Abstract：
:We examined whether manipulations of fat metabolism influence the feeding response to peripheral or central administration of 5-thio-D-glucose (5-TG), a potent inhibitor of glucose utilization. The increase in food intake produced by peritoneal (50 mg/kg) or fourth ventricular (50, 100, 150 micrograms) 5-TG was potentiated by administration of the fatty acid oxidation inhibitor, methyl palmoxirate (10 mg/kg, p.o.). In addition, rats maintained on a high-fat diet ate less in response to fourth ventricular 5-TG (150 micrograms) than did rats maintained on an equicaloric low-fat diet. These results suggest that the feeding response to 'glucoprivation' is determined by the interaction of glucose and fat oxidation.
journal_name
Brain Resjournal_title
Brain researchauthors
Tordoff MG,Flynn FW,Grill HJ,Friedman MIdoi
10.1016/0006-8993(88)91181-xsubject
Has Abstractpub_date
1988-04-05 00:00:00pages
216-21issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(88)91181-Xjournal_volume
445pub_type
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