Potassium and calcium channel dependence of bursting in cultured neuronal networks.

abstract：:Habituation kinetics were found to vary considerably in different polysynaptic pathways of the brain stem in man. The exteroceptive reflex of the digastric muscle habituates markedly, even for stimuli repeated at 1-min intervals. The second component of the blink reflex habituates for intervals below about 8 sec, but ...

journal_title：Brain research

authors： Desmedt JE,Godaux E

更新日期：1976-04-16 00:00:00

abstract：:To study the regulation of hypothalamic vasopressin (VP) and oxytocin (OT) gene expression in relation to the development of hypertension, levels of VP mRNA and OT mRNA were determined in spontaneously hypertensive rats (SHR). Differences in VP and OT mRNA content of the supraoptic nucleus (SON) and paraventricular nu...

journal_title：Brain research

authors： van Tol HH,van den Buuse M,de Jong W,Burbach JP

更新日期：1988-12-01 00:00:00

abstract：:Patches excised from fields CA1 and CA3 of the hippocampus were used to study AMPA receptor responses to repetitive application of brief pulses of agonist. AMPA receptors in field CA1 exhibited a larger degree of paired-pulse depression and a slower recovery rate from desensitization than those from CA3 patches. Respo...

journal_title：Brain research

authors： Arai A,Lynch G

更新日期：1996-04-15 00:00:00

abstract：:Aluminum (Al) concentrations of the rat frontal cortex, parietal cortex, and hippocampus were measured by atomic absorption spectroscopy 16 days after a unilateral intracerebroventricular injection of Na gluconate, Al gluconate, or the cholinotoxin AF64A. A fourth group of rats were injected with AF64A 6 days before i...

journal_title：Brain research

authors： Szerdahelyi P,Kása P

更新日期：1988-03-22 00:00:00

abstract：:Acute administration of diazepam (2 mg/kg i.p.) to rats decreased the number of head-dips, locomotor activity and the number of rears made in the holeboard apparatus, indicating sedative effects. After daily treatment for 7 days with diazepam (2 mg/kg) tolerance developed to all these behavioural effects, despite seru...

journal_title：Brain research

authors： Fernandes C,File SE,Berry D

更新日期：1996-09-23 00:00:00

abstract：:Sex steroid hormones regulate various neural functions that control vertebrate sociosexual behavior. A number of sex steroids can be synthesized de novo in the brain, including estrogens by the enzyme aromatase. Aromatase, the neuropeptides arginine vasotocin/vasopressin, and the monoamine neurotransmitter dopamine ha...

journal_title：Brain research

authors： Marsh KE,Creutz LM,Hawkins MB,Godwin J

更新日期：2006-12-18 00:00:00

abstract：:We have recently reported that the burst firing neurons are found in layer III as well as in layer V of cat sensorimotor cortex in vitro. In the present study, we examined the synaptic excitability of layer III neurons by white matter stimulation and compared with their firing patterns against the current injections t...

journal_title：Brain research

authors： Kitagawa H,Nishimura Y,Yamamoto T

更新日期：1999-09-18 00:00:00

abstract：:Event-related potentials (ERPs) were recorded using a large electrode array while subjects engaged in tasks designed to dissociate control from storage/maintenance processes in verbal working memory (WM). Increased ERP negativity (450-900 ms post-stimulus onset) over left frontal regions emerged only when required dyn...

journal_title：Brain research

authors： Kiss I,Watter S,Heisz JJ,Shedden JM

更新日期：2007-10-03 00:00:00

abstract：:The effect of high acetaldehyde (ACe) on acetylcholine (ACh) release was studied in vivo in the medial frontal cortex (mfc) of freely moving rats using brain microdialysis coupled with high performance liquid chromatography and an electrochemical detector. Ethanol (EtOH) and ACe concentrations were quantified simultan...

journal_title：Brain research

authors： Jamal M,Ameno K,Wang W,Kumihashi M,Ameno S,Ikuo U,Shinji A,Ijiri I

更新日期：2005-03-28 00:00:00

abstract：:Molecular mechanism underlying ischemic stroke remains poorly understood. We previously reported glucose 6-phosphate dehydrogenase (G6PD) activity in pentose phosphate pathway (PPP) is activated via heat shock protein 27 (HSP27) phosphorylation at serine 85 (S85) by ataxia telangiectasia mutated (ATM) kinase during ce...

journal_title：Brain research

authors： Yamamoto Y,Hosoda K,Imahori T,Tanaka J,Matsuo K,Nakai T,Irino Y,Shinohara M,Sato N,Sasayama T,Tanaka K,Nagashima H,Kohta M,Kohmura E

