Abstract：
:Recent studies have demonstrated the neuroprotective properties of the novel imidazoquinoline benzodiazepine receptor partial agonist, PNU-101017, in the gerbil forebrain ischemia model. The compound effectively reduces delayed post-ischemic (5 min bilateral carotid occlusion) hippocampal CA1 neuronal degeneration even when its administration is withheld until 4 h after reperfusion and the effect is unrelated to hypothermia. The purpose of the present study was to determine the comparative abilities of PNU-101017 versus the full agonist diazepam to attenuate post-ischemic CA1 damage. Male gerbils were treated either 30 min before ischemia induction or immediately after reperfusion with an initial dose of PNU-101017 (30 mg/kg i.p.) or diazepam (10 mg/kg i.p.) with a second dose being given at 2 h after reperfusion. Possible hypothermic effects of either compound were prevented by external heating. In vehicle (0.05 N HCl)-treated gerbils, the loss of hippocampal CA1 neurons at 5 days was 85%. PNU-101017 pretreatment reduced the loss to 50% (p<0.05 vs. vehicle) whereas pretreatment with diazepam attenuated damage to only 17% (p<0.001 vs. vehicle). Delaying treatment with PNU-101017 until just after reperfusion still resulted in a reduction in CA1 degeneration statistically that was indistinguishable from that seen with pretreatment. In contrast, diazepam post-treatment did not significantly decrease CA1 neuronal loss. These results suggest that a benzodiazepine receptor partial agonist may have greater neuroprotective practicality than a full agonist for the treatment of global cerebral ischemia. The mechanistic basis for this difference may relate to the partially pro-excitatory neuronal response to endogenous GABA before and after neuronal insult.
journal_name
Brain Resjournal_title
Brain researchauthors
Hall ED,Fleck TJ,Oostveen JAdoi
10.1016/s0006-8993(98)00478-8subject
Has Abstractpub_date
1998-07-06 00:00:00pages
325-9issue
1-2eissn
0006-8993issn
1872-6240pii
S0006-8993(98)00478-8journal_volume
798pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Ontogenic development of the dopaminergic system in rat brain was investigated. This was accomplished by monitoring changes in postsynaptic dopamine receptor formation and presynaptic dopamine content in the midbrain tegmentum, frontal cortex and corpus striatum from the 18th day of gestation through adulthood. The do...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(88)90186-1
更新日期：1988-06-01 00:00:00
abstract：:In rats, True Blue (or Granular Blue) was injected into the hippocampus of one hemisphere and Nuclear Yellow into a homotopic site of the hippocampus of the contralateral hemisphere. Following restricted injections into the septal part of area dentata fluorescent neurons were found in hilus fasciae dentate on both sid...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90463-7
更新日期：1981-05-18 00:00:00
abstract：:The suprachiasmatic nuclei receive photic input information directly through a retinohypothalamic tract (RHT) and indirectly through a projection from the intergeniculate leaflet of the lateral geniculate complex, the geniculohypothalamic tract (GHT). Prior work has established that the RHT is sufficient for entrainme...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90374-5
更新日期：1988-09-20 00:00:00
abstract：:Two D-amino acid substitution angiotensin analogues were compared against native angiotensin II (AII) and angiotensin III (AIII) for their resistance to brain tissue-induced degradation and for pressor potency when intracerebroventricularly (i.c.v.) infused in Sprague-Dawley rats. The in vitro results indicate that [D...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90428-e
更新日期：1990-04-23 00:00:00
abstract：:The effect of 4% ethanol on pacemaker currents of Aplysia neurons was studied under voltage clamp. In normal seawater the n-shape in the I-V disappeared and outward current increased. Ion substitution and drug blocking experiments determined that leakage current and the slow inward calcium current were decreased and t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90268-8
更新日期：1983-11-14 00:00:00
abstract：:The neurotoxic effects of exogenous glutamate were studied in the rat cochlea. Glutamate-treated rats (4 g/kg/day i.p., postnatal days 2-9) exhibited electrophysiologically-measured elevations in high frequency thresholds usually associated with hair cell loss in the basal region of the cochlea. While surface preparat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90090-i
更新日期：1991-06-28 00:00:00
abstract：:The postnatal development of retinogeniculate, retinopretectal and retinotectal projections has been studied by the anterograde transport of proline-labeled proteins in 20 pouch young opossums aged from 10 to 60 days. Radioautographical findings suggest delayed development of uncrossed as compared to crossed projectio...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(78)90971-x
