Abstract：
:Choroid plexuses from the lateral (LVCP) and fourth ventricles (FVCP) of rats or rabbits were incubated in artificial cerebrospinal fluid (CSF) containing 1 microM [14C]L-carnitine with various concentrations of L-carnitine ranging from 0.01 mM to 1.0 mM. The time course of 1 microM [14C]L-carnitine uptake by the choroid plexus indicated that it increased linearly for the first 15 min. Steady-state levels were reached by 30 min with tissue concentrations more than 20 (FVCP)- to 30 (LVCP)-fold greater than the concentration in the medium. The uptake of [14C]L-carnitine was increased with increasing concentrations of the substrate in the medium and this uptake followed Michaelis-Menten kinetics. The uptake by the rat choroid plexus took place against a concentration gradient via a saturable process and kinetic analysis revealed Km of 32 microM (LVCP) and 34 microM (FVCP) and Vmax of 21 (LVCP) and 17 nmol/ml/min (FVCP), respectively. Ouabain inhibited the uptake by 51% (FVCP) and 48% (LVCP) and hypothermia (0 degrees C) produced inhibition by 97% (FVCP) and 96% (LVCP), respectively. However, the uptake of L-carnitine was not sensitive to probenecid or tyrosine, which indicates the presence of an independent carrier for L-carnitine in the choroid plexus. Similar results were obtained with the rabbit choroid plexus.
journal_name
Brain Resjournal_title
Brain researchauthors
Kim CS,Roe CRdoi
10.1016/0006-8993(91)90188-2subject
Has Abstractpub_date
1991-07-19 00:00:00pages
193-7issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(91)90188-2journal_volume
554pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:The neurosteroid allopregnanolone is a potent and efficacious modulator of gamma-aminobutyric acid (GABA) type A receptors. The effects of intracerebroventricular injection of allopregnanolone (5 to 15 micrograms/5 microliters) on basal and stress-induced release of acetylcholine were investigated in various regions o...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01478-0
更新日期：1996-02-26 00:00:00
abstract：:The retinal spreading depression has been used as a tool to investigate the action of nitric oxide (NO) as a diffusible neurotransmitter which in many cases acts by raising the cGMP level in target cells. The role of NO as a vasodilating agents has been well-established and it has been suggested that the vasodilatatio...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00737-b
更新日期：1995-09-11 00:00:00
abstract：:A subset of olfactory receptor neurons of the Caribbean spiny lobster Panulirus argus possesses receptors for L-glutamate that can mediate both excitatory and inhibitory responses (P.C. Daniel, M.F. Burgess, C.D. Derby, Responses of olfactory receptor neurons in the spiny lobster to binary mixtures are predictable usi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00816-0
更新日期：1997-10-17 00:00:00
abstract：:A procedure has been developed for the stable long-term recording of nerve signals in unanesthetized mammals, which should have wide application in basic research on the nervous system and also in clinical areas such as the derivation of control signals for powered prostheses. Methods are fully described for construct...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(77)90233-5
更新日期：1977-06-03 00:00:00
abstract：:We have used the post-embedding immunogold labelling method using antibodies to gamma-aminobutyric acid (GABA) to obtain quantitative data on the distribution, frequency, postsynaptic targets and ultrastructural characteristics of GABA-immunoreactive (GABA-IR) boutons in the trigeminal motor nucleus of rats. We have a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90757-m
更新日期：1991-10-04 00:00:00
abstract：:[3H]Paroxetine binding to human brain tissue was characterized. Competition studies in the putamen and frontal cortex revealed single-site binding models for binding sensitive to 5-hydroxytryptamine (5-HT) (Ki 1-3 microM) and citalopram (Ki 0.6 nM), which displaced the same amount of binding. However, desipramine, nor...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90511-8
更新日期：1989-05-08 00:00:00
abstract：:Uptake of 5-hydroxytryptamine (5-HT) by adult and fetal rabbit's ileum was studied. The adult myenteric plexus accumulated tritium when incubated with tritiated 5-HT. However, in addition to labeled 5-HT, tritiated 5-hydroxyindole acetic acid and, when monoamine oxidase (MAO) was inhibited, 5-HT-o-glucuronide were fou...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90360-7
更新日期：1976-10-22 00:00:00
abstract：:The presence of adrenocorticotropic hormone (ACTH)-immunoreactive cells and melanocortin (MC) receptors (MC4 and to a lesser extent MC3) has been demonstrated in the medullary reticular formation in the general area where rostral ventrolateral medullary pressor area (RVLM) is located. The importance of RVLM in the reg...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.05.002
更新日期：2006-08-02 00:00:00
abstract：:The dorsolateral funiculus (DLF) spinal pathway has previously been identified as a major pathway involved in descending modulation of pain. While bilateral lesions of the DLF attenuated systemic morphine analgesia as measured by the tail-flick test, they failed to attenuate analgesia as measured by the formalin test....
