Abstract：
:The blood-nerve barrier consists of continuous layers of cells linked by tight junctions and includes the endothelial cells which line the endoneurial capillaries and the perineurial cells which surround fascicles of nerve fibers. A facilitated transport carrier protein allows D-glucose to penetrate the barrier. To determine the specific cellular location of the transport system, an antiserum to a synthetic peptide corresponding to the carboxyl-terminus of the glucose transporter protein was used for light and electron immunocytochemical analyses. Glucose transporters were abundant both in endoneurial capillaries and the perineurial sheath. In perineurium, transporters were located in the plasma membranes and cytoplasm of the perineurial cells. Approximately two-thirds of the transporters associated with perineurial cells were localized in the plasma membranes. Perineurial cells are thus similar to cerebral endothelial cells in that they lack a large intracellular pool of transporters which might be sensitive to hormonal regulation. The presence of hexose carriers in perineurium suggests that glucose transport from epineurium to endoneurium may play a significant role in the metabolism of peripheral nerve fibers. These results support the concept that the blood-nerve barrier serves as an important nutrient delivery system.
journal_name
Brain Resjournal_title
Brain researchauthors
Gerhart DZ,Drewes LRdoi
10.1016/0006-8993(90)91115-wsubject
Has Abstractpub_date
1990-01-29 00:00:00pages
46-50issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(90)91115-Wjournal_volume
508pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：BACKGROUND:Intermittent hypoxia during sleep (IH), as occurs in sleep disordered breathing (SDB), induces spatial learning deficits associated with regulation of transcription factors associated with learning and memory in the hippocampal CA1 region in rats. high fat refined carbohydrate diet (HF/RC) can induce similar...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.03.046
更新日期：2006-05-23 00:00:00
abstract：:Antisense oligodeoxynucleotides (ODNs) are used for the selective inhibition of gene expression. Antisense ODNs are promising tools for the investigation of physiological implications of proteins in the central nervous system of rodents in vivo. We have previously demonstrated that a phosphorothioate antisense ODN to ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00463-0
更新日期：1997-08-08 00:00:00
abstract：:The nonsteroidal anti-inflammatory drugs are presumed to produce their analgesic effects by inhibiting the cyclooxygenase catalyzed metabolism of arachidonic acid to hyperalgesic prostanoids. This study examined the hyperalgesic effect of a range of prostaglandins. We found, employing the rat paw-withdrawal test, that...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90389-s
更新日期：1990-12-24 00:00:00
abstract：:There is growing behavioural evidence that the phospholipid growth factor lysophosphatidic acid (LPA) modulates nociceptive responses in vivo. The present study investigated further the effects of LPA on peripheral nociceptive processing. Effects of intraplantar injection of LPA on ongoing and peripheral mechanically ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.07.005
更新日期：2004-10-01 00:00:00
abstract：:The insular cortex (IC) has been reported to modulate the cardiac parasympathetic activity of the baroreflex in unanesthetized rats. However, which neurotransmitters are involved in this modulation is still unclear. In the present study, we evaluated the possible involvement of local IC-noradrenergic neurotransmission...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.08.013
更新日期：2009-10-27 00:00:00
abstract：:(1) Visual, auditory and olfactory input were not necessary for the performance of the lordosis reflex by female rats. Since taste is not involved in this behavior, somatosensory input must be sufficient for triggering the lordosis reflex. (2) Surgical cutaneous denervation markedly reduced the frequency and strength ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90987-2
更新日期：1976-01-09 00:00:00
abstract：:Notch signaling is a highly conserved pathway that regulates cell fate decisions during embryonic development. We have recently identified that in ischemic stroke, activity of γ-secretase and the resulting Notch activation may endanger neurons by modulating NF-κB and HIF-1α pathways. Notch signaling can also modulate ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2014.08.054
更新日期：2014-10-24 00:00:00