更新日期：1978-05-12 00:00:00
abstract：:Fluctuation analysis has been used to study the influence of temperature on the conductance and mean open time of Cl- permeable ion channels induced by gamma-aminobutyric acid (GABA) and glycine in the membrane of tissue cultured mouse spinal neurons. The conductance of GABA- and glycine-activated channels increased s...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90875-1
更新日期：1981-11-16 00:00:00
abstract：:Binding of [125I]-labeled Bolton-Hunter substance P ([125I]-BHSP) to NK1 receptors was investigated in the spinal cord of young (3-4 month) and aged (14-16 month) rats. In homogenates of whole spinal cord, the affinity (equilibrium dissociation constant, approximately 210 pM) and maximum density of [125I]-BHSP binding...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01463-7
更新日期：1998-03-09 00:00:00
abstract：:Power spectral analysis of the electroencephalogram (EEG) is a non-invasive method to examine infant brain maturation. Preterm fetal growth restricted (p-FGR) neonates display an altered EEG power spectrum compared to appropriate-for-gestational-age (AGA) peers, suggesting delayed brain maturation. Longitudinal studie...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2017.10.010
更新日期：2018-01-01 00:00:00
abstract：:The double-labeling, fluorescent dye technique was used in order to demonstrate the extent to which the central processes of renal afferent neurons directly project to the brainstem. One injection of a fluorescent dye was placed in the cortex of the left kidney of male rats, and a second injection of a different dye w...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)91154-5
更新日期：1984-04-23 00:00:00
abstract：:High-intensity stimulation of the supraorbital region elicits, together with a blink reflex, a reflex inhibition of the jaw-closing muscles in normal man. The response differs from the well known inhibition obtained by intra- and perioral stimulation in two main features. Firstly, it consists of a single late silent p...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90366-5
更新日期：1986-04-23 00:00:00
abstract：:The response of granule cells and CA1 pyramidal neurones to NMDA was studied in the presence and absence of Mg2+ using an in vitro slice preparation. In the absence of Mg2+ the depolarizing response of hippocampal neurones to NMDA is accompanied by a decrease in input resistance. In the presence of Mg2+ ions, however,...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90107-0
更新日期：1984-10-08 00:00:00
abstract：:Milk ejection-related bursts of action potentials recurred at fairly regular intervals during suckling in oxytocin cells of anesthetized lactating rats. Additional milk ejection-related bursts were frequently induced in response to vaginal distension. The latency for the induced response was 2.9 +/- 0.2 s and the size...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91397-7
更新日期：1987-02-24 00:00:00
abstract：:Regional brain glucose utilization was investigated in lean and fatty Zucker rats when feeding status was changed. Ad-lib-fed fat rats exhibited lower glucose utilization in the central amygdala than ad-lib-fed lean rats. Food deprivation for 72 h enhanced glucose utilization in the ventromedial hypothalamus, lateral ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90628-2
更新日期：1988-12-20 00:00:00
abstract：:We report the localization of angiotensin-converting enzyme (kininase II, EC 3.4.15.1) in discrete nuclei and areas of the rat brain by a quantitative autoradiographic technique using image processing coupled to computerized microdensitometry, after incubation of brain sections with the specific converting enzyme inhi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90746-8
更新日期：1986-06-11 00:00:00
abstract：:Microarray analysis has been used to understand how gene regulation plays a critical role in neuronal injury, survival and repair following ischemic stroke. To identify the transcriptional regulatory elements responsible for ischemia-induced gene expression, we examined gene expression profiles of rat brains following...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.11.052
更新日期：2013-02-07 00:00:00
abstract：:Diffuse white matter (WM) response to traumatic brain injury (TBI) and transplantation of human bone marrow stromal cells (hMSCs) after the injury were non-invasively and dynamically investigated. Male Wistar rats (300-350 g) subjected to TBI were intravenously injected with 1 ml of saline (n = 10) or with hMSCs in su...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2019.04.020
更新日期：2019-08-15 00:00:00
