Abstract:
:Neuropeptide-Y (NPY) cells in the intergeniculate leaflet (IGL) are known to modulate effects of arousal on the mammalian circadian system. However, the route through which this information reaches the IGL has not been established. Here, we provide evidence that the orexins (hypocretins) are uniquely positioned as a potential source of activity state feedback to the IGL in the grass rat, Arvicanthis niloticus. Specifically, many NPY cells in the grass rat IGL exhibit orexin-A (OXA) fiber appositions. Furthermore, NPY cells contacted by OXA fibers are significantly more likely to express Fos during nocturnal wheel running than are NPY cells without such contacts (P < 0.001).
journal_name
Brain Resjournal_title
Brain researchauthors
Nixon JP,Smale Ldoi
10.1016/j.brainres.2005.06.043subject
Has Abstractpub_date
2005-08-16 00:00:00pages
33-7issue
1-2eissn
0006-8993issn
1872-6240pii
S0006-8993(05)00874-7journal_volume
1053pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::This study determined if vasopressin generates superoxide anion (O2(-)) in a cyclooxygenase dependent manner and if such production contributes to impairment of dilation to activators of ATP sensitive K(+) (K(ATP)) and calcium sensitive K(+) (K(ca)) channels following fluid percussion brain injury (FPI) in newborn pig...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)02716-0
更新日期:2001-08-10 00:00:00
abstract::The distribution of nitric oxide synthase (NOS)-, choline acetyltransferase (ChAT)-, and vasoactive intestinal polypeptide (VIP)-immunoreactivities, and nicotinamide adenine dinucleotide phosphate diaphorase (NADPHd)-reactivities in the sphenopalatine ganglia (SPG), and perivascular nerves in middle cerebral arteries ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00548-4
更新日期:1998-08-10 00:00:00
abstract::The responses of single neurons in the insular cortex to electrical stimulation of the chorda tympani (CT), lingual-tonsillar branch of the glossopharyngeal (LT-IXth) nerve, pharyngeal branch of the glossopharyngeal (PH-IXth) nerve, and superior laryngeal (SL) nerve were recorded in anaesthetized and paralyzed rats. N...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)00483-6
更新日期:1997-07-25 00:00:00
abstract::We have studied the effects of prenatal protein malnutrition on development of the hippocampal and frontal cortical electroencephalographic (EEG) activity. Using power spectral analyses in rats of several age groups we found that protein malnutrition, instituted prenatally and continued postnatally, produces marked al...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(85)90172-5
更新日期:1985-10-01 00:00:00
abstract::We have investigated the receptor subtype(s) mediating the noradrenergic inhibition of cerebellar Purkinje cell spontaneous firing rate using local application of specific agonists and antagonists, in situ, via pressure microejection. Extracellular action potentials were recorded from Purkinje neurons in anesthetized ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90552-5
更新日期:1988-10-18 00:00:00
abstract::Intracellular Neurobiotin-injections were used to label functionally identified neurons in the rostro-dorsomedial part of the trigeminal oral nucleus (Vo.r) in the cat. The labeled Vo.r neurons with the mechanoreceptive field in oral tissues innervated bilaterally either jaw-opening motoneurons or jaw-closing motoneur...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2004.12.042
更新日期:2005-03-02 00:00:00
abstract::In order to determine the origin of the catecholamine innervation of the rat piriform cortex (PC), we combined retrograde transport of the B subunit of the cholera toxin (CTb) with tyrosine hydroxylase (TH) immunohistochemistry. A substantial number of CTb retrogradely labeled cells was found in the parabrachial pigme...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)01279-6
更新日期:1996-02-26 00:00:00
abstract::Until now, there has been no effective therapy for chronic sensorineural hearing impairment. This study investigated the role of bone marrow cells (BMCs) in cochlear dysfunction. BALB/c mice (2 months of age), a non-presbycusis-prone mouse strain, were lethally irradiated and then transplanted with BMCs from SAMP1 mic...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.08.074
更新日期:2006-11-20 00:00:00
