Abstract：
:Parkinson's disease (PD) is the second most common neurodegenerative disease worldwide. It is typically associated with motor symptoms originating from the degeneration of nigrostriatal dopamine (DA) neurons. Early stages of PD have been associated with an alteration in DA production in intestinal DAergic neurons along with inflammation. Interestingly, decreased serum concentrations of ethanolamine plasmalogens (PlsEtn) have been reported in PD patients. Ethanolamine plasmalogens play a role in vesicular fusion and release during neurotransmission, and store neuroprotective polyunsaturated fatty acids, such as docosahexaenoic acid (DHA) and are strong anti-oxidants, highlighting areas of potential therapeutic interest. Docosahexaenoic acid is known to play important roles in both the central nervous and peripheral systems, in addition to acting as a precursor of several molecules that regulate the resolution of inflammation. The present study investigated the neuroprotective and anti-inflammatory properties of the DHA-containing PlsEtn precursor, PPI-1011, in the intestine of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mice. Treatment with PPI-1011 prevented the MPTP-induced decrease in PlsEtn levels. In addition it prevented the loss of tyrosine hydroxylase (TH) expression and reduced the infiltration of macrophages in the myenteric plexus of MPTP-treated mice. The protective effects of PPI-1011 were observed regardless of whether it was administered pre- or post- MPTP treatment. These results suggest that PPI-1011 has neuroprotective and anti-inflammatory properties in the gut and indicate its potential utility as a treatment for both early and more advanced stages of PD.
journal_name
Brain Resjournal_title
Brain researchauthors
Nadeau J,Smith T,Lamontagne-Proulx J,Bourque M,Al Sweidi S,Jayasinghe D,Ritchie S,Di Paolo T,Soulet Ddoi
10.1016/j.brainres.2019.146460subject
Has Abstractpub_date
2019-12-15 00:00:00pages
146460eissn
0006-8993issn
1872-6240pii
S0006-8993(19)30514-1journal_volume
1725pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Endothelins are potent vasoconstrictors and signaling molecules. Their effects are broad, impacting processes ranging from neurovascular and cardiovascular health to cell migration and survival. In stroke, traumatic brain injury or subarachnoid hemorrhage, endothelin-1 (ET-1) is induced resulting in cerebral vasospasm...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2014.09.022
更新日期：2014-11-07 00:00:00
abstract：:The action of 5-hydroxytryptamine (5-HT) via the 5-HT1A receptor on dissociated rat dorsal raphe neurons was characterized under the whole-cell mode by using the nystatin-perforated patch-clamp technique. Under voltage-clamp conditions, 5-HT induced an inwardly rectifying K+ current (I5-HT) in a concentration-dependen...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)01141-9
更新日期：1997-01-16 00:00:00
abstract：:In neonates, ventilatory responses to hypoxia are 'biphasic,' with an augmentation followed by a decline. The hypoxia-induced augmentations in ventilation are attenuated and the depressions are accentuated following denervation of the peripheral chemoreceptors. Piglets that were decerebrated at a rostral mesencephalic...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)01310-9
更新日期：1999-02-20 00:00:00
abstract：:Influence of dopamine agonists, methamphetamine (MAT, 1 mg/kg, i.p.) and apomorphine (APO, 1 mg/kg, i.p.), on the effects of amygdaloid lesions on thresholds for the defensive attack behavior elicited by electrical stimulation of the ventromedial hypothalamic nucleus was studied in cats. The thresholds were measured i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90665-7
更新日期：1986-01-15 00:00:00
abstract：:Studies of potentials for dorsal spinal nerve root axons to regrow into the spinal cord involved placement of the tracer HRP/WGA-HRP on the cut end of the nerve root. Following this procedure, labeled neurons were found within the spinal dorsal gray matter. Analyses revealed that spinal neurons influenced by the prese...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00501-5
更新日期：1997-07-18 00:00:00
abstract：:Extracellular recordings were obtained from spontaneously active neurones located in the dorsal motor nucleus of vagus nerve ( DMX ) in slices of the rat brainstem. Oxytocin applied to the bath at concentrations of 10(-7) M or 10(-6) M excited 79% of these cells in a concentration-dependent, reversible manner. The rem...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)91342-8
更新日期：1984-05-21 00:00:00
abstract：:Aromatization of testosterone in the preoptic area of the male ring dove is required for the expression of specific estrogen-sensitive sexual behavior. Estradiol metabolism and/or binding of the aromatization product(s) to the preoptic estrogen receptors (ER) could interfere with the apparent increase in estradiol for...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90203-5
