Chloride-dependent pH regulation in connective glial cells of the leech nervous system.

Abstract:

:We used double-barreled pH-sensitive microelectrodes to study the mechanisms by which the intracellular pH is regulated in the connective glial cells of the medicinal leech. The experiments indicate that a Cl(-)- and HCO3(-)-dependent mechanism mediates some recovery from intracellular alkalosis even in the absence of external Na+. This suggests the presence of Na(+)-independent Cl-/HCO3- exchange in the connective glial membrane. At alkaline pHi, this exchange most likely operates in the direction of net acid loading (i.e. HCO3- efflux).

journal_name

Brain Res

journal_title

Brain research

authors

Szatkowski MS,Schlue WR

doi

10.1016/0006-8993(94)91144-4

subject

Has Abstract

pub_date

1994-11-28 00:00:00

pages

1-4

issue

1

eissn

0006-8993

issn

1872-6240

pii

0006-8993(94)91144-4

journal_volume

665

pub_type

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