当前位置： SCI文献检索 > BRAIN RESEARCH期刊下所有文献 > A histologically derived stereotaxic atlas and substance P immunohistochemistry in the brain of the least shrew (Cryptotis parva) support its role as a model organism for behavioral and pharmacological research.

A histologically derived stereotaxic atlas and substance P immunohistochemistry in the brain of the least shrew (Cryptotis parva) support its role as a model organism for behavioral and pharmacological research.

Abstract：

:Chemotherapy is an effective treatment but difficult to tolerate due to side effects like vomiting. Studies on the etiology of chemotherapy-related emesis have implicated brainstem nuclei and the neurotransmitter substance P, among other substrates. Since rodents do not vomit, other species have been necessary as alternative models of chemotherapy-induced emesis. Of these, the least shrew (Cryptotis parva) has proven valuable due to its small size, hardiness, and close phylogenetic relationship with primates. However, very little neuroanatomical data on C. parva exist. We used histological and immunohistochemical techniques to provide neuroanatomical data to help validate C. parva as a model organism, especially for emesis research. Brains were sectioned and stained for Nissl substance or myelin, or immunofluorescently labeled for substance P. Sections were photographed, traced, and reconstructed with standardized zero points, and these data used to create a stereotaxic atlas. The brain of C. parva was similar to but smaller than other mammalian brains, with the cerebellum and hippocampus demonstrating the biggest differences. Differences appeared to be related to the small size of the brain and the metabolic compromises required of such a small mammal. Substance P-like immunoreactivity (SPL-IR) was semiquantitatively mapped, and correlated very well with SPL-IR observed in other species. Dense SPL-IR areas included the periaqueductal grey, trigeminal nuclei, dorsal raphe, and emesis-related brainstem nuclei including the area postrema and solitary tract nucleus. These data demonstrate that the anatomical differences between C. parva and other mammals will not preclude its use as a model organism.

journal_name

Brain Res

journal_title

Brain research

authors

Ray AP,Darmani NA

doi

10.1016/j.brainres.2007.04.061

subject

Has Abstract

pub_date

2007-07-02 00:00:00

pages

99-111

eissn

0006-8993

issn

1872-6240

pii

S0006-8993(07)00988-2

journal_volume

1156

pub_type

杂志文章

相关文献

BRAIN RESEARCH文献大全
  • Reduction by central beta-funaltrexamine of food intake in rats under freely-feeding, deprivation and glucoprivic conditions.

    abstract：:The present study evaluated the central effects of beta-funaltrexamine (B-FNA), a non-equilibrium antagonist of mu-opioid receptors and a reversible agonist of kappa-opioid receptors upon food intake in rats under freely-feeding, deprivation and glucoprivic conditions. B-FNA elicited distinct short-term and long-term ...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(90)91828-5

    authors： Arjune D,Standifer KM,Pasternak GW,Bodnar RJ

    更新日期：1990-12-03 00:00:00

  • The characterization of alpha-bungarotoxin receptors on the surface of parasympathetic neurons in the frog heart.

    abstract：:Receptors for alpha-bungarotoxin are found on the surface of parasympathetic neurons in the frog cardiac ganglion by light microscopic autoradiography. Competition studies suggest that these receptors are cholinergic and indicate that they are also recognized by neuronal bungarotoxin (kappa-bungarotoxin). These recept...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(95)00250-t

    authors： Sargent PB,Garrett EN

    更新日期：1995-05-22 00:00:00

  • Role of iron in brain lipocalin 2 upregulation after intracerebral hemorrhage in rats.

    abstract：:Brain iron overload has a detrimental role in brain injury after intracerebral hemorrhage (ICH). Lipocalin 2 (LCN2), a siderophore-binding protein, is involved in cellular iron transport. The present study investigated changes in LCN2 expression after ICH and the role of iron in those changes. Male Sprague-Dawley rats...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2013.02.008

    authors： Dong M,Xi G,Keep RF,Hua Y

    更新日期：2013-04-10 00:00:00

  • The significance of retrograde axonal transport for the accumulation of systemically administered nerve growth factor (NGF) in the rat superior cervical ganglion.

    abstract：:The present study has shown that after intravenous injection of [125I]NGF the time-course of appearance of radioactivity in all organs studied with the exception of sympathetic and sensory ganglia, roughly paralleled that of the blood. The highest levels were reached immediately after injection, after which the radioa...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(76)90530-8

    authors： Stoeckel K,Guroff G,Schwab M,Thoenen H

    更新日期：1976-06-11 00:00:00

  • Dynamic cerebral autoregulation and baroreflex sensitivity during modest and severe step changes in arterial PCO2.