abstract::The immunolocalization of the 14-3-3 eta isoform in the anterior horn cells (AHCs) of patients with sporadic amyotrophic lateral sclerosis (ALS) and controls was examined. Compared with the immunolocalization of other 14-3-3 isoforms, the immunolocalization of the 14-3-3 eta isoform was either synaptic at the peripher...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2016.05.051
更新日期:2016-09-01 00:00:00
abstract::Extracellular recordings were made from 29 respiration-phased neurons in the upper cervical spinal cord (C1-C3) in nine anesthetized rats while ipsilateral and contralateral vagi were stimulated via platinum hook electrodes. Neuronal responses to vagal stimulation were recorded using peristimulus histograms. An accumu...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)91143-3
更新日期:1992-10-30 00:00:00
abstract::The responses of single alpha motoneurons to various "natural' stimuli were recorded from dissected ventral root filaments in lightly anesthetized control and recently decerebellate cats. The identity of the motoneurons was established by recording the unitary responses to orthodromic stimulation of nerves innervating...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(75)90208-5
更新日期:1975-09-12 00:00:00
abstract::The epileptogenic properties of the mast cell degranulating peptide (MCD) have been investigated in the CA3 region of the hippocampal slice preparation. Brief (3-5 min) bath application of MCD (0.5-2 microM) to CA3 hippocampal neurones produced an enhancement of the spontaneous synaptic activity and the appearance of ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)91077-3
更新日期:1988-03-29 00:00:00
abstract::Immunocytochemical and immunoblotting technique have been used to characterize the antigens recognized by two monoclonal antibodies (MAbs C6 and D5) produced against dissociated cells from punches of neonatal supraoptic (SON) and paraventricular (PVN) hypothalamic nuclei of the rat. Peroxidase immunocytochemistry reve...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)91281-5
更新日期:1991-04-05 00:00:00
abstract::The ontogenic development of neurophysin has not been investigated so far. To study this problem, electron microscopic immunohistochemistry was performed on ultrathin sections of the posterior pituitary of foetal and newborn rats. A concomitant appearance of secretory granules and neurophysin was first noted in the po...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(77)90007-5
更新日期:1977-07-01 00:00:00
abstract::This study investigated the effects of N6-cyclopentyladenosine (CPA), a potent and selective adenosine A1 receptor (A1R) agonist in normal and nerve-injured rats and mechanisms of its action by behavioral tests and electrophysiological technique. The results showed: (1) In normal rats, intraperitoneal administration o...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.09.034
更新日期:2010-11-18 00:00:00
abstract::Inorganic mercury (Hg2+) reduced voltage-gated calcium channel currents irreversibly in two different preparations. In cultured rat dorsal root ganglion (DRG) neurons, studied with the whole cell patch clamp technique, a rapid concentration-dependent decrease in the L/N-type currents to a steady state was observed wit...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91146-j
更新日期:1993-12-31 00:00:00
abstract::We examined the involvement of tumor necrosis factor (TNF)-alpha on glutamate-induced cytotoxicity in a differentiated neuronal cell line. In this study, we used nerve growth factor (NGF)-differentiated PC12h cells. Glutamate cytotoxicity was assessed using the MTS and TUNEL assays. To detect TNF-alpha levels in cultu...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.09.006
更新日期:2006-11-29 00:00:00
abstract::Temperature dysregulation is well known in generalized convulsive status epilepticus but so far has not been reported in non-convulsive forms. In order to detect possible subtle alterations, we have analyzed the capability to compensate for external cooling in an animal model of limbic status epilepticus. Rats with el...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.10.034
更新日期:2007-01-05 00:00:00
abstract::The distribution of creatine kinase BB-isoenzyme in the human central nervous system (CNS) was investigated immunohistochemically and the findings were compared with the distributions of tubulin and astroprotein. Creatine kinase BB-isoenzyme existed both in neurons and astrocytes, and was universally distributed withi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)91338-0
更新日期:1983-04-11 00:00:00