更新日期：2018-05-15 00:00:00

abstract：:The effects on fusimotor discharge rate of algesic agents (bradykinin, potassium chloride, histamine, 5-hydroxytryptamine) and lactic acid, applied by close arterial injection into triceps surae muscles, were investigated in decerebrate cats. Fusimotor discharge was recorded from filaments dissected free from otherwis...

journal_title：Brain research

authors： Jovanović K,Anastasijević R,Vuco J

更新日期：1990-06-25 00:00:00

abstract：:The number of adults in the US affected by bipolar disorder, depression, or schizophrenia is approaching 15 million. Despite decades of research, etiologies of these illnesses remain elusive. Theories of aberrant brain morphology, neurotransmission, and signal conduction have provided the heuristic framework for a lar...

journal_title：Brain research

authors： Maida ME,Hurley SD,Daeschner JA,Moore AH,O'Banion MK

更新日期：2006-08-04 00:00:00

abstract：:Recently we have reported that methamphetamine (METH) neurotoxicity in rats depends on the environmental temperature. Here, we evaluate whether a cold environment (4 degrees C) or drugs which chloride and glutamate ion channel function block METH neurotoxicity in mice. Adult male CD mice received METH i.p. (4 x 10 mg/...

journal_title：Brain research

authors： Ali SF,Newport GD,Holson RR,Slikker W Jr,Bowyer JF

更新日期：1994-09-26 00:00:00

abstract：:A progressive model of Parkinson's disease has been recently developed in the rat where a unilateral excitotoxic injection into the globus pallidus leads to a gradual loss of dopaminergic neurons in the ipsilateral substantia nigra over a period of at least 6 weeks. In this model microglial activation is observed in t...

journal_title：Brain research

authors： Wright AK,Miller C,Williams M,Arbuthnott G

更新日期：2008-06-24 00:00:00

abstract：:Several studies, using electrical stimulation of parts of the hypothalamus, have shown, that different parts of the hypothalamus yield different behavioural responses upon stimulation. In order to differentiate between stimulation of neuronal cell bodies and passing fibres and to investigate the role of GABA in hypoth...

journal_title：Brain research

authors： Roeling TA,Kruk MR,Schuurmans R,Veening JG

更新日期：1993-06-25 00:00:00

abstract：:Nucleotide-repeat expansions underlie a heterogeneous group of neurodegenerative and neuromuscular disorders for which there are currently no effective therapies. Recently, it was discovered that such repetitive RNA motifs can support translation initiation in the absence of an AUG start codon across a wide variety of...

journal_title：Brain research

authors： Green KM,Linsalata AE,Todd PK

更新日期：2016-09-15 00:00:00

abstract：:The inhibitory neurotransmitter γ-aminobutyric acid (GABA) is known to be fundamental to the neuronal processes underlying visual orientation and vibrotactile frequency and amplitude discrimination. Previous studies have demonstrated that performance on visual and vibrotactile psychophysics tasks is associated with in...

journal_title：Brain research

authors： Mikkelsen M,Harris AD,Edden RAE,Puts NAJ

更新日期：2018-12-15 00:00:00

abstract：:Adenosine receptor antagonists, DMPX, PACPX and theophylline, produce contralateral rotations in unilateral 6-hydroxydopamine-lesioned rats. DMPX and theophylline markedly increase rotations produced by bromocriptine (a dopamine D2 receptor agonist) and/or SKF38393A (a dopamine D1 receptor agonist). All of these effec...

journal_title：Brain research

authors： Jiang H,Jackson-Lewis V,Muthane U,Dollison A,Ferreira M,Espinosa A,Parsons B,Przedborski S

更新日期：1993-06-11 00:00:00

abstract：:Spreading depression (SD) is characterized by a transient breakdown of neuronal function concomitant with a massive failure of ion homeostasis. It is a phenomenon that can be induced in neocortical tissue by raising excitability, e.g. injection of K(+), application of glutamatergic agonists, or blocking Na(+)/K(+) ATP...

journal_title：Brain research

authors： Köhling R,Koch UR,Hagemann G,Redecker C,Straub H,Speckmann EJ

更新日期：2003-06-13 00:00:00

abstract：:Pineal glands of male Syrian hamsters stimulated in vivo with isoproterenol (ISO) for 4 h before the onset of darkness showed a 4-h advance in the timing of the nighttime increases in both N-acetyltransferase activity and melatonin levels. When ISO (1 mg/kg) was administered every 2 h to animals kept in light during t...