    abstract：:Changes in the partial pressure of arterial CO2 (PaCO2) regulates cerebrovascular tone and dynamic cerebral autoregulation (CA). Elevations in PaCO2 also increases autonomic neural activity and may alter the arterial baroreflex. We hypothesized that hypercapnia would impair, and hypocapnia would improve, dynamic CA an...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2008.07.048

    authors： Ainslie PN,Celi L,McGrattan K,Peebles K,Ogoh S

    更新日期：2008-09-16 00:00:00

  • The effects of neonatal thyroid deficiency on acetylcholine synthesis and glucose oxidation in rat corpus striatum.

    abstract：:The effects of propylthiouracil (PTU)-induced thyroid deficiency on [14C]acetylcholine synthesis and 14CO2 production from [U-14C]glucose in vitro, by fine prisms of the corpus striatum were investigated in developing rats. Consistent with deficits in choline uptake and choline acetyltransferase activity (Kalaria et a...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0165-3806(85)90114-2

    authors： Kalaria RN,Prince AK

    更新日期：1985-06-01 00:00:00

  • Evidence to suggest that extracellular acetate is accumulated by rat hippocampal cholinergic nerve terminals for acetylcholine formation and release.

    abstract：:It is well established that extracellular choline is transported into central cholinergic nerve terminals by 'high' and 'low' affinity processes to form the neurotransmitter acetylcholine (ACh). The intent of the present investigation was to ascertain whether extracellular acetate might also be transported into centra...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/s0006-8993(96)01485-0

    authors： Carroll PT

    更新日期：1997-04-04 00:00:00

  • Thrombin inhibition attenuates neurodegeneration and cerebral edema formation following transient forebrain ischemia.

    abstract：:The disturbance of microcirculation following cerebral ischemia leads to an enlargement of cerebral infarct volume. Endogenous thrombin may play a role in this disturbance of microcirculation following cerebral ischemia. Therefore, the inhibition of thrombin may improve neurodegeneration and the accumulation of cerebr...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/s0006-8993(01)02354-x

    authors： Ohyama H,Hosomi N,Takahashi T,Mizushige K,Kohno M

    更新日期：2001-06-01 00:00:00

  • Passive electrical properties of motoneurons in aged cats following axotomy.

    abstract：:The objective of this study was to determine whether the aging process influences the changes in the electrophysiological properties of motoneurons that occur as a consequence of axotomy. Accordingly, using intracellular recording and stimulating techniques, the basic electrical properties of control (unaxotomized) an...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(92)90594-y

    authors： Yamuy J,Engelhardt JK,Morales FR,Chase MH

    更新日期：1992-01-20 00:00:00

  • Conditioned taste aversion and latent inhibition following extensive taste preexposure in rats with insular cortex lesions.

    abstract：:Lesions of the insular cortex (IC) attenuate acquisition of conditioned taste aversions (CTAs). We have suggested that this impairment is the expected consequence of a failure of IC-lesioned (ICX) rats to recognize unfamiliar taste stimuli as novel. That is, ICX rats treat novel taste stimuli as if they are familiar a...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2008.12.058

    authors： Roman C,Lin JY,Reilly S

    更新日期：2009-03-09 00:00:00

  • The effect of reticular stimulation on spontaneous and evoked activity in the cat visual cortex.

    abstract：:The mesencephalic reticular formation (MRF) of cats anesthetized with N2O was stimulated electrically, and the effects of this stimulation on activity in the striate cortex were studied. The variations of intra- and extracellularly recorded unit activity and the changes in the extracellular potassium concentration wer...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(76)90576-x

    authors： Singer W,Tretter F,Cynader M

    更新日期：1976-01-30 00:00:00

  • Primed-burst potentiation occludes the potentiation phenomenon and enhances the epileptiform activity induced by transient pentylenetetrazol in the CA1 region of rat hippocampal slices.

    abstract：:The effects of pentylenetetrazol (PTZ) following induction of long-term potentiation (LTP) on population spikes in CA1 of hippocampal slices were investigated. Population spikes were evoked by activation of Schaffer collaterals with a range of stimulation intensities. LTP was induced using θ-pattern primed burst...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/s0006-8993(00)02672-x

    authors： Omrani A,Fathollahi Y,Mohajerani HR,Semnanian S

    更新日期：2000-09-22 00:00:00

  • Two distinct unit activity responses to morphine in the rostral ventromedial medulla of awake rats.

    abstract：:Past research investigating the rostral ventromedial medulla (RVM) in anesthetized animals has found two distinct classes of cells, ON and OFF, noted for their distinct responses to noxious stimuli and to morphine. However, only one class (ON) has been found in the awake animal paradigm. We report in this paper that w...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(93)90385-z

    authors： McGaraughty S,Reinis S,Tsoukatos J

    更新日期：1993-02-26 00:00:00

  • Cathepsin L is involved in 6-hydroxydopamine induced apoptosis of SH-SY5Y neuroblastoma cells.

