Abstract：
:The postnatal maturation of the medial preoptic area (MPOA) of male and female rats was studied by means of light and electron microscopy. In Golgi-Kopsch preparations, bi- and multipolar cells were present at birth in both sexes; the perikarya of most of these cells, as seen with the electron microscope, exhibited an immature appearance characterized by a sparse organelle content. During the next 5-10 days, an increase in cell size and cytoplasmic differentiation occurred in each sex. By 10 days, many of the MPOA neurons displayed an increased organelle density with the most prominent change being a proliferation of rough endoplasmic reticulum. Further neuronal development was also evidenced by a greater frequency of dendritic spines than seen at either birth or 5 days. Lastly, the number of synapses per unit area increased rapidly in each sex during the first two weeks of postnatal life. Thus, a period of increasing cytological maturation and synaptic organization closely paralleled previously demonstrated stages of functional differentiation of gonadotrophin regulatory mechanisms in the rat brain.
journal_name
Brain Resjournal_title
Brain researchauthors
Reier PJ,Cullen MJ,Froelich JS,Rothchild Idoi
10.1016/0006-8993(77)90454-1subject
Has Abstractpub_date
1977-02-25 00:00:00pages
415-36issue
3eissn
0006-8993issn
1872-6240pii
0006-8993(77)90454-1journal_volume
122pub_type
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