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90582-7
更新日期：1985-05-13 00:00:00
abstract：:A quantitative bioassay for nerve growth factor (NGF) has been previously described which employs PC13 rat pheochromocytoma cells. The basis of this assay is that rapid neurite regeneration by PC12 cells pretreated ('primed') with NGF for at least a week is quantitatively related to the amount of NGF present in the cu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)91218-0
更新日期：1983-03-14 00:00:00
abstract：:Long-term exposure to different antidepressant treatments induces increased motor response to central stimulants, due to a selective supersensitivity of dopamine D2 receptors in the limbic areas. Such an effect is accompanied by down-regulation of dopamine D1 receptor number, and by a decreased response of adenylyl cy...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91570-i
更新日期：1993-03-19 00:00:00
abstract：:Neovascularization within syngeneic rat fetal neocortical grafts transplanted into a previously prepared cavity in the cerebral cortex was studied 1 to 3 months after transplantation, utilizing scanning electron microscopy of vascular corrosion casts. The grafts were easily identified and the outer surface of the graf...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00304-9
更新日期：1995-05-29 00:00:00
abstract：:Regeneration of severed hypothalamic peptidergic neurosecretory axons into the ventral pia-arachnoid was observed in rats at the light microscopic and fine-structural levels. A temporal increase occurred in the number of neurophysin-positive axons regenerating into the leptomeninges for distances up to 3.3 mm by 40 da...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91557-0
更新日期：1988-05-31 00:00:00
abstract：:Immunohistochemical studies in rats have demonstrated dopaminergic input onto medium spiny neurons of the striatum. Medium spiny neurons, however, are known to consist of two major neuropeptide-specific types, those containing substance P (SP) and those containing enkephalin. Although both of these types have been sho...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90490-z
更新日期：1992-02-14 00:00:00
abstract：:The effects of selective axotomy of serotoninergic neurons produced by an intracerebroventricular injection of 5,7-dihydroxytryptamine (200 micrograms free base) on 5-HT1B binding sites labeled with S-CM-G-[125I]TNH2 were investigated by quantitative autoradiography in the rat brain. Results show, 21 days after surger...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91452-x
更新日期：1993-10-01 00:00:00
abstract：:Double impregnation staining of tissue was used to study on thick sections the three-dimensional configuration of the peripheral endoplasmic reticulum in neurosecretory neurons of the supraoptic nucleus in control and water-deprived rats. According to the spatial organization of the endoplasmic reticulum, two types of...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(79)90105-7
更新日期：1979-07-13 00:00:00
abstract：:Potassium-evoked cholecystokinin (CCK) release from slices of caudate-putamen and cerebral cortex, but not hippocampus incubated in vitro was increased by 152-175% by preincubation for 40 min with 10 mM lithium. These results and previous studies suggest that although different physiological agents regulate CCK releas...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91030-4
更新日期：1987-06-16 00:00:00
abstract：:MicroRNAs (miRNAs) are a class of non-coding small RNAs that regulate the expression of target genes. They derive from pre-miRNAs that are enzymatically processed by dicer to ∼22 nucleotide mature miRNAs. Members of the pre-miRNA lethal-7 (let-7) are known to regulate cell proliferation and apoptosis. Here, we showed ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2018.01.032
更新日期：2018-04-15 00:00:00
abstract：:The blood-brain barrier consists of the cerebral microvascular endothelium, pericytes, astrocytes, and neurons. In this study, we analyzed the influence of primary porcine brain capillary pericytes on the barrier integrity of primary porcine brain capillary endothelial cells in a species-consistent in vitro coculture ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.05.096
更新日期：2010-08-06 00:00:00
