Immunohistochemical localization of creatine kinase BB-isoenzyme in human brain: comparison with tubulin and astroprotein.

Abstract:

:The distribution of creatine kinase BB-isoenzyme in the human central nervous system (CNS) was investigated immunohistochemically and the findings were compared with the distributions of tubulin and astroprotein. Creatine kinase BB-isoenzyme existed both in neurons and astrocytes, and was universally distributed within the CNS. Tubulin was visualized only in the neuronal elements, namely perikarya, dendrites and axons, while astroprotein was exclusively visualized in astrocytes. A combination of immunohistochemistry for structural and soluble proteins may be a useful tool for the investigation of pathophysiological conditions within the CNS.

journal_name

Brain Res

journal_title

Brain research

authors

Yoshimine T,Morimoto K,Homburger HA,Yanagihara T

doi

10.1016/0006-8993(83)91338-0

subject

Has Abstract

pub_date

1983-04-11 00:00:00

pages

101-8

issue

1

eissn

0006-8993

issn

1872-6240

pii

0006-8993(83)91338-0

journal_volume

265

pub_type

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