In vivo chronic lead exposure alters [3H]nitrendipine binding in rat striatum.

abstract：BACKGROUND:Toll-like receptor 4 (TLR4) is an important mediator of the innate immune response. It significantly contributes to neuroinflammation and may be involved in ischemic tolerance. It is unknown how cerebral ischemia in the cortex and postconditioning might affect inflammatory reactions in the hippocampus or whe...

journal_title：Brain research

authors： Feng R,Li S,Li F

更新日期：2011-04-12 00:00:00

abstract：:A daily variation of tryptophan hydroxylase (TrH) activity was observed in the raphe dorsalis (RD), raphe centralis (RC) and striatum (St) of 3 inbred strains of mice (BALB/c, C57BL/6, C57BR) and of the reciprocal hybrids obtained from Balb/c and C57BL6. Significant differences of the characteristics of these rhythms ...

journal_title：Brain research

authors： Natali JP,McRae-Degueurce A,Chouvet G,Pujol JF

更新日期：1980-06-02 00:00:00

abstract：:The response of granule cells and CA1 pyramidal neurones to NMDA was studied in the presence and absence of Mg2+ using an in vitro slice preparation. In the absence of Mg2+ the depolarizing response of hippocampal neurones to NMDA is accompanied by a decrease in input resistance. In the presence of Mg2+ ions, however,...

journal_title：Brain research

authors： Crunelli V,Mayer ML

更新日期：1984-10-08 00:00:00

abstract：:The intracellular injection technique of HRP with simultaneous recordings of intracellular potential was applied to the crab X-organ-sinus gland peptidergic neurosecretory neurons. At least two classes of neurons were discriminated from the usual type of neurosecretory neurons morphologically as well as electrophysiol...

journal_title：Brain research

authors： Nagano M

更新日期：1986-01-08 00:00:00

abstract：:To test the hypothesis that stimulation of glial peroxidase activity by estrogens may play a role in the pathogenesis of the previously reported degenerative changes in the hypothalamic arcuate nucleus that occur in female rats treated with a long-acting estrogen preparation, the cellular localization and number of pe...

journal_title：Brain research

authors： Schipper HM,Lechan RM,Reichlin S

更新日期：1990-01-22 00:00:00

abstract：:Insulin-like growth factor (IGF) II receptors were studied in human adult brain by using autoradiography with [125I]IGF-II. Receptors were found to be widely distributed throughout all neuronal regions. The highest densities were found in plexus choroideus, granular layer of the cerebellar cortex, gyrus dendatus and p...

journal_title：Brain research

authors： Wilczak N,De Bleser P,Luiten P,Geerts A,Teelken A,De Keyser J

更新日期：2000-04-28 00:00:00

abstract：:The possible involvement of protein kinase A (PKA) in the muscarinic inhibition of the slow afterhyperpolarizing current (IAHP) was investigated in rat hippocampal pyramidal cells. IAHP was recorded using the whole cell method in hippocampal slices, and Rp-cAMPS, a PKA antagonist, was applied intracellularly. The inhi...

journal_title：Brain research

authors： Blitzer RD,Wong T,Nouranifar R,Landau EM

更新日期：1994-05-23 00:00:00

abstract：:Ontogenic development of the dopaminergic system in rat brain was investigated. This was accomplished by monitoring changes in postsynaptic dopamine receptor formation and presynaptic dopamine content in the midbrain tegmentum, frontal cortex and corpus striatum from the 18th day of gestation through adulthood. The do...

journal_title：Brain research

authors： Noisin EL,Thomas WE

更新日期：1988-06-01 00:00:00

abstract：:Microglial cyclo-oxygenase (COX) expression is considered to be important in the pathogenesis of Alzheimer's disease (AD) and, therefore, constitutes a key target for therapeutic intervention. We investigated the influence of AD plaque associated factors on COX-1 and COX-2 expression and activity in adult human microg...

journal_title：Brain research

authors： Hoozemans JJ,Veerhuis R,Janssen I,van Elk EJ,Rozemuller AJ,Eikelenboom P

更新日期：2002-10-04 00:00:00

abstract：:The double-labeling, fluorescent dye technique was used in order to demonstrate the extent to which the central processes of renal afferent neurons directly project to the brainstem. One injection of a fluorescent dye was placed in the cortex of the left kidney of male rats, and a second injection of a different dye w...