更新日期：1989-02-20 00:00:00
abstract：:Axonal transport of fluorescent dyes applied to the cut distal ends of rat L4 dorsal and ventral spinal roots was studied in order to characterize the population of dorsal root ganglion (DRG) neurons emitting axons entering the ventral root. Ca. 9% of DRG neurons, principally of small or medium size, can be labeled fr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90053-9
更新日期：1987-02-03 00:00:00
abstract：:Prepro-vasoactive intestinal peptide (prepro-VIP) is processed to at least three biologically active peptides: VIP, peptide histidine isoleucine (PHI) and an extended PHI, peptide histidine valine (PHV). The aim of the present investigation was by chromatography combined with RIA and immunocytochemistry to determine w...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91370-6
更新日期：1994-09-05 00:00:00
abstract：:The immunocytochemical localization of the enzyme choline acetyltransferase (ChAT) was examined in the guinea pig organ of Corti to determine if both lateral and medial systems of efferents would show immunoreactive labeling for this specific enzyme marker of cholinergic neurons. Cochleae were also examined after lesi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90242-2
更新日期：1985-07-08 00:00:00
abstract：:Analysis of rat hypothalamic extracts by gel filtration and HPLC revealed the presence of a form of substance P-like immunoreactivity with a molecular weight of approximately 5,700 (6k-SP). 6k-SP is probably an N-terminally extended form of substance P; the peptide may be an intermediate in SP biosynthesis, or may fun...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90310-x
更新日期：1984-12-10 00:00:00
abstract：:Chemical synaptic transmission was studied with microelectrode techniques in isolated frog cerebella maintained in vitro. Purkinje cell (PC) EPSPs, elicited by selective monosynaptic electrical stimulation of both the parallel fiber (PF) and climbing fiber (CF) inputs, could be inverted by depolarizing (outward) curre...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)91005-2
更新日期：1976-09-10 00:00:00
abstract：:Experiments were performed to test the hypothesis that subarachnoid hemorrhage (SAH) causes functionally relevant perturbations of cyclooxygenase activity in cerebral arteries. Four groups of rabbits were formed: (I) controls; (II) sham injected animals (2 ml physiological solution in the cisterna magna); (III) SAH gr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00053-5
更新日期：1998-04-20 00:00:00
abstract：:Previous studies have reported that schizophrenia (SZ) patients showed selective reinforcement learning deficits and abnormal feedback-related event-related potential (ERP) components. However, how the brain networks and their topological properties evolve over time during transient feedback-related cognition processi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2020.146979
更新日期：2020-11-01 00:00:00
abstract：:Amphetamine withdrawal is associated with heightened anxiety-like behavior, which is directly driven by blunted stress-induced glucocorticoid receptor-dependent serotonin release in the ventral hippocampus. This suggests that glucocorticoid availability in the ventral hippocampus during stress may be reduced during am...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.05.030
更新日期：2016-08-01 00:00:00
abstract：:Glucocorticoids (GCs) predispose hippocampal neurons to damage during metabolic stressors. One component of hippocampal GC-endangerment may be changes in neuronal defenses against oxidative challenge. Previous experiments showed a decrease in basal levels of copper/zinc superoxide dismutase (Cu/Zn SOD) and glutathione...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00104-8
更新日期：1998-04-27 00:00:00
abstract：:The rostral brainstem and thalamus of awake cats were studied for depth correlates of a surface-recorded midlatency auditory evoked potential, wave "A', with a latency range of 17-25 ms. In response to clicks or pure tones, midlatency potentials were recorded from the level of the cuneiform nucleus (14-15 ms latencies...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)91120-4
更新日期：1983-03-28 00:00:00
abstract：:Chick neural cultures were used to study effects of insulin, thyrotropin releasing hormone, growth hormone and glucagon on myelin lipid synthesis in vitro. The incorporation of [3H]galactose into myelin associated lipids such as cerebroside and sulfatide was used as an index for various hormonal effects on myelination...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90831-0
更新日期：1986-04-16 00:00:00
abstract：:We measured soleus H-reflex in the Sprague-Dawley rat as a function of time of day. H-reflex amplitude displayed a marked diurnal variation, even though background EMG and M-response amplitude were stable through the day. The H-reflex was largest in the late morning and smallest around midnight. Thus, its rhythm was o...