abstract：:A rabbit polyclonal antibody (91-01) was raised against recombinant human glia maturation factor beta (r-hGMF-beta). The antibody did not cross-react with a number of other growth factors on ELISA test. When compared with the monoclonal antibody G2-09 previously obtained, 91-01 immunoblotted the same protein band in r...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90971-b
更新日期：1992-09-18 00:00:00
abstract：:Three priming injections with the D1/D2 dopamine agonist apomorphine permits a challenge with the D2 agonist quinpirole to elicit robust contralateral rotation and ipsilateral striatal Fos expression in 6-hydroxydopamine lesioned rats. Pretreatment with NMDA glutamate antagonists MK-801 or CPP dose-dependently attenua...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02086-8
更新日期：2001-04-06 00:00:00
abstract：:Mouse embryonic stem (ES) cells were transplanted into the cochlea of adult guinea pigs in order to explore their survival, differentiation, and possible integration with the host tissue. With the purpose of investigating the possible effect of manipulating the local embryonic microenvironment, ES cells were transplan...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.06.016
更新日期：2005-07-27 00:00:00
abstract：:When rat striatal membranes, photolabeled with [3H]dopamine under assay conditions similar to those used for dopamine-sensitive adenylate cyclase, were subjected to sodium dodecyl sulfate (SDS) polyacrylamide gel electrophoresis, several radioactively labeled bands appeared. Labeling of these bands was reduced in the ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90426-1
更新日期：1981-12-28 00:00:00
abstract：:The central axon of a primary afferent neuron that responded to light mechanical stimulation of the lower premolar teeth in a fast adapting fashion was intra-axonally injected with horseradish peroxidase in the cat. The labeled terminals within the rostrodorsomedial (Vo.r) and dorsomedial (Vo.dm) parts of subnucleus o...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91588-j
更新日期：1993-03-19 00:00:00
abstract：:We examined for immediate and persistent changes in nAChRs in cerebral cortex, thalamus and striatum of male rats caused by prenatal exposure to nicotine from gestational day 3 to postnatal day 10 (PN10), and how such exposure affected the responses of adolescents to subsequent nicotine challenge. Receptor numbers wer...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.10.076
更新日期：2009-01-23 00:00:00
abstract：:In previous studies we have tested the hypothesis that the termination of the period of sexual behavior in female guinea pigs results from the loss of progestin receptors from hypothalamic cell nuclei. We have shown that hormonal manipulations that delay heat termination also delay loss of hypothalamic nuclear progest...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90320-3
更新日期：1986-05-14 00:00:00
abstract：:Peripheral input to lamina VIII interneurones was investigated by using extracellular and/or intracellular records from them. The interneurones were located in the L4-L5 spinal segments and projected to contralateral motor nuclei in the L7 segment. They constituted a non-homogeneous population but their input from mus...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91618-q
更新日期：1990-12-10 00:00:00
abstract：:The content of arginine vasopressin and oxytocin in various extrahypothalamic sites of the rat brain and spinal cord was determined by specific radioimmunoassays after lesions had been made in either the paraventricular (PVN), supraoptic (SON) or suprachiasmatic nuclei (SCN). In some animals all 3 nuclei were destroye...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91093-5
更新日期：1985-10-28 00:00:00
abstract：BACKGROUND:Previous experimental work using in situ zymography has shown very early increased plasminogen activation in ischemic regions after 3 h of ischemia with and without reperfusion. The objective of the present study was to evaluate the time course and extent of plasminogen activation in long-term permanent foca...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02769-4
更新日期：2000-11-03 00:00:00
abstract：:The postnatal development of retinogeniculate, retinopretectal and retinotectal projections has been studied by the anterograde transport of proline-labeled proteins in 20 pouch young opossums aged from 10 to 60 days. Radioautographical findings suggest delayed development of uncrossed as compared to crossed projectio...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(78)90971-x
更新日期：1978-05-12 00:00:00
abstract：:At present, the ability of polyunsaturated fatty acids (PUFAs) to regulate individual glutamate transporter subtypes is poorly understood and very little information exists on the mechanism(s) by which PUFAs achieve their effects on the transport process. Here we investigate the effect of cis-4,7,10,13,16,19-docosahex...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.01.008