journal_title：Brain research

authors： Wyss JM,Donovan MK

更新日期：1984-04-23 00:00:00

abstract：:Opioid modulation of ingestion includes general opioid antagonism of deprivation-induced water intake and intake of sucrose and saccharin solutions. Previous studies using selective subtype antagonists indicated that opioid effects upon deprivation-induced water intake occurred through the mu2 receptor and that opioid...

journal_title：Brain research

authors： Beczkowska IW,Koch JE,Bostock ME,Leibowitz SF,Bodnar RJ

更新日期：1993-08-06 00:00:00

abstract：:We investigated whether the weak febrile response to pyrogens in newborns is due to a diminished activation of the putative pyrogen mediator, prostaglandin (PG)E2. Indwelling cannulas in the third ventricle of lambs (age, 5-31 days) and adult ewes were used to collect cerebrospinal fluid (CSF) for radioimmunoassay of ...

journal_title：Brain research

authors： Coceani F,Bishai I,Engelberts D,House RV,Adamson SL

更新日期：1995-11-27 00:00:00

abstract：:A monoclonal antibody was made using the spleen cells of a mouse immunized with chick synaptic membranes and designated as mAb 1D12. It immunoprecipitated 25% of the omega-conotoxin binding protein but no dihydropyridine binding protein solubilized from chick brain membranes. By immunoblotting, a polypeptide of 58-kDa...

journal_title：Brain research

authors： Takahashi M,Arimatsu Y,Fujita S,Fujimoto Y,Kondo S,Hama T,Miyamoto E

更新日期：1991-06-14 00:00:00

abstract：:Hippocampal CA1 pyramidal cell neurons are sensitized to depolarization by L-2-amino-4-phosphonobutanoic acid (L-AP4) following exposure to L-quisqualic acid (QUIS). It has been proposed that induction of this 'QUIS-effect' involves uptake of L-QUIS by hippocampal cells. We have used o-phthaldialdehyde (OPA) derivatiz...

journal_title：Brain research

authors： Schulte MK,Roon RJ,Koerner JF

更新日期：1993-03-05 00:00:00

abstract：:We have previously raised a monoclonal antibody (69A1) which recognises a cell-surface antigen expressed on rat cerebellar neurons both in culture and in tissue sections of the developing cerebellum prior to postnatal day 17. In our current study we have undertaken a detailed analysis of the loss of labelling from the...

journal_title：Brain research

authors： Pigott R,Kelly JS

更新日期：1986-09-01 00:00:00

abstract：:Ouabain (5 X 10(-4) M) induced a 6-fold increase in intracellular Na+ and a 65% loss of cellular K+ in C6 glial cells which was accompanied by a 12 mV decrease in the resting membrane potential. Following ouabain washout intracellular ion concentrations and the membrane potential returned to control levels suggesting...

journal_title：Brain research

authors： Kukes G,De Vellis J,Elul R

更新日期：1976-03-05 00:00:00

abstract：:With the use of [3H]p-aminoclonidine (PAC), alpha 2-adrenergic binding sites were mapped in the brain of the Japanese quail (Coturnix coturnix japonica). The sites were labeled with the use of in vitro quantitative autoradiography. Special attention was given to areas implicated in the control of sexually dimorphic re...

journal_title：Brain research

authors： Ball GF,Nock B,McEwen BS,Balthazart J

更新日期：1989-07-03 00:00:00

abstract：:Alpha-lipoic acid (ALA) is an endogenous short-chain fatty acid that has beneficial protective effects against various vascular diseases. In this study, we sought to determine whether ALA could induce pre- or post-treatment protective effects against simulated ischemia and reperfusion-induced cerebral endothelial cell...

journal_title：Brain research

authors： Xie R,Li X,Ling Y,Shen C,Wu X,Xu W,Gao X

更新日期：2012-10-30 00:00:00

abstract：:Cell transplantation using ventral mesencephalic tissue is an experimental approach to treat Parkinson's disease. This approach is limited by poor survival of the transplants and the high number of dopaminergic neurons needed for grafting. Increasing the yield of dopaminergic neurons in donor tissue is of great import...

journal_title：Brain research

authors： Seiler S,Di Santo S,Sahli S,Andereggen L,Widmer HR

更新日期：2017-08-01 00:00:00

abstract：:Flexion movements induced by cortical stimulation and the associated postural adjustments in bilaterally pyramidotomised cats have been studied by means of an apparatus which measures separately the changes of force under each limb in the upright position of the animal. The results show: (1) The general motor behaviou...

