Orexin fibers form appositions with Fos expressing neuropeptide-Y cells in the grass rat intergeniculate leaflet.

Abstract:

:Neuropeptide-Y (NPY) cells in the intergeniculate leaflet (IGL) are known to modulate effects of arousal on the mammalian circadian system. However, the route through which this information reaches the IGL has not been established. Here, we provide evidence that the orexins (hypocretins) are uniquely positioned as a potential source of activity state feedback to the IGL in the grass rat, Arvicanthis niloticus. Specifically, many NPY cells in the grass rat IGL exhibit orexin-A (OXA) fiber appositions. Furthermore, NPY cells contacted by OXA fibers are significantly more likely to express Fos during nocturnal wheel running than are NPY cells without such contacts (P < 0.001).

journal_name

Brain Res

journal_title

Brain research

authors

Nixon JP,Smale L

doi

10.1016/j.brainres.2005.06.043

subject

Has Abstract

pub_date

2005-08-16 00:00:00

pages

33-7

issue

1-2

eissn

0006-8993

issn

1872-6240

pii

S0006-8993(05)00874-7

journal_volume

1053

pub_type

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