更新日期：2005-03-10 00:00:00
abstract：:Female golden-mantled ground squirrels that sustained complete ablation of the suprachiasmatic nucleus (SCNx) were housed pre- and post-operatively at 23 degrees C and then at 6.5 degrees C for 5-7 yr. SCNx and control animals held at the higher temperature manifested circannual rhythms (CARs) in body mass. In contras...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01263-8
更新日期：1998-01-26 00:00:00
abstract：:Melatonin is synthesized rhythmically under control of circadian oscillators by the retinas of non-mammalian vertebrates. Here we report that the retinas of some strains of laboratory mice exhibit robust circadian rhythms of melatonin synthesis which can be entrained by light in vitro. The rd mutation results in progr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01446-7
更新日期：1998-04-13 00:00:00
abstract：:Large bilateral aspiration lesions of the hippocampus had no significant effect on septal kindling, whereas large bilateral DC lesions of the pyriform lobe resulted in a small but significant increase in the number of septal stimulations required to complete kindling. Bilateral aspiration lesions of the dorsal hippoca...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90826-8
更新日期：1988-06-28 00:00:00
abstract：:Mouse brain expresses three principal glucose transporters. Glut1 is an endothelial marker and is the principal glucose transporter of the blood-brain barrier. Glut3 and Glut6 are expressed in glial cells and neural cells. A mouse line with a null allele for Glut3 has been developed. The Glut3(-/-) genotype is intraut...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.02.014
更新日期：2011-04-12 00:00:00
abstract：:Retinal afferents to the dorsal raphe nucleus (DRN) have been described in a number of species, including Mongolian gerbils, but functional correlates of this optic pathway are unknown at present. To determine whether temporally modulated photostimulation can affect c-Fos expression in the gerbil DRN, quantitative ana...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.10.054
更新日期：2005-01-21 00:00:00
abstract：:Kindling is an experimental model for epilepsy in which repeated stimuli induce longer electrographic seizures and eventually cause behavioral convulsions. Although kindling has some features that are similar to chronic human epilepsy, it is not known whether this process plays a role in the development of chronic sei...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91071-y
更新日期：1993-10-22 00:00:00
abstract：:The time course and the relation to dose of regional cerebral metabolic rates for glucose (rCMRglc) were measured in awake male adult Fischer-344 rats after administration of quipazine, a serotonin 5-HT2-3 receptor agonist. rCMRglc was determined, using the quantitative autoradiographic [14C]deoxyglucose technique, in...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91380-b
更新日期：1993-01-15 00:00:00
abstract：:Recent studies have reported microglia that are activated in the central nervous system (CNS) in patients with temporal lobe epilepsy and animal models of epilepsy. However, limited data are available on the dynamic changes of the proportions of various phenotypes of microglia throughout epileptogenesis and whether IL...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.12.006
更新日期：2017-02-15 00:00:00
abstract：:Embryonic cortex from 19-day fetuses was transplanted in a medial frontal cortex wound cavity of 105-day-old male rats. Nissl-stained tissue revealed little internal laminar organization. Graft sections impregnated by the Loyez method exhibited bands of myelinated fibers surrounding implants as well as long-interconne...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91177-2
更新日期：1987-01-13 00:00:00
abstract：:The analysis of the dynamic properties of epileptiform activity in vitro has led to a better understanding of the time course of neural synchronization and seizure states. Nonlinear analysis is thus potentially useful for the prediction of seizure onset. We have used nonlinear analysis methods to investigate the devel...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)03166-8
更新日期：2001-02-02 00:00:00
abstract：:Small injections of the lectin Phaseolus vulgaris-leucoagglutinin (PHA-L) in the external segment of the pallidum (GPe) in the squirrel monkey (Saimiri sciureus) and in the rhesus monkey (Macaca mulatta) led to anterograde labeling of fibers in the internal segment of the pallidum (GPi). These fibers formed numerous l...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91813-v
更新日期：1990-11-12 00:00:00