journal_title：Brain research
pub_type： 杂志文章
doi：
更新日期：1994-06-13 00:00:00
abstract：:In the present study we found that mesencephalic trigeminal (Mes-V) neurons of the rat are innervated by nitrergic fibers and that nitric oxide (NO) modifies the electrophysiological properties of these cells. Mes-V neurons were surrounded by a network of fibers that contained neuronal nitric oxide synthase (nNOS); th...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03776-9
更新日期：2003-01-17 00:00:00
abstract：:The activity of the crayfish caudal photoreceptor (Ph) was studied during the application of a classical conditioning paradigm. This cell is a primary photoreceptor and, at the same time, a secondary neuron in the mechanoreceptive pathway. The electrical stimulation of afferent mechanoreceptor fibers, the analog of th...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(77)90946-5
更新日期：1977-04-01 00:00:00
abstract：:In decerebrate rats, the responses of tilt-sensitive neurons in the lateral and descending vestibular nuclei were studied during constant velocity 10 degrees off-vertical axis rotations (OVAR) in the clockwise (VW) and counterclockwise (CCW) directions. Seventy three otolith-related units showed a sinusoidal position-...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00687-l
更新日期：1995-09-25 00:00:00
abstract：:An investigation of reflex responses of leg muscles to sural stimulation during stepping was performed on human subjects. Non-noxious electrical stimulation applied during the swing phase or the latter half of the stance phase produced a mixed increase and decrease of EMG activity in the hamstring muscles. No response...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90123-3
更新日期：1983-12-12 00:00:00
abstract：:The immunohistochemical distribution of Ca2+/calmodulin-dependent protein kinase II (CaM kinase II) alpha and beta isoforms in the rat forebrain was examined by using monoclonal antibodies specific to each isoform. The present study confirmed that alpha and beta immunoreactivities are localized only in neuronal elemen...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90877-x
更新日期：1994-10-03 00:00:00
abstract：:Anisomycin is both a well-established protein synthesis inhibitor and a potent activator of the p38/JNK MAPK pathway. It has been used to block the late phase of long-term potentiation (LTP) and long-term depression (LTD) in hippocampus. In this study, we have found that anisomycin produces a time-dependent decline in...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.02.015
更新日期：2006-04-26 00:00:00
abstract：:Aluminum (Al) is among the most abundant elements on earth, it has been associated with the etiology of Alzheimer's disease. In the present study, AlCl(3) was administered with the dose of 10, 50 or 300 mg/kg b.wt/day through diet for 100 days. On day 101, overnight-fasted animals were sacrificed, the whole brains wer...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.02.024
更新日期：2010-04-09 00:00:00
abstract：:The family of EF-hand calcium binding proteins is composed of more than 250 members. In search for other neuronal markers, we studied the expression pattern of Necab-1, -2 and -3 in the Ammons horn of adult mice at the gene- and protein levels using in-situ hybridization and immunohistochemistry. The genes for the thr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2013.06.004
更新日期：2013-08-28 00:00:00
abstract：:Programmed cell death has been implicated in the loss of neurons that occurs in many neurodegenerative diseases. This has led to an increased interest in the types of stimuli that can initiate neurons to undergo programmed cell death. Previously, we have shown that cross-linking of membrane receptors with the lectin c...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00309-6
更新日期：1998-06-15 00:00:00
abstract：:Spreading depression (SD) is a wave of cellular depolarization which contributes to neuronal damage in experimental focal ischaemia, and may also underlie the migraine aura. The purpose of this study was to examine the effects of probenecid, an inhibitor of organic anion transport, on K+-evoked SD in vivo. Microdialys...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00434-4
更新日期：1997-08-01 00:00:00
abstract：:The involvement of the dopaminergic pathway from the ventral tegmental area (VTA) to the nucleus accumbens (NAcc) in the reinforcing properties of many drugs of abuse is well established. Though the prefrontal cortex (PFC) exhibits significant influence over activity in this pathway, its role in drug abuse is less def...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.01.003
更新日期：2006-02-23 00:00:00