journal_title：Brain research

authors： Gonzalez-Brito A,Reiter RJ,Santana C,Menendez-Pelaez A,Guerrero JM

更新日期：1988-12-20 00:00:00

abstract：:Despite insights into an increasingly significant role for delta opioid receptors in thermoregulation, it is unclear whether delta receptors located in the brain or periphery play the more critical role in body temperature regulation. Moreover, it is not entirely clear which delta receptor phenotype, delta1 or delta2,...

journal_title：Brain research

authors： Rawls SM,Hewson JM,Inan S,Cowan A

更新日期：2005-07-05 00:00:00

abstract：:Dynamic microvascular remodeling maintains an optimal continuous supply of oxygen and nutrients to the brain to account for prolonged environmental variations. The objective of this study was to determine the relative time course of capillary regression during re-oxygenation after exposure to prolonged moderate hypoxi...

journal_title：Brain research

authors： Benderro GF,LaManna JC

更新日期：2014-06-20 00:00:00

abstract：:The melanocortin (MC)4 receptor is important for food intake and weight homeostasis as it mediates the orexigenic and anorexigenic effects of the MCs. OLETF (Otsuka-Long-Evans-Tokushima-Fatty) rats are a selective inbred strain of polygenic variant rats which overeat and develop obesity with elevated leptin levels. We...

journal_title：Brain research

authors： Lindblom J,Schiöth HB,Watanobe H,Suda T,Wikberg JE,Bergström L

更新日期：2000-01-03 00:00:00

abstract：:Extracellular recordings were obtained from spontaneously active neurones located in the dorsal motor nucleus of vagus nerve ( DMX ) in slices of the rat brainstem. Oxytocin applied to the bath at concentrations of 10(-7) M or 10(-6) M excited 79% of these cells in a concentration-dependent, reversible manner. The rem...

journal_title：Brain research

authors： Charpak S,Armstrong WE,Mühlethaler M,Dreifuss JJ

更新日期：1984-05-21 00:00:00

abstract：:Trisomy 21 (Down syndrome) results in abnormalities in electrical membrane properties of cultured human fetal dorsal root ganglion (DRG) neurons. Action potentials have faster rates of depolarization and repolarization, with decreased spike duration, compared to diploid neurons. In order to analyze the faster depolari...

journal_title：Brain research

authors： Caviedes P,Ault B,Rapoport SI

更新日期：1990-03-05 00:00:00

abstract：:The neurotoxicity of ionomycin, a Ca2+ ionophore, was investigated in cultured cortical neurons from embryonic rats. While about 90% of neurons survived 2 h after exposure to ionomycin, the surviving neurons had decreased by about 30 to 40% at 16 h. Both RNA and protein synthesis inhibitors blocked this neurotoxicity....

journal_title：Brain research

authors： Takei N,Endo Y

更新日期：1994-07-25 00:00:00

abstract：:The distribution of neurocalcin-immunoreactive (NC-ir) primary sensory neurons was examined in the trigeminal ganglion (TG), mesencephalic trigeminal tract nucleus (Mes5) and intraoral structures. NC-ir primary sensory neurons were located in the TG but not the Mes5. The coexpression study demonstrated that virtually ...

journal_title：Brain research

authors： Ichikawa H,Hidaka H,Sugimoto T

更新日期：2000-05-02 00:00:00

abstract：:Serial ion-exchange and high-performance liquid chromatography separations were employed for the tissue extraction and purification of kynurenic acid (KYNA). Subsequently, the compound isolated from postmortem human brain tissue was unequivocally identified as KYNA by nuclear magnetic resonance and mass spectrometric ...

journal_title：Brain research

authors： Turski WA,Nakamura M,Todd WP,Carpenter BK,Whetsell WO Jr,Schwarcz R

更新日期：1988-06-28 00:00:00

abstract：:Hippocampal cholinergic neurostimulating peptide (HCNP), originally isolated from soluble fraction of young rat hippocampus and released from hippocampus by the stimulation of N-methyl-d-aspartate (NMDA) receptors, enhances the cholinergic phenotype development in vitro. HCNP precursor protein (HCNP-pp) has multiple f...

journal_title：Brain research

authors： Yamada K,Matsukawa N,Yuasa H,Hattori M,Nakazawa H,Borlongan CV,Ojika K

更新日期：2007-07-16 00:00:00

abstract：UNLABELLED:The hypothesis that the lower midbrain, specifically in and around the retrorubral field (RRF) and/or rubrospinal tract (rs), contains a tonic inhibitory mechanism on non-shivering thermogenesis (NST) was examined in urethane-anesthetized rats. It has been proposed that removal of the tonic inhibitory mechan...

journal_title：Brain research

authors： Shibata M,Uno T,Hashimoto M

更新日期：1999-07-03 00:00:00