Abstract：
:The role of the central noradrenergic system in the supraoptic neuroendocrine regulation was investigated using slices of the guinea pig hypothalamus. Noradrenaline produced a complex membrane effect comprising two distinct depolarizations: one, associated with a moderate increase in input resistance and resulting in an augmentation of the spontaneous firing rate; the other, unaccompanied by a detectable change in input resistance and resulting in depression of the firing rate. The former depolarization was reproducible by applying specific alpha-agonist, phenylephrine, whereas the latter was induced by a beta-adrenergic agonist, isoproterenol. The actions of phenylephrine and isoproterenol were blocked by phentolamine and propranolol, respectively. Amplitude of the phenylephrine-induced depolarization was voltage-dependent with the estimated reversal potential of about - 115 mV and changed as a function of [K+]o. On the contrary, amplitude of the isoproterenol-induced depolarization was voltage-independent and was insensitive to changes in external concentrations of K+, Na+, Cl- and Ca2+. We conclude that catecholamines directly modulate the activity of supraoptic neurons through two functionally distinct adrenoceptive sites on neurosecretory cells. The activation of alpha-receptors may increase cellular excitability through suppression of membrane K+ conductance while the activation of beta-receptors would depress neuronal firings, possibly through some mechanism which is not directly linked to ionic channels.
journal_name
Brain Resjournal_title
Brain researchauthors
Ogata N,Matsuo Tdoi
10.1016/0006-8993(86)91553-2subject
Has Abstractpub_date
1986-10-15 00:00:00pages
122-35issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(86)91553-2journal_volume
385pub_type
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