    abstract：:Our previous study reported that cathepsin L may contribute to the death of dopaminergic neurons in rodent model of Parkinson's disease (PD). In this study we detected the changes in the expression of lysosomal cathepsin L in cellular models of PD. In human neuroblastoma SH-SY5Y cells, treatment with 6-hydroxydopamine...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2011.02.092

    authors： Xiang B,Fei X,Zhuang W,Fang Y,Qin Z,Liang Z

    更新日期：2011-04-28 00:00:00

  • Habenular and other midbrain raphe afferents demonstrated by a modified retrograde tracing technique.

    abstract：:Afferents to th midbrain dorsal and median raphe nuclei in the rat were studied by means of the horseradish peroxidase (HRP) retrograde transport method. The HRP was given by means of a modified iontophoretic delivery technique. This technique permitted an efficient and localized deposition of a high concentration of ...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(77)90291-8

    authors： Aghajanian GK,Wang RY

    更新日期：1977-02-18 00:00:00

  • Differences between strychnine and penicillin epileptogenesis suggest a laminar organization of neocortical inhibition.

    abstract：:Transient foci of epileptiform alteration in neuronal population activity were induced by microinjection of strychnine sulfate into different layers of cat striate cortex. Potentials evoked by visual field-specific photic stimulation were recorded from microelectrodes at the injection site and in adjacent laminae. Epi...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(85)90938-2

    authors： Ebersole JS,Chatt AB

    更新日期：1985-08-12 00:00:00

  • Sex difference in Onuf's nucleus homologue in the Asian musk shrew.

    abstract：:Perineal muscles essential for copulatory functioning are innervated by Onuf's nucleus in humans and the spinal nucleus of the bulbocavernosus (SNB) and dorsolateral nucleus (DLN) in rats. These structures sexually differentiate as a result of developmental androgen exposure in most species examined. The homologous st...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2010.05.056

    authors： Polak K,Freeman LM

    更新日期：2010-07-30 00:00:00

  • Alterations of resting state functional connectivity in the default network in adolescents with autism spectrum disorders.

    abstract：:Autism spectrum disorders (ASD) are associated with disturbances of neural connectivity. Functional connectivity between neural structures is typically examined within the context of a cognitive task, but also exists in the absence of a task (i.e., "rest"). Connectivity during rest is particularly active in a set of s...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2009.11.057

    authors： Weng SJ,Wiggins JL,Peltier SJ,Carrasco M,Risi S,Lord C,Monk CS

    更新日期：2010-02-08 00:00:00

  • Latent NOTCH3 epitopes unmasked in CADASIL and regulated by protein redox state.

    abstract：:Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy CADASIL is caused by more than a hundred NOTCH3 mutations. Virtually all encoded mutant proteins contain an odd number of cysteines. As such, structural changes in NOTCH3 may be the primary molecular abnormality in CADASIL. Thus...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2014.08.018

    authors： Zhang X,Lee SJ,Young KZ,Josephson DA,Geschwind MD,Wang MM

    更新日期：2014-10-02 00:00:00

  • Vanadate ions: central nervous system action on glucoregulation.

    abstract：:Vanadate (VO-3), an essential trace element with insulin-mimetic actions, produces systemic hyperglycemia following central administration in mice. The hyperglycemic effect is due to specific action of vanadate or its reduced form, vanadyl (VO2+); other ions of similar atomic weight (Cr, Mn) or structure (phosphate) h...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(87)90615-9

    authors： Amir S,Meyerovitch J,Shechter Y

    更新日期：1987-09-01 00:00:00

  • Adrenergic innervation in the tibial and vagus nerves of rats with streptozotocin-induced diabetes.

    abstract：:Adrenergic innervation of tibial and vagus nerves was studied after 1-16 weeks duration of streptozotocin (STZ)-induced diabetes in rats. Sucrose-phosphate glyoxylic acid (SPG) histochemistry and the formaldehyde-induced fluorescence (FIF) method were used to demonstrate adrenergic nerve fibers in the epi-perineurial ...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(90)91095-x

    authors： Koistinaho J,Wadhwani KC,Rapoport SI

    更新日期：1990-04-09 00:00:00

  • Description and quantification of cocaine withdrawal signs in Planaria.

    abstract：:Previous work provided indirect evidence that planarians undergo abstinence-induced withdrawal from cocaine. The present study's purpose was to determine if planarians display withdrawal signs and, if so, to quantify the behaviors. Planarians were soaked in cocaine then transferred to either the same cocaine concentra...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2004.10.052

    authors： Raffa RB,Desai P

    更新日期：2005-01-25 00:00:00

  • Nuclear translocation of alpha-synuclein increases susceptibility of MES23.5 cells to oxidative stress.