abstract：:Intracerebral injections of 6-hydroxydopamine (6-OHDA) which produce deficits in locomotor behaviour and motor performance cause localized accumulation of monoamines as well as depletion of central catecholamines (CA). To determine whether the localized increases in monoamines could be contributing to the behavioural ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90659-5
更新日期：1983-05-05 00:00:00
abstract：:Ginseng is one of most extensively used traditional oriental medicines worldwide with beneficial efficacy on cognitive function disorders. Pharmacological researches on its active ingredient--ginsenoside Rg1 revealed that it can improve learning and memory potentially via modulating neurotransmission in the central ne...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.03.096
更新日期：2010-05-28 00:00:00
abstract：:Infusion of 1 microgram of carbachol, a potent cholinergic agonist, into the lateral septum of the urethane-anaesthetized rat systematically caused the induction of clear-cut hippocampal theta (theta). However, infusion of an equivalent amount of the drug into the hippocampus, close to the recording electrode, failed ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91551-3
更新日期：1993-12-24 00:00:00
abstract：:The synaptic protein alpha-synuclein is found throughout the brain, although its function remains ill-defined. Abnormal accumulations of alpha-synuclein have been recognised to be associated with a number of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. Nevertheless, little is know...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2003.10.072
更新日期：2004-04-09 00:00:00
abstract：:Myelin-associated glycoprotein (MAG) is susceptible to proteolysis by a calcium-activated neutral protease which is located in myelin. The conversion of MAG (M(r) 100,000) to its soluble derivative dMAG (M(r) 90,000) occurs much more rapidly in myelin from human white matter than in myelin from rat brain, and the rate...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)00882-7
更新日期：1996-11-25 00:00:00
abstract：:The olfactory sensory neurons are unique in the vertebrate nervous system in that they are replaced following experimentally induced degeneration. Unilateral removal of the olfactory bulb in hamster results in degeneration of all mature receptor neurons followed by a neurogenesis and partial replacement of the recepto...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90483-9
更新日期：1984-07-30 00:00:00
abstract：:The effect of perinatal androgen exposure on the sexually dimorphic distribution of serotonin (5-HT)-immunoreactive fibers in the medial preoptic nucleus (MPN) of the rat was evaluated with an indirect immunohistochemical method. Female animals treated with testosterone propionate (TP) perinatally, postnatally or with...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90777-2
更新日期：1985-08-05 00:00:00
abstract：:In sections of rat brain treated for Wisteria floribunda agglutinin (WFA) labelling the occurrence of parvalbumin (PARV)-, calbindin (CALB)- or choline acetyltransferase (ChAT) immunoreactivity was analyzed in the basal forebrain using dual-peroxidase and double-fluorescence methods. Only PARV-immunoreactive (-ir) neu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91205-7
更新日期：1993-12-17 00:00:00
abstract：:There are sex differences in the neurochemistry of brainstem nuclei that participate in the control of breathing as well as sex differences in respiratory responses to hypoxia. Central chemoreception refers to the detection within the brain of minute changes in carbon dioxide (CO(2)) levels and the subsequent modulati...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.11.037
更新日期：2010-01-22 00:00:00
abstract：:Melanotropinergic neurons in the brain may mediate the known modulatory effects of alpha-melanocyte stimulating hormone (alpha-MSH) and adrenocorticotropic hormone (ACTH) on brain functions including thermoregulation, pituitary regulation, learning and behavior. To determine the distribution of brain melanotropin rece...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90016-5
更新日期：1990-12-17 00:00:00
abstract：:Slow field potentials (SFP) lasting up to 5 s followed penicillin-induced bursts in CA3 of guinea pig hippocampal slices and accounted for most of the interburst interval. The longest lasting component of the SFP which was maximal in the distal apical dendritic region was usually absent in s. pyramidale. Potassium flu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90138-7
更新日期：1987-02-10 00:00:00
