Ischemic tolerance following low dose NMDA involves modulation of cellular stress proteins.


:Mild NMDA receptor activation is correlated with neuroprotection in models of cerebral ischemia. Neuroprotection with NMDA manifests as a form of ischemic tolerance and involves the induction of cellular stress systems sensitive to disturbances in cellular calcium homeostasis. Unilateral micro-injection of 10, 160 and 320 microM NMDA into the prefrontal cortex of a rat 30 min prior to permanent occlusion of the middle cerebral artery (MCAO) significantly reduced the area of infarct observed after 4 h of ischemia. The highest dose of NMDA (320 microM) prevented the propagation of ischemic damage through a direct toxicity on neuronal tissue adjacent to the injection site as demonstrated in thionin-stained sections. As a result, the degree of ischemia-induced damage was similar to that measured in rats pretreated with the low dose of NMDA (10 microM). Expression of heat shock protein (HSP) 70 and glucose-regulated protein (GRP) 94 in cortical samples taken from the region of infarct following MCAO was significantly reduced in rats pretreated with 10 microM NMDA compared to saline-injected control rats and rats pretreated with higher doses of NMDA. Furthermore, 10 microM NMDA did not appear to influence expression of m-calpain or GRP78, however, higher doses of NMDA did significantly induce expression of both proteins as assessed by Western blotting. In summary, our data demonstrate an in vivo rodent model of ischemic tolerance in which 30 min of neuronal preconditioning with 10 microM NMDA confers protection against a 4 h period of MCAO-induced ischemia. This effect may involve modulation of cellular stress signals, in particular HSP70 and GRP94.


Brain Res


Brain research


Saleh MC,Connell BJ,Saleh TM




Has Abstract


2009-01-09 00:00:00












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    journal_title:Brain research

    pub_type: 杂志文章


    authors: Werth JL,Park TS,Silbergeld DL,Rothman SM

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    journal_title:Brain research

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    authors: Totterdell S,Hanger D,Meredith GE

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  • Anticonvulsant effect of enhancement of noradrenergic transmission in the superior colliculus in genetically epilepsy-prone rats (GEPRs): a microinjection study.

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    authors: Dellmann HD,Lue LF,Bellin SI,Ouassat M

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    journal_title:Brain research

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    authors: Yoshida H,Peterfi Z,García-García F,Kirkpatrick R,Yasuda T,Krueger JM

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    pub_type: 杂志文章,评审


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    journal_title:Brain research

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    authors: Feng P,Zhang A,Su M,Cai H,Wang X,Zhang Y

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  • ERP correlates of the conflict level in the multi-response Stroop task.

    abstract::This EEG study (N=33) examined event-related potentials associated with conflict between activated responses in the Stroop task, in order to examine the conflict monitoring theory of cognitive control, which predicts the strength of exerted control to be proportional to the detected level of conflict. However, existin...

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  • Dopamine and salsolinol levels in rat hypothalami and striatum after schedule-induced self-injection (SISI) of ethanol and acetaldehyde.

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  • Instability of motor unit firing rates during prolonged isometric contractions in human masseter.

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    journal_title:Brain research

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    journal_title:Brain research

    pub_type: 杂志文章


    authors: Berlind A

    更新日期:1993-04-23 00:00:00

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    pub_type: 杂志文章


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