abstract：:Although an auditory area has been found over the exposed area of lobules VI-VIII in the posterior cerebellar vermis of the cat, there has been little information on its buried portion. This point should be of some concern, since very little of the brain tissue in lobules VI-VIII of the cerebellar cortex is exposed. W...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90825-g
更新日期：1991-07-12 00:00:00
abstract：:In rats with unilateral 6-hydroxydopamine lesions of the substantia nigra, a specific D1 dopamine receptor agonist, SKF 38393A, at a dose that does not itself produce turning, significantly increased the contralateral rotation observed following a low dose of the specific D2 agonist LY 171555. Doses of SKF 38393A or t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91178-9
更新日期：1986-10-08 00:00:00
abstract：:Two separate in vitro assays were used to examine the biosynthesis of the broad spectrum excitatory amino acid receptor antagonist kynurenic acid (KYNA) during the life span of the adult rat. Assessment of KYNA's anabolic enzyme kynurenine aminotransferase revealed steady increases between 3 and 24 months of age in al...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)91337-e
更新日期：1992-08-14 00:00:00
abstract：:Cytogenesis in the kitten retina has been investigated with [3H]thymidine autoradiography and a stain for mitotic figures. The nuclei of cells in S-phase are located adjacent to the inner margin of the cytoblast layer, near the inner plexiform layer. The nuclei then migrate toward the outer limiting membrane (OLM) to ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(85)90235-4
更新日期：1985-03-01 00:00:00
abstract：:Previous studies indicate that 3-acetylpyridine (3-AP) intoxication produces discrete lesions of the inferior olive (IO) and other central structures in rats and mice. As a result, it has been widely employed in investigations of the influences of climbing fibers on cerebellar function. This study examines the central...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-0173(85)90017-7
更新日期：1985-04-01 00:00:00
abstract：:Thermoregulation is a complex intercommunicative function requiring coordination between core body temperature (CBT), the central nervous system, and peripheral vasculature. In menopausal women, dysregulation of thermoregulatory mechanisms leads to hot flushes and night sweats. A previous study in ovariectomized (OVX)...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.09.050
更新日期：2006-12-06 00:00:00
abstract：:The neuroactive steroid 5 beta-pregnan-3 alpha-ol-20-one (5 beta 3 alpha) modulates GABAA receptor function by potentiating postsynaptic GABA currents. While much is now known about the postsynaptic action of neurosteroids, far less is known about how they affect neurotransmission. We have investigated the synaptic ac...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00809-3
更新日期：1997-10-03 00:00:00
abstract：:An interesting feature of the kindling phenomenon relates to the finding that kindling established in one region of the brain may reduce the number of stimulations required to establish the phenomenon in a second region. It has been proposed that this 'transfer' phenomenon reflects the extent to which seizures arising...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00779-8
更新日期：1997-10-10 00:00:00
abstract：:Antagonism of the alpha receptor sub-type at gamma-aminobutyric acid (GABA) recognition sites in developing pigs was evaluated using the GABAA receptor antagonist bicuculline. The effect of bicuculline infusions was to produce an increase of phrenic and hypoglossal discharge amplitudes. This bicuculline-induced effect...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90222-4
更新日期：1994-07-04 00:00:00
abstract：:Dysfunction in the hypothalamic GABAergic system has been implicated in panic syndrome in humans. Furthermore, several studies have implicated the hypothalamus in the elaboration of pain modulation. Panic-prone states are able to be experimentally induced in laboratory animals to study this phenomenon. The aim of the ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.09.096
更新日期：2009-12-11 00:00:00
abstract：:In anesthetized cats, medial gastrocnemius motor units (MUs) were electrically stimulated via their ventral-root axons with independent random patterns. Muscle tension and homonymous alpha-motoneuron (alpha-MN) membrane potential fluctuations in response to these stimuli were recorded simultaneously. Cross-correlating...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90763-2
更新日期：1985-09-23 00:00:00
abstract：:Altered noradrenergic function is associated with alcoholism. Reduced brain norepinephrine (NE) concentrations and beta-adrenergic receptor supersensitivity following chronic alcohol consumption suggest a reduced level of noradrenergic neurotransmission. To further elucidate the reason for changes in noradrenergic fun...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90199-6
更新日期：1994-07-04 00:00:00