abstract::The mechanism(s) underlying age-associated diminutions in the rat striatal D2 dopamine receptor (D2-receptor) number was investigated. The levels of D2-receptor mRNA in 4-, 12- and 18-month-old rat striata were found not to change. In contrast, the levels of 110 kDa protein, labeled with a D2-receptor specific antibod...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)90095-q
更新日期:1992-03-20 00:00:00
abstract::Infrared differential interference contrast (IR DIC) videomicroscopy was used to measure and characterize cell swelling induced by activation of glutamate receptors (GluR) in a neostriatal brain slice preparation. This swelling is, in many cases, a prelude to necrotic cell death. Activation of N-methyl-D-aspartate (NM...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(96)00323-x
更新日期:1996-06-17 00:00:00
abstract::The discontinuous terminal distributions of thalamo- and nigrostriatal axons were examined in adjacent tissue sections from single cat brains by combined anterograde labeling with tritiated proline autoradiography and wheat germ-horseradish peroxidase histochemistry. Injection of one tracer into the centromedian-paraf...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90287-2
更新日期:1985-05-27 00:00:00
abstract::The aim of the present study was to develop a model culture system for the study of factors controlling regeneration of axons from injured adult mammalian central nervous system. We show, for the first that retinal ganglion cells (RGC) dissociated from adult rat retina, regrow processes in vitro over long distances un...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(88)90204-0
更新日期:1988-07-01 00:00:00
abstract::Serum-free aggregating cell cultures of fetal rat telencephalon grown in the presence of 3 ng/ml (5 X 10(-10) M) epidermal growth factor (EGF) until day 12 showed 2- to 3-fold increased activities in the two glial enzymes, glutamine synthetase (GLU-S) and 2',3'-cyclic nucleotide 3'-phosphohydrolase (CNPase). This effe...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(83)90222-5
更新日期:1983-12-01 00:00:00
abstract::By the use of anti-omega-CTx antibodies in indirect immunofluorescence we demonstrated the presence of omega-CTx binding sites in the presynaptic compartment of frog nerve-muscle preparations. The images we obtained indicate that omega-CTx-sensitive channels are clustered at discrete sites corresponding in distributio...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90981-z
更新日期:1991-05-03 00:00:00
abstract::To elucidate the anatomical distribution of the serotonergic neurotransmitter system, we identified serotonin transporter (5-HTT) in the hippocampus of rats and monkeys by immunohistochemistry. A widespread and heterogeneous distribution of 5-HTT-immunoreactive fine fibers was noted in the rat brain. However, in monke...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2004.03.013
更新日期:2004-06-04 00:00:00
abstract::The development of glial precursor cells in the mammalian optic nerve depends on retinal ganglion cell (RGC) axons, but the signals that mediate this neuron-to-glia interaction have not been fully characterized. Sonic hedgehog (Shh) is expressed by RGCs, and we showed previously that it is required for the specificati...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.06.058
更新日期:2008-09-04 00:00:00
abstract::Increases in concentration of brain NO are proposed to initiate and mediate migraine headache. Triggered by focal depolarisation, spreading depression (SD) represents a suitable mechanism for eliciting widespread release of nitric oxide. The current study examines the effect of sumatriptan, a 5-HT(1B/1D) agonist and e...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02400-8
更新日期:2000-07-07 00:00:00
abstract::Endothelin-1 (ET-1) has been implicated in hematoma-induced cerebral vasoconstriction and modification of cerebral microvascular reactivity, particularly attenuation of vasodilation to cAMP-dependent dilators and enhanced vasoconstriction to ET-1. We examined effects of the ET-1 antagonist, BQ-123, on hematoma-induced...
journal_title:Brain research
pub_type: 杂志文章
doi:
更新日期:1996-09-23 00:00:00
abstract::Specific binding of [3H]naloxone to rat brain tissue in vitro was inhibited by the excitant organochlorinated insecticides (OCI), by ether (E) and octanol (OCT), and by the convulsant indoklon (IND) and its anesthetic isomer, isoindoklon (ISO). In the presence of 100 mM NaCl the inhibition of naloxone binding by E, OC...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)90277-8
更新日期:1981-08-24 00:00:00