Abstract：
:Mice which carry both the shiverer (shi) and the jimpy (jp) mutations have a morphological phenotype with features of each single mutation by itself but in milder form: the number of myelin sheaths is increased relative to jp, the thickness of sheaths and amount of major dense line is increased relative to shi, and the abnormal, lipid-filled cells characteristic of jp are not seen. However, the abnormal bundles of oligodendrocyte microprocesses and errors in the targeting of myelination which characterize shi are not altered by the presence of the jp mutation. This morphological evidence suggests partial reciprocal intergenic suppression in shiverer jimpy double mutant mice and therefore agrees with conclusions based on biochemical data presented by Kerner and Carson (Brain Research, 374 (1986) 45-53).
journal_name
Brain Resjournal_title
Brain researchauthors
Billings-Gagliardi S,Wolf MK,Kirschner DA,Kerner ALdoi
10.1016/0006-8993(86)90394-xsubject
Has Abstractpub_date
1986-05-21 00:00:00pages
54-62issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(86)90394-Xjournal_volume
374pub_type
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