained rats to incident power densities of 0, 20 or 65 mW/cm2 for 30, 90 or 180 min. Additional rats were exposed ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-0173(84)90022-5
更新日期:1984-05-01 00:00:00
abstract::Transplantation of mesenchymal stem cells (MSCs) prepared from adult bone marrow (BMSCs) has been reported to ameliorate functional deficits in several CNS diseases in experimental animal models. Bone marrow was enriched in MSCs by selecting for plastic-adherent cells that were grown to confluency in appropriate cultu...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.09.044
更新日期:2006-12-06 00:00:00
abstract::Short-term potentiation of extracellular field excitatory postsynaptic potentials (EPSP's) was investigated in the stratum radiatum of CA1 of the rat hippocampal slice in vitro. A presynaptic tetanus consisting of a single train of stimuli at 250 Hz evoked short-term potentiation (STP), but not long-term potentiation ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90304-6
更新日期:1988-08-30 00:00:00
abstract::An in vitro preparation of the medulla oblongata of the rat was used to examine the responses to reducing pH, at constant CO2, of neurons in several identified nuclei. Neurons in an area close to the ventral surface, which is thought to be the location of pH-sensitive central respiratory chemoreceptors, did not respon...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)90300-1
更新日期:1983-07-25 00:00:00
abstract::Experiments were carried out in rats to (1) elaborate upon the sepcificity of drug action in the periaqueductal gray matter (PAG), and (2) to evaluate the posible congruence of PAG sites of morphine-induced and stimulation-produced analgesis (SPA) applied at virtually identical PAG loci. It was demonstrated that the e...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(77)90886-1
更新日期:1977-03-25 00:00:00
abstract::The postnatal development of the terminal Schwann cell, an analogue of the lamellar cell in cutaneous sensory receptors, was examined by histochemistry for non-specific cholinesterase and immunohistochemistry for S-100 protein in the periodontal Ruffini endings of the rat incisor. Double immunohistochemistry for S-100...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)02463-4
更新日期:2000-03-06 00:00:00
abstract::The effects of glucagon injections (25, 100 and 200 ng) into the paraventricular nucleus of the hypothalamus (PVN) were investigated in an open-circuit calorimeter. Wistar rats were tested, with no food available during the tests. High doses of glucagon (100 and 200 ng) produced small and short-lasting increases in en...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90663-8
更新日期:1993-12-10 00:00:00