    abstract：:α-Synuclein (α-syn) and oxidative stress play pivotal roles in the pathogenesis of Parkinson's disease (PD). However, the mechanisms underlying the interaction between α-syn and oxidative stress remain poorly understood. The present study provides evidence to suggest that the nuclear translocation of α-syn increases d...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2013.01.024

    authors： Zhou M,Xu S,Mi J,Uéda K,Chan P

    更新日期：2013-03-15 00:00:00

  • Specificity of tactile connections in neonatal cuneate nucleus.

    abstract：:In the neonatal kitten, cuneate neurones activated by tactile stimulation of the forelimb foot pads are divisible into 3 functional classes each of which appears to receive its glabrous skin input selectively from a single class of tactile receptors. Their properties suggest that the functionally specific patterns of ...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0165-3806(81)90081-x

    authors： Ferrington DG,Rowe MJ

    更新日期：1981-06-01 00:00:00

  • Dynamics of 7B2 and galanin expression in solitary magnocellular hypothalamic vasopressin neurons of the homozygous Brattleboro rat.

    abstract：:The homozygous Brattleboro rat (di/di), displaying a hypothalamic form of diabetes insipidus, synthesizes a vasopressin (VP) precursor with an abnormal C-terminus. The phenotypic expression of coexisting peptides in mutant magnocellular VP cells shows a differential pattern. 7B2 is one of the peptides which is not det...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(92)91218-4

    authors： Gabreëls BA,Sonnemans MA,Seidah NG,Chrétien M,van Leeuwen FW

    更新日期：1992-07-10 00:00:00

  • Succinic semialdehyde dehydrogenase deficiency: GABAB receptor-mediated function.

    abstract：:The succinic semialdehyde dehydrogenase (SSADH) null mouse (SSADH(-/-)) represents a viable animal model for human SSADH deficiency and is characterized by markedly elevated levels of both gamma-hydroxybutyric acid (GHB) and gamma-aminobutyric acid (GABA) in brain, blood, and urine. In physiological concentrations, GH...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2006.02.131

    authors： Buzzi A,Wu Y,Frantseva MV,Perez Velazquez JL,Cortez MA,Liu CC,Shen LQ,Gibson KM,Snead OC 3rd

    更新日期：2006-05-23 00:00:00

  • Climbing and parallel fiber responses recorded intracellularly from Purkinje cell dendrites in guinea pig cerebellar slices.

    abstract：:Climbing fiber responses (CFRs) evoked by white matter stimulation and parallel fiber responses (PFRs) elicited by the stimulation of the surface of the folium were compared using intracellular recording from the dendrites of Purkinje cells in the in vitro slice preparation of the guinea pig cerebellum. Intracellular ...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(85)90439-1

    authors： Kimura H,Okamoto K,Sakai Y

    更新日期：1985-12-02 00:00:00

  • Genetic studies of daily variations of first-step enzymes of monoamines metabolism in the brain of inbred strains of mice and hybrids. I. Daily variations of tryptophan hydroxylase activity in the nuclei raphe dorsalis, raphe centralis and in the striatum

    abstract：:A daily variation of tryptophan hydroxylase (TrH) activity was observed in the raphe dorsalis (RD), raphe centralis (RC) and striatum (St) of 3 inbred strains of mice (BALB/c, C57BL/6, C57BR) and of the reciprocal hybrids obtained from Balb/c and C57BL6. Significant differences of the characteristics of these rhythms ...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(80)90322-4

    authors： Natali JP,McRae-Degueurce A,Chouvet G,Pujol JF

    更新日期：1980-06-02 00:00:00

  • Domoic acid enhances Bcl-2-calcineurin-inositol-1,4,5-trisphosphate receptor interactions and delayed neuronal death in rat brain slices.

    abstract：:Mechanisms of neuronal death following neuronal damage due to domoic acid are not completely defined. Bcl-2, a survival protein, protects neurons from ischemia and excitotoxin-induced damage. We previously demonstrated that Bcl-2 shuttles calcineurin to its substrates and may regulate calcium release from internal sto...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2004.03.076

    authors： Erin N,Billingsley ML

    更新日期：2004-07-16 00:00:00

  • Escapable and inescapable stress differentially alter extracellular levels of 5-HT in the basolateral amygdala of the rat.

    abstract：:The effects of escapable and yoked inescapable electric tailshocks on extracellular levels of serotonin (5-HT) in the basolateral amygdala were measured by in vivo microdialysis. Inescapable, but not escapable, shock increased extracellular 5-HT in the amygdala relative to restrained controls. Basal levels of 5-HT wer...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/s0006-8993(98)00960-3

    authors： Amat J,Matus-Amat P,Watkins LR,Maier SF

    更新日期：1998-11-23 00:00:00