journal_title：Brain research

authors： Nieoullon A,Gahéry Y

更新日期：1978-06-23 00:00:00

abstract：:In intact guinea pigs a passive horizontal rotation of the body about the fixed head induces compensatory ocular movements (cervico-ocular reflex). When the static neck deviation is maintained, a significant ocular displacement is observed. In acutely hemilabyrinthectomized animals, static body deviation towards the l...

journal_title：Brain research

authors： Pettorossi VE,Petrosini L

更新日期：1984-12-17 00:00:00

abstract：:Regeneration of descending supraspinal projections were identified in adult goldfish following administration of HRP to different levels of the spinal cord. While in the untreated normal fish 17 nuclei were shown to project into the spinal cord, only 11 of them seem to have participated in the process of regeneration....

journal_title：Brain research

authors： Sharma SC,Jadhao AG,Rao PD

更新日期：1993-08-27 00:00:00

abstract：:Previous studies have shown that chronic morphine increases levels of the G-protein subunits Gia and Goa, adenylate cyclase, cyclic AMP-dependent protein kinase, and certain phosphoproteins in the rat locus coeruleus, but not in several other brain regions studied, and that chronic morphine decreases levels of Gia and...

journal_title：Brain research

authors： Terwilliger RZ,Beitner-Johnson D,Sevarino KA,Crain SM,Nestler EJ

更新日期：1991-05-10 00:00:00

abstract：:The actions of sodium valproate (NaVP) were studied in the in vitro hippocampus using extracellular, intracellular and voltage-clamp recording techniques. In the CA1 region, concentrations of 30-200 microM NaVP reduced the amplitude but not the time course of post-tetanic potentiation (PTP) of dendritic field excitato...

journal_title：Brain research

authors： Griffith WH,Taylor L

更新日期：1988-11-22 00:00:00

abstract：:Previous studies have shown that microinjection of morphine into the prefrontal ventrolateral orbital cortex (VLO) produces antinociception. The current study examined whether gamma-aminobutyric acid (GABA) containing neurons in the VLO were involved in this antinociception. Under light anesthesia, the GABA(A) recepto...

journal_title：Brain research

authors： Qu CL,Tang JS,Jia H

更新日期：2006-02-16 00:00:00

abstract：:Large neuronal perikarya isolated in bulk fractions from adult bovine ventral spinal cord and examined by electron microscopy have discontinuities in their plasma membrane. A systematic investigation of the possible causes of the membrane defects indicates that the act of mechanical dissociation of the neurons from th...

journal_title：Brain research

authors： Hester S,Capps-Covey P,McIlwain DL

更新日期：1978-12-22 00:00:00

abstract：:The changes in the excitability of lumbosacral spinothalamic neurons produced by activating afferents in the trigeminal nerve using electrical or mechanical stimuli was investigated in cats anesthetized with alpha-chloralose. In most spinothalamic neurons, weak electrical stimuli or step indentations of the skin of th...

journal_title：Brain research

authors： McCreery DB,Bloedel JR,Hames EG

更新日期：1979-11-16 00:00:00

abstract：:Rabbits passively oscillated in the horizontal plane with a free hand tended to stabilize their head in space (re: earth-fixed surroundings) by moving the head on the trunk (neck angular deviation, NAD) opposite the passively imposed body rotation. The gain (NAD/body rotation) of head stabilization varied from 0.0 to ...

journal_title：Brain research

authors： Fuller JH

更新日期：1981-02-02 00:00:00

abstract：:The postnatal development of the distribution of 3 different ionic channel proteins in rat brain was studied using light microscopic autoradiography. [3H]Ethylenediaminetetrodotoxin, [125I]apamin and (-)-[3H]desmethoxyverapamil were used to label one class of voltage-dependent Na+ channel proteins, one class of Ca2+-d...

journal_title：Brain research

authors： Mourre C,Cervera P,Lazdunski M

更新日期：1987-08-04 00:00:00

abstract：:The recently identified neuropeptide QRFP(26) is predominantly expressed in the hypothalamus and was suggested to play a role in the regulation of food intake following the observation of an acute orexigenic effect after central administration in mice. QRFP(26) exerts its effect via GPR103 and a newly identified recep...

journal_title：Brain research

authors： Kampe J,Wiedmer P,Pfluger PT,Castaneda TR,Burget L,Mondala H,Kerr J,Liaw C,Oldfield BJ,Tschöp MH,Bagnol D

更新日期：2006-11-13